Stuart J. Edelstein

Recent Research Publications   SELECTED_EARLIER_PUBLICATIONS

Menny, A., Lefebvre, S.N., Schmidpeter, P.A., Drège, E., Fourati, Z., Delarue, M., Edelstein, S.J., Nimigean, C.M. , Joseph, D., Corringer, P.J. (2017) Identification of a pre-active conformation of a pentameric channel receptor. Elife DOI: 10.7554/eLife.23955. [pdf].

Edelstein, S.J., & Changeux J.-P. (2016) Biased Allostery. Biophys J. 111.902-908. [pdf].

Dutta-Roy, R., Rosenmund, C., Edelstein, S.J., & Le Novère, N. (2015) Ligand-Dependent Opening of the Multiple AMPA Receptor Conductance States: A Concerted Model. PLoS One 10(1): e0116616. doi:10.1371/journal.pone.0116616. [pdf].

Lai, M., Brun, D., Edelstein, S.J., & Le Novère, N. (2015) Modulation of Calmodulin Lobes by Different Targets: An Allosteric Model with Hemiconcerted Conformational Transitions. PLoS Comput. Biol.11: e1004063, 28 pages. [pdf].

Edelstein, S.J. (2014). A novel equation for cooperativity of the allosteric state function.J. Mol. Biol. 426: 39-42. [pdf]

Prevost, M.S., Moraga-Cid, G., Van Renterghem, C., Edelstein, S.J., Changeux, J.P., and Corringer, P.J. (2013). Intermdiate closed state for glycine receptor function revealed by cysteine cross-linking. Proc. Natl. Acad. Sci. USA 110: 17113-8. [pdf]

Edelstein, S. J. (2013). Allosteric Interactions after 50 Years. J. Mol. Biol. 425, 1391-5. [pdf]

Edelstein, S. J. & Le Novere, N. (2013). Cooperativity of Allosteric Receptors. J. Mol. Biol. 425, 1424-32.[pdf]

Edelstein, S. J., EDITOR'S PREFACE TO: Crick, F. H. & Wyman, J. (2013). A footnote on allostery. J. Mol. Biol. 425, 1500-8. [pdf]

Poitevin, F. & Edelstein, S. J. (2013). Derivation of the Crick-Wyman Equation for Allosteric Proteins Defining the Difference between the Number of Binding Sites and the Hill Coefficient. J. Mol. Biol. 425, 1497-9. [pdf] [Corrigendum]

Endler, L., Stefan, M. I., Edelstein, S. J., and Le Novère, N. (2012), Using chemical kinetics to model neuronal signaling pathways. In Computational Systems Neurobiology, Le Novère, N., ed. Springer. ISBN-13: 978-9400738577. [pdf]

Changeux, J.-P. & Edelstein, S. J. (2012). The brain as a chemical machine: Nicotinic receptors and neuronal communication Odile Jacob Publishing Corporation, New York.[web site]

Changeux, J.-P. and Edelstein, S.J. (2011). Conformational selection or induced fit? Fifty years of debate resolved. F1000 Biology Reports 3:19. [pdf]

Edelstein, S.J. and Changeux, J.-P. (2010). Relationships between structural dynamics and functional kinetics in oligomeric membrane receptors. Biophys. J. 98; 2045-2052. [pdf]

Edelstein, S. J., Stefan, M.I., and Le Novère, N. (2010). Ligand depletion in vivo modulates the dynamic range and cooperativity of signal transduction. PLoS ONE 5: e8449, 10 pages. [pdf]

Stefan, M.I., Edelstein, S. J., and Le Novère, N. (2009). Computing phenomomenologic Adair-Klotz constants from microscopic MWC parameters. BMC Systems Biology 3: 68 [pdf]

Stefan, M.I., Edelstein, S. J., and Le Novère, N. (2008). An allosteric model of calmodulin explains differential activation of PP2B and CaMKII. Proc. Natl. Acad. Sci. U.S.A. 105: 10768-10773. [pdf]

Changeux, J.-P. and Edelstein, S. J. (2005). Nicotinic Acetylcholine Receptors: From Molecular Biology to Cognition. Editions Odile Jacob/Johns Hopkins University Press, 296 pages. [web site]

Changeux, J.-P. and Edelstein, S. J. (2005). Allosteric mechanisms of signal transduction. Science. 308:1424-1428. [pdf]

Caburet, S., Conti, C., Schurra, C. Lebofsky, R., Edelstein, S. J. and Bensimon, A. (2005). Human Ribosomal RNA gene arrays display a broad range of palindromic structures. Genome Res. 15:1079-1095.[pdf]

Edelstein, S. J. (2005). Structures of the lac operon proteins. C. R. Biol. 328: 511-513. [pdf]

Grutter, T., de Carvalho, L. P. Dufresne, V., Taly, A., Edelstein, S. J. and Changeux, J.-P. (2005) Molecular tuning of fast gating in pentameric ligand-gated ion channels.Proc Natl Acad Sci U S A. 102:18207-12. [pdf]

Grutter, T., Prado de Carvalho, L., Le Novere, N., Corringer, P. J., Edelstein, S. and  Changeux, J.-P. (2003).
An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors. EMBO J. 22: 1990-2003.  [pdf] 

Edelstein S. J. (2003). John Edsall and ligand-linked subunit interactions in hemoglobin. Biophys. Chem. 100: 117-121. [pdf]

Changeux, J.-P. and Edelstein, S. J. (2001). Allosteric mechanisms in normal and pathological nicotinic acetylcholine receptors. Curr. Opin. Neurobiol. 11: 369-77. [pdf]

Palanche, T., Ilien, B., Zoffmann, S., Reck, M. P., Bucher, B., Edelstein, S. J., and Galzi, J. L. (2001). The Neurokinin A Receptor Activates Calcium et cAMP Responses through Distinct Conformational States. J. Biol. Chem. 276:, 34853-34861. [pdf]

Martinez, K. L., Corringer, P. J., Edelstein, S. J., Changeux, J. P., and Merola, F. (2000). Structural Differences in the Two Agonist Binding Sites of the Torpedo Nicotinic Acetylcholine Receptor Revealed by Time-Resolved Fluorescence Spectroscopy. Biochemistry 39: 6979-6990. [pdf]

Changeux, J.-P. and Edelstein, S. J. (1998) Allosteric Receptors after 30 Years. Neuron 21: 959-980. [pdf]

Edelstein, S.J. and Changeux, J.-P. (1998). Allosteric Transitions of the Acetylcholine Receptor. Adv.Prot.Chem. 51: 121-184. [pdf

Corringer, P.J., Bertrand, S., Bohler, S., Edelstein, S.J., Changeux, J.-P. and Bertrand, D. (1998). Critical elements determining diversity in agonist binding and desensitization of neuronal nicotinic acetylcholine receptors. J.Neurosci. 18: 648-657. [pdf]

Kiger, L., Dumoulin, A., Edelstein, S. J., Abraham, D. J., Prome, D., Poyart, C., Marden, M. C., and Pagnier, J. (1998). Chimeric beta-EF3-alpha hemoglobin (Psi): energetics of subunit interaction and ligand binding. Biochemistry 37: 7328-39. [pdf]

Edelstein, S.J. and Bardsley, W.G. (1997). Contributions of individual molecular species to the Hill coefficient for ligand binding by an oligomeric protein. J.Mol.Biol. 267: 10-16. [pdf]

Edelstein, S.J., Schaad, O. and Changeux, J.-P. (1997). Myasthenic nicotinic receptor mutant interpreted in terms of the allosteric model. C.R.Acad.Sci.Paris 320: 953-961. [pdf]

Edelstein, S.J., Schaad, O. and Changeux, J.P. (1997). Single binding versus single channel recordings: a new approach to study ionotropic receptors. Biochemistry 36:13755-13760. [pdf]

Galzi, J.L., Edelstein, S.J. and Changeux, J.P. (1996). The multiple phenotypes of allosteric receptor mutants. Proc.Natl.Acad.Sci.USA 93: 1853-1858. [pdf]

Edelstein, S.J. (1996). An allosteric theory for hemoglobin incorporating asymmetric states to test the putative molecular code for cooperativity. J. Mol. Biol. 257: 737-744. [pdf]

Edelstein, S.J., Schaad, O., Henry, E., Bertrand, D. and Changeux, J.P. (1996). A kinetic mechanism for nicotinic acetylcholine receptors based on multiple allosteric transitions. Biol.Cybern. 75: 361-379. [pdf]


last update: 6 September 2013