Robert Gurny

Professeur honoraire


 

Address :    

Section des sciences pharmaceutiques
Université de Genève - Université de Lausanne
Pavillon Ansermet
Quai Ernest-Ansermet 24
CH-1211 Genève 4

Room :   111
Phone :     +41 79 37 519 81
Fax :     +41 22 37 965 67
e-mail :     Robert.Gurny@unige.ch


CURRICULUM VITAE


Professor Robert GURNY
University of Geneva , School of Pharmaceutical Sciences, Department of Pharmaceutics and Biopharmaceutics

ROBERT GURNY is the former President of the School of Pharmaceutical Sciences (2004-2008) and professor at the Department of Pharmaceutics and Biopharmaceutics at the University of Geneva, Switzerland. Born in Zurich , he first studied pharmaceutical sciences at the Federal Institute of Technology in Zurich and later joint the University of Geneva , where he obtained a PhD in 1976. After a prolonged stay at the Universities of Purdue and Stanford in the United States , he became in 1979 Research Associate at the Department of Pharmaceutical Technology and Biopharmaceutics at the University of Geneva . In 1991, he became professor in the some department.

Today, Professor Gurny heads a group of more than twenty five researchers. He is one of the pioneers in the field of novel drug carriers and drug targeting. In addition, he developed new degradable biopolymers, long acting implants and more recently he established a working group on protein delivery and gene therapy. The improvement of ocular therapy, especially intravitreal and subretinal medication represent an additional field of interest. Currently he is working in area such as PVR and DMLA.

For over ten years , Professor Gurny has been the Scientific Secretary of the "Controlled Release Society". In 1998, he was Vice President of the International Association for Pharmaceutical Technology (APV).

Professor Gurny's research has been recognized by several prestigious awards such as the Merck Award in 1994, the APV Prize in 1995, the Phoenix Award in 1996 and the "Prix Roger Barre" of the University of Montreal in 1999. He also received in 1996 an award for the supervision of the best thesis in pharmaceutical technology, written by Dr. Alain Merkli. Prof. Gurny has been named "Fellow" of the American Association of Pharmaceutical Scientists in 1997, and in 1999 "Fellow" of the American Institute for Medical and Biological Engineering. He is also an honorary member of the Alpilles Academy .
In 2003, he received the medal of the International Association of Pharmaceutical Technology. In 2004, he received a CRS award for the best paper together with his student Sergio Capancioni and in 2005 for the work of his student Stefanie Siepe-Hornung. In 2007 "Fellow" of the Swiss Society of Pharmaceutical Sciences (SSPhS).

He is the author of more than 330 peer reviewed articles, several books and, more than 80 abstracts of presentations as well as the inventor of over 25 patents. Until now, some 23 three doctoral theses were presented at the Faculty of Sciences under his direction and 13 theses are currently under progress.



Publications

2010    
  B. NOTTELET, C. DI TOMMASO, K. MONDON, R. GURNY et M. MÖLLER
“Fully biodegradable polymeric micelles based on hydrophobic- and hydrophilic-functionalized poly(lactide) block copolymers”
Journal of Polymer Science: Part A: Polymer Chemistry, 48,3244-3254 (2010)
 
  M. GAUMET, R. GURNY et F. DELIE
“Interaction of biodegradable nanoparticles with intestinal cells: The effect of surface hydrophilicity”
International Journal of Pharmaceutics, 390, 45-52 (2010)
 
  A. CIRTOIU-HAPCA, F. BUCHEGGER, N. LANGE, L. BOSSY, R. GURNY et F. DELIE
“Benefits of anti-HER2-coated paclitaxel-loaded immune-nanoparticles in the treatment of disseminated ovarian cancer: Therapeutic efficacy and biodistribution in mice”
Journal of Controlled Release, 144, 324-331 (2010)
 
  L. LUCA, M.H. CAPELLE, G. MACHAIDZE, T. ARVINTE, O. JORDAN et R. GURNY
“Physical instability, aggregation and conformational changes of recombinant human bone morphogenetic protein-2 (rhBMP-2)”
International Journal of Pharmaceutics, 391, 48-54 (2010)
 
  C. DI TOMMASO, C. COMO, R. GURNY et M. MÖLLER
“Investigations on the lyophilisation of MPEG-hexPLA micelle based pharmaceutical formulations”
European Journal of Pharmaceutical Sciences, 40, 38-47 (2010)
 
  F. GUILLAUMIE, P. FURRER, O. FELT-BAEYENS, B.L. FUHLENDORFF, S. NYMAND, P. WESTH, R. GURNY et K. SCHWACH-ABDELLAOUI
“Comparative studies of various hyaluronic acids produced by microbial fermentation for potential topical ohphtalmic applications”
Journal of Biomedical Materials Research. Part A, 92(4), 1421-1430 (2010)
 
  P. FURRER et R. GURNY
"Recent advances in confocal microscopy for studying drug delivery to the eye: concepts and pharmaceutical applications"
European Journal of Pharmaceutics and Biopharmaceutics, 74, 33-40 (2010)
 
2009  
  N. FOTINOS, J. MIKULIC, M. CONVERT, M.A. CAMPO, J.-C. PIFFARETTI, R. GURNY et N. LANGE
"5-ALA derivative-mediated photoinactivation of Propionibacterium acnes"
Journal of Dermatological Science, 56, 212-214 (2009)
 
  V. MALATERRE, J. OGORKA, N. LOGGIA et R. GURNY
"Oral osmotically driven systems: 30 years of development and clinical use"
European Journal of Pharmaceutics and Biopharmaceutics (2009)
 
  B. DEMEULE, C. PALAIS, G. MACHAIDZE, R. GURNY et T. ARVINTE
"New methods allowing the detection of protein aggregates. A case study on trastuzumab"
mAbs, 1(2), 142-150 (2009)
 
  L. LUCA, O. JORDAN, A.-L. ROUGEMONT, B.H. WALPOTH et R. GURNY
"rhBMP-2-loaded chitosan hydrogel: Influence of formulation parameters on ectopic bone formation"
Poster, 22nd European Conference on Biomaterials, 07-11th September, 2009, Lausanne, Switzerland.
 
  S.EPERON, L. BOSSY-NOBS, R. GURNY et Y. GUEX-CROSIER
"Biodegradable implants and cataract surgery"
Poster, 22nd European Conference on Biomaterials, 07-11th September, 2009, Lausanne, Switzerland.
 
  D. GABRIEL, N. BUSSO, A. SO, R. GURNY, H.VAN DEN BERGH et N. LANGE
"Thrombin-sensitive photodynamic agents: A novel strategy for selective synovectomy"
Poster, 22 nd European Conference on Biomaterials, 07-11 th September, 2009, Lausanne, Switzerland.
 
  D. MANDRACCHIA, F. INNOCENTE, B. NOTTELET, J.-C. TILLE, S. DE VALENCE, R. GURNY, B. H. WALPOTH et M. MÖLLER
"Assessment of paclitaxel in the prevention of vascular graft intima hyperplasia formation"
Proceeding 22nd European Conference on Biomaterials, 07-11th September, 2009, Lausanne, Switzerland.
 
  B.H. WALPOTH, D. MUGNAI, J.-C. TILLE, F. INNOCENTE, B. NOTTELET, C. BERTHONNECHE, X. MONTET, S. DE VALENCE, W. MROWCZYNSKI, A. KALANGOS R. GURNY et M. MOELLER
"Biodegradable synthetic small-calibre vascular grafts: 1-year results after replacement of the rat aorta"
Proceeding 22nd European Conference on Biomaterials, 07-11th September, 2009, Lausanne, Switzerland.
 
  M. MÖLLER, K. MONDON, C. DI TOMMASO, L. ASMUS et R. GURNY
"Injectable biodegradable poly(hexyl-substituted lactides) for drug delivery"
Proceeding 22nd European Conference on Biomaterials, 07-11th September, 2009, Lausanne, Switzerland.
 
  A.CIRSTOIU-HAPCA, F. BUCHEGGER, L. BOSSY, M. KOSINSKI, R. GURNY et F. DELIE
"Nanomedicines for active targeting: Physico-chemical characterization of paclitaxel-loaded anti-HER2 immunonanoparticles and in vitro functional studies on target cells"
European Journal of Pharmaceutical Sciences, 38, 230-237 (2009) doi: 10.1016/j.ejps.2009.07.006
 
  K. MONDON, R. GURNY, M. MÖLLER
"Hexyl-substituted polylactide based micelles for cyclosporine A drug delivery"
Proceeding 36th Annual Meeting & Exposition of the Controlled Release Society, July 18-22, 2009, Copenhagen, Denmark
 
  P. MARKLAND, G.A. WINCHESTER, R. GURNY, M. MÖLLER
"Injectable poly(hexyl-substituted lactides) for peptide delivery"
Proceeding 36th Annual Meeting & Exposition of the Controlled Release Society, July 18-22, 2009, Copenhagen, Denmark
 
  M. VEURINK, C. STELLA, C. TABATABAY, C.J. POURNARAS, R. GURNY
"Bevacizumab and ranibizumab in association with anti-inflammatory drugs: An in-vitro stability study"
Proceeding 36th Annual Meeting & Exposition of the Controlled Release Society, July 18-22, 2009, Copenhagen, Denmark
 
  C. EENSCHOOTEN, F. LONGIN, M. BORKOVEC, R. GURNY, K. SCHWACH-ABDELLAOUI
"Development of soft nanocarriers from novel amphiphilic hyaluronic acid derivatives towards drug delivery"
Proceeding 36th Annual Meeting & Exposition of the Controlled Release Society, July 18-22, 2009, Copenhagen, Denmark
 
  D. MANDRACCHIA, F. INNOCENTE, B. NOTTELET, J.C. TILLE, S. DE VALENCE, R. GURNY, B.H. WALPOTH et M. MÖLLER
"Evaluation of paclitaxel-releasing synthetic biodegradable vascular grafts for the prevention of intima hyperplasia"
Proceeding 36th Annual Meeting & Exposition of the Controlled Release Society, July 18-22, 2009, Copenhagen, Denmark
 
  V. MALATERRE, J. OGORKA, N. LOGGIA et R. GURNY
" Approach to design push-pull osmotic pumps"
International Journal of Pharmaceutics, 376(1-2), 56-62 (2009) doi: 10.1016/j.ijpharm.2009.04.015
 
  D. GABRIEL, N. BUSSO, A. SO, H. VAN DEN BERGH, R. GURNY et N. LANGE
"Thrombin-sensitive photodynamic agents: A novel strategy for selective synovectomy in rheumatoid arthritis"
Journal of Controlled Release, 138(3), 225-234 (2009) doi: 10106/j.jconrel.2009.05.012
 
  M. ZEISSER-LABOUEBE, M. MATTIUZZO, N. LANGE, R. GURNY et F. DELIE
"Quenching-induced deactivation of photosensitizer by nanoencapsulation to improve phototherapy of cancer"
Journal of Drug Targeting, 17(8), 619-626 (2009)
 
  A. VARGAS, N. LANGE, A. TUDOR, C. RADOVAN, R. GURNY et F. DELIE
"Toward the understanding of the photodynamic activity of m-THPP encapsulated in PLGA nanoparticles: correlation between nanoparticle properties and in vivo activity"
Journal of Drug Targeting, 17(8), 599-609 (2009)
 
  F. INNOCENTE, D. MANDRACCHIA, E. PEKTOK, B. NOTTELET, J.-C. TILLE, S. DE VALENCE, G. FAGGIAN, A. MAZZUCCO, A. KALANGOS, R. GURNY, M. MOELLER et B. B. WALPOTH
"Paclitaxel-eluting biodegradable synthetic vascular prosthese. A step towards reduction of neointima formation?"
Circulation, 120 (11 suppl1), S37-S45 (2009) doi: 10.1161/CIRCULATIONAHA.109.848242
 
 

M. ZEISSER-LABOUEBE, F. DELIE, R. GURNY et N. LANGE
"Screening of nanoparticulate delivery systems for the photodetection of cancer in a simple and cost-effective model "
Nanomedicine (London, England), 4(2), 135-43 (2009 )

 
 

V. MALATERRE, M. PEDERSEN, J. OGORKA, R. GURNY, N. LOGGIA et P.F. TADAY
"Terahertz pulsed imaging, a novel process analytical tool to investigate the coating characteristics of push-pull osmotic systems"
European Journal of Pharmaceutics and Biopharmaceutics (2009) doi: 10.1016/j.ejpb.2008.10.011

 
 

M.A.H. CAPELLE, R. GURNY et T. ARVINTE
"A high throughput protein formulation platform: Case study of salmon calcitonin"
Pharmaceutical Research, 26 (1), 118-128 (2009) doi: 10.1007/s11095-008-9662-8

 
 

V. MALATERRE, H. METZ, J. OGORKA, R. GURNY, N. LOGGIA et K. MÄDER
"Benchtop-magnetic resonance imaging (BT-MRI) characterization of push-pull osmotic controlled release systems"
Journal of Controlled Release, 133, 31-36 (2009) doi: 10.1016/j.jconrel.2008.09.007

 
 

M. GAUMET, R. GURNY et F. DELIE
" Localization and quantification of biodegradable particles in an intestinal cell model: the influence of particle"
European Journal of Pharmaceutical Sciences, 36, 465-473 (2009) doi: 10.1016/j.ejps.2008.11.015

 
 

E. FURRER, M. BERDUGO, C. STELLA, F. BEHAR-COHEN, R. GURNY, U. FEIGE, P.D. LICHTLEN et D.M. URECH
"Pharmacokinetics and posterior segment biodistribution of ESBA105, an anti-TNF- a single-chain antibody, upon topical administration to the rabbit eye"
Investigative Ophthalmology & Visual Science, 50 (2), 771-778 (2009) doi: 10.1167/iovs.08-2370

 
 

V. MALATERRE, J. OGORKA, N. LOGGIA et R. GURNY
"Evaluation of the tablet core factors influencing the release kinetics and the loadability of push-pull osmotic systems"
Drug Development and Industrial Pharmacy , 35 (4), 433-439 (2009) doi: 10.1080/03639040802425230

 
 

M. ZEISSER-LABOUEBE, F. DELIE, R. GURNY et N. LANGE
"Benefits of nanoencapsulation fort the hypercin-mediated photodetection of ovarian micrometastases"
European Journal of Pharmaceutics and Biopharmaceutics, 71, 207-213 (2009) doi:10.1016/j.ejpb.2008.10.005

 
 

E. PATOIS, S.OSORIO-DA CRUZ, J.-C. TILLE, B. WALPOTH, R. GURNY et O. JORDAN
"Novel thermosensitive chitosan hydrogels: In vivo evaluation"
Journal of Biomedical Material Research Part A, doi: 10.1002/jbm.a.32211

 
 

B. NOTTELET, E. PEKTOK, D. MANDRACCHIA, J.-C. TILLE, B. WALPOTH, R. GURNY et M. MOELLER
"Factorial design optimization and in vivo feasibility of poly( e -caprolactone)-micro-and nanofiber-based small diameter vascular grafts"
Journal of Biomedical Materials Research Part A, doi: 10.1002/jbm.a.32023

 
2008  
  K. MONDON, R. GURNY et M. MOELLER
"Colloidal drug delivery systems. Recent advances with polymeric micelles"
Chimia, 62 (10), 832-840 (2008). doi: 10.2533/chimia.2008.832
 
  A.M.M. SADEGHI, F.A. DORKOOSH, M.R. AVADI, M. WEINHOLD, A. BAYAT, F. DELIE, R. GURNY, B. LARIJANI, M. RAFIEE-TEHRANI et H.E. JUNGINGER
"Permeation enhancer effect of chitosan and chitosan derivatives: Comparison of formulations as soluble polymers and nanoparticulate systems on insulin absorption in Caco-2 cells"
European Journal of Pharmaceutics and Biopharmaceutics, 70, 270-278 (2008)
 
  E. PEKTOK, B. NOTTELET, J.-C. TILLE, R. GURNY, A. KALANGOS, M. MOELLER et B.H. WALPOTH
"Degradation and healing characteristics of small-diameter poly( e -caprolactone)vascular grafts in the rat systemic arterial circulation"
Circulation, 2563-2570 (2008) doi: 101161/CIRCULATIONAHA.108.795732
 
  M. BERDUGO POLAK, F. VALAMANESH, O. FELT, A. TORRIGLIA, J.-C. JEANNY, J.-L. BOURGES, P. RAT, A. THOMAS-DOYLE, D. BENEZRA, R. GURNY et F. BEHAR-COHEN
"Controlled delivery of 5-chlorouracil using poly(ortho esters) in filtering surgery for glaucoma "
Investigative ophthalmology & visual science, 49(7), 2993-3003 (2008)
 
  S. COLLAUD, Q. PENG, R. GURNY et N. LANGE
"Thermosetting gel for the delivery of 5-aminolevulinic acid esters to the cervix"
Journal of Pharmaceutical Sciences, 97(7), 2680-2690 (2008)
 
 

S. SIEPE, B. LUECKEL, A. KRAMER, A. RIES et R. GURNY
"Assessment of tailor-made HPMC-based matrix minitablets comprising a weakly basic drug compound"
Drug Development and Industrial Pharmacy, 34, 46-52 (2008)

 
  S. EPERON, L. BOSSY-NOBS, I.K. PETROPOULOS, R. GURNY et Y. GUEX-CROSIER
"A biodegradable drug delivery system for the treatment of postoperative inflammation"
International Journal of Pharmaceutics, 352, 240-247 (2008)
 
 

N. FOTINOS, M. CONVERT, J.-C. PIFFARETTI, R. GURNY et N. LANGE
"Effects on gramm-negative and gram-positive bacteria mediated by 5-aminolevulinic acid and 5-aminolevulinic acid derivatives"
Antimicrobial agents and Chemotherapy, 52 (4), 1366-1373 (2008)

 
 

M. GAUMET, A. VARGAS, R. GURNY et F. DELIE
"Nanoparticles for drug delivery: The need for precision in reporting particle size parameters"
European Journal of Pharmaceutics and Biopharmaceutics, 69, 1-9 (2008)

 
 

A. VARGAS, M. EID, M. FANCHAOUY, R. GURNY et F. DELIE
In vivo photodynamic activity of photosensitizer-loaded nanoparticles: Formulation properties, administration parameters and biological issues involved in PDT outcome”
European Journal of Pharmaceutics and Biopharmaceutics, 69, 43-53 (2008)

 
  M.A.H. CAPELLE, R. GURNY et T. ARVINTE
“High throughput methods to characterize protein permeation and release”
International Journal of Pharmaceutics, 350, 272-278 (2008)
 
  Y.B. SCHUETZ, R. GURNY et O. JORDAN
"A novel thermoresponsive hydrogel based on chitosan"
European Journal of Pharmaceutics and Biopharmaceutics, 68, 19-25 (2008)
 
2007  
 

S. COLLAUD, T. WARLOE, O. JORDAN, R. GURNY et N. LANGE
"Clinical evaluation of bioadhesive hydrogels for topical delivery of hexylaminolevulinate to Barrett's esophagus"
Journal of Controlled Release, 123, 203-210 (2007)

 
 

A. VARGAS, M. ZEISSER-LABOUEBE, N. LANGE, R. GURNY et F. DELIE
"The chick embryo and its chorioallantoic membrane (CAM) for the in vivo evaluation of drug delivery systems"
Advanced Drug Delivery Reviews, 59, 1162-1176 (2007)

 
 

M. GAUMET, R. GURNY et F. DELIE
"Fluorescent biodegradable PLGA particles with narrow size distributions: Preparation by means of selective centrifugation"
International Journal of Pharmaceutics, 342, 222-230 (2007)

 
 

I. BAER, R. GURNY et P. MARGOT
"NIR analysis of cellulose and lactose. Application to ecstasy tablet analysis"
Forensic Science International,167, 234-241 (2007)

 
 

F. LALLEMAND, E. VARESIO, O. FELT-BAEYENS, L. BOSSY, G. HOPFGARTNER et R. GURNY
"Biological conversion of a water-soluble prodrug of cyclosporine A"
European Journal of Pharmaceutics and Biopharmaceutics, 67, 555-561 (2007)

 
 

M.A. CAMPO, D. GABRIEL, P. KUCERA, R. GURNY et N. LANGE
"Polymeric photosensitizer prodrugs for photodynamic therapy"
Photochemistry and Photobiology, 83, 958-965 (2007)

 
 

D. GABRIEL, M.A. CAMPO, R. GURNY et N. LANGE
"Tailoring protease-sensitive photodynamic agents to specific disease-associated enzymes"
Bioconjugate Chem., 18, 1070-1077 (2007)

 
  M.-F. ZULUAGA, C. MAIHOS, G. ROBINSON, D.T. SHIMA, R. GURNY et N. LANGE
"Synergies of VEGF inhibition and photodynamic therapy in the treatment of age-related macular degeneration"
Investigative Ophthalmology & Visual Science, 48 (4), 1767-1772 (2007)
 
  T. TRIMAILLE, R. GURNY et M. MÖLLER
"Poly(hexyl-substituted lactides): Novel injectable hydrophobic drug delivery systems"
Journal of Biomedical Materials Research Part A., 80(1), 55-65 (2007)
 
  B. DEMEULE, M.J. LAWRENCE, A.F. DRAKE, R. GURNY et T. ARVINTE
"Characterization of protein aggregation: The case of a therapeutic immunoglobulin"
Biochimica et Biophysica Acta, 1774, 146-153 (2007)
 
  A. CIRSTOIU-HAPCA, L. BOSSY-NOBS, F. BUCHEGGER, R. GURNY et F. DELIE
"Differential tumor cell targeting of anti-HER2 (Herceptin(R) ) and anti-CD20 (Mabthera(R) ) coupled nanoparticles"
International Journal of Pharmaceutics, 331(2), 190-196 (2007)
 
  B. DEMEULE, R. GURNY et T. ARVINTE
"Detection and characterization of protein aggregates by fluorescence microscopy"
International Journal of Pharmaceutics, 329, 37-45 (2007)
 
  M.A.H. CAPELLE, R. GURNY et T. ARVINTE
"High throughput screening of protein formulation stability: Pratical considerations"
European Journal of Pharmaceutics and Biopharmaceutics, 65, 131-148 (2007)
 
2006  
  S. SIEPE, B. LUECKEL, A. KRAMER, A. RIES et R. GURNY
"Strategies for the design of hydrophilic matrix tablets with controlled microenvironmental pH"
International Journal of Pharmaceutics, 316, 14-20 (2006)
 
  J.B. BOURGES, C. BLOQUEL, A. THOMAS, F. FROUSSART, A. BOCHOT, F. AZAN, R. GURNY, D. BENEZRA et F. BEHAR-COHEN
"Intraocular implants for extended drug delivery: Therapeutic applications"
Advanced Drug Delivery Reviews, 58, 1182-1202 (2006)
 
  J.L. BOURGES, F. LALLEMAND, E. AGLA, K. BESSEGHIR, J.M. DUMONT, D. BENEZRA, R. GURNY et F. BEHAR-COHEN
"Evaluation of a topical clyclosporine A prodrug on corneal graft rejection in rats"
Molecular Vision, 12, 1461-1466 (2006)
 
  M. ZEISSER-LABOUEBE, N. LANGE, R. GURNY et F. DELIE
"Hypericin-loaded nanoparticles for the photodynamic treatment of ovarian cancer"
International Journal of Pharmaceutics, 326, 174-181 (2006)

  C.A. NGUYEN, Y. KONAN-KOUAKOU, E. ALLEMANN, E. DOELKER, D. QUINTANAR- GUERRERO, H. FESSI et
R. GURNY
"Preparation of surfactant-free nanoparticles of methacrylic acid copolymers used for film coating"
AAPS PharmSciTech, 7(3), article 63 (2006)

  N. FOTINOS, M.A. CAMPO, F. POPOWYCZ, R. GURNY et N. LANGE
"5-Aminolevulinic acid derivatives in photomedicine: Characteristics, application and persperctives"
Photochemistry and Photobiology, 82, 994-1015 (2006)

  O. FELT-BAEYENS, S. EPERON, P. MORA, D. LIMAL, S. SAGODIRA, P. BRETON, B. SIMONAZZI, L. BOSSY-NOBS, Y. GUEX-CROSIER et R. GURNY
"Biodegradable scleral implants as new triamcinolone acetonide delivery systems"
International Journal of Pharmaceutics, 322, 6-12 (2006)

  T. TRIMAILLE, K. MONDON, R. GURNY et M. MÖLLER
"Novel polymeric micelles for hydrophobic drug delivery based on biodegradable poly(hexyl- substituted lactides)"
International Journal of Pharmaceutics, 319, 147-154 (2006)


  S. COLLAUD, P. JICHLINSKI, A. MARTI, D. AYMON, R. GURNY et N. LANGE
"An open pharmacokinetic study of hexylaminolevulinate-induced photodiagnosis after intravesical administration"
Drugs in R&D , 7 (3), 173-186 (2006)

  S. SIEPE, W. HERRMANN, H.-H. BORCHERT, B. LUECKEL, A. KRAMER, A. RIES et R. GURNY
"Microenvironmental pH and microviscosity inside pH-controlled matrix tablets: An EPR imaging study"
Journal of Controlled Relase, 112, 72-78 (2006)

  L. NOBS, F. BUCHEGGER, R. GURNY et E. ALLEMANN
"Biodegradable nanoparticles for direct or two-step tumor immunotargeting"
Bioconjugate Chemistry, 17(1), 139-145 (2006)

  M.A.H. CAPELLE, R. GURNY et T. ARVINTE
"High throughput screening of protein-protein interactions"
Proc. 5 th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Geneva , 27-30 March (2006)

  M. ZEISSER-LABOUEBE, N. LANGE, R. GURNY et F. DELIE
"Hypericin-loaded nanoparticles for photodynamic therapy of ovarian cancer"
Proc. 5 th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Geneva , 27-30 March (2006)

  A. VARGAS, T. ARVINTE, R. GURNY et F. DELIE
"Vascular occlusion induced by photosensitizer-loaded nanoparticles: Pharmaceutical and photophysical parameters"
Proc. 5 th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Geneva , 27-30 March (2006)

  A.G. SARRAF, S. CHERKAOUI , R. GURNY et E. DOELKER
"Controlled release extrudates tailored by processing parameters: A chemometric design study"
Proc. 5 th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Geneva , 27-30 March (2006)

  M. POURTIER, R. GURNY et F. DELIE
"In vitro screening of biodegradable polymeric particles for oral administration of drugs"
Proc. 5 th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Geneva , 27-30 March (2006)

  N. BUSSO, G.KIRDAITE, M.A. CAMPO, P.KUCERA, R. GURNY, A. SO et N. LANGE
"Enzyme activated photodynamic therapy of rheumatoid arthritis"
Proc. 5 th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Geneva , 27-30 March (2006)
 
  M. MÖLLER, T. TRIMAILLE, K. MONDON et R. GURNY
"Poly(hexyl-substituted-lactides): Novel functionalized PLA for delivery of hydrophobic drugs from semi-solid homo polymers and PEG-copolymer-micelles"
Proc. 5 th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Geneva , 27-30 March (2006)

  A. HAPCA, L. BOSSY-NOBS, F. BUCHEGGER, R. GURNY et F. DELIE
"Evaluation of Herceptin ® and Mabthera ® labeled nanoparticles for specific tumor targeting"
Proc. 5 th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Geneva , 27-30 March (2006)
 
  S. COLLAUD, E. CINESI, Q.PENG, R. GURNY et N. LANGE
"Evaluation of a topical formulation of 5-aminolevulinic acid esters for the photodynamic treatment of cervical neoplasia"
Proc. 5 th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Geneva , 27-30 March (2006)

  M.A. CAMPO, D. GABRIEL R. GURNY et N. LANGE
"New targeting strategies in photodynamic therapy: Proteolytically induced photosensitization"
Proc. 5 th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Geneva , 27-30 March (2006)

  B. DEMEULE, R. GURNY et T. ARVINTE
"Where disease pathogenesis meets protein formulation: Renal deposition of immunoglobulin aggregates"
European Journal of Pharmaceutics and Biopharmaceutics, 62, 121-130 (2006)

2005  
  F. LALLEMAND, P. PEROTTET, O. FELT-BAEYENS, W. KLOETI, F. PHILIPPOZ, J. MARFURT, K. BESSEGHIR et R. GURNY
"A water-soluble prodrug of cyclosporine A for ocular application: A stability study"
European Journal of Pharmaceutical Sciences, 26, 124-129 (2005)

  T. TRIMAILLE, R. GURNY et M. MÖLLER
"Synthesis and properties of novel poly(hexyl-substituted lactides) for pharmaceutical applications"
Chimia, 59 (6), 348-352 (2005)

  R.A. BEJJANI, F. BEHAR-COHEN, D. BENEZRA, R. GURNY et F. DELIE
"Polymeric nanoparticles for drug delivery to the posterior segment of the eye"
Chimia, 59 (6), 344-347 (2005)

  P. FURRER, F. LALLEMAND, G.M. PALADINO, M.G. MAZZONE et R. GURNY
"Study by confocal laser scanning microscopy of the influence of hydrogels on the wound healing rate after mechanical corneal injury"
Chimia, 59 (6), 340-343 (2005)
 
  P. MORA, S. EPERON, O. FELT-BAEYENS, R. GURNY, S. SAGODIRA, P. BRETON et Y. GUEX-CROSIER
"Trans-scleral diffusion of triamcinolone acetonide"
Current Eye Research, 30, 355-361 (2005)

  F.LALLEMAND, P. FURRER, O. FELT-BAEYENS, M. GEX-FABRY, J.-M. DUMONT, K. BESSEGHIR et R. GURNY
"A novel water-soluble cyclosporine A prodrug: Ocular tolerance and in vivo kinetics"
International Journal of Pharmaceutics, 295, 7-14 (2005)

  Y.N.KONAN-KOUAKOU, R. BOCH, R. GURNY et E. ALLEMANN
"In vitro and in vivo activities of verteporfin-loaded nanoparticles"
Journal of Controlled Releasse, 103, 83-91 (2005)
 

J. BERGER, M. REIST, A. CHENITE, O. FELT-BAEYENS, J.M. MAYER et R. GURNY 
"Pseudo-thermosetting chitosan hydrogels for biomedical application" 
International Journal of Pharmaceutics, 288, 17-25 (2005) 


F. LALLEMAND, O. FELT-BAEYENS. S. RUDAZ, A.R. HAMEL, F. HUBLER, R. WENGER, M.MUTTER, K. BESSEGHIR et R. GURNY
"Conversion of cyclosporine A prodrugs in human tears vs rabbits tears" 
European Journal of Pharmaceutics and Biopharmaceutics, 59, 51-56 (2005) 

2004

A. VARGAS, B. PEGAZ, E. DEBEFVE, Y. KONAN-KOUAKOU, N. LANGE, J.-P. BALLINI, H.VAN DEN BERGH, R. GURNY et F.DELIE
"Improved photodynamic activity of porphyrin loaded into nanoparticles: as in vivo evaluation using chick embryos" 
International Journal of Pharmaceutics, 286, 131-145 (2004) 


F. LALLEMAND, F. BEHAR-COHEN, O. FELT-BAEYENS, S. RUDAZ, P. FURRER, K. BESSEGHIR, J.-M. DUMONT et R. GURNY
"Cyclosporine A prodrug for topical delivery to the eye" 
Proceed 5th International Symposium, Monte Carlo, Monaco, pp 105-109 (2004) 
 

O. FELT-BAEYENS, E. EPERON, P. MORA, D. LIMAL, S.SAGODIRA, P. BRETON, Y. GUEX-CROSIER et R. GURNY
"Scleral implants: A potential route of administration?" 
Proceed 5th International Symposium, Monte Carlo, Monaco, pp 41-46 (2004) 


L. NOBS, F. BUCHEGGER, R. GURNY et E. ALLEMANN
"Poly(lactic acid) nanoparticles labeled with biologically active NeutravidinTM for active targeting" 
European Journal of Pharmaceutics and Biopharmaceutics, 58, 483-490 (2004) 


T. TRIMAILLE, M. MÖLLER et R. GURNY 
"Synthesis and ring-opening polymerization of new monoalkyl-substituted lactides"
Journal of Polymer Science: Part A: Polymer Chemistry, 42, 4379-4391 (2004)


L. NOBS, F. BUCHEGGER, R. GURNY et E. ALLÉMANN 
"Current methods for attaching targeting ligands to liposomes and nanoparticles"
Journal of pharmaceutical sciences, 93(8), 1980-1992 (2004)


L. BAYDOUN, P. FURRER, R. GURNY et C. MÜLLER-GOYMANN 
"New surface-active polymers for ophthalmic formulations: evaluation of ocular tolerance"
European Journal of Pharmaceutics and Biopharmaceutics, 58, 169-175 (2004)


G. SCHWACH, N. OUDRY, J.-P. GILIBERTO, P. BROQUA, M. LÜCK, H. LINDNER et R. GURNY 
"Biodegradable PLGA microparticles for sustained release of a new GnRH antagonist: part II. in vivo performance"
European Journal of Pharmaceutics and Biopharmaceutics, 57, 441-446 (2004)


J. BERGER, M. REIST, J.M. MAYER, O. FELT et R. GURNY 
"Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications" 
European Journal of Pharmaceutics and Biopharmaceutics, 57, 35-52  (2004)
 

J. BERGER, M. REIST, J.M. MAYER, O. FELT, N.A. PEPPAS et R. GURNY 
"Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications" 
European Journal of Pharmaceutics and Biopharmaceutics, 57, 19-34  (2004)

2003

F. LALLEMAND, O. FELT-BAEYENS, K. BESSEGHIR, F. BEHAR-COHEN et R. GURNY 
"Cyclosporine A delivery to the eye: A pharmaceutical challenge" 
European Journal of Pharmaceutics and Biopharmaceutics, 56, 307-318  (2003)


G. SCHWACH, N. OUDRY, S. DELHOMME, M. LÜCK, H. LINDNER et R. GURNY 
"Biodegradable microparticles for sustained release of a new GnRH antagonist- part I: screening commercial PLGA and formulation technologies" 
European Journal of Pharmaceutics and Biopharmaceutics, 56 (3), 327-336 (2003)


S. EINMAHL, S. PONSART, R. A. BEJJANI, F. D'HERMIES, M. SAVOLDELLI, J. HELLER, 
C. TABATABAY, R. GURNY et F. BEHAR-COHEN 
"Ocular biocompatibility of a poly(ortho ester) characterized by autocatalyzed degradation" 
Journal of Biomedical Materials Research, 67A(1), 44-53 (2003)


Y.N. KONAN, J. CHEVALLIER, R. GURNY et E. ALLEMANN 
"Encapsulation of THPP into nanoparticles: Cellular uptake subcellular localization and effect of serum on photodynamic activity" 
Photochemistry and Photobiology, 77 (6), 638-644 (2003) 


C.A. NGUYEN, E. ALLEMANN, G. SCHWACH, E. DOELKER et R. GURNY 
"Synthesis of a novel fluorescent poly(d,l-lactide) end-capped with 1-pyrenebutanol used for the preparation of nanoparticles" 
European Journal of Pharmaceutical Sciences, 20 (2), 217-222 (2003)


J.-L. BOURGES, S. E. GAUTIER, F. DELIE, R. A. BEJJANI, J.-C. JEANNY, R. GURNY, D. BENEZRA et 
F. F. BEHAR-COHEN 
"Ocular drug delivery targeting the retina and retinal pigment epithelium using polylactide nanoparticles" 
Investigative Ophthalmology & Visual Science, 44 (8), 3562-3569 (2003)


S. CAPANCIONI, K. SCHWACH-ABDELLAOUI, W. KLOETI, W. HERRMANN, H. BROSIG, 
H.-H. BORCHERT, J. HELLER et  R. GURNY 
" In vitro monitoring of poly(ortho ester) degradation by electron paramagnetic resonance imaging".
Macromolecules, 36, 6135-6141 (2003)


Y.N. KONAN, M. BERTON, R. GURNY et E. ALLÉMANN 
"Enhanced photodynamic activity of meso-tetra(4-hydroxyphenyl)porphyrin by incorporation into sub-200nm nanoparticles" 
European Journal of Pharmaceutical Sciences, 18, 241-249 (2003) 
 

C.A. NGUYEN, E. ALLÉMANN, G. SCHWACH, E. DOELKER et R. GURNY 
"Cell interaction studies of PLA-MePEG nanoparticles" 
International Journal of Pharmaceutics, 254, 69-72 (2003) 


Y.N. KONAN, R. CERNY, J. FAVET, M. BERTON, R. GURNY et E. ALLÉMANN 
"Preparation and characterization of sterile sub-200 nm meso-tetra(4-hydroxylphenyl)porphyrin-loaded 
nanoparticles for photodynamic therapy" 
European Journal of Pharmaceutics and Biopharmaceutics, 55, 115-124 (2003) 


L. NOBS, F. BUCHEGGER, R. GURNY et E. ALLEMANN 
"Surface modification of poly(lactic acid) nanoparticles by covalent attachment of thiol groups by means of three methods" 
International Journal of Pharmaceutics, 250, 327-337 (2003) 

2002

V. BAEYENS, O. FELT-BAEYENS, S. ROUGIER, S. PHEULPIN, B. BOISRAME et R. GURNY 
"Clinical evaluation of bioadhesive ophthalmic drug inserts (BODI R ) for the treatment of external ocular infections in dogs" 
Journal of Controlled Release, 85, 163-168 (2002) 


J. HELLER, J. BARR, S. Y. NG, H.-R. SHEN, K. SCHWACH-ABDELLAOUI, R. GURNY, N. VIVIEN-CASTIONI, P. J. LOUP, P. BAEHNI et A. MOMBELLI 
"Poly(ortho esters): synthesis, characterization, properties and uses" 
Advanced Drug Delivery Reviews, 54 (7), 1015-1039 (2002) 


K. SCHWACH-ABDELLAOUI, M. MOREAU, M. SCHNEIDER, B. BOISRAME et R. GURNY 
"Controlled delivery of metoclopramide using an injectable semi-solid poly(ortho ester) for veterinary application" 
International Journal of Pharmaceutics, 248, 31-37 (2002) 
 

J. HELLER, J. BARR, S. NG, H.-R. SHEN, R. GURNY, K. SCHWACH-ABDELLAOUI, A. ROTHEN-WEINHOLD et M. van de WEERT 
"Development of poly(ortho esters) and their application for bovine serum albumin and bupivacaine delivery" 
Journal of Controlled Release, 78, 133-141 (2002) 


K. SCHWACH-ABDELLAOUI, R. GURNY. J. HELLER et J. BARR 
"Control of molecular weight for auto-catalyzed poly(ortho ester) obtained by polycondensation reaction"
International Journal of Polymer Analysis and Characterization, 7 (1-2), 145-161 (2002) 


K. SCHWACH-ABDELLAOUI, P. J. LOUP, N. VIVIEN-CASTIONI,  A. MOMBELLI, P. BAEHNI, J. BARR, J. HELLER et R. GURNY 
"Bioerodible injectable poly(ortho ester) for tetracycline controlled delivery to periodontal pockets: preliminary trials in humans" 
AAPS PharmSci, 4(4), article 20 (2002) 


S. EINMAHL, M. SAVOLDELLI, F. D'HERMIES, C. TABATABAY, R. GURNY et F. BEHAR-COHEN 
"Evaluation of a novel biomaterial in the suprachoroidal space of the rabbit eye" 
Investigative Ophthalmology & Visual Science, 43(5), 1533-1539 (2002) 


P. FURRER, J.M. MAYER et R. GURNY 
"Ocular tolerance of preservatives and alternatives" 
European Journal of Pharmaceutics and Biopharmaceutics, 53, 263-280 (2002) 


C.A. NGUYEN, G. SCHWACH, E. ALLEMANN, T. ARVINTE, E. DOELKER et R. GURNY 
"PLA-PEG nanoparticles: copolymerization, cell interation studies and surface characterization of particles" 
Proceed. 4th World Meeting ADRITELF/APGI/APV, 711-712 (2002) 


L. NOBS, F. BUCHEGGER, R. GURNY et E. ALLEMANN 
"Preparation of  Avidin-labeled poly(lactic acid) nanoparticles" 
Proceed. 4th World Meeting ADRITELF/APGI/APV, 715-716 (2002)


Y.N. KONAN, M. BERTON, R. GURNY et E. ALLEMANN 
"Improving the photodynamic activity of m-THPP by incorporation into sub-200 nm nanoparticles" 
Proceed. 4th World Meeting ADRITELF/APGI/APV, 749-750 (2002)


S. CAPANCIONI, K. SCHWACH-ABDELLAOUI, P. ZANELLO, J. GUYONNET, V. KALTSATOS et R. GURNY 
"Semi-solid autocatalyzed poly(ortho ester) as a new veterinary drug delivery system for estrus synchronization in ewes" 
Proceed. 4th World Meeting ADRITELF/APGI/APV, 1539-1540 (2002) 


Y.N. KONAN, R. GURNY et E. ALLEMANN 
"Preparation and characterization of sterile and freeze-dried sub-200 nm nanoparticles" 
International Journal of Pharmaceutics., 233 (1-2), 239-252 (2002)


P. FURRER, J.M. MAYER, B. PLAZONNET et R.GURNY 
"Ocular tolerance of absorption enhancers in ophthalmic preparations" 
AAAPS PharmSci, 4 (2), 1-5 (2002)
 

Y. N. KONAN, R. GURNY et E. ALLEMANN 
"State of the art in the delivery of photosensitizers for photodynamic therapy" 
Journal of Photochemistry and Photobiology B: Biology, 66, 89-106 (2002)


J. HELLER, J. BARR, S. NG,H.-R. SHEN, R. GURNY, K. SCHWACH-ABDELLAOUI, A. ROTHEN-WEINHOLD et M. VAN DE WEERT 
"Development of poly(ortho esters) and their application for bovine serum albumin and bupivacaine delivery" 
Journal of Controlled Release, 78 (1-3), 133-141 (2002) 

2001

S. EINMAHL, F. BEHAR-COHEN, C. TABATABAY et R. GURNY 
"Treatment of intraocular diseases with poly(ortho ester)-based drug delivery systems" 
Macromol. Symp., 172, 73-86 (2001) 


A. ROTHEN-WEINHOLD, J. BARR, S.Y.NG, H.-R. HUI et R.GURNY 
"Protein release from poly(ortho ester) extruded rods" 
Macromol. Symp., 172, 67-72 (2001) 


A.G. SARRAF, H. TISSOT, P.TISSOT, D. ALFONSO, R. GURNY et E. DOELKER 
"Influence of hot-melt extrusion and compression molding on polymer structure organization, investigated by differential scanning calorimetry" 
J. App. Polym. Sci., 81 (13), 3124-3132 (2001) 
 

I. BRIGGER, P.CHAMINADE, V. MARSAUD, M. APPEL, M. BESNARD, R. GURNY, M. RENOIR et P. COUVREUR 
"Tamoxifen encapsulation within polyethylene glycol-coated nanospheres. A new antiestrogen formulation." 
Int. J. Pharm., 214 (1-2), 37-42 (2001) 


S. EINMAHL, S. CAPANCIONI, K. SCHWACH-ABDELLAOUI, M. MOELLER, F. BEHAR-COHEN et R. GURNY 
"Therapeutic applications of viscous and injectable poly(ortho esters)" 
Advanced Drug Delivery Reviews, 53 (1), 45-73 (2001) 


M. BERTON, P. TURELLI, D. TRONO,CY A. STEIN, E. ALLEMANN et R. GURNY 
"Inhibition of HIV-1 in cell culture by oligonucleotide-loaded nanoparticles" 
Pharm. Res., 18 (8), 1096-1101 (2001) 


O. FELT, R. GURNY, P: BURI et V. BAEYENS 
"Delivery of antibiotics to the eye using a positively charged polysaccharides as vehicle" 
AAPS PharmSci, 3 (4), 34 (2001) 


M. BERTON, A. ROHMANN, M. JUNGHANS, D. LOCHMANN, CY A. STEIN, R. GURNY et A. ZIMMER 
"Evaluation of nanoparticles containing complexed oligonucleotides for the delivery of antisense drugs" 
Proceed. Int'l Symp. Control. Rel. Biact. Mater., 28, 1207-1208 (2001) 


S.EINMAHL, F. BEHAR-COHEN, C. TABATABAY, D. CHAUVAUD et R. GURNY 
"A novel route of ocular drug delivery: suprachoroidal injections of a sustained release systems" 
Proceed. Int'l Symp. Control. Rel. Biact. Mater., 28, 293-294 (2001) 


L. NOBS, F. BUCHEGGER, R. GURNY et E. ALLÉMANN 
"Surface modification of poly(lactic acid) nanoparticles with thiol functions" 
Proceed. Int'l. Symp. Control. Rel. Bioact. Mater., 28, 1364-1365, San Diego (USA), 2001


G. SCHWACH, N. OUDRY, P. BROQUA, H. LINDNER, M. LUCK, J. ANDERSON et R. GURNY 
"PLGA-based microparticles containing a hydropholic GnRH antagonist of the new generation" 
Proceed. Int'l Symp. Control. Rel. Biact. Mater., 28, 890-891 (2001) 


A.G. SARRAF, F. BARJA, L. OUALI, E.G. SARRAF, R. GURNY et E. DOELKER 
"Effect of polymer orientation induced by melt-extrusion on drug release" 
Proceed. Int'l Symp. Control. Rel. Biact. Mater., 28, 423-424 (2001) 


K. SCHWACH-ABDELLAOUI, V. KALTSATOS, M. MOREAU, B. BOISRAME et R. GURNY 
"Controlled delivery of an antiemetic agent using an injectable semi-solid poly(ortho ester) for the treatment of gastrointestinal disorder in dogs" 
Proceed. Int'l Symp. Control. Rel. Biact. Mater., 28, 1245-1246 (2001) 
 

K. SCHWACH-ABDELLAOUI, P.J. LOUP, N. VIVIEN-CASTIONI, A. MOMBELLI, P. BAEHNI, J. HELLER et R. GURNY 
"A novel bioerodible injectable system based on poly(ortho ester) for the adjunctive treatment of advanced 
periodontal disease" 
Proceed. Int'l Symp. Control. Rel. Biact. Mater., 28, 305-306 (2001)


F. DELIE, R. GURNY et A. ZIMMER 
"Fluorescence correlation spectroscopy for the characterisation of drug delivery systems" 
Biol. Chem., 382, 487-490 (2001)


K. SCHWACH-ABDELLAOUI, A. MONTI, J. BARR, J. HELLER et R. GURNY 
"Optimization of a novel bioerodible device based on auto-catalyzed poly(ortho esters) for controlled delivery of tetracycline to periodontal pocket" 
Biomaterials, 22, 1659-1666 (2001)


P. FURRER, J. BERGER J. M. MAYER et R. GURNY 
"Etude comparative de la tolérance oculaire de 3 spécialités à base de timolol: influence du conservateur sur la tolérance oculaire" 
J. Fr. Ophtalmol., 24 (1), 13-19 (2001)


S. EINMAHL, F. BEHAR-COHEN, F. D'HERMIES, S. RUDAZ, C. TABATABAY, G. RENARD et R. GURNY 
"A new poly(ortho ester)-based drug delivery system as an adjunct treatment in filtering surgery" 
IOVS, 42 (3), 695-700 (2001)


F. DE JAEGHERE, E. ALLÉMANN, E. DOELKER, R. GURNY, R. CERNY, B. GALLI, A. F. STEULET, I. MÜLLER et H. SCHÜTZ 
"pH-dependent dissolving nano- and microparticles for improved peroral delivery of a highly lipophilic compound in dogs" 
AAPS Pharmsci, 3 (1), article 8 (2001)


A. ROTHEN-WEINHOLD, K. SCHWACH-ABDELLAOUI, J. BARR, S.Y. NG, H.-R. SHEN, R. GURNY et J. HELLER 
"Release of BSA from poly(ortho ester) extruded thin strands" 
J. Controlled Rel. 71, 31-37 (2001) 


S. EINMAHL, F. BEHAR-COHEN, M. SAVOLDELLI, F. D'HERMIES, D. CHAUVAUD, C. TABATABAY et R. GURNY 
"Evaluation of a new biomaterial injected in the suprachoroidal space of the rabbit eye" 
Proceed. ARVO Annual Meeting, Fort Lauderdale (USA), (2001)


S. EINMAHL, K. SCHWACH-ABDELLAOUI, J. HELLER et R. GURNY 
"Poly(ortho esters) : recent developments for biomedical applications" 
Chimia, 55, (3), 218-222 (2001)


F. DELIE, M. BERTON, E. ALLÉMANN et R. GURNY 
"Comparison of two methods of encapsulation of an oligonucleotide into poly(D,L-lactic acid) particles" 
Intern. J. Pharm., 214, 25-30 (2001)


J. HELLER, J. BARR, S. NG, H.-R. SHEN, K. SCHWACH-ABDELLAOUI et R. GURNY 
"Development of poly(ortho esters)" 
dds&s, 1 (3), 79-84 (2001)


F.F. BEHAR-COHEN, D. BENEZRA, S. EINMAHL et R. GURNY 
"Challenges of intraocular drug delivery" 
European Pharmaceutical Review, Materials, 35-39 (2001)

2000

S. EINMAHL, F. BEHAR-COHEN, C. TABATABAY, M. SAVOLDELLI, F. D'HERMIES, D. CHAUVAUD, J. HELLER et  R. GURNY 
"A viscous bioerodible poly(ortho ester) as a new biomaterial for intraocular application" 
Biomed. Mater. Res. 50, 566-573 (2000)


F. DE JAEGHERE, E. ALLÉMANN, J. FEIJEN, T. KISSEL, E. DOELKER et R. GURNY 
"Freeze-drying and lyopreservation of diblock and triblock poly(lactic acid)-poly(ethylene oxide) (PLA-PEO) copolymer nanoparticles" 
Pharm. Dev. Technol., 5 (4), 473-483 (2000)


S. Y. NG, H.-R. SHEN, J. BARR, A. ROTHEN-WEINHOLD, S. EINMAHL, K. SCHWACH-ABDELLAOUI,  R. GURNY et J. HELLER 
"Poly (ortho esters) - A versatile drug delivery system" 
Proceed. Int.'l Symp. Biomater. Drug Delivery Systems, Korea, 6-3,  31 (2000)


A. ROTHEN-WEINHOLD, N. OUDRY, K. SCHWACH-ABDELLAOUI, S. FRUTIGER-HUGHES, G. J. 
HUGHES, D. JEANNERAT, U. BURGER, K. BESSEGHIR et R. GURNY
"Formation of peptide impurities in polyester matrices during implant manufacturing" 
Eur. J. Pharm. Biopharm. , 49, 253-257 (2000)


O. FELT, A. CARREL, P. BAEHNI, P. BURI et R. GURNY 
"Chitosan as tear substitute : A wetting agent endowed with antimicrobial efficacy" 
J. Ocul. Pharmacol. Ther., 16 (3), 261-270 (2000) 


F. DE JAEGHERE, E. ALLÉMANN, J. FEIJEN, T. KISSEL, E. DOELKER et R.GURNY 
"Cellular uptake of PEO surface-modified nanoparticles : Evaluation of nanoparticles made of PLA : PEO diblock and triblock copolymers" 
J. Drug Target., 8 (3), 143-153 (2000) 


K. SCHWACH-ABDELLAOUI, N. VIVIEN-CASTIONI et  R. GURNY 
"Local delivery of antimicrobial agents for the treatment of periodontal diseases" 
Eur. J. Pharm. Biopharm. 50, 83-99 (2000) 


M. ZIGNANI, T. LE MINH, S. EINMAHL, C. TABATABAY, J. HELLER, J.M. ANDERSON et  R. GURNY 
"Improved biocompatibility of a viscous bioerodible poly(ortho ester) by  controlling the environmental pH during degradation" 
Biomaterials, 21, 1773-1778 (2000) 


A. ROTHEN-WEINHOLD, M. DAHN et R. GURNY 
"Formulation and technology aspects of controlled drug delivery in animals" 
PSTT, 3 (7), 222-231 (2000)


F. DE JAEGHERE, E. ALLÉMANN, F. KUBEL, B. GALLI, R. COZENS, E. DOELKER et  R. GURNY  "Oral bioavailability of a poorly water soluble HIV-1 protease inhibitor incorporated into pH-sensitive particles : effect of the particle size and nutritional state" 
J. Control. Rel. 68, 291-298 (2000)


M. ZIGNANI, S. EINMAHL, V. BAEYENS, E. VARESIO, J.-L. VEUTHEY, J. ANDERSON, J. HELLER, C. TABATABAY et R. GURNY 
"A poly(ortho ester) designed for combined ocular delivery of dexamethasone sodium phosphate and 5-fluorouracil : subconjunctival tolerance and in vitro release" 
Eur. J. Pharm. Biopharm. 50, 251-255 (2000) 


I. BRIGGER, D. DESMAËLE, P. CHAMINADE, M.T. PERACCHIA, J. D'ANGELO, R. GURNY, J.M. RENOIR et P. COUVREUR 
"A novel analytical approach for the characterization 
poly(MePEGcyanoacrylate- co -hexadecylcyanoacrylate) nanoparticles" 
Proceed. Int.'l Symp. Control. Rel. Bioact. Mater. 27, 41-42 (2000)


Y. N. KONAN, E. ALLÉMANN et R. GURNY 
"Preparation and characterization of sterile and freeze-dried SUB-200 nm nanoparticles" 
Proceed. Int.'l Symp. Control. Rel. Bioact. Mater. 27, 321-322 (2000) 


A. ROTHEN-WEINHOLD, J. HELLER, J. BARR et R. GURNY 
"Poly (ortho esters) implants for the sustained delivery of a protein : farctors influencing the release behaviour of BSA in vitro
Proceed. Int.'l Symp. Control. Rel. Bioact. Mater. 27, 968-969 (2000) 


P. FURRER, B. PLAZONNET, J. M. MAYER et R. GURNY 
"Application of in vivo confocal microscopy to the objective evaluation of ocular irritation induced by surfactants" 
Int. J. Pharm., 207, 89-98 (2000) 

1999

F. De JAEGHERE, E. ALLÉMANN, J.-C. LEROUX, W. STEVELS, J. FEIJEN, E. DOELKER et R. GURNY 
"Formulation and lyoprotection of poly(lactic acid-co-ethylene oxide) nanoparticles: Influence on physical stability and in vitro cell uptake" 
Pharm. Res. 16 (6), 859-866 (1999) 


S. EINMAHL, M. ZIGNANI, E. VARESIO, J. HELLER, J.-L. VEUTHEY, C. TABATABAY et R. GURNY 
"Concomitant and controlled release of dexamethasone and 5-fluorouracil from  poly(ortho ester)" 
International Journal of Pharmaceutics, 185, 189-198 (1999)


A. ROTHEN-WEINHOLD, K. BESSEGHIR, E. VUARIDEL, E. SUBLET, N. OUDRY, F. KUBEL et R. GURNY 
"Injection-molding versus extrusion as manufacturing technique for the preparation  of biodegradable implants" 
European Journal of Pharmaceutics and Biopharmaceutics, 48, 113-121 (1999)


A. ROTHEN-WEINHOLD, N. OUDRY, K. SCHWACH-ABDELLAOUI, S. FRUTIGER-HUGHES, G.J. HUGHES, K. BESSEGHIR et R. GURNY 
"How to avoid the formation of peptide impurities during manufacturing of implants  by melt-extrusion ? " 
Proceed. Int.'l Symp. Controlled Release Bioact. Mater. 26, 681-682 (1999)


O. FELT, P. FURRER, J.-M. MAYER, B. PLAZONNET, P. BURI et R. GURNY 
"Topical use of chitosan in ophthalmology : tolerance assessment and evaluation of precorneal retention" 
Int. J. Pharm. 180, 185-193 (1999) 
 

A. ZIMMER, F. DELIE-SALMON et R. GURNY 
"Application of fluorescence correlation spectroscopy for the characterization of drug  delivery systems" 
Proceed. Int.'l Symp. Controlled Release Bioact. Mater. 26, 671-672 (1999)


A. ROTHEN-WEINHOLD, K. BESSEGHIR, E. VUARIDEL, E. SUBLET, N. OUDRY et R. GURNY 
"Stability studies of a somatostatin analogue in biodegradable implants" 
Int. J. Pharm. 178, 213-221 (1999)


F. DE JAEGHERE, E. ALLÉMANN, J. FEIJEN, T. KISSEL, E. DOELKER et R. GURNY 
"Cellular uptake of nanoparticles made of poly(lactic acid), poly(ethylene oxide)  diblock and triblock copolymers" 
Proceed. Int.'l Control. Rel. Bioact. Mater. 26, 685-686 (1999)


M. BERTON, L. BENIMETSKAYA, E. ALLÉMANN, C.A. STEIN et R. GURNY 
"Uptake of oligonucleotide loaded nanoparticles in prostatic cancer cells and their intracellular localization" 
Europ. J. Pharm. Biopharm. 47,  119-123 (1999)


P. FURRER, J. M. MAYER et R. GURNY 
"Ocular tolerance of preservatives on the murine cornea" 
Eur. J. Pharm. Biopharm. 47, 105-112 (1999)


K. SCHWACH-ABDELLAOUI, J. HELLER et R. GURNY 
"Synthesis and characterization of self-catalyzed poly(ortho esters) based on decanediol and decanediol-lactate designed for sustained drug release" 
J. Biomater. Sci. Polymer Edn. 10 (3), 375-389 (1999) 


J. HELLER, S.Y. NG, R-H SHEN, J. BARR, A. ROTHEN-WEINHOLD et R. GURNY 
"Protein delivery from extruded poly(ortho esters)" 
Proceed. Asian Conference on Controlled Release, Hong Kong, , 132-133 (1999)


A. ROTHEN-WEINHOLD, K. BESSEGHIR et R. GURNY 
"Production of biodegradable implants for the sustained release of pharmaceuticals" 
Proceed. Asian Conference on Controlled Release, Hong Kong, 72-73 (1999)


S. EINMAHL, F. BEHAR-COHEN, C. TABATABAY, D. CHAUVAUD, J.  HELLER et R. GURNY 
"Poly(ortho ester) : A new biocompatible intraocular drug delivery system" 
Proceed. Asian Conference on Controlled Release, Hong Kong, , 70-71 (1999)


R. GURNY, A. ROTHEN-WEINHOLD et K. BESSEGHIR 
"Biodegradable implants" 
Proceed. Asian Conference on Controlled Release, Hong Kong, 46-47 (1999)


M. BERTON, E. ALLÉMANN, CY A. STEIN et R. GURNY 
"Highly loaded nanoparticulate carrier using an hydrophobic antisense  oligonuccleotide complex" 
Eur. J. Pharm. Sci., 9, 163-170 (1999)


K. SCHWACH-ABDELLAOUI, J. HELLER et R. GURNY 
"Bioerodible devices based on poly(ortho esters) for controlled delivery of tetracycline to periodontal pocket" 
Proceed. Int.'l Symp. Controlled Release Bioact. Mater., 26, 697-698 (1999)


S. EINMAHL, F. BEHAR-COHEN, C. TABATABAY et R. GURNY 
"Evaluation of poly(ortho ester) for intraocular application in rabbits: biocompatibility assessement and in vitro degradation" 
Proceed. Int.'l Symp. Controlled Release Bioact. Mater., 26, 679-680 (1999)


O. FELT, C. MICHEL, P. BURI et R. GURNY 
"Gamma scintigraphy as tool for the evaluation of precorneal residence time :  influence of the methodology" 
Proceed. Int.'l Symp. Controlled Release Bioact. Mater. 26, 615-616 (1999)


G. MOLINARO, A. ADAM, M. ZIGNANI, J. TAILLEFER, K. SCHWACH-ABDELLAOUI, R. GURNY et J.C. LEROUX 
"Evaluation of the local and systemic inflammatory responses induced by the  subcutaneous injection of different biopolymers" 
Proceed. Int.'l Symp. Controlled Release Bioact. Mater. 26, 611-612 (1999)


F. DE JAEGHERE, E. ALLÉMANN, J. FEIJEN, E. DOELKER et R. GURNY 
"Freeze-drying of PLA-PEO nanoparticles - from basic principles to rational optimization" 
Proceed. Int.'l Symp. Controlled Release Bioact. Mater. 26, 573-574 (1999)


J. HELLER, S.Y.NG, J. BARR, R. GURNY, K. SCHWACH-ABDELLAOUI et E. SCHACHT 
"Erosion, properties and drug release from a new family of poly(ortho esters)" 
Proceed. Int.'l Symp. Controlled Release Bioact. Mater. 26, 232-233 (1999)


K. SCHWACH-ABDELLAOUI, J. HELLER et R. GURNY 
"Hydrolysis and erosion studies of autocatalyzed poly(ortho esters) containing lactoyl-lactyl acid dimers" 
Macromolecules 32 (2), 301-307 (1999)

1998

M. SINTZEL, K. SCHWACH-ABDELLAOUI, K. MÄDER, R. STÖSSER, J. HELLER, C. TABATABAY et R. GURNY 
"Influence of irradiation sterilization on semi-solid poly(ortho ester)" 
Int. Journal Pharm. 175, 165-176 (1998) 


M. SINTZEL, J. HELLER, SY. NG, C. TABATABAY,  K. SCHWACH-ABDELLAOUI  et R. GURNY 
" In-vitro drug release from self-catalyzed poly(ortho ester) : case study of 5-fluorouracil and mitomycin C" 
J. Controlled Rel. 55, 213-218 (1998) 


E. ALLÉMANN, J.C. LEROUX et R. GURNY 
"Polymeric nano- and microparticles for the oral delivery of peptides and peptidomimetics" 
Adv. Drug Delivery Reviews 34, 171-189 (1998) 


O. FELT, P. BURI et R. GURNY 
"Chitosan : a unique polysaccharide for drug delivery" 
Drug Dev. Ind. Pharm. 24 (11), 979-993 (1998) 


M. ZIGNANI, S.F. BERNATCHEZ, T. LeMINH, C. TABATABAY, J.M. ANDERSON et R. GURNY 
"Subconjunctival biocompatability of a viscous bioerodable poly(ortho ester)" 
J. Biomed. Mater. Res. 39 (2), 277-285 (1998) 


M.B. SINTZEL, J. HELLER, S.Y. NG, M.S. TAYLOR, C. TABATABAY et R. GURNY 
"Synthesis and characterization of self-catalyzed poly(ortho ester)" 
Biomaterials 19, 791-800 (1998) 


V. BAEYENS, V. KALTSATOS, B. BOISRAME, M. FATHI et R. GURNY 
"Evaluation of soluble bioadhesive ophthalmic drug inserts (BODI R ) for prolonged release of gentamicin : lachrymal Pharmacokinetics and ocular tolerance" 
J. Ocular Pharm. 14, 263-272 (1998)
 

A.A. DESHPANDE, J. HELLER et R. GURNY 
"Bioerodible polymers for ocular drug delivery" 
Crit. Rev. Ther. Drug. Carrier Syst. 15(4), 381-420 (1998) 


A. MERKLI, C. TABATABAY, R. GURNY et J. HELLER 
"Biodegradable polymers for the controlled release of ocular drugs" 
Prog. Polym. Sci. 23, 563-580 (1998) 
 

N. VIVIEN, P.-C. BAEHNI et R. GURNY 
"Current status in oral fluoride pharmacokinetics and implications for the prophylaxis against dental caries" 
Eur. J. Pharm. Biopharm. 45, 101-111 (1998) 
 

M.B. SINTZEL, K. SCHWACH-ABDELLAROUI, K. MÄDER. R. STÖSSER, J. HELLER, C. TABATABAY et R. GURNY 
"Influence of irradiation sterilization on semi-solid poly(ortho ester)" 
Int. J. Pharm. 175,  165-176 (1998) 


K. SCHWACH-ABDELLAOUI, J. HELLER et R. GURNY 
"Understandig of degradation mechanism of autocatalyzed poly(ortho esters) containing lactoyl-lactic dimers" 
Proceed. Int'l. Symp. Control. Rel. Bioact. Mater., 25, 713-714, Las Vegas (USA) 1998


V. BAEYENS, V. KALTSATOS, B. BOISRAME, E. VARESIO, J.-L. VEUTHEY, M. FATHI, L.P. BALANT, M. GEX-FABRY et R. GURNY 
"Optimized release of dexamethasone and gentaicin from a soluble ocular insert for the treatment of external ophthalmic infections" 
J.  Controlled Rel. 52, 215-220 (1998) 
 

A. ROTHEN-WEINHOLD, K. BESSEGHIR, Y. De ZELICOURT et R. GURNY 
"Development and evaluation in vivo of a long-term delivery system for vapreotide, a somatostatin analogue" 
J. Controlled Rel. 52, 205-213 (1998) 


K. SCHWACH-ABDELLAOUI, J. HELLER et R. GURNY 
"Synthesis and characterization of new bioerodible polymers designed for controlled drug release applications" 
Proceed. 2nd World Meeting APGI/APV, Paris, 1998, p. 275-276


A. ROTHEN-WEINHOLD, K. BESSEGHIR, E. VUARIDEL et R. GURNY 
"Injection-moulding versus extrusion for the preparation of long-acting biodegradable implants" 
Proceed. 2nd World Meeting APGI/APV, Paris, 1998, p. 357-358


O. FELT, P. FURRER, J.M. MAYER, B. PLAZONNET, P. BURI et R. GURNY 
"Topical use of chitosan in ophthalmology: tolerance assessment by confocal microscopy and precorneal retention evaluation by gamma scintigraphy" 
Proceed. 2nd World Meeting APGI/APV, Paris, 1998, p. 913-914
 

S. EINMAHL, M. ZIGNANI, V. BAEYENS, E. VARESIO, J.-L. VEUTHEY, J. HELLER, C. TABATABAY et R. GURNY 
"A biodegradable polymer designed for concomitant delivery of dexamethasone and 5-fluorouracil to the eye" 
Proceed. 2nd World Meeting APGI/APV, Paris, 1998, p. 969-970


F. DE JAEGHERE, E. ALLÉMANN, F. KUBEL, B. GALLI, E. DOELKER et R. GURNY 
"pH-sensitive microparticles as oral delivery systems for antiinfective agents of poor water solubility" 
Proceed. 2nd World Meeting APGI/APV, Paris, 1998, p. 559-560


V. BAEYENS, V. KALTSATOS, B. BOISRAMÉ, Ph. DRUET, J.-L. DAVOT et R. GURNY 
"Clinical evaluation of bioadhesive ophthalmic drug inserts (Bodi) containing gentamicin for the treatment of external ophthalmic infection" 
Proceed. 2nd World Meeting APGI/APV, Paris, 1998, 991-992


M. BERTON, E. ALLÉMANN, H. TÜRLER, R. WEIL, L. ZWILLENBERG et R. GURNY 
"Poly(D,L-lactic acid) nanoparticles as phosphorothioate oligonucleotide carriers in U937 cells" 
Proceed. 2nd World Meeting APGI/APV, Paris, 1998, p. 1119-1120

1997

V. BAEYENS, C. PERCICOT, M. ZIGNANI, A. A. DESHPANDE, V. KALTSATOS et R. GURNY 
"Ocular drug delivery in veterinary medicine"
Adv. Drug Delivery Rev. 28, 335-361 (1997)


P. FURRER, J. M. MAYER et R. GURNY 
"Confocal microscopy as a tool for the investigation of the anterior part of the eye" 
J. Ocular Pharmcol. Ther. 13, 559-578 (1997) 


M. ZIGNANI, A. MERKLI, M.B. SINTZEL, S.F. BERNATCHEZ, W. KLOETI, J. HELLER, C. TABATABAY et R. GURNY 
"New generation of poly(ortho esters) : synthesis, characterization, kinetics, sterilization and biocompatibility" 
J. Controlled Rel. 48, 115-129 (1997) 


M. B. SINTZEL, A. MERKLI, C. TABATABAY et R. GURNY 
"Influence of irradiation sterilization on polymers used as drug carriers - A review" 
Drug Dev. Ind. Pharm. 23, 857-878 (1997) 


V. BAEYENS, E. VARESIO, J-.L. VEUTHEY et R. GURNY 
"Determination of Dexamethasone in tears by capillary electrophoresis " 
J. Chromatogr. B. 692, 222-226 (1997) 


A. ROTHEN-WEINHOLD et R. GURNY 
"Controlled and/or prolonged parenteral delivery of peptides from the hypothalamic pituitary axis" 
Eur. J. Pharm. Biopharm. 43, 115-131 (1997) 


A. ROTHEN-WEINHOLD, K. BESSEGHIR et R. GURNY 
"Analysis of the influence of polymer characteristics and core loading on the in vivo release of a somatostation analogue" 
Eur. J. Pharm. Sci., 5, 303-313 (1997) 


E. ALLÉMANN, P. GRAVEL, J.C. LEROUX, L. BALANT et R. GURNY 
"Kinetics of blood component adsorption on poly(D,L-lactic acid) nanoparticles : evidence of complement C3 component involvement" 
J. Biomed Mater Res. 37, 229-234, (1997) 


Y. JACQUES, T. NGUYEN-XUAN,  E. IONESCU, G.P. RAVELLI, P. BURI, P. BAEHNI et R. GURNY 
" In-vivo evaluation of hydrophilic and hydrophobic mucoadhesive semi-solid formulations containing sucralfate and lidocaine for intraoral use" 
Eur. J. Pharm. Biopharm.  43, 59-63 (1997) 


M.B. SINTZEL, S.Y. Ng, M.S. TAYLOR, J. HELLER, C. TABATABAY et R. GURNY 
"Synthesis and characterization of ointment-like self-catalyzed poly(ortho ester)" 
Proceed. Int.'l Symp. Controlled Release Bioact. Mater., 24, 909-910 (1997)
 

M. ZIGNANI, T. LE MINH, C. TABATABAY et R. GURNY 
"Improved biocompatibility of a viscous bioerodable poly(ortho ester) by controlling the environmental pH" 
Proceed. Int.'l Symp. Controlled Release Bioact. Mater., 24, 907-908 (1997)


N. VIVIEN-CASTIONI, R. GURNY, V. KALTSATOS et P. BAEHNI 
"Prophylaxis of caries - in vivo evaluation of various oral fluoride containing preparations designed to optimize salivary concentrations" 
Proceed. Int.'l Symp. Controlled Release Bioact. Mater., 24, 905-906 (1997)


F. DE JAEGHERE, E. ALLÉMANN, J.-C. LEROUX, W. STEVELS, P.J. DIJKSTRA, F. FEIJEN, E. DOELKER et R. GURNY 
"PLA-PEG nanoparticles: preparation and cell interaction studies" 
Proceed. Int.'l Symp. Controlled Release Bioact. Mater., 24, 831-832 (1997)


A. ROTHEN-WEINHOLD, K. BESSEGHIR et R. GURNY 
"Development of a long-term delivery system for RC-160, a somatostatin analog" 
Proceed. Int.'l Symp. Controlled Release Bioact. Mater., 24, 827-828 (1997)


M. BERTON, K. HOWARD, L. BENIMETSKAYA, E. ALLÉMANN, R. WEIL, L.O. ZWILLENBERG, C.A. STEIN et R. GURNY 
"Uptake of oligonucleotide loaded nanoparticles in prostatic cancer cells and their intracellular localization" 
Proceed. Int.'l Symp. Controlled Release Bioact. Mater., 24, 669-670 (1997)


V. BAEYENS, E. VARESIO, J.-L. VEUTHEY, V. KALTSATOS, B. BOISRAME, M. FATHI et R. GURNY 
"Combined release of dexamethasone and gentamicin from an ocular insert for treatment of external ophthalmic infections" 
Proceed. Int.'l Symp. Controlled Release Bioact. Mater., 24, 143-144 (1997)


V. BAEYENS et R. GURNY 
"Chemical and physical parameters of tears relevant for the design of ocular drug delivery formulations" 
Pharm. Acta Helv. 72 191-202 (1997)


M.B. SINTZEL, A. MERKLI, J. HELLER, C. TABATABAY et R. GURNY 
"Synthesis and analysis of viscous poly (ortho-ester) analogs for controlled drug release" 
International Journal of Pharmaceutics, 155, 263-269 (1997)


A.A. DESHPANDE, C. TABATABAY, P.M. HUGHES et R. GURNY 
"Therapeutic applications of retinoids in ophthalmology" 
International Journal of Pharmaceutics, 157, 1-15 (1997)

1996

M. ZIGNANI, S.F. BERNATCHEZ, C. TABATABAY et R. GURNY 
"Poly ortho ester : a semisolid biodegradable polymer for ocular drug delivery" 
Eur. J. Pharm. Biopharm. 42, 59S (1996) 


G. MESEGUER, P. BURI, B. PLAZONNAT, A. ROZIER et R. GURNY 
"Gamma scintigraphic comparison of eyedrops containing pilocarpine in healthy volunteers" 
J. Ocular Pharm.col. Therap. 12, 481-488 (1996) 


M. B. SINTZEL, C. TABATABAY et R. GURNY 
"Biomaterials in ophthalmic drug delivery" 
Eur. J. Pharm. Biopharm. 42, 358-374 (1996) 
 

J. KRISTL, E. ALLÉMANN et R. GURNY 
"Formulation and evaluation of zinc-phthalocyanine loaded  poly(DL-lactic acid) nanoparticles" 
Acta Pharm. Helv. 46, 1-12 (1996) 


A. MERKLI, J. HELLER, C. TABATABAY et R. GURNY 
"Purity and stability assessment of a semi-solid poly(ortho ester) used in drug delivery system" 
Biomaterials 17, 897-902 (1996) 


F. GURTLER, V. KALTSATOS, B. BOISRAME et R. GURNY 
"Development and optimization of a novel soluble ophthalmic insert : evaluation of  ocular tolerance in rabbits" 
Eur. J. Pharm. Biopharm. 42, 393-398 (1996) 


J.C. LEROUX, E. ALLÉMANN, F. DE JAEGHERE, E. DOELKER et R. GURNY 
"Biodegradable nanoparticles - from sustained release formulations to improved site specific drug delivery" 
J. Controlled Rel. 39, 339-350 (1996) 
 

T. NGUYEN-XUAN, R. TOWART, A. TERRAS, Y. JACQUES, P. BURI et R. GURNY 
"Mucoadhesive semi-solid formulations for intraoral use containing sucralfate" 
Eur. J. Pharm. Biopharm. 42, 133-137 (1996) 


V. H.L. LEE, H. YAMAHARA, R. GURNY, M.B. SINTZEL, M. MARTENET, M. GEX-FABRY, L. BALANT, S. OHDO et S.K. PODDER 
"Basis for dosing time-dependent changes in the ocular and systemic absorption of topically applied timolol" 
J. Ocular Pharmcol. 12, 103-113 (1996) 


J.-C. LEROUX, R.M. COZENS, J.L. ROESEL, B. GALLI, E. DOELKER et R. GURNY 
"pH-sensitive nanoparticles: an effective means to improve the oral delivery of HIV-1 protease inhibitors in dogs" 
Pharmaceutical Research, 13, 485-487 (1996)

1995

J.C. LEROUX, R. COZENS, J. L. ROESEL, B. GALLI, F. KUBEL, E. DOELKER et R. GURNY 
"Pharmacokinetics of a novel HIV-1 protease inhibitor incorporated into biodegradable or enteric nanoparticles following intravenous and oral administration to mice" 
Pharm. Sci. 84, 1387-1391 (1995)


A. MERKLI, C. TABATABAY et R. GURNY 
"Use of insoluble biodegradable polymers in ophthalmic systems for the sustained release of drugs" 
Eur. J. Pharm. Biopharm. 41, 271-283 (1995) 


M. ZIGNANI, C. TABATABAY et  R. GURNY
"Topical semi-solid drug delivery : kinetics and tolerance of ophthalmic hydrogels" 
Adv. Drug Delivery Rev. 16, 51-60 (1995) 


F. GURTLER, V. KALTSATOS, B. BOISRAME, J. DELEFORGE, M. GEX-FABRY, L. BALANT et  R. GURNY 
"Ocular availability of gentamicin in small animal after topical administration of a conventional eye drop solution and a novel long acting bioadhesive Ophthalmic Drug Insert (BODI)" 
Pharm. Res. 12, 1791-95 (1995) 


J.C. LEROUX, F. DE JAEGHERE, B. ANNER, E. DOELKER et R. GURNY 
"An investigation on the role of plasma and serum opsonins on the internalization of biodegradable poly(D,L.-lactic acid) nanoparticles by human monocytes" 
Life Sci. 57 (7), 695 - 703 (1995) 


J.C. LEROUX, E. ALLEMANN, E. DOELKER et R. GURNY 
"New approach for the preparation of nanoparticles by an emulsification-diffusion method" 
Eur. J. Pharm. Biopharm 41 (1), 14-18 (1995) 


F. GURTLER, R. GURNY, V. KALTSATOS et B. BOISRAME 
"Ophthalmic inserts increase the contact time between a preparation and the eye. Adding a bioadhesive to the insert keeps the device in place, ensuring better drug delivery" 
Chemtech, 25, 33-34 (1995) 


F. GURTLER, V. KALTSATOS, B. BOISRAME et R. GURNY 
"Long acting soluble bioadhesive ophtalmic drug insert (BODI) containing gentamicin for veterinary use: optimization and clinical investigation" 
J. Controlled Rel. 33, 231-236 (1995) 


E. ALLEMANN, N. BRASSEUR, O. BENREZZAK, J. ROUSSEAU, J.C. LEROUX, R. GURNY et J.E. VAN LIER 
"PEG-coated poly(lactic acid) nanoparticles for the delivery of hexadecafluoro zinc  phthalocyanine to EMT-6 mouse mammary tumours" 
J. Pharm. Pharm.col. 47, 382-387 (1995) 
 

A. MERKLI, J. HELLER, C. TABATABAY et R. GURNY 
"The use of acidic and basic excipients in the release of 5-fluorouracil and  mitomycin C from a semisolid bioerodible poly(ortho ester)" 
J. Controlled Rel. 33, 415-421 (1995) 


F. GURTLER et R. GURNY 
"Patent literature review of ophthalmic inserts" 
Drug Dev. Ind. Pharm. 21, 1-18 (1995) 

1994

C. TABATABAY,  S.F. BERNATCHEZ et R. GURNY 
"Proceed with caution whenever using commercial 5-fluorouracil solution in glaucoma filtration surgery" 
Ocular Surgery News, Int. Ed. 5, 19 (1994) 


R.GURNY, S.F. BERNATCHEZ, A. MERKLI et C. TABATABAY 
"New semi solid poly(ortho esters) designed for controlled drug delivery of injectable products" 
Bull. Gattefossé 87, 63-66 (1994)


S.F. BERNATCHEZ, A. MERKLI, T. LE MINH, C. TABATABAY, J.M. ANDERSON et R. GURNY 
"Biocompatibility of a new semisolid bioerodible poly(ortho ester) intended for the ocular delivery of 5-fluorouracil" 
J. Biomed. Mater. Res. 28, 1037-1046 (1994) 


F. LESCURE, R. GURNY et E. DOELKER 
" In vitro and in vivo evaluation of progesterone implants based on new biodegradable polypeptidic copolymers" 
J. Biomater. Sci., Polym. Edn.6, 797-807 (1994) 


G. MESEGUER, P.BURI et R. GURNY 
"Application of medical imaging to Pharmaceutical research: the example of gamma scintigraphy.  Technological aspects." 
Eur. J. Pharm. Biopharm. 40, 111-121 (1994) 


G. MESEGUER, R. GURNY et P. BURI 
" In vivo evaluation of dosage forms: application of gamma scintigraphy to non-enteral   routes of administration" 
J. Drug Target. 2, 269-288 (1994)


A. MERKLI, J. HELLER, C. TABATABAY et R. GURNY 
"Gamma sterilization of a semi-solid poly(ortho ester) designed for controlled drug  delivery - Validation and radiation effects" 
Pharm. Res. 11, 1485-1491 (1994) 


S.F. BERNATCHEZ, C. TABATABAY et R. GURNY 
"Sodium hyaluronate as a vehicle for an improved tolerance of 5-fluorouracil  administered subconjunctivally to rabbits" 
Int. J. Pharm.,106, 161-166 (1994) 


J.C. LEROUX, P. GRAVEL, L. BALANT, B. VOLET, B.M. ANNER, E. ALLEMANN, E. DOELKER et R. GURNY 
"Internalization of poly(D,L-lactic acid) nanoparticles by isolated human leukocytes  and analysis of plasma proteins adsorbed on to the particles" 
J. Biomed. Mater. Res.,28, 471-481 (1994)


A. MERKLI, J. HELLER, C. TABATABAY et R. GURNY 
"Semi-solid hydrophobic bioerodible poly(ortho ester) for potential application in  glaucoma filtering surgery" 
J. Controlled Rel., 29, 105-112 (1994)


E. ALLÉMAN, R. GURNY, E., DOELKER. F.S. SKINNER et H. SCHUTZ 
"Distribution, kinetics and elimination of radioactivity after intravenous and  intramuscular injection of 14C-savoxepine loaded poly(D,L-lactic acid) nanospheres to  rats" 
J. Controlled Rel.,29, 97 - 104 (1994)

1993

A. MERKLI, J. HELLER, C. TABATABAY et R. GURNY 
"Synthesis and characterization of a new biodegradable semi-solid poly(ortho  ester) for drug delivery systems" 
J. Biomater. Sci., Polymer Edn., 4, 505-516 (1993) 


G. MESEGUER, R. GURNY, P. BURI, A. ROZIER et B. PLAZONNET 
"Gamma scintigraphic study of precorneal drainage and assessment of miotic response  in rabbits of various ophthalmic formulations containing pilocarpine" 
Int. J. Pharm., 95, 229-234 (1993) 


S.F. BERNATCHEZ, C. TABATABAY et R. GURNY 
"Sodium hyaluronate 0,25 % used as a vehicule increases the bioavailability of topically  administered gentamicin" 
Graefe's Arch. Clin. Exp. Ophthalmol., 231, 157-171 (1993) 


R. GURNY, C. TABATABAY, S.F. BERNATCHEZ, A. MERKLI, E. ALLEMAN, C. AFTABROUCHAD, F. LESCURE et E. DOELKER 
"Biodegradable polymers - Contemporary issues and new directions" 
Eur. J. Hosp. Pharm., 3, 15-19 (1993)
 

E. ALLÉMANN, E. DOELKER et R. GURNY 
"Drug loaded poly(lactic acid) nanoparticles produced by a reversible salting-out  process : Purification of an injectable dosage form" 
Eur. J. Pharm. Biopharm., 39, 13-18 (1993) 


E. ALLÉMANN, J.-C. LEROUX, R. GURNY et E. DOELKER 
" In vitro extended-release properties of drug-loaded poly(DL-lactic acid) nanoparticles  produced by  salting-out procedure" 
Pharmaceutical Research, 10, 1732-1737 (1993)


E. ALLÉMANN, R. GURNY, E. DOELKER 
"Drug-loaded nanoparticles - Preparation methods and drug targeting issues" 
European Journal of Pharmaceutics and Biopharmaceutics, 39 (5), 173-191 (1993)
 

S.F. BERNATCHEZ, A. MERKLI, C. TABATABAY, R. GURNY, Q.H. ZHAO, J.M. ANDERSON et J. HELLER 
"Biotolerance of a semisolid hydrophobic biodegradable poly(ortho ester) for  controlled drug delivery" 
J. Biomed. Mat. Res. 27, 677-681 (1993)

1992

E. ALLÉMAN, R. GURNY et E. DOELKER
"Preparation of aqueous polymeric nanodispersions by a reversible salting-out process,  influence of process parameters on particle size" 
Int. J. Pharm., 87, 247-253 (1992) 


F. LESCURE, R. GURNY, E. DOELKER et J.M. ANDERSON 
"Long term histopathological study of new polypeptidic biomaterials" 
Biomaterials, 13,1009-1011 (1992) 


H. IBRAHIM, C. BINDSCHAEDLER, E. DOELKER, P. BURI et R. GURNY 
"Aqueous nanodispersions prepared by a salting-out process" 
Int. J. Pharm., 87, 239-246 (1992) 


A. MERKLI, P. WUTHRICH, J. HELLER, C. TABATABAY et R. GURNY 
"Semi-solid hydrophobicc biodegradable poly(ortho ester) for controlled ocular drug delivery" 
Invest. Ophthalmol. & Vis. Sci. suppl., 33, 1392 (1992) 


S.F. BERNATCHEZ, C. TABATABAY, R. GURNY, T. LE MINH, T. SEEMAYER et J.M. ANDERSON 
"In vivo biocompatibility of an injectable poly(ortho ester) a preliminary study" 
Invest. Ophthalmol. & Vis. Sci. suppl., 33, 1391 (1992) 


G. MESEGUER, R. GURNY, P. BURI, A. ROZIER et B. PLAZONNET 
"A gamma scintigraphy evaluation and assessment of miotic response of various hydrogels containing pilocarpine in rabbits" 
Invest. Ophthalmol. & Vis. Sci. suppl., 33, 996 (1992) 


G. MESEGUER, R. GURNY, P. BURI, A. ROZIER et B. PLAZONNET 
"Precorneal drainage of various pilocarpine-containing formulations assessed by gamma scintigraphy and comparison of residence time with prolongation of miotic response in rabbits" 
6e Congrès International de Technologie Pharmaceutique, APGI, Vol. IV, 35-42, Paris (1992)


E. ALLÉMANN, R. GURNY et E. DOELKER 
"Preparation and optimization of nanoparticles by a reversible salting-out process avoiding surfactants" 
6e Congrès International de Technologie Pharmaceutique, APGI, Vol. Ill, 15-21, Paris (1992)

1991

H. IBRAHIM, C. BINDSCHAEDLER, E. DOELKER, P. BURI et R. GURNY 
"Concept and development of ophtalmic pseudo-latexes triggered by pH" 
Int. J. Pharm., 77, 211-219 (1991) 
 

V. BELTRAMI, R. GURNY et E. DOELKER 
"Comparative swelling behavior of crosslinked vinyl alcohol homo- and copolymers" 
18th Intern. Symp. Control. Rel. Bioact. Mater., Amsterdam (1991)
 
1990

B. GANDER, V. BELTRAMI, R. GURNY et E. DOELKER 
"Effects of the method of drug incorporation and the sizes of the monolith on drug release from crosslinked polymers" 
Int. J. Pharm., 58, 63-71 (1990) 
 

A.-F. RIME, F. LESCURE, D. MORDIER, R. GURNY et E. DOELKER 
"A new high performance data acquisition system interfacing an instrumented tablet machine to a microcomputer" 
Acta Pharm. Technol., 36, 264-268 (1990) 
 

R. GURNY, J.E. RYSER, C. TABATABAY, M. MARTENET, P. EDMAN et O. CAMBER 
"Precorneal residence time in humans of sodium hyaluronate as measured by gamma scintigraphy" 
Graefe's Arch. Clin. Exp. Ophthalmol., 228, 510-512 (1990) 
 

V. BELTRAMI, R. GURNY et E. DOELKER 
"Le poly(alcool de vinyle) dans les formes à libération prolongée destinées à la voie orale" 
Pharm. Acta Helv., 65, 130-142 (1990) 
 

H. IBRAHIM, R. GURNY, P. BURI, J. GROVE, A. ROZIER et B. PLAZONNET 
"Ocular bioavailability of pilocarpine from a phase transition latex system triggered by pH" 
Communication : 4e Congrès Européen de Biopharmacie et de Pharmacocinétique, Genève  (1990)
 

F. LESCURE, R. GURNY, E. DOELKER et D. BICHON 
"Effect of various factors on the in vitro release of progesterone from a new class of implantable polypeptide" 
Communication : 4e Congrès Européen de Biopharmacie et de Pharmacocinétique, Genève (1990)
 
1989

F. LESCURE, R. GURNY, E. DOELKER, M.L. PELAPRAT, D. BICHON et  J.M. ANDERSON 
"Acute histopathological response to a new biodegradable polypeptidic polymer for implantable drug delivery system" 
J. Biomed. Mater. Res., 23, 1299-1313 (1989)
 

B. GANDER, R. GURNY, E. DOELKER et N.A. PEPPAS 
"Effect of polymeric network structure on drug release from crosslinked poly(vinyl alcohol) micromatrices" 
Pharm. Res., 6, 578-584 (1989)
 

F. LESCURE, R. GURNY, E. DOELKER et J. AUGUSTYNSKI 
"Utilisation du principe de l'iontophorèse ou de l'électrophorèse pour le contrôle de la libération de substances médicamenteuses" 
Pharm. Acta Helv., 64, 210-219 (1989) 
 

R. DIEPOLD, J. KREUTER, J. HIMBER, R. GURNY, V.H.L. LEE, J.R. ROBINSON, M.F. SAETTONE et O.E. SCHNAUDIGEL 
"Comparison of different models fo the testing of pilocarpine eyedrops using conventionnal eyedrops and a novel depot formulation (nanoparticles)" 
Graefe's Arch. Clin. Exp. Ophthalmol., 227, 188-193 (1989)
 

V. BELTRAMI, R. GURNY et E. DOELKER 
"Matrices de poly(alcool de vinyle) à libération contrôlée, influence de l'inactivation de l'agent de réticulation sur les caractéristiques de gonflement, de chargement en principes actifs et sur les profils de libération" 
5ème Congrès international de technologie Pharmaceutique, AGPI, Paris, Vol. V, 205-214 (1989) 
 

C. BINDSCHAEDLER, R. GURNY et E. DOELKER 
"Influence of emulsifiers on film formation from cellulose acetate latexes. II: Modeling approach to the fate of emulsifiers in highly plasticized films" 
J. Appl. Polym. Sci., 37, 173-182 (1989) 
 

A.-F. RIME, F. LESCURE, D. MORDIER, R. GURNY et E. DOELKER 
"Nouveau système d 'acquisition de données pour machine à comprimer instrumentée développée sur micro-ordinateur" 
Compte rendu 5e Congrès International de Technologie Pharmaceutique, APGI, Paris, Vol. IV, 425-432 (1989) 
 

B. GANDER, R. GURNY et E. DOELKER 
"Structural analysis of poly(vinyl alcohol) cross-linked by gamma irradiation in the presence of cosolutes, possibilities and limitations in formulation" 
Compte rendu 5e Congrès International de Technologie Pharmaceutique, APGI, Paris, Vol. 1, 261-267 (1989) 
 

H. IBRAHIM, R. GURNY, C. BINDSCHAEDLER ET P. BURI 
"Nouvelle technologie pour la préparation de systèmes médicamenteux microparticulaires à usage ophtalmique" 
Compte rendu 5e Congrès International de Technologie Pharmaceutique, APGI, Paris, Vol. 1, 70-76 (1989)
 
1988

H. IBRAHIM. P. BURI et R. GURNY 
"Composition, structure et paramètres physiologiques du système lacrymal impliqués dans la conception des formes ophtalmiques" 
Pharm. Acta Helv., 63, 146-154 (1988)
 

B. GANDER, R. GURNY, E. DOELKER et N.A. PEPPAS 
"Crosslinked poly(alkylene oxides) for the preparation of controlled release micromatrices" 
J. Controlled Rel., 5, 271-283 (1988) 
 

F. LESCURE, R. GURNY, E. DOELKER et J. AUGUSTYNSKI 
" In vitro evaluation of a new electrophoretically controlled drug delivery system based on a crosslinked gel" 
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 15, 362-363 (1988)
 

B. GANDER, R. GURNY, E. DOELKER et N.A. PEPPAS 
"Macromolecular network characteristics and their effect on drug release from cross-linked poly(vinyl alcohol) micromatrices " 
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 15, 109-110 (1988)
 

F. LESCURE, R. GURNY, E. DOELKER, M. L. PELAPRAT, D. BICHON et J. M. ANDERSON 
"Evaluation of new poly(glutamic acid esters) from implantable drug delivery systems" Proceed, intern. Symp. Control. Rel. Bioact. Mater. 15, 107-108 (1988)
 

V. BELTRAMI, R. GURNY et E. DOELKER 
"Drug loading conditions for highly dosed crosslinked PVA matrices with controlled release properties" 
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 15, 46-47 (1988)
 
1987

C. BINDSCHAEDLER, R. GURNY et E. DOELKER 
"Influence of emulsifiers on film formation from cellulose acetate latex. I: Experimental study of phase separation phenomena due to sodium sulfate" 
J. Appl. Polym. Sci., 34, 2631-2647 (1987) 
 

C. BINDSCHAEDLER, R. GURNY et E. DOELKER 
"Osmotic watertransport through cellulose acetate membranes produced from a latex system" 
J. Pharm. Sci., 76, 455-460 (1987) 
 

R. GURNY, H. IBRAHIM, A. AEBI, P. BURI, C.G. WILSON, N. WASHINGTON, P. EDMAN et O. CAMBER 
"Design and evaluation of controlled release systems for the eye" 
J. Controlled Rel., 6, 367-373 (1987) 
 

O. CAMBER, P. EDMAN et R. GURNY 
"Influence of sodium hyaluronate in the miotic effect of pilocarpine in rabbits" 
Current Eye Res., 6 (6), 779-784 (1987)
 

H. IBRAHIM, T. BOYE, M. WERMEILLE, R. GURNY et P. BURI 
"Determination of pilocarpine by HPLC in presence of isopilocarpine and a pH-sensitive polymer in ophthalmic dispersions" 
J. Pharm. Biomed. Anal.,  5, 379-382  (1987)
 

C. BINDSCHAEDLER, R. GURNY et E. DOELKER 
"Influence of emulsifiers on film formation from cellulose acetate latices. I : Experimental study of phase separation phenomena due to sodium dodecyl sulfate" 
J. Appl. Polym. Sci., 4, 2631-2647 (1987)


E. DOELKER, R. GURNY, J. SCHURZ, A. JANOSI et N. MATIN 
"Degrees of cristallinity and polymerization of modified cellulose powders for direct tableting" 
Powder Technol., 52, 207-213 (1987) 
 

C. BINDSCHAEDLER, R. GURNY et E. DOELKER 
"Osmotic water transport through cellulose acetate membranes produced from a latex system" 
J. Pharm. Sci., 76, 455-460 (1987) 


F. GUMOWSKI, E. DOELKER et R. GURNY 
"The use of a new redispersible aqueous enteric coating material" 
Pharm. Technol., 11 (2), 26-32 (1987) 
 

C. BINDSCHAEDLER, R. GURNY et E. DOELKER 
"Mechanically strong films produced from cellulose acetate latexes" 
J. Pharm. Pharmacol. 39, 335-338  (1987)
 
1986

B. GANDER, R. GURNY et E. DOELKER 
"Crosslinked poloxamers as a versatile monolithic drug delivery system" 
Drug Dev. Ind. Pharm., 12, 1613-1623 (1986) 
 

T. HARMIA, J. KREUTER, P. SPEISER, T. BOYE, R. GURNY et A. KUBIS 
"Enhancement of the myotic response of rabbits with pilocarpine-loaded polybutylcyanoacrylate nanoparticles" 
Int. J. Pharm., 33, 187-193 (1986) 
 

R. GURNY, F. GUMOWSKY et E. DOELKER 
"Enrobage entérique avec une nouvelle forme de latex redispersible d'acétophtalate de cellulose" 
4e Congrès International de Technologie Pharmaceutique APGI, Vol. V, 117-122, Paris (1986) 
 

B. GANDER, R. GURNY et E. DOELKER 
"Matrices à libération contrôlée par le gonflement du polymère. I Mécanismes de pénétration des solvants dans les polymères" 
Pharm. Acta Helv., 61, 130-134 (1986)
"Matrices à libération contrôlée par le gonflement du polymère. II Préparation des systèmes médicamenteux et analyse de la cinétique de libération" 
Pharm. Acta Helv., 61, 178-184 (1986) 
 

C. BINDSCHAEDLER, R. GURNY et E. DOELKER 
"Osmotically controlled drug delivery systems produced from organic solutions and aqueous dispersions of cellulose acetate" 
J. Control. Release 4, 203-212 (1986) 
 

C. BINDSCHAEDLER, R. GURNY et E. DOELKER 
"Processus de formation de films semi-perméables d 'acétate de cellulose à partir de solutions organiques et de dispersions aqueuses submicroscopiques, rôle du tensio-actif dans les phénomènes de séparation de phases" 
4e Congrès International de Technologie Pharmaceutique APGI, Vol V, 123-132, Paris (1986) 
 

H. IBRAHIM, R. GURNY et P. BURI 
"Méthodologie pour le choix de solvants dans la fabrication de pseudo-latex à base d'acétophtalate de cellulose" 
4e Congrès International de Technologie Pharmaceutique APGI, Vol. IV, 282-290, Paris (1986)
 
1985

C. BINDSCHAEDLER, R. GURNY, E. DOELKER et N.A. PEPPAS 
"Equilibrium behaviour of polymer particles in ternary emulsion systems" 
Makromol. Chem., Rapid Commun. 6, 267-270 (1985) 
 

C. BINDSCHAEDLER, R. GURNY, E. DOELKER et N.A. PEPPAS 
"Thermodynamics of swelling of polymer latex particles by a water-soluble solvent. II Experimental results on cellulose acetate latices" 
J. Colloid Interface Sci., 108, 83-94 (1985) 
 

C. BINDSCHAEDLER, R. GURNY, E. DOELKER et N.A. PEPPAS 
"Thermodynamics of swelling of polymer latex particles by a water-soluble solvent. I. Theorical considerations" 
J. Colloid Interface Sci., 108, 75-82 (1985)
 

B. GANDER, K. VENTOURAS, R. GURNY et E. DOELKER 
" In vitro dissolution medium with supramicellar surfactant concentration and its relevance for in vivo absorption" 
Int. J. Pharm., 27, 117-124 (1985)
 

B. GANDER, R. GURNY et E. DOELKER 
"Einfluss der Zerfallseigenschaften von Tabletten auf die Freigabe und Absorption einer quasi unlöslichen Modellsubstanz" 
Acta Pharm. Technol., 31, 77-84 (1985) 
 

R. GURNY, T. BOYE, H. IBRAHIM et P. BURI 
"Recent developments in controlled drug delivery to the eye" 
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 12, 300-301 (1985) 
 

R. GURNY, T. BOYE et H. IBRAHIM 
"Ocular therapy with nanoparticulate systems for controlled drug delivery" 
J. Control. Release, 2, 353-361 (1985)
 
1984

R. GURNY, J.-M. MEYER et N.A. PEPPAS 
"Bioadhesive intraoral release systems : Design, testing and analysis" 
Biomaterials, 5, 336-340 (1984)
 

T. BOYE, R. GURNY et P. BURI 
"Développement et évaluation d'un nouveau type de forme ophtalmique à libération prolongée" 
2e Congrès Européen de Biopharmacie et Pharmacocinetique Salamanca (avril 1984)
 
1983

R. KORSMEYER, R. GURNY, E. DOELKER, P. BURI et N.A. PEPPAS 
"Mechanisms of potassium chloride release from compressed, hydrophilic, polymeric matrices : Effect of entrapped air" 
J. Pharm. Sci., 72, 1189-1191 (1983)
 

C. BINDSCHAEDLER, R. GURNY et E. DOELKER 
"Notions théoriques sur la formation des films obtenus à partir de micro-dispersions aqueuses et application à l'enrobage" 
Labo-Pharm., 31, 389-394 (1983) 
 

P. HUMBERT-DROZ, R. GURNY, D. MORDIER et E. DOELKER 
"Densification behaviour of powder mixtures" 
Int. J. Pharm. Techn. & Prod. Mfr., 4, 29-35 (1983) 
 

R. GURNY et N.A. PEPPAS 
"Relation entre la structure des polymères et la libération contrôlée" 
Pharm. Acta Helv., 57, 2-8 (1983) 
 

R. KORMSEYER, R. GURNY, E. DOELKER et N.A. PEPPAS 
"Mechanisms of solute release from porous hydrophilic polymers" 
Int. J. Pharm., 15, 25-35 (1983) 
 

R. GURNY, E. DOELKER, P. BURI, R.W. KORSMEYER et N.A. PEPPAS 
"Nouvelles observations sur le mécanisme de libération d'un soluté à partir de polymères hydrophiles" 
3e Congrès International de Technologie Pharmaceutique APGI, Vol. II, 97-105, Paris, 1983
 
1982

R. GURNY et W. KLOETI 
"A new device for measuring the miotic response of drugs" 
Pharm. Acta Helv., 57, 274-275 (1982)
 

J. CHEHADE, R. GURNY, E. DOELKER et P. BURI 
"Aqueous coating with the laboratory apparatus Hi-Coater* HCT-20 Mini" 
Acta Pharm. Technol., 28, 141-148 (1982) 
 

C. BINDSCHAEDLER et R. GURNY 
"Optimisation de formulation Pharmaceutique par la méthode du SIMPLEX au moyen d'une calculatrice TX 59" 
Pharm. Acta Helv., 57, 251-255 (1982)
 

R. GURNY, E. DOELKER et N.A. PEPPAS 
"Modelling of sustained release of water-soluble drugs from porous, hydrophobic polymers" 
Biomaterials, 3, 27-32 (1982) 
 
1981

R. GURNY, N.A. PEPPAS, D.D. HARRINGTON et G.S. BANKER 
"Development of biodegradable and injectable latices for controlled release of potent drugs" 
Drug Dev. Ind. Pharm., 7, 1-25 (1981) 


R. GURNY 
"Preliminary study of prolonged acting drug delivery system for the treatment of glaucoma" 
Pharm. Acta Helv., 56, 130-132 (1981)
 

R. GURNY, W. KLOETI et P. BURI 
"Développement d'un systeme électro-optique permettant la mesure continue du diametre pupillaire" 
Premier Congrès Europeen de Biopharmacie et Pharmacocinetique - Pharmacocinetique experimentale Vol. 2, 398-402, Clermont-Ferrand  (avril 1981)
 
1980

N.A. PEPPAS, R. GURNY, E. DOELKER et P. BURI 
"Modelling of drug diffusion through swellable polymeric systems" 
J. Membr. Sci., 7, 241-253 (1980)
 

J.L. YEAGER, R. GURNY, M.A. GONZALES, R. SJOQVIST et G.S. BANKER 
"Bioavailability assessment of polymer interacted dextro-propoxyphene from rectal dosage forms" 
Pharm. Ind., 42, 1141-1143 (1980) 
 

E. DOELKER, R. GURNY et D. MORDIER 
"Study of the effect of binding agents on the compression characteristics using work balance and densification parameters" 
Acta Pharm. Technol., 26, 155-158 (1980)
 

L. GURNY, P. VUAGNAT, R. GURNY et I. KAPETANIDIS 
"Cultures de cals de Digitalis purpurea L" 
Pharm. Acta Helv., 55, 302 (1980) 

1979

R. GURNY, G.S. BANKER et D.O., KILDSIG 
"The Determination of the Entrapment Efficiency for a Molecular Dispersion System" 
Drug Dev. Ind. Pharm., 5, 437-445 (1979) 
 

R. GURNY, S.P. SIMMONS, G.S. BANKER, D. HOCH, M.A. LIBBER, R. MEEKER et R.E. MYERS 
"A new biocompatible drug delivery system for implants in animal brains" 
Pharm. Acta Helv., 54, 349-352 (1979) 
 

R. GURNY et G.S. BANKER 
"Report on molecular scale drug entrapment of retinylacetate as a method of enhancing drug stability to oxydation, light and moisture" 
Drug Dev. Ind. Pharm., 5, 31 (1979) 


R. GURNY, G.S. BANKER et P. BURI 
"Développement d'un injectable de testostérone à action prolongée à base de latex biodégradable" 
III Congreso N acionali Congrès hispano-français de Biopharmacie et Pharmacocinétique Tome 2, 173-179, Barcelona (1979)
 
1978
 

R. GURNY, M. BOYMOND-GENOUD et P. GUITARD 
"Analyse par régression multiple de l'influence de la taille des particules et de la présence de lactose sur la dissolution des capsules gélatineuses de phénacétine et d'acétanilide" 
J. Pharm. Belg., 33, 6-10 (1978) 
 
1977

R. GURNY, P. BURI, H. LEUENBERGER et H. SUCKER 
"Réalisation et développement théorique de formes médicamenteuses à libération contrôlée par des films méthacryliques. 4ème communication " Etudes des paramètres de formulation et de production par une analyse de régression multiple". 
Pharm. Acta Helv., 52, 247-251 (1977) 
 

R. GURNY, P. BURI, P. GUITARD, H. LEUENBERGER et  H. SUCKER 
"Réalisation et développement théorique de formes médicamenteuses à libération contrôlée par des films 
méthacryliques. 3ème communication : Préparation et caractérisation des formes galéniques à libération contrôlée" 
Pharm. Acta Helv., 52, 182-187 (1977) 
 

R. GURNY, P. BURI, H. SUCKER, P. GUITARD et H. LEUENBERGER 
"Réalisation et développement de formes médicamenteuses à libération contrôlée par des films méthacryliques 
(2e communication :"Etude par analyse orthogonale des facteurs influençant le transport à travers un film plan") 
Pharm. Acta Helv. 52, 175-181 (1977)
 

R. GURNY, P. GUITARD et P. BURI 
"Bestimmung der Wasserdampfpermeabilität von Methacrylacopolymeren verschiedener Zusammensetzungen" 
Acta Pharm. Technol., 23, 29-38 (1977) 
 
1976

R. GURNY, D. MORDIER et P. BURI 
"Réalisation et développement théorique des formes médicamenteuses à libération contrôlée par des films méthacryliques. 1ère communication : Fabrication et évaluation de films plans libres" 
Pharm. Acta Helv., 51, 383-390 (1976)
 

R. GURNY, C. REVILLARD et E. DOELKER 
"Computation of RRSW distribution by maximum likelihood method for drug release from solid dosage forms" 
Pharm. Ind., 10, 913-914 (1976) 
 

M. ROUILLER, R. GURNY et E. DOELKER 
"Possibilité de production avec un appareil à lit fluidisé de laboratoire. II. L'enrobage des comprimés" 
Acta Pharm. Technol., 22, 55-68 (1976) 
 

R. GURNY 
"Perméabilité à la vapeur d'eau de polymères, sous forme de films libres, utilisés pour l'enrobage" 
Pharm. Acta Helv. 51, 1-10 (1976)
 
1975
 

M. ROUILLER, R. GURNY et E. DOELKER 
"Possibilité de production avec un appareil à lit fluidisé de laboratoire. I. La granulation" 
Acta Pharm. Technol., 21, 129-138 (1975) 
 
1972 J.M.J. TRONCHET, R. GRAF et R. GURNY 
"Utilisation d'ylides du phosphore en chimie des sucres X" 
Helv. Chimica Acta, 56, 613 (1972)

1971 J.M.J. TRONCHET, J.B. BOURGEOIS, J.M. CHALET, R. GRAF, R. GURNY et J. TRONCHET 
"Utilisation d'ylides du phosphore en chimie des sucres VII" 
Helv. Chimica Acta, 55, 687 (1971)



Book Chapters


 

P. FURRER, O. FELT et R. GURNY
"Bioadhesive Ophthalmic Drug Inserts (BODI) for veterinary use"
in: Drugs and the pharmaceutical sciences, volume 184, second edition, volume 2edited by M.J. Rathbone et al.
Modified-release drug delivery technology, part II: Ocular Technologies, 7, 101-107 (2008)

 
  L. BOSSY, S. ERICKSON, R. GURNY et F. DELIE
"Intraocular implants for controlled drug delivery"
in: Drugs and the pharmaceutical sciences, volume 184, second edition, volume 2edited by M.J. Rathbone et al.
Modified-release drug delivery technology, part II: Ocular Technologies, 6, 85-99 (2008)
 
  L. BOSSY-NOBS, R. GURNY et E. ALLEMANN
"Coupling methods to obtain ligand-targeted liposomes and nanoparticles"
in: Drugs and the pharmaceutical sciences, edited by Simon Benita, 2nd edition. Microencapsulation: methods and Industrial Applications 123-147 (2006)
 
  J.-C. LEROUX, A. VARGAS, E. DOELKER, R. GURNY et F. DELIE
"The use of drug-loaded nanoparticles in cancer chemotherapy"
in: Drugs and the pharmaceutical sciences, edited by Simon Benita, 2nd edition. Microencapsulation: methods and Industrial Applications, 625-671 (2006)
 

O. FELT, S. EINMAHL, R. GURNY, P. FURRER et V. BAEYENS 
"Polymeric systems for ophthalmic drug delivery" 
in: Polymeric Biomaterials (2nd Edition), 377-421 (2002)


O. FELT-BAEYENS et R. GURNY 
"Bioadhesive Ophthalmic Drug Insert (BODI)" 
in: Drugs and the pharmaceutical sciences, volume 126, edited by M.J. Rathbone et al. 
Modified-release drug delivery technology, 28, 341-347 (2002) 


V. BAEYENS, O. FELT, R. GURNY, F. BEHAR-COHEN, C. PERCICOT et A. REGNIER 
"Design and development of controlled release veterinary drug delivery systems to the eye" 
in: Controlled Release of Veterinary Drugs. -Biological and Pharmaceutical Considerations. M.J. Rathbone and R. Gurny, Elsevier, chap. 5, 115-171 (2000) 


S.Y. NG, H.-R. SHEN, J. BARR, A. ROTHEN-WEINHOLD, S. EINMAHL, K. SCHWACH-ABDELLAOUI, R. 
GURNY et J. HELLER 
"Poly(ortho esters) - A versatile drug delivery system" 
in: Biomaterials and Drug Delivery toward New Millenium. K.D. Park, I.C. Knon, N. Yui, S.Y. Jeong And K. 
Park (eds). Part II, 147-156 (2000)


J. HELLER et R. GURNY 
"Poly(ortho esters)" 
in : Encyclopedia of controlled drug delivery (vol. 2), E. Mathiowith, John Wiley & Sons, Inc. 852-874 (1999) 


F. DE JAEGHERE, A.A. DESHPANDE, C.TABATABAY et R. GURNY 
"Nanoparticles" 
in : Encyclopedia of controlled drug delivery (vol. 2), E. Mathiowith, John Wiley & Sons, Inc. 641-664 (1999) 


S. EINMAHL, A.A. DESHPANDE, C. TABATABAY et R. GURNY 
"Mucosal drug delivery, intravitreal" 
in : Encyclopedia of controlled drug delivery (vol. 2), E. Mathiowith, John Wiley & Sons, Inc. 564-592 (1999) 


O. FELT, V. BAEYENS, M. ZIGNANI, P. BURI et R. GURNY 
"Mucosal drug delivery, ocular" 
in : Encyclopedia of controlled drug delivery (vol. 2), E. Mathiowith, John Wiley & Sons, Inc. 605-626 (1999) 


E. ALLEMANN, J.C. LEROUX et R. GURNY 
"Biodegradable nanoparticles of poly(lactic acid) and poly(lactic-co-glycolic acid) for parenteral administration" 
in: Pharmaceutical dosage form : Disperse Systems (vol. 3, second edition) Marcel Dekker, Inc.  163-193 
(1998) 


J.C. LEROUX, E. DOELKER et R. GURNY 
"The use of drug-loaded nanoparticles in cancer chemotherapy" 
in: Microencapsulation methods and industrial applications, 535-575. Edited by Simon Benita, The Hebrew 
University of Jerusalem Marcel Dekker Inc. (1995) 


A. MERKLI, J. HELLER, C. TABATABAY et R. GURNY 
"Synthesis and characterization of a new biodegradable semi-solid poly(ortho ester) for drug delivery systems" 
in: Polymer Biomaterials in Solution, as Interfaces and as Solides, editors : S.L. Cooper, C.H. Baumford and T. Tsuruta (1995) 


R. GURNY, H. IBRAHIM et P. BURI 
"The development and use of in-situ formed gels, triggered by pH" 
in: CRC-Press "Biopharmaceutics of Ocular Drug Delivery, 82-90 (1993) 


S.F. BERNATCHEZ, O. CAMBER, C. TABATABAY et R. GURNY 
"Use of hyaluronic acid in ocular therapy" 
in: CRC-Press "Biopharmaceutics of Ocular Drug Delivery", 105-120 (1993) 


B. GANDER, R. GURNY et E. DOELKER 
"Crosslinked poloxamers as a versatile monolithic drug delivery system" 
in : Pharmaceutical Technology : controlled drug release, M.H. Rubisntein, edn., Ellis Horwood Ltd. Vol. I, 34-40 (1987) 


 R. GURNY 
"Latex and thermosensitive gels as sustained delivery systems" 
in : Ophtalmic Drug Delivery : BioPharmaceutical, technological and clinical aspects" M.F. Saettone, M. Bucci and P. Speiser, éds, Fidia Research Series, Liviana Press, Padova, Vol. II, 27-36 (1987) 


R. GURNY 
"Bioadhesive intraoral release systems" 
in : Biopolymers, E. Piskin, edn., Nato-AST, 212-220 (1984) 


R. GURNY 
"Ocular therapy with nanoparticles" 
in : Nanoparticles, P. Couvreur and P. Guyot, edn. CRC Press Inc., Boca Raton, E.-U. (1984)


R. GURNY 
"Controlled drug delivery with colloidal polymeric systems" 
in : Biopolymers, E. Piskin, edn., Nato-AST, 195-211 (1984) 


R. GURNY 
"Latex systems" 
in : Topics in Pharmaceutical Sciences, D.D. Breimer and P. Speiser, edn. Elsevier, Amsterdam, 277-288 (1983)




Patents

 

Schuetz Y., Caratti-Besson V., Jordan O. et Gurny R.
WO2007/073749-2007
"Thermosetting neutralized chitosan composition forming a hydrogel, lyophilizate, and processes for producing the same"

 

M. Moeller, T. .Trimaille et R. Gurny
WO2007012979 - 2007
"Polylactide compositions and uses thereof"

 
 

J. Berger, R. Gurny et M. Reist-Oechslin
EP1730216 - 2006
"Pseudo-thermosetting neutralized chitosan composition forming a hydrogel and a process for producing the same".

 
 

D. Zimmermann, N. .Nurdin, E. Allémann, E. Doelker, R. Gurny, E. Drift, R. Scheffer et S..Baum
US2006162249 - 2006
"Product for use in agriculture or horticulture"

 
 

A. Rothen-Weinhold, R. Gurny, P. Orsolini et F. Heimgartner
DE69833375D - 2006
"Implants for controlled release of pharmaceutically active principles and method for making same".

 
 

R. Gurny et O. Felt
DE69828451T - 2006
"Wässrige ophthalmische Formulierungen mit Chitosan".

 
 

R. Gurny, E. Allémann et J.-C. Leroux
PT835103T - 2005
"Nanoparticulas para administracao oral de agents farmaceuticos de Baixa solubilidade".

 
 

R. Gurny et O. Felt
SI1128809T - 2005
"Aqueous ophthalmic formulations comprising chitosan".

 
 

D. Zimmermann, E. Allémann, R. Gurny, R. Scheffer, N. Nurdin, E. Doelker, E. Van der Grift et S. Baum
ZA200403881 - 2005
"A product for use in agriculture or horticulture".

 
 

R. Gurny et O. Felt
DK1128809T - 2005
"Vandige oftalmiske formuleringer omfattende chitosan".

 
 

E. Allémann, Y. Konan, R. Gurny et R. Boch
EP1503796 - 2005
" Compositions and methods for delivery of photosensitive drugs".

 
 

E. Allémann, Y. Konan, R.Gurny et R. Boch
US2004047913 - 2004
"Compositions and methods for delivery of photosensitive drugs".

 
 

R. Gurny, E. Alléman et J.-C. Leroux
US2004018236 - 2004
"Nanoparticles for oral administration of pharmaceutical agents of low solubility".

 
 

P. Zanello, E. Boivin, V. Kaltsatos, S.Capancioni, K. Schwach-Abdellaoui et R. Gurny
EP1270014 - 2003
"Biodegradable semi-solid injectable composition assuring a particular release profile".

 

R. Gurny, M. Zignani et C. Tabatabay
US6440460 - 2002
"Pharmaceutical compositions containing buffered ortho ester polymers".

 
 

R. Gurny et O. Felt
PL347735 - 2001
"Antibacterial aqueous ophthalmic solution containing ofloxacin and application of chitosane for solubilising ofloxacin dispersed in an aqueous solution".

 
 

A. Rothen-Weinhold, R. Gurny, P. Orsolini et F. Heimgartner
US6245346 - 2001
" Pharmaceutical compositions for the sustained release of insoluble active principles".

 
 

D. Quintanar-Guerrero, E. Allémann, R. Gurny, H. Fessi et E. Doelker
WO0102087 - 2001
" Method for producing aqueous colloidal dispersions of nanoparticles".

 
 

R. Gurny et O. Felt
WO0030609 - 2000
"Aqueous ophthalmic formulations comprising chitosan".

 
 

D. Quintanar-Guerrero, E. Allémann, R. Gurny, H. Fessi H. et E. Doelker
WO9933558 - 1999
"Method for producing an aqueous colloidal dispersion of nanoparticles".

 
 

R. Gurny, M. Zignani et C. Tabatabay
EP0885014 - 1998
"Pharmaceutical compositions containing buffered ortho ester polymers".

 
 

R. Gurny, V. Kaltsatos, V. Baeyens et B. Boisramé
WO9856346 - 1998
"Therapeutic or hygienic composition with controlled and prolonged release of the active principle(s), in particular for ophthalmic use".

 
  R. Gurny
AU6616398 - 1998
"RNA- and DNA- based active agents in nanoparticles".
 
  R. Gurny
WO9833478 - 1998
"RNA- and DNA- based active agents in nanoparticles".
 
  F. Gurtler et R. Gurny
ES2115735T - 1998
"Bioadhesive Ophthalmic Insert".
 
 

F. Gurtler et R. Gurny
US5773021 - 1998
"Bioadhesive Ophthalmic Insert".

 
  R. Gurny
AR002049 - 1998
"Nanoparticles for oral administration of pharmaceutical agents of low solubility"
 
 

C. Tabatabay, M. Zignani et R. Gurny
CA2243988 - 1997
"Pharmaceutical composition containing buffered ortho ester polymers".

 
 

R. Gurny, E. Allémann, J.-C. Leroux, J. Kristl et E. Doelker
WO9710811 - 1997
" Nanoparticles in photodynamic therapy".

 
  C. Bindschadler, R. Gurny et E. Doelker
KR960002225B - 1996
"Process for preparing a powder of water-insoluble polymer which".
 
 

F. Gurtler et R. Gurny
CA2119109 - 1995
" Bioadhesive Ophtalmic Insert".

 

C. Bindschadler, R. Gurny et E. Doelker
ES2035949T
- 1993
"Procedimiento de preparar un polvo de polimero insoluble en agua que puede redispersarse en una fase liquida y procedimiento de preparar une dispersion del polimero en polvo."


C. Bindschadler, R. Gurny et E. Doelker
DE3877678D - 1993
"Verfahren zur Herstellung eines Wasserunlöslichen Polymerpulvers, das in einer flüssigen Phase redispergiert werden kann und verfahren zur Herstellung einer Dispersion des Polymerpulvers".


C. Bindschadler, R. Gurny et E. Doelker
AT84806T - 1993
"Verfahren zur Herstellung eines Wasserunlöslichen Polymerpulvers, das in einer flüssigen Phase redispergiert werden kann und verfahren zur Herstellung einer Dispersion des Polymerpulvers".


C. Bindschadler, R. Gurny et E. Doelker
BR8806902 - 1989
"Processo para preparacao de um po de polimero insoluvel em agua que pode ser redispersado em uma fase liquida, po resultante e sua utilizacao".


C. Bindschadler, R. Gurny et E. Doelker
DK698688 - 1988
"Femgangsmaade til fremstilling af vanduoploselight polymerpulver".


C. Bindschadler, R. Gurny et E. Doelker
F1885767 - 1988
"Menetelmä veteen liukenemattoman polymeerijauheen valmistamiseksi, joka voidaan dispergoida uudelleen nestefaasiin"


 



Team members