285. Q. Perron, A. Alexakis,
     “Catalytic Asymmetric Bromine-Lithium Exchange: A New Tool to Build Axial Chirality”
     Adv. Synth. Catal. 2010, 352, 2611-2620.

We present here the first catalytic desymmetrization of the 2,2′,6,6-tetrabromobiphenyl 1 and analogues, by a bromine-lithium exchange catalyzed by either diamines or diether derivatives (0.5 equiv.), yielding axially chiral compounds in high yield (up to 89%) and high enantioselectivity (up to 82%).

DOI : 10.1002/adsc.201000517 

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