275. L. Palais, L. Babel, A. Quintard, S. Belot, A. Alexakis,
     “Copper-Catalyzed Enantioselective 1,4-Addition to α,β-Unsaturated Aldehydes”
     Org. Lett. 2010, 12, 1988-1991.

The first asymmetric Cu-catalyzed conjugate addition of dialkylzinc zinc reagents to a large scope of enals in presence of phosphoramidite, SimplePhos, or (R)-BINAP ligands with enantiomeric excesses up to 90% is reported. Moreover, ACA of Grignard reagents afforded moderate to good 1,4-regioselectivities with enantioselectivities up to 90%.

DOI : 10.1021/ol100441r 

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