Recent Research Publications

SELECTED_EARLIER_PUBLICATIONS

Edelstein, S.J. and Changeux, J.-P. (2010). Relationships between structural dynamics and functional kinetics in oligomeric membrane receptors. Biophys. J. 98; 2045-2052. [pdf]

Edelstein, S. J., Stefan, M.I., and Le Novère (2010). Ligand depletion in vivo modulates the dynamic range and cooperativity of signal transduction. PLoS ONE 5: e8449, 10 pages. [pdf]

Stefan, M.I., Edelstein, S. J., and Le Novère (2009). Computing phenomomenologic Adair-Klotz constants from microscopic MWC parameters. BMC Systems Biology 3: 68 [pdf]

Stefan, M.I., Edelstein, S. J., and Le Novère (2008). An allosteric model of calmodulin explains differential activation of PP2B and CaMKII. Proc. Natl. Acad. Sci. U.S.A. 105: 10768-10773. [pdf]

Changeux, J.-P. and Edelstein, S. J. (2005). Nicotinic Acetylcholine Receptors: From Molecular Biology to Cognition. Editions Odile Jacob/Johns Hopkins University Press, 296 pages. [web site]

Changeux, J.-P. and Edelstein, S. J. (2005). Allosteric mechanisms of signal transduction. Science. 308:1424-1428. [pdf]

Caburet, S., Conti, C., Schurra, C. Lebofsky, R., Edelstein, S. J. and Bensimon, A. (2005). Human Ribosomal RNA gene arrays display a broad range of palindromic structures. Genome Res. 15:1079-1095.[pdf]

Edelstein, S. J. (2005). Structures of the lac operon proteins. C. R. Biol. 328: 511-513. [pdf]

Grutter, T., de Carvalho, L. P. Dufresne, V., Taly, A., Edelstein, S. J. and Changeux, J.-P.  (2005) Molecular tuning of fast gating in pentameric ligand-gated ion channels.Proc Natl Acad Sci U S A. 102:18207-12. [pdf]

Grutter, T., Prado de Carvalho, L., Le Novere, N., Corringer, P. J., Edelstein, S. and  Changeux, J.-P. (2003). An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors. EMBO J. 22, 1990-2003.  [pdf] 

Edelstein S. J. (2003). John Edsall and ligand-linked subunit interactions in hemoglobin. Biophys. Chem. 100, 117-121. [pdf]

Changeux, J.-P. and Edelstein, S. J. (2001). Allosteric mechanisms in normal and pathological nicotinic acetylcholine receptors. Curr. Opin. Neurobiol. 11: 369-77. [pdf]

Palanche, T., Ilien, B., Zoffmann, S., Reck, M. P., Bucher, B., Edelstein, S. J., and Galzi, J. L. (2001). The Neurokinin A Receptor Activates Calcium et cAMP Responses through Distinct Conformational States. J. Biol. Chem. 276:, 34853-34861. [pdf]

Martinez, K. L., Corringer, P. J., Edelstein, S. J., Changeux, J. P., and Merola, F. (2000). Structural Differences in the Two Agonist Binding Sites of the Torpedo Nicotinic Acetylcholine Receptor Revealed by Time-Resolved Fluorescence Spectroscopy. Biochemistry 39:6979-6990. [pdf]

Changeux, J.-P. and Edelstein, S. J. (1998) Allosteric Receptors after 30 Years. Neuron 21: 959-980. [pdf]

Edelstein, S.J. and Changeux, J.-P. (1998). Allosteric Transitions of the Acetylcholine Receptor. Adv.Prot.Chem. 51: 121-184. [pdf

Corringer, P.J., Bertrand, S., Bohler, S., Edelstein, S.J., Changeux, J.-P. and Bertrand, D. (1998). Critical elements determining diversity in agonist binding and desensitization of neuronal nicotinic acetylcholine receptors. J.Neurosci. 18: 648-657. [pdf]

Kiger, L., Dumoulin, A., Edelstein, S. J., Abraham, D. J., Prome, D., Poyart, C., Marden, M. C., and Pagnier, J. (1998). Chimeric beta-EF3-alpha hemoglobin (Psi): energetics of subunit interaction and ligand binding. Biochemistry 37: 7328-39. [pdf]

Edelstein, S.J. and Bardsley, W.G. (1997). Contributions of individual molecular species to the Hill coefficient for ligand binding by an oligomeric protein. J.Mol.Biol. 267: 10-16. [pdf]

Edelstein, S.J., Schaad, O. and Changeux, J.-P. (1997). Myasthenic nicotinic receptor mutant interpreted in terms of the allosteric model. C.R.Acad.Sci.Paris 320: 953-961. [pdf]

Edelstein, S.J., Schaad, O. and Changeux, J.P. (1997). Single binding versus single 36:13755-13760. [pdf]

Galzi, J.L., Edelstein, S.J. and Changeux, J.P. (1996). The multiple phenotypes of allosteric receptor mutants. Proc.Natl.Acad.Sci.USA 93: 1853-1858. [pdf]

Edelstein, S.J. (1996). An allosteric theory for hemoglobin incorporating asymmetric 257:737-744. [pdf]

Edelstein, S.J., Schaad, O., Henry, E., Bertrand, D. and Changeux, J.P. (1996). A kinetic mechanism for nicotinic acetylcholine receptors based on multiple allosteric transitions. Biol.Cybern. 75: 361-379. [pdf]

 

last update 7 Jan 2010