WELCOME TO THE CITI LABORATORY

 
 

The goal of the Citi laboratory is to understand at the molecular level how the apical junctional complex of vertebrate epithelial cells controls epithelial function, morphogenesis, differentiation and proliferation.


Epithelial tissues play a fundamental role in the separation of different body compartments, and in the absorption and secretion functions of major organs (kidney, liver, lung, intestine, exocrine and endocrine glands, etc). The vast majority of cancers arises within epithelial organs, and invasion and metastasis correlate with disruption or loss of cell-cell junctions. Epithelia are also the first target of pathogens. Endothelial cells play a fundamental role in cardiovascular physiology.


We are interested in clarifying how specific protein components of epithelial tight and adherens junctions regulate signaling molecules and contribute to different aspects of epithelial cell function (barrier, adhesion, pathogen interaction, etc.).  


We use a combination of biochemical, cellular and in vivo approaches, including the generation and characterization of knockout mice, which help us to frame the significance of our discoveries within the context of a whole vertebrate organism.


Please browse the Research and Publications pages for more details of our work!




 

SIGNALLING AT VERTEBRATE CELL-CELL JUNCTIONS

Prof. Sandra Citi, MD, PhD


Dept. Cell Biology

University of Geneva

SciencesIII

4, Boulevard d’Yvoy

1211-4 Geneva

Switzerland


HOW TO REACH US:

http://www.unige.ch/sciences/biologie/bicel/directions.html


HOW TO CONTACT US

sandra.citi@unige.ch

Tel (Secretary): +41-22-3796194

Fax. +41-22-3796868

MDCKII CELLS