SHORT RÉSUMÉ
TEACHING ACTIVITIE
RESEARCH INTEREST
THE 5 KEY REFERENCES OF DOCTOR SOLDATI
 THE GROUP
Alumni from 1995

SHORT RÉSUMÉ

After studying biochemistry in Geneva, Thierry Soldati started his PhD in 1987 at the Institute of cell biology in the Swiss Federal Institute of Technology, Zurich, Switzerland, with Prof. Jean-Claude Perriard, working on muscle cell cytoarchitecture. From 1991, he was a postdoc in the Department of biochemistry at Stanford University, USA, with Prof. Suzanne Pfeffer, unraveling the function of Rab GTPases in endosomal membrane trafficking. In 1995, he joined the Max-Planck-Institute for medical research in Heidelberg, Germany, as an independent group leader in the Department of Prof. Wolfhard Almers. In 2001, he was appointed as a Lecturer in the Department of biological sciences at Imperial College London, UK. In 2004, he joined the Department of biochemistry of the University of Geneva as a Senior Lecturer

TEACHING ACTIVITIE

Doctor Thierry Soldati introduces the 1st year BSc students in biochemistry to the marvels of cell motility and the function of the cytoskeleton. He then shares his interest for the mechanisms of membrane traffic and endocytosis in particular with the 3rd year BSc students in biochemistry and biology. He also teaches a course on the structure organisation and function of the cytoskeleton, for the PhD programme in life science and the 3rd year BSc students

RESEARCH INTEREST

The main interest of Doctor Soldati's lab is to understand the integration, the cooperation of signalling, cytoskeleton and membrane trafficking in cellular processes such as cell motility and endocytosis/phagocytosis. In particular, the focus is on the importance of unconventional myosins and actin dynamics in these processes.

Doctor Soldati's team uses Dictyostelium discoideum as a model organism as it is a professional phagocyte very similar to mammalian neutrophiles in morphology and behaviour, but which is genetically and biochemically tractable.

The recent work of the team has concentrated on the proteomic characterisation of phagosomal components, as well as a comprehensive two-dimensional gel cartography and time-resolved profiling of phagosomal proteins.

Finally, Dictyostelium is being used as a model host to study infection and persistence of Mycobacterium marinum, a close cousin of the pathogen responsible for tuberculosis in human

THE 5 KEY REFERENCES OF DOCTOR SOLDATI

M. Hagedorn, K.H. Rohde, D.G. Russell and T. Soldati (2009). Infection by Tubercular Mycobacteria is Spread by Nonlytic Ejection from their Amoeba Hosts. Science, 323, 1729-1733.

M. Hagedorn and T. Soldati (2007). Flotillin and the RacH GTPase modulate intracellular immunity of Dictyostelium to Mycobacterium marinum infection. Cell Microbiol, 9, 2716-2733.

D. Gotthardt, V. Blancheteau, A. Bosserhoff, T. Ruppert, M. Delorenzi and T. Soldati (2006). Proteomics Fingerprinting of Phagosome Maturation and Evidence for the Role of a Ga during Uptake. Mol. Cell. Proteomics, 5, 2228-2243.

K. Yoshida and T. Soldati (2006). Dissection of Amoeboid Movement into two Mechanically Distinct Modes. J. Cell Sci., 119, 3833-3844.

E.M. Neuhaus, W. Almers and T. Soldati (2002). Morphology and Dynamics of the Endocytic Pathway in Dictyostelium discoideum. Mol. Biol. Cell, 13, 1390-1407.

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 THE GROUP

Alumni from 1995

Heidrun Geissler

Eva Schwarz (eva.schwarz@uniklinik-saarland.de)

Bettina Ulbricht

Eva Neuhaus (Eva.Neuhaus@ruhr-uni-bochum.de)

Thorsten Lang (tlang@mpibpc.gwdg.de)

Jean Monnat

Claudia Kistler (C.Kistler@dkfz-heidelberg.de)

Narayan Agrawal

Ronald Ullmann

Hans-Jörg Warnatz

Fengwei Wang (fw2003@columbia.edu)

Frank Schönsiegel

Marius Stefan Pop (Marius.Pop@pharmakol.uni-freiburg.de)

Frank Reichardt

Daniel Gotthardt (Daniel.Gotthardt@med.uni-heidelberg.de)

Yosuke Stefan von Heyden (y.vonheyden@imperial.ac.uk)

Kunito Yoshida (k.yoshida@imperial.ac.uk)

Vincent Blancheteau (v.blancheteau@imperial.ac.uk)

Mowe Saha (m.saha@imperial.ac.uk)

Jonathan G Matthews (jonathan.g.matthews@imperial.ac.uk)