224. C.A. Falciola, A. Alexakis,
     “1,4-Dichloro- and 1,4-Dibromo-2-butenes as Substrate for Cu-catalyzed Asymmetric Allylic Substitution”
     Angew. Chem. Int. Ed. 2007, 46, 2619-2622.

Cu at the AAA meeting: Difunctionalized allylic substrates can undergo Cu-catalyzed asymmetric allylic alkylation (AAA) reactions with high enantioselectivities. The products have a functional group that remains for further transformation through substitution with a nucleophile (Nu) or electrophile (E) with conservation of optical purity (see scheme; TC=thiophene carboxylate).

DOI : 10.1002/anie.200604963 

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