210. A. Alexakis, C. Malan, L. Lea, K. Tissot-Croset, D. Polet, C. Falciola,
     “The copper-catalyzed asymmetric allylic substitution”
     CHIMIA 2006, 60, 124-130.

This mini-review discusses the rapidly growing field of asymmetric copper-catalyzed chemistry. Although the allylic substitution has been less studied than the conjugate addition, recent breakthroughs have made this methodology a very valuable synthetic tool. Thus, a primary allylic halide or phosphate reacts with Grignard or diorganozinc reagents to afford the S_N' product (or γ-product) in high regio- and enantioselectivities. Besides the results of the authors, we present also other, different approaches to this reaction, with emphasis on the organo-metallic and the type of chiral ligand used.

Lien : http://www.ingentaconnect.com/content/scs/chimia/2006/00000060/00000003/art00002 

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