Welcome to the Hoogendoorn Lab



We are a new Chemical Biology lab at the University of Geneva. The goal of our research is to develop innovative chemical tools to answer questions in biology. Our research interests are in cellular signaling, with a focus on the Hedgehog signaling pathway and the specialized organelle which it requires, the primary cilium. We use a combination of organic chemistry, cell biology and genetic (screening) methodologies to obtain small molecules that interact with the Hh pathway at different levels (i.e. by altering cilium formation or function or by affecting downstream effector proteins). Furthermore, we are developing methodologies to elucidate the mechanism of action and intracellular target of small molecules, a particular challenge when obtaining hit compounds from phenotypic screens.
 

Latest Publications

  List    

  1. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies
    D. K. Breslow, S. Hoogendoorn, A. R. Kopp, D. W. Morgens, B. K. Vu, M. C. Kennedy, K. Han, A. Li, G. T. Hess, M. C. Bassik, J. K. Chen, M. V. Nachury
    Nat. Genet. 2018, 50, 460-471
  1. Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes
    W. W. Kallemeijn, S. Scheij, S. Hoogendoorn, M. D. Witte, D. Herrera Moro Chao, C. P. A. A. van Roomen, R. Ottenhoff, H. S. Overkleeft, R. G. Boot, J. M. F. G. Aerts, A. Dardis
    PLoS ONE 2017, 12, 0170268
  1. Enantioselective synthesis of adamantylalanine and carboranylalanine and their incorporation into the proteasome inhibitor bortezomib
    G. de Bruin, E. D. Mock, S. Hoogendoorn, A. M. C. H. van den Nieuwendijk, J. Mazurek, G. A. van der Marel, B. I. Florea, H. S. Overkleeft
    Chem. Commun. 2016, 52, 4064-4067