Acknowledgements
1 Summaries
1.1 Abstracts
1.2 Résumé en français
1.2.1 Introduction
1.2.2 Matériel et méthodes
1.2.3 Résultats
1.2.4 Discussion
2 Introduction
2.1 Local Delivery Devices
2.2 Poly (ortho esters)
2.3 Previous experiments
2.4 Purpose
3 Material and methods
3.1 Subjects
3.2 Formulations
3.3 Clinical protocol
3.3.1 Part I
3.3.2 Part II
3.3.3 Part III
3.4 Laboratory procedures
4 Results
4.1 Part I
4.1.1 Tolerance
4.1.2 Retention
4.2 Part II
4.2.1 Tolerance
4.2.2 Retention
4.3 Part III
4.3.1 Tolerance
4.3.2 Retention
4.4 Release of tetracycline
5 Discussion
5.1 Retention
5.2 Bioavailability
5.3 Release kinetics
6 Conclusion
7 References
8 Appendix