216. D. Martin, S. Kehrli, M. d'Augustin, H. Clavier, M. Mauduit, A. Alexakis,
     “Copper-catalyzed asymmetric conjugate addition of Grignard reagents to trisubstituted enones. Construction of all-carbon quaternary centers”
     J. Am. Chem. Soc. 2006, 128, 8416-8417.

The copper-catalyzed asymmetric conjugate addition of Grignard reagents to trisubstituted cyclic enones affords enantioenriched all-carbon quaternary centers with up to 96% ee. The chiral ligand is a diaminocarbene, directly generated in situ. The combination of Grignard reagent and diaminocarbene is unprecedented in conjugate addition, and the additon of the phenyl group, on such enones, cannot be done by other conjugate addition methods.

DOI : 10.1021/ja0629920 

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