209. I.S. Mikhel, G. Bernardinelli, A. Alexakis,
     “Chiral P-monodentate phosphoramidite and phosphite ligands forthe enantioselective Pd-catalyzed allylic alkylation”
     Inorg. Chim. Acta 2006, 359, 1826-1836.

The improved synthesis of the chiral phosphoramidite Ia, based on a biphenol backbone and bearing chiral bis(1-phenylethyl)amine group on the phosphorus atom, is described together with its Pd(II) complex. The chiral complex cis-PdCl₂L₂ (L = Ia) has been characterized by X-ray crystal structure analysis and spectroscopic data. The series of the chiral P-monodentate phosphoramidite and phosphite ligands was tested in Pd-catalyzed enantioselective allylic substitution of different substrates. In the palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenylallyl acetate with dimethylmalonate, up to 79% ee was achieved with [Pd₂(dba)₃] × CHCl₃ as precatalyst.

DOI : 10.1016/j.ica.2005.06.040 

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