311. H. Li, D. Müller, L. Guénée, A. Alexakis,
     “Copper-Catalyzed Enantioselective Synthesis of Axially Chiral Allenes”
     Org. Lett. 2012, 14, 5880-5883.

A simple copper-catalyzed enantioselective synthesis of axially chiral chloroallenes from the propargylic dichlorides is reported, employing a catalytic amount of easily prepared SimplePhos ligand. Exclusive formation of the desired allenes was observed with good enantioselectivities (ee’s 62–96%). Further transformations to trisubstituted allenes or terminal alkynes with a propargylic quaternary carbon center keep a high level of enantiopurity.

DOI : 10.1021/ol302790e 

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