Marko Kaksonen

Publications

2020

  • Lehal, Rajwinder; Zaric, Jelena; Vigolo, Michele; Urech, Charlotte; Frismantas, Viktoras; Zangger, Nadine; Cao, Linlin; Berger, Adeline; Chicote, Irene; Loubéry, Sylvain; Choi, Sung Hee; Koch, Ute; Blacklow, Stephen C.; Palmer, Hector G.; Bornhauser, Beat; González-Gaitán, Marcos; Arsenijevic, Yvan; Zoete, Vincent; Aster, Jon C.; Bourquin, Jean-Pierre; Radtke, Freddy (2020) Pharmacological disruption of the Notch transcription factor complex. Proc. Natl. Acad. Sci. USA 117 (28) 16292-16301.
  • Castanon, Irinka; Hannich, Joerg Thomas; Abrami, Laurence; Huber, Florian; Dubois, Marine; Müller, Markus; van der Goot, F. Gisou; Gonzalez-Gaitan, Marcos (2020) Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish. Nat. Commun. 11 art. num 3317.
  • Bürgi, Jérôme; Abrami, Laurence; Castanon, Irinka; Abriata, Luciano Andres; Kunz, Beatrice; Yan, Shixu Emili; Lera, Manuel; Unger, Sheila; Superti-Furga, Andrea; Peraro, Matteo Dal; Gonzalez Gaitan, Marcos; van der Goot, Francoise Gisou (2020) Ligand Binding to the Collagen VI Receptor Triggers a Talin-to-RhoA Switch that Regulates Receptor Endocytosis. Dev. Cell 53 (4) 418-430.e4.

2019

  • Manenschijn, Hetty E.; Picco, Andrea; Mund, Markus; Rivier-Cordey, Anne-Sophie; Ries, Jonas; Kaksonen, Marko (2019) Type-I myosins promote actin polymerization to drive membrane bending in endocytosis. eLife 8 e44215.

2018

  • Mund, Markus; van der Beek, Johannes Albertus; Deschamps, Joran; Dmitrieff, Serge; Hoess, Philipp; Monster, Jooske Louise; Picco, Andrea; Nédélec, François; Kaksonen, Marko; Ries, Jonas (2018) Systematic Nanoscale Analysis of Endocytosis Links Efficient Vesicle Formation to Patterned Actin Nucleation. Cell 174 (4) 884-896.e17.
  • Picco, Andrea; Kaksonen, Marko (2018) Quantitative imaging of clathrin-?mediated endocytosis. Curr. Opin. Cell Biol. 53 105-110.
  • Picco, Andrea; Kukulski, Wanda; Manenschijn, Hetty E.; Specht, Tanja; Briggs, John A. G.; Kaksonen, Marko (2018) The contributions of the actin machinery to endocytic membrane bending and vesicle formation. Mol. Biol. Cell 29 (11) 1346-1358.
  • Picco, Andrea; Kukulski, Wanda; Manenschijn, Hetty E.; Specht, Tanja; Briggs, John A. G.; Kaksonen, Marko (2018) The contributions of the actin machinery to endocytic membrane bending and vesicle formation. Mol. Biol. Cell 29 (11) 1346-1358.
  • Kaksonen, Marko; Roux, Aurélien (2018) Mechanisms of clathrin-mediated endocytosis. Nat. Rev. Mol. Cell Biol. 19 313-326.
  • Garcia-Alai, Maria M.; Heidemann, Johannes; Skruzny, Michal; Gieras, Anna; Mertens, Haydyn D. T.; Svergun, Dmitri I.; Kaksonen, Marko; Uetrecht, Charlotte; Meijers, Rob (2018) Epsin and Sla2 form assemblies through phospholipid interfaces. Nat. Commun. 9 (1) 328.

2017

2016

  • Kukulski, Wanda; Picco, Andrea; Specht, Tanja; Briggs, John A. G.; Kaksonen, Marko (2016) Clathrin modulates vesicle scission, but not invagination shape, in yeast endocytosis. eLife 5 e16036.
  • Bertipaglia, Chiara; Schneider, Sarah; Jakobi, Arjen J.; Tarafder, Abul K.; Bykov, Yury S.; Picco, Andrea; Kukulski, Wanda; Kosinski, Jan; Hagen, Wim J. H.; Ravichandran, Arvind C.; Wilmanns, Matthias; Kaksonen, Marko; Briggs, John A. G.; Sachse, Carsten (2016) Higher-order assemblies of oligomeric cargo receptor complexes form the membrane scaffold of the Cvt vesicle. EMBO Rep. 17 (7) 1044-1060.

2015

  • Avinoam, Ori; Schorb, Martin; Beese, Carsten J.; Briggs, John A. G.; Kaksonen, Marko (2015) Endocytic sites mature by continuous bending and remodeling of the clathrin coat. Science 348 (6241) 1369-1372.
  • Skruzny, Michal; Desfosses, Ambroise; Prinz, Simone; Dodonova, Svetlana O.; Gieras, Anna; Uetrecht, Charlotte; Jakobi, Arjen J.; Abella, Marc; Hagen, Wim J.H.; Schulz, Joachim; Meijers, Rob; Rybin, Vladimir; Briggs, John A.G.; Sachse, Carsten; Kaksonen, Marko (2015) An Organized Co-assembly of Clathrin Adaptors Is Essential for Endocytosis. Dev. Cell 33 (2) 150-162.
  • Picco, Andrea; Mund, Markus; Ries, Jonas; Nédélec, François; Kaksonen, Marko (2015) Visualizing the functional architecture of the endocytic machinery. eLife 4 e04535.

2014

  • Boeke, Dominik; Trautmann, Susanne; Meurer, Matthias; Wachsmuth, Malte; Godlee, Camilla; Knop, Michael; Kaksonen, Marko (2014) Quantification of cytosolic interactions identifies Ede1 oligomers as key organizers of endocytosis. Mol. Syst. Biol. 10 (11) 756-756.
  • Merrifield, Christien J.; Kaksonen, Marko (2014) Endocytic Accessory Factors and Regulation of Clathrin-Mediated Endocytosis. Cold Spring Harbor Perspect. Biol. 6 (11) a016733.
  • Xiol, Jordi; Spinelli, Pietro; Laussmann, Maike A.; Homolka, David; Yang, Zhaolin; Cora, Elisa; Couté, Yohann; Conn, Simon; Kadlec, Jan; Sachidanandam, Ravi; Kaksonen, Marko; Cusack, Stephen; Ephrussi, Anne; Pillai, Ramesh S. (2014) RNA Clamping by Vasa Assembles a piRNA Amplifier Complex on Transposon Transcripts. Cell 157 (7) 1698-1711.
  • Brach, Thorsten; Godlee, Camilla; Moeller-Hansen, Iben; Boeke, Dominik; Kaksonen, Marko (2014) The Initiation of Clathrin-Mediated Endocytosis Is Mechanistically Highly Flexible. Curr. Biol. 24 (5) 548-554.

2013

  • Godlee, Camilla; Kaksonen, Marko (2013) From uncertain beginnings: Initiation mechanisms of clathrin-mediated endocytosis. The Journal of Cell Biology 104 (10) 3793-725.
  • Maeda, Kenji; Anand, Kanchan; Chiapparino, Antonella; Kumar, Arun; Poletto, Mattia; Kaksonen, Marko; Gavin, Anne-Claude (2013) Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins. Nature 501 (7466) 257-261.
  • Gallego, Oriol; Specht, Tanja; Brach, Thorsten; Kumar, Arun; Gavin, Anne-Claude; Kaksonen, Marko; Keen, James (2013) Detection and Characterization of Protein Interactions In Vivo by a Simple Live-Cell Imaging Method. PLoS ONE 8 (5) e62195.

2012

2011

  • Brach, Thorsten; Specht, Tanja; Kaksonen, Marko (2011) Reassessment of the role of plasma membrane domains in the regulation of vesicular traffic in yeast. J. Cell Sci. 124 (3) 328-337.
  • Kukulski, Wanda; Schorb, Martin; Welsch, Sonja; Picco, Andrea; Kaksonen, Marko; Briggs, John A.G. (2011) Correlated fluorescence and 3D electron microscopy with high sensitivity and spatial precision. J. Cell Biol. 208 (1) 3-119.

2010

  • Gallego, Oriol; Betts, Matthew J.; Gvozdenovic-Jeremic, Jelena; Maeda, Kenji; Matetzki, Christian; Aguilar-Gurrieri, Carmen; Beltran-Alvarez, Pedro; Bonn, Stefan; Fernández-Tornero, Carlos; Jensen, Lars Juhl; Kuhn, Michael; Trott, Jamie; Rybin, Vladimir; Müller, Christoph W.; Bork, Peer; Kaksonen, Marko; Russell, Robert B.; Gavin, Anne-Claude (2010) A systematic screen for protein–lipid interactions in Saccharomyces cerevisiae. Mol. Syst. Biol. 6 (1) 430.

2008

2007

  • Sun, Yidi; Carroll, Susheela; Kaksonen, Marko; Toshima, Junko Y.; Drubin, David G. (2007) PtdIns(4,5)P2 turnover is required for multiple stages during clathrin- and actin-dependent endocytic internalization. J. Cell Biol. 177 (2) 355-367.

2006

2005

2003

  • Kaksonen, Marko; Sun, Yidi; Drubin, David G. (2003) A Pathway for Association of Receptors, Adaptors, and Actin during Endocytic Internalization. Cell 115 (4) 475-487.
  • Sekiya-Kawasaki, Mariko; Groen, Aaron Chris; Cope, M. Jamie T. V.; Kaksonen, Marko; Watson, Hadiya A.; Zhang, Chao; Shokat, Kevan M.; Wendland, Beverly; McDonald, Kent L.; McCaffery, J. Michael; Drubin, David G. (2003) Dynamic phosphoregulation of the cortical actin cytoskeleton and endocytic machinery revealed by real-time chemical genetic analysis. J. Cell Biol. 162 (5) 765-772.

2002

  • Kaksonen, Marko; Pavlov, Ivan; Võikar, Vootele; Lauri, Sari E.; Hienola, Anni; Riekki, Ruusu; Lakso, Merja; Taira, Tomi; Rauvala, Heikki (2002) Syndecan-3-Deficient Mice Exhibit Enhanced LTP and Impaired Hippocampus-Dependent Memory. Mol. Cell. Neurosci. 21 (1) 158-172.
  • Pavlov, Ivan; Võikar, Vootele; Kaksonen, Marko; Lauri, Sari E.; Hienola, Anni; Taira, Tomi; Rauvala, Heikki (2002) Role of Heparin-Binding Growth-Associated Molecule (HB-GAM) in Hippocampal LTP and Spatial Learning Revealed by Studies on Overexpressing and Knockout Mice. Mol. Cell. Neurosci. 20 (2) 330-342.

2001

  • Reizes, Ofer; Lincecum, John; Wang, Zihua; Goldberger, Olga; Huang, Li; Kaksonen, Marko; Ahima, Rexford; Hinkes, Michael T.; Barsh, Gregory S.; Rauvala, Heikki; Bernfield, Merton (2001) Transgenic Expression of Syndecan-1 Uncovers a Physiological Control of Feeding Behavior by Syndecan-3. Cell 106 (1) 105-116.

2000

  • Kaksonen, Marko; Peng, H. Benjamin; Rauvala, Heikki (2000) Association of cortactin with dynamic actin in lamellipodia and on endosomal vesicles. J. Cell Sci. 113 (24) 4421-4426.
  • Rauvala, Heikki; Huttunen, Henri J.; Fages, Carole; Kaksonen, Marko; Kinnunen, Tarja; Imai, Shinji; Raulo, Erkki; Kilpeläinen, Ilkka (2000) Heparin-binding proteins HB-GAM (pleiotrophin) and amphoterin in the regulation of cell motility. Matrix Biol. 19 (5) 377-387.
  • Kilpelainen, Ilkka; Kaksonen, Marko; Kinnunen, Tarja; Avikainen, Hanna; Fath, Melissa; Linhardt, Robert J.; Raulo, Erkki; Rauvala, Heikki (2000) Heparin-binding Growth-associated Molecule Contains Two Heparin-binding beta -Sheet Domains That Are Homologous to the Thrombospondin Type I Repeat. J. Biol. Chem. 275 (18) 13564-13570.

1999

  • Kinnunen, Anu; Niemi, Maria; Kinnunen, Tarja; Kaksonen, Marko; Nolo, Riitta; Rauvala, Heikki (1999) Heparan sulphate and HB-GAM (heparin-binding rowth-associated molecule) in the development of the thalamocortical pathway of rat brain. Eur. J. Neurosci. 11 (2) 491-502.

1998

  • Imai, Shinji; Kaksonen, Marko; Raulo, Erkki; Kinnunen, Tarja; Fages, Carole; Meng, Xiaojuan; Lakso, Merja; Rauvala, Heikki (1998) Osteoblast Recruitment and Bone Formation Enhanced by Cell Matrix-associated Heparin-binding Growth-associated Molecule (HB-GAM). J. Cell Biol. 143 (4) 1113-1128.
  • Fages, Carole; Kaksonen, Marko; Kinnunen, Tarja; Punnonen, Eeva-Liisa; Rauvala, Heikki (1998) Regulation of mRNA localization by transmembrane signalling: local interaction of HB-GAM (heparin-binding growth-associated molecule) with the cell surface localizes beta-actin mRNA. J. Cell Sci. 111 (20) 3073-3080.
  • Kinnunen, Tarja; Kaksonen, Marko; Saarinen, Juhani; Kalkkinen, Nisse; Peng, H. Benjamin; Rauvala, H. Benjamin (1998) Cortactin-Src Kinase Signaling Pathway Is Involved in N-syndecan-dependent Neurite Outgrowth. J. Biol. Chem. 273 (17) 10702-10708.
  • Kinnunen, Anu; Kinnunen, Tarja; Kaksonen, Marko; Nolo, Riitta; Panula, Pertti; Rauvala, Heikki (1998) N-Syndecan and HB-GAM (Heparin-Binding Growth-Associated Molecule) associate with early axonal tracts in the rat brain. Eur. J. Neurosci. 10 (2) 635-648.

1996

  • Nolo, Riitta; Kaksonen, Marko; Rauvala, Heikki (1996) Developmentally Regulated Neurite Outgrowth Response from Dorsal Root Ganglion Neurons to Heparin-binding Growth-associated Molecule (HB-GAM) and the Expression of HB-GAM in the Targets of the Developing Dorsal Root Ganglion Neurites. Eur. J. Neurosci. 8 (8) 1658-1665.

1995

  • Nolo, Riitta; Kaksonen, Marko; Raulo, Erkki; Rauvala, Heikki (1995) Co-expression of heparin-binding growth-associated molecule (HB-GAM) and N-syndecan (syndecan-3) in developing rat brain. Neurosci. Lett. 191 (1-2) 39-42.