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Publication 317  


  1. B. Pezzati, M.F. Chellat, J.J. Murphy, C. Besnard, G. Reginato, J.C. Stephens, A. Alexakis,
    “Organocatalytic Asymmetric Annulation of 1,3-Bis(alkoxycarbonyl)buta-1,3-dienes and Aldehydes”
    Org. Lett. 2013, 15, 2950-2953.

Asymmetric organocatalytic annulation of E/Z isomeric mixtures of bis(alkyl carboxylate)buta-1,3-dienes and aldehydes has been realized via enamine catalysis. In the presence of α,α-diphenyl-2-pyrrolidinemethanol trimethylsilyl ether, excellent stereo- and enantioselectivities were achieved for a broad spectrum of substrates.

DOI : 10.1021/ol401042b 

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