Congratulations to Lingzi Li for her successful thesis defence
On Friday, December 8th 2017, Lingzi Li from the lab of Prof. Pierre Maechler successfully defended her thesis entitled “Mitochondrial Function and Morphology in Prohibitin 2 Deleted ß-Cells and Hepatocytes”.
Lingzi began her PhD studies in February 2014, which focused on characterizing the metabolic defects and cytopathology of mice bearing conditional deletion of Prohibitin-2 (PHB2). Prohibitins are proteins expressed on the mitochondrial inner membrane whose functions are not entirely understood but are required for optimal mitochondrial architecture and function, and thus energy homeostasis. Importantly, previous work in the Maechler lab has shown that PHB2 deletion in mouse pancreatic β cells induces diabetes. Lingzi’s work now goes a step further characterizing the impact of PHB2 deletion in the pancreas and liver, and may reveal new insights into cellular and molecular mechanisms that can lead to diabetes and fatty liver disease. Lingzi is grateful for the kindness and professional help from all the people in PHYM department during her PhD journey.
Wishing her all the best in her future endeavors!
Posted by: P. Nunes-Hasler20 December 2017