262. J. Wencel, M. Mauduit, H. Hénon, S. Kehrli, A. Alexakis,
     “Chiral, Chelating, Hydroxyalkyl and Hydroxyaryl N-Heterocyclic Carbenes: Design, Synthesis, and Application in Copper-Catalyzed Asymmetric Conjugate Addition (Cu-ACA)”
     Aldrichim. Acta 2009, 42, 43-50.

Since their discovery in 1968 by Öfele and Wanzlick, and their first isolation in the free state by Arduengo in the early 1990s, N-heterocyclic carbene (NHC) ligands have received a growing attention from the scientific community, notably in organometallic chemistry. These ligands are likely to surpass in popularity well-known phosphorus-based ligands because of their remarkable ability to establish strong bonds with the metal center and their capacity to permit significant doping of catalyst activity in a wide range of chemical transformations such as olefin metathesis, carbon-carbon and carbon-nitrogen cross-coupling reactions, hydrogenation, and hydrosilylation.

Lien : http://www.sigmaaldrich.com/ifb/acta/v42/acta-vol42-2009.html#50 

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