Stefan Matile


Stefan Matile is a Full Professor in the Department of Organic Chemistry at the University of Geneva and a founding member of the National Centre of Competence in Research (NCCR) Chemical Biology and the NCCR Molecular Systems Engineering. In 2010, he became an ERC Advanced Investigator. He is the co-author of more than 250 publications, many in top journals (45 JACS, etc), and has delivered more than 230 lectures all over the world. Half of the more than 80 students he has trained so far (PhD, postdoc) are now active in academia (China, France, Germany, India, Japan, Spain, Switzerland, USA, etc); others preferred a career in industry (Firmenich, Nestle, DuPont Geneva, Siegfried, BASF, Roche, Novartis, etc). Educated at the University of Zurich (PhD, with Wolf Woggon) and Columbia University in New York (postdoc, with Koji Nakanishi), he started his independent academic career as an Assistant Professor at Georgetown University, Washington DC, before moving to Geneva.

 Research Interests  details

At the interface of synthetic organic, biological and supramolecular materials chemistry. Emphasis is on molecules and supramolecular systems that are synthesized from scratch, have interesting functions, address lessons from nature and integrate unorthodox interactions. Functions of current interest concern catalysis, cellular uptake and mechanosensitive fluorescent probes. Other topics of longstanding interest are artificial photosystems on solid surfaces and transport and sensing in lipid bilayer membranes. "Exotic" interactions of current interest include anion-π and ion pair-π interactions (catalysis, spectral tuning), mechanosensitive bonds, halogen bonds and orthogonal dynamic covalent bonds, particularly disulfide exchange in strained monomers, polymers and on the surface of cells.

 Recent Key Publications all publications

Zhao, Y.; Cotelle, Y.; Avestro, A.-J.; Sakai, N.; Matile, S. "Asymmetric Anion-π Catalysis: Enamine Addition to Nitroolefins on π-Acidic Surfaces," J. Am. Chem. Soc., in press.

Dal Molin, M.; Verolet, Q.; Colom, A.; Letrun, R.; Derivery, E.; Gonzalez-Gaitan, M.; Vauthey, E.; Roux, A.; Sakai, N.; Matile, S. "Fluorescent Flippers for Mechanosensitive Membrane Probes," J. Am. Chem. Soc. 2015, 137, 568-571.

Gasparini, G.; Sargsyan, G.; Bang, E.-K.; Sakai, N.; Matile, S. "Ring Tension Applied to Thiol-Mediated Cellular Uptake," Angew. Chem. Int. Ed. 2015, 54, 7328-7331.

Fujisawa, K.; Humbert-Droz, M.; Letrun, R.; Vauthey, E.; Wesolowski, T. A.; Sakai, N.; Matile, S. "Ion Pair-π Interactions," J. Am. Chem. Soc. 2015, 137, 11047-11056.

Gasparini, G.; Bang, E.-K.; Molinard, G.; Tulumello, D. V.; Ward, S.; Kelley, S. O.; Roux, A.; Sakai, N.; Matile, S. "Cellular Uptake of Substrate-Initiated Cell-Penetrating Poly(disulfide)s," J. Am. Chem. Soc. 2014, 136, 6069-6074.

Hayashi, H.; Sobczuk, A.; Bolag, A.; Sakai, N.; Matile, S. "Antiparallel Three-Component Gradients in Double-Channel Surface Architectures," Chem. Sci. 2014, 5, 4610-4614.

Curriculum vitae pdf