Multiple Ag atoms were doped inside Au38(SCH2CH2Ph)24 nanoclusters using the metal exchange method for the first time for the synthesis of AgxAu38â€“x(SCH2CH2Ph)24. MALDI-TOF mass spectrometry revealed the time dependence of the synthesis. Cluster species with different numbers of Ag atoms (different x values) migrate differently on a chromatography (HPLC) column, which allows one to isolate cluster samples with a narrowed distribution of exchanged metal atoms. The enantiomers of selected AgxAu38â€“x(SCH2CH2Ph)24 samples (average x = 6.5 and 7.9) have been separated by HPLC. Doping changes the electronic structure, as is evidenced by the significantly different CD spectra. UVâ€“vis spectra of the doped sample also show diminished features. The temperature required for complete racemization follows Au38 > AgxAu38â€“x (x = 6.5) > AgxAu38â€“x (x = 7.9). To our surprise, the racemization of AgxAu38â€“x(SCH2CH2Ph)24 (x = 7.9) occurred even at 20 Â°C. Racemization involves a rearrangement of the staple motifs at the cluster surface. The results therefore show an increased flexibility of the cluster with increasing silver content. The weaker Agâ€“S bonds compared to Auâ€“S are proposed to be at the origin of this observation. The experimentally determined activation energy for the racemization is ca. 21.5 kcal/mol (x = 6.5) and 19.5 kcal/mol (x = 7.9), compared to 29.5 kcal/mol for Au38(SCH2CH2Ph)24, suggesting no complete metalâ€“S bond breaking in the process.