Stefan Matile

stefan Stefan Matile is a Full Professor in the Department of Organic Chemistry at the University of Geneva and a founding member of the National Centre of Competence in Research (NCCR) Chemical Biology and the NCCR Molecular Systems Engineering. In 2010, he became an ERC Advanced Investigator. He is the co-author of more than 270 publications, many in top journals (48 JACS, etc), and has delivered more than 240 lectures all over the world. Half of the more than 90 junior researchers he has trained so far (PhD, postdoc) are now active in academia (China, France, Germany, India, Italy, Japan, Spain, Switzerland, USA, etc); others preferred a career in industry (Firmenich, Nestle, DuPont Geneva, Siegfried, BASF, Roche, etc), or elsewhere. Educated at the University of Zurich (PhD, with Wolf Woggon) and Columbia University in New York (postdoc, with Koji Nakanishi), he started his independent academic career as an Assistant Professor at Georgetown University, Washington DC, before moving to Geneva.

Research Interests

At the interface of synthetic organic, biological and supramolecular materials chemistry. Emphasis is on functional molecular and supramolecular systems that are synthesized from scratch.

Recent Key Publications

Zong, L.; Bartolami, E.; Abegg, D.; Adibekian, A.; Sakai, N.; Matile, S. "Epidithiodiketopiperazines: Strain-Promoted Thiol-Mediated Cellular Uptake at the Highest Tension," ACS Cent. Sci., in press.

Benz, S.; López-Andarias, J.; Mareda, J.; Sakai, N.; Matile, S. "Catalysis with Chalcogen Bonds," Angew. Chem. Int. Ed. 2017, 56, 812-815.

Liu, L.; Cotelle, Y.; Avestro, A.-J.; Sakai, N.; Matile, S. "Asymmetric Anion-π Catalysis of Iminium/Nitroaldol Cascades to Form Cyclohexane Rings with Five Stereogenic Centers Directly on π-Acidic Surfaces," J. Am. Chem. Soc. 2016, 138, 7876-7879.

Cotelle, Y.; Lebrun, V.; Sakai, N.; Ward, T. R.; Matile, S. "Anion-π Enzymes," ACS Cent. Sci. 2016, 2, 388-393.

Dal Molin, M.; Verolet, Q.; Colom, A.; Letrun, R.; Derivery, E.; Gonzalez-Gaitan, M.; Vauthey, E.; Roux, A.; Sakai, N.; Matile, S. "Fluorescent Flippers for Mechanosensitive Membrane Probes," J. Am. Chem. Soc. 2015, 137, 568-571.

Gasparini, G.; Bang, E.-K.; Molinard, G.; Tulumello, D. V.; Ward, S.; Kelley, S. O.; Roux, A.; Sakai, N.; Matile, S. "Cellular Uptake of Substrate-Initiated Cell-Penetrating Poly(disulfide)s," J. Am. Chem. Soc. 2014, 136, 6069-6074.

Hayashi, H.; Sobczuk, A.; Bolag, A.; Sakai, N.; Matile, S. "Antiparallel Three-Component Gradients in Double-Channel Surface Architectures," Chem. Sci. 2014, 5, 4610-4614.