Stefan Matile


Stefan Matile received both Diploma (1989) and PhD (1994) from the University of Zurich for research on the bioorganic chemistry of porphyrins under the direction of Wolf Woggon.  After a postdoc on the circular dichroism spectroscopy of porphyrins with Koji Nakanishi at Columbia University, New York (1994-1996), he joined the faculty of Georgetown University, Washington DC, as an Assistant Professor.  In 1999, he moved to the University of Geneva, where he is currently Full Professor in the Department of Organic Chemistry and the National Centre of Competence in Research (NCCR) in Chemical Biology.  He is an ERC Advanced Investigator

 Research Interests  details

At the interface of synthetic organic, biological and supramolecular materials chemistry.  Emphasis is on molecules and supramolecular systems that are synthesized from scratch, have interesting functions, address lessons from nature and integrate less recognized, exotic interactions (anion-π, halogen bonds).  For their preparation, multistep organic synthesis, dynamic covalent chemistry, surface-initiated polymerization, self-assembly, self-sorting, self-repair, templated synthesis and stack exchange are explored.  Functions of interest concern artificial photosystems, transport and sensing in lipid bilayer membranes, cellular uptake and catalysis.

 Recent Key Publications all publications

Zhao, Y.; Domoto, Y.; Orentas, E.; Beuchat, C.; Emery, D.; Mareda, J.; Sakai, N.; Matile, S. Catalysis with Anion-π Interactions, Angew. Chem. Int. Ed. 2013, 52, 9940-9943.

Sforazzini, G.; Orentas, E.; Bolag, A.; Sakai, N.; Matile, S.  Toward Oriented Surface Architectures with Three Coaxial Charge-Transporting Pathways, J. Am. Chem. Soc. 2013, 135, 12082-12090.

Bang, E.-K.; Gasparini, G.; Molinard, G.; Roux, A.; Sakai, N.; Matile S.  Substrate-Initiated Synthesis of Cell-Penetrating Poly(disulfide)s, J. Am. Chem. Soc. 2013, 135, 2088-2091.

Fin, A.; Vargas Jentzsch, A.; Sakai, N.; Matile, S.  Oligothiophene Amphiphiles as Planarizable and Polarizable Fluorescent Membrane Probes, Angew. Chem. Int. Ed. 2012, 51, 12736-12739.

Orentas, E.; Lista, M.; Lin, N.-T.; Sakai, N.; Matile, S.  A Quantitative Model for the Transcription of 2D Patterns into Functional 3D Architectures, Nature Chem. 2012, 4, 746-750.

Vargas Jentzsch, A.; Emery, D.; Mareda, J.; Nayak, S. K.; Metrangolo, P.; Resnati, G.; Sakai, N.; Matile, S. Transmembrane Anion Transport Mediated by Halogen-Bond Donors, Nature Commun. 2012, 3, 905.

Curriculum vitae pdf