Remerciements
1. Summaries
1.1. Abstracts
1.1.1. Cytokine response to plaque accumulation in smokers and non-smokers.
1.1.2. CYTOKINES DU FLUIDE GINGIVAL APRES ACCUMULATION DE PLAQUE CHEZ DES FUMEURS ET NON-FUMEURS
1.2. Résumé en français
1.2.1. Introduction
1.2.2. Matériel et méthodes
1.2.3. Résultats
1.2.4. Discussion
1.2.5. Conclusions
2. Introduction
2.1. The role of cigarette smoking in the pathogenesis of periodontal disease
2.2. Diagnosis of periodontal disease activity
2.3. Cytokines
2.4. Experimental gingivitis
2.5. Aim of the study
3. Material and Methods
3.1. Subject population
3.2. Outline of the study
3.3. Site selection
3.4. Clinical examination
3.4.1. Criteria for the Plaque Index system (Silness & Loe 1964)
3.4.2. Criteria for the Gingival Index system (Loe 1967)
3.5. Gingival crevicular fluid sampling
3.6. Analysis of cytokine production
3.6.1. The ELISA method (Voller et al. 1976)
3.7. Data analysis
4. Results
4.1. Reproducibility
4.2. Clinical characteristics
4.3. Gingival crevicular fluid mediator levels
5. Discussion
6. Conclusion
7. Acknowledgements
References
Appendix