136. “Asymmetric Lewis Acid-Catalyzed 1,3-Dipolar Cycloadditions”
     A. Bădoiu, Y. Brinkmann, F. Viton, E.P. Kündig,
     Pure Appl. Chem. 2008, 80, 1013-1018.

Highly tuned, one-point binding chiral iron and ruthenium complexes selectively coordinate and activate α,β-unsaturated aldehydes and ketones toward asymmetric catalytic Diels-Alder cycloaddition reactions. Here we focus on the application of these transition-metal Lewis acids to asymmetric catalytic 1,3-dipolar cycloaddition reaction between enals and cyclic and acyclic nitrones as well as aryl nitrile oxides to give isoxazolidines and isoxazolines, respectively.

DOI : 10.1351/pac200880051013 

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