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  1. L. Palais, A. Alexakis,
    “Copper-catalyzed asymmetric conjugate addition with Grignard reagents and SimplePhos ligands”
    Tetrahedron: Asymmetry 2009, 20, 2866-2870.

Herein we report the copper-catalyzed asymmetric conjugate addition of Grignard reagents to cyclic and acyclic enones, with SimplePhos as chiral ligands. A variety of Grignard reagents can be added to a range of cyclic and acyclic enones, with moderate to good enantioselectivities (ee’s up to 86%).

DOI : 10.1016/j.tetasy.2009.11.016 

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