Liste   Précédente   Suivante  

Publication 162  


  1. “Electronic effects in 1,3-dipolar cycloaddition reactions of N-alkyl and N-benzyl nitrones with dipolarophiles”
    A. Bădoiu, E.P. Kündig,
    Org. Biomol. Chem. 2012, 10, 114-121.

1,3-Dipolar cycloadditions afforded fast access to isoxazolidines bearing N-alkyl or N-benzyl substituents. The electronic properties of the substituents in the nitrones define the activity of the dipoles and modulate diastereoselectivity in the non-catalyzed reactions. Using a chiral one-point binding ruthenium Lewis acid catalyst, products were obtained in good yields and with excellent regio-, diastereo-, and enantioselectivity.

DOI : 10.1039/C1OB06144E 

archive ouverte unige:17734