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The Pathology Department conducts research into anatomical and clinical correlations in human pathology, and in the fields of cell biology, general immunology and immunopathology. 

Concerning cell biology, several teams study:

  • growth factors and the oncogenes involved in the differentiation and functioning of the lymphohematopoietic system
  • the functional role of certain parts of the cytoskeletal apparatus, in particular actin and intermediary filaments, and how they change in the course of the arterial pathology of scar-tissue formation and the development of epithelial tumours and conjunctive tissue
  • the structure and function of the cell membrane

Research in immunology focusses on:

  • Functional specialisation of T lymphocyte subsets under experimental and pathological conditions
  • Synthesis and function of cytokines secreted by cells of the immune system under experimental and pathological conditions
  • Regulation and function of antigen presentation under experimental and pathological conditions

Research in pathology focusses on:

  • Cellular interactions promoting the development of spontaneous and provoked autoimmunity
  • Role of antibodies and immune complexes in triggering vascular lesions
  • Role of immune responses in pathological manifestations associated with infectious disease
  • Intra- and inter-cellular communication leading to the development of cardiovascular disease

 

Research Groups

  • Beat Imhof
    Adhesion molecules and the process of cell migration
  • Marisa Jaconi
    Cardiogenesis of human pluripotent stem cells and strategies of cell therapy                          
  • Brenda Kwak
    Connexins in cardiovascular disease
  • Karl-Heinz Krause
    Reactive oxygen species (ROS) and Embryonic stem cells
  • Doron Merkler
    Multiple Sclerosis
  • Walter Reith
    Regulation of antigen presentation and antigen presenting cells
  • Stéphanie Hugues
    Antigen presentations, autoimmune diseases, peripheral T-Cell tolerance.

Affiliated Clinical Groups

  • Constance Barazzone  (Department of Paediatrics)
    Role of oxidative stress in acute and chronic lung disease                                    
  • Wolf-Henning Boehncke  (Department of Internal Medicine Specialities)
    Mechanisms of the pathologies of the cutaneous inflammation
  • Carlo Chizzolini (Department of Internal Medicine Specialities)
    Inflammation, autoimmunity and extracellular matrix
  • Cem Gabay (Department of Internal Medicine Specialities)
    Mechanisms of articular inflammation and joint damage in arthritis
  • Claire-Anne Siegrist (Department of Pediatry)
    Center of Vaccinology and Neonatal Immunology
  • Patrice Lalive d'Epinay (Department of Clinical Neurosciences)
    Neuroimmunology, Experimental autoimmune encephalitis, Multiple sclerosis.
  • Barbara Wildhaber (Department of Pediatry)
    Lentiviral hepatocyte ex vivo gene therapy of rare inborn metabolic liver diseases: improvement of the therapeutic efficacy and biosafety by combination with stem cell technology.
  • Jean Villard and Sylvie Ferrari-Lacraz (Department of Internal Medicine Specialities)
    Transplantations and Osteoimmonology

 

Department of Clinical Pathology, Hospital Department of Medical Genetics and Laboratory
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