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(29) |
Structure-activity Relationship in the Iridium-catalyzed Isomerization of Primary Allylic Alcohols
Luca Mantilli, David Gérard, Céline Besnard, Clément Mazet*
Eur. J. Inorg. Chem. 2012, in press
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(28) |
Atropoisomeric (P,N) Ligands for the Highly Enantioselective Pd-Catalyzed Intramolecular Asymmetric α-Arylation of α-Branched Aldehydes
Pradeep Nareddy, Luca Mantilli, Laure Guénée, Clément Mazet*
Angew. Chem. Int. Ed. 2012, 51, 3826-3831
open archive unige:19419  full text [restricted access]
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A short synthetic route readily gives access to a new class of chiral (P,N) ligands characterized by three distinct elements of chirality. These ligands are highly enantioselective in the challenging Pd-catalyzed intramolecular asymmetric α-arylation of α-branched aldehydes. |
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(27) |
Privileged Chiral Ligands and Catalysts (book review)
Clément Mazet*
Angew. Chem. Int. Ed. 2012, 51, 305
open archive unige:18011 full text [restricted access]
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(26) |
New Catalytic Asymmetric Strategies to Access Chiral Aldehydes
Clément Mazet*
Chimia 2011, 65, 802-805
open archive unige:17329 full text [restricted access]
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(25) |
Platinum Metals in the Asymmetric Isomerization of Allylic Alcohols
Luca Mantilli, Clément Mazet*
Chem. Lett. 2011, 40, 341-344
open archive unige:14900 full text [restricted access]
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(24) |
Access to High Levels of Molecular Complexity by One-Pot Iridium/Enamine Asymmetric Catalysis
Adrien Quintard, Alexandre Alexakis,* Clément Mazet*
Angew. Chem. Int. Ed. 2011, 50, 2354-2358
open archive unige:14494 full text [restricted access]
[ selected as a 'Hot Paper' and Highlighted in: Synfacts 2011, 0519 and Chimia 2011, 65, 360.] |
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Independent workers with team spirit: A catalytic sequence that exploits the compatibility of (chiral) cationic iridium catalysts for the isomerization of primary allylic alcohols to aldehydes with organocatalysts has been developed for the highly enantioselective α functionalization of aldehydes (see scheme: up to 66 % yield, d.r. 49:1, 99 % ee). The reaction displayed useful generality with respect to both the nucleophile and the electrophile. |
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(23) |
Highly Regio- and Enantioselective Catalytic Asymmetric Hydroboration of α-Substituted Styrenyl Derivatives
Clément Mazet,* David Gérard
Chem. Commun. 2011, 47, 298-300
open archive unige:12843 full text [restricted access]
[ Highlighted in: Synfacts 2011, 0402] |
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The catalytic asymmetric hydroboration of a variety of 1,1-disubstituted olefins has been achieved with excellent yields, perfect regioselectivity and high levels of enantioselectivity. |
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(22) |
Improved Catalysts for the Iridium-catalyzed Asymmetric Isomerization of Primary Allylic Alcohols Based on Charton Analysis
Luca Mantilli, David Gérard, Sonya Torche, Céline Besnard, Clément Mazet*
Chem. Eur. J. 2010, 16, 12736-12745
open archive unige:12267 full text [restricted access]
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An improved generation of chiral cationic iridium catalysts for the asymmetric isomerization of primary allylic alcohols is disclosed. The design of these air stable complexes relied on preliminary mechanistic information available and on Charton analyses using two preceding generations of iridium catalysts developed for this highly challenging transformation. |
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(21) |
The 3rd Young Faculty Meeting – Looking Back at the Past to Better Anticipate the Future
Barbara Winter-Werner,* Clément Mazet*
Chimia 2010, 64, 621-622
open archive unige:11031 full text [free access]
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(20) |
The 45th EUCHEM Conference on Stereochemistry (Bürgenstock Conference 2010)
Clément Mazet,* Cristina Nevado*
Chimia 2010, 64, 421-424
open archive unige:8499 full text [restricted access]
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(19) |
Highly Enantioselective Isomerization of Primary Allylic Alcohols Catalyzed by (P,N)-iridium complexes
Luca Mantilli, David Gérard, Sonya Torche, Céline Besnard, Clément Mazet*
Pure Appl. Chem. 2010, 82, 1461-1469
open archive unige:8440 full text [free access]
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(18) |
Copper-Catalyzed Asymmetric β-Boration of α,β-Unsaturated Carbonyl Derivatives
Luca Mantilli, Clément Mazet*
ChemCatChem 2010, 2, 501-504
open archive unige:6440 full text [restricted access]
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(17) |
Expanded Scope for the Iridium-catalyzed Asymmetric Isomerization of Primary Allylic Alcohols Using Readily Accessible Second-generation Catalysts
Luca Mantilli, Clément Mazet*
Chem. Commun. 2010, 46, 445-447
open archive unige:4863
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A second generation of chiral (P,N)-iridium catalysts—readily accessible from inexpensive L-serine—displays expanded scope for the asymmetric isomerization of primary allylic alcohols. |
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(16) |
Organic Chemistry à la Genevoise
Clément Mazet, Andreas Zumbuehl, Damien Jeannerat, Jiri Mareda, Alexandre Alexakis, E. Peter Kündig, Jérôme Lacour, Stefan Matile
Chimia 2009, 63, 816-821
open archive unige:7946 full text [restricted access]
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(15) |
Iridium-catalyzed Asymmetric Isomerization of Primary Allylic Alcohols
Luca Mantilli, David Gérard, Sonya Torche, Céline Besnard, Clément Mazet*
Angew. Chem. Int. Ed. 2009, 48, 5143-5147
open archive unige:7934 full text [restricted access]
[ Highlighted in: Synfacts 2009, 1000 and Chimia 2009, 63, 776] |
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Nothing to sm(Ir)k at: Under appropriate reaction conditions, iridium hydride catalysts promote the isomerization of primary allylic alcohols. The best catalysts, like (R)-1 (P green, O red, N blue, Ir yellow), deliver the desired chiral aldehydes with excellent enantioselectivity and good yields. Mechanistic hypotheses have been developed on the basis of preliminary investigations. |
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(14) |
Iridium-catalyzed Isomerization of Primary Allylic Alcohols Under Mild Reaction Conditions
Luca Mantilli, Clément Mazet*
Tetrahedron Lett. 2009, 50, 4141-4144
open archive unige:8418 full text [restricted access]
[ Supporting Information]
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(13) |
Iridium-catalyzed Isomerization of Primary Allylic Alcohols
Luca Mantilli, Clément Mazet*
Chimia 2009, 63, 35-37
open archive unige:7944 full text [restricted access]
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(12) |
Chiral Boron-Bridged Bisoxazoline (Borabox) Ligands: Structures and Reactivities of Pd and Cu Complexes
Valentin Köhler, Clément Mazet, Aurélie Toussaint, Klaus Kulicke, Daniel Häussinger, Markus Neuburger, Silvia Schaffner, Stefan Kaiser, Andreas Pfaltz*
Chem. Eur. J. 2008, 14, 8530-8539
open archive unige:7034 full text [restricted access]
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(11) |
Dinuclear {(salen)Al} Complexes Display Expanded Scope in the Conjugate Cyanation of α,β-Unsaturated Imides
Clément Mazet, Eric N. Jacobsen*
Angew. Chem. Int. Ed. 2008, 47, 1762-1765
open archive unige:7053 full text [restricted access]
[ Highlighted in: Synfacts 2008, 487]
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(10) |
Kinetic Resolution of Diols and Pyridyl Alcohols by Cu(II)(borabox)-Catalyzed Acylation
Clément Mazet, Stephen Roseblade, Valentin Köhler, Andreas Pfaltz*
Org. Lett. 2006, 8, 1879-1882
open archive unige:6933 full text [restricted access]
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(9) |
Synthesis of Chiral Boron-bridged Anionic C2-symmetric Bisoxazolines and their Applications in Asymmetric Catalysis
Clément Mazet,* Valentin Köhler, Stephen Roseblade, Aurélie Toussaint, Andreas Pfaltz*
Chimia 2006, 60, 195-198
open archive unige:7736 full text [restricted access]
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(8) |
Chiral Boron-Bridged Bisoxazolines: Readily Available Anionic Ligands for Asymmetric Catalysis
Clément Mazet, Valentin Köhler, Andreas Pfaltz*
Angew. Chem. Int. Ed. 2005, 44, 4888-4891
open archive unige:6980 full text [restricted access]
[ Highlighted in: Chem. Eng. News 2005, 83(36), 40-48]
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(7) |
A Combined Experimental and Computational Study of Dihydrido-Phosphinooxazoline Iridium Complexes
Clément Mazet, Sebastian P. Smidt, Markus Meuwly,* Andreas Pfaltz*
J. Am. Chem. Soc. 2004, 126, 14176-14181
open archive unige:6991 full text [restricted access]
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(6) |
Synthesis and Coordination Chemistry of the First C2-Chiral Bisoxazine Ligand
Clément Mazet, Lutz H. Gade*
Inorg. Chem. 2003, 42, 210-215
open archive unige:7017 full text [restricted access]
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(5) |
[Bis(oxazolinyl)pyrrole]palladium Complexes as Catalysts in Heck- and Suzuki-Type C-C Coupling Reactions
Clément Mazet, Lutz H. Gade*
Eur. J. Inorg. Chem. 2003,, 1161-1168
open archive unige:7919 full text [restricted access]
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(4) |
Double Bonds in Motion: Bis(oxazolinylmethyl)pyrroles and Their Metal-Induced Planarization to a New Class of Rigid Chiral C2-symmetric Complexes
Clément Mazet, Lutz H. Gade*
Chem. Eur. J. 2003, 9, 1759-1767
open archive unige:7771 full text [restricted access]
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(3) |
Charging and Deforming the Pybox Ligand: Enantiomerically Pure Double Helices and Their Interconversion
Clément Mazet, Lutz H. Gade*
Chem. Eur. J. 2002, 8, 4308-4318
open archive unige:7769 full text [restricted access]
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(2) |
Solution Structure and Decomposition Pathway of Zwitterionic Zirconium(IV) Benzyl Complexes
Régis M. Gauvin, Clément Mazet, Jacky Kress*
J. Organomet. Chem. 2002, 658, 1-8
open archive unige:7760 full text [restricted access]
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(1) |
A Bis(oxazolinyl)pyrrole as a New Monoanionic Tridentate Supporting Ligand: Synthesis of a Highly Active Palladium Catalyst for Suzuki-Type C-C Coupling
Clément Mazet, Lutz H. Gade*
Organometallics 2001, 20, 4144-4146
open archive unige:6940 full text [restricted access]
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