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Our research focuses on design, synthesis and study of organic functional systems; emphasis is on conceptual innovation - integrating unorthodox interactions and addressing lessons from and challenges in nature - for broad applications such as cellular uptake, fluorescent probes or catalysis.  Click here for details.

Latest Publications

Zong, L.; Bartolami, E.; Abegg, D.; Adibekian, A.; Sakai, N.; Matile, S. “Epidithiodiketopiperazines: Strain-Promoted Thiol-Mediated Cellular Uptake at the Highest Tension”, ACS Cent. Sci. 2017, in press.

Liu, L.; Cotelle, Y.; Klehr, J.; Sakai, N.; Ward, T. R.; Matile, S. “Anion-π Catalysis: Bicyclic Products with Four Contiguous Stereogenic Centers from Otherwise Elusive Diastereospecific Domino Reactions on π-Acidic Surfaces”, Chem. Sci. 2017, in press.

Macchione, M.; Chuard, N.; Sakai, N.; Matile, S. “Planarizable Push-Pull Probes: Overtwisted Flipper Mechanophores”, ChemPlusChem 2017, in press.

What's New

March: Our alumni Javier Montenegro and Toshihide Takeuchi received a young investigators award from human frontier science program. Congratulations!

Feb: Javier Lopez received a prestigious Marie Sklodowska-Curie Action (MSCA) grant from the EC (Horizon 2020) in support of his research on catalysis with chalcogen bonds.

Dec: Press release on the hidden face of sulfur, catalysis with chalcogen bonds, published in Angew. Chem., reported in RTS, Le Temps, 20 Minutes and Tribune de Genève.

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