Ultrasonographia and Neurovascular Pathology
1. A novel risk index combining degree of stenosis and plaque morphology of the carotid artery: a multicenter study on asymptomatic 60-80% or symptomatic 50-69% carotid stenosis
High resolution ultrasound is a useful tool to caracterise the structure of the carotid plaque. We developed a method based on a colour mapping of the grey-scale values of the whole plaque as well as of its surface. The purpose of the present study is to determine the predictive value of a novel risk index calculated on the ground of the degree of stenosis and of the proportion of the predominant colour at the surface of the plaque.
2. PET-CT and ultrasonography of the carotid plaque: a comparative study on symptomatic and asymptomatic patients
Vulnerable atherosclerotic plaques responsible for ischemic strokes are characterized by high numbers of inflammatory cells and proteins.
The aim of our study is to evaluate whether PET co-registered with CT shows an increased accumulation of 18FDGin carotid artery plaques, with a higher uptake in symptomatic as compared with asymptomatic ones.
3. Morphological charactéristics of the patent foramen ovale and occurrence of cerebrovascular events : an MRI study in patients woth cryptogenic stroke.
Patent foramen ovale (PFO) is a well established cause of ischemic stroke in young patients with cryptogenic stroke. A certain number of studies suggest that interatrial septal aneurysm which may be associated to the patent foramen increases the risk of stroke recurrence. Other studies however do not allow demonstrate any particular association between the size of the foramen ovale and the embolic risk. The aim of our study is to determine the correlation between the morphological characteristics of the PFO and the number as well as the distribution of lesions on MRI.
4. Etude TRUST : transcranial ultrasound enhanced thormbolysis) (PI: Prof R Baumgartner, University Hospital, Zurich).
Thrombolysis with intravenous (iv) tissue plasminogen activator (t-PA) is the only effective and approved therapy for acute ischemic stroke. The most frequent cause of ischemic stroke is thrombosis of the middle cerebral artery (MCA).