Gerrit Borchard

Professeur ordinaire


 
Address :    

Université de Genève
Section des sciences pharmaceutiques
Biopharmacie
Rue Michel-Servet 1
CH-1211 Genève 4

Room :   B08.1711.a
Phone :     +41 22 37 969 45
Fax :     +41 22 37 965 67
e-mail :     Gerrit.Borchard@unige.ch


Curriculum Vitae

GERRIT BORCHARD is a licensed pharmacist and obtained his Ph.D. in pharmaceutical technology from the University of Frankfurt (Germany). After holding several academic posts, including a lecturer position at Saarland University (Germany) and an Assistant and Associate Professorship at Leiden University (The Netherlands), he joined Enzon Pharmaceuticals, Inc. (USA) as Vice President Research. In 2005, he was appointed Full Professor of Biopharmaceutical Sciences at the University of Geneva (Switzerland), and Scientific Director of the Centre Pharmapeptides in Archamps (France), an international center for biopharmaceutical research and training.

Prof. Borchard's areas of scientific interest are:

  • macromolecular drug formulation and delivery, including protein formulation, colloidal carrier systems and PEGylation;
  • molecular biopharmaceutics, including development and validation of cell-based assays for drug transport and immunogenicity assessment;
  • mucosal vaccination, including development and evaluation of DNA and subunit vaccines against infectious diseases and cancer, as well as assessment of novel mucosal adjuvants.

At present, he has (co-)authored more than 80 papers and book chapters, co-edited one book on protein formulation, and is named as inventor on six patents.

Prof. Borchard has served as editor of the European Journal of Pharmaceutics and Biopharmaceutics (2005-2010), and is member of the editorial boards of three scientific journals (International Journal of Pharmaceutics, Journal of Pharmaceutical Sciences and Scientia Pharmaceutica). He frequently engages in the review process for numerous journals, as well as for international organizations. On a regular basis, he serves as advisor for the pharmaceutical and biotech industry, and is involved in due diligence procedures for international consulting firms.

In 2006, Prof. Borchard was appointed member of the WHO Steering Committee on Vaccine Delivery Systems. In the past, he has served as Scientific Advisor for the Controlled Release Society (CRS), as Scientific Secretary of the European Association of Pharmaceutical Biotechnology (EAPB), and has headed the Academic Section of the International Association for Pharmaceutical Technology (APV).

In 2008, Prof. Borchard was elected Vice President of the School of Pharmaceutical Sciences Geneva-Lausanne.

Due to his working in both academia and industry, and living in four countries, Prof. Borchard has acquired extensive experience in diverse working and cultural environments, and is fluent in the German, English, Dutch and French languages. 


Functions and Positions

  Vice President of the School of Pharmaceutical Sciences Geneva-Lausanne. 2008-
 

Member of the WHO Steering Committee on Vaccine Delivery Systems 2006-2008.

 

Member of the Scientific Advisory Board of the International Controlled Release Society (CRS), 2003-2006.

 

Head of the Academic Section of the International Association for Pharmaceutical Technology (APV), 2002-2003. Member of the Interest Group Biotechnology of APV since 2003.

 

Member of the Organizing Committee of the 50 th International Meeting of APV in Nuremberg, Germany, March 2004.

 

Foundation member and Scientific Secretary of the European Association of Pharma Biotechnology (EAPB), 2000-2002.

 

Member of the Board of the Dutch Anselmus Foundation, 2002-2003. Organisation of scientific symposia for clinical pharmacists.

 
Editor, European Journal for Pharmaceutics and Biopharmaceutics.

 

Section Editor for Drug Discovery Today.

 

Member of the Editorial Advisory Boards of the Biopharmaceutics & Drug Disposition Journal , the International Journal of Pharmaceutics and the Journal of Pharmaceutical Sciences .

 

Ad-hoc reviewer for the German Science Foundation (DFG), the Dutch Technical Sciences Foundation (STW), the Alberta Cancer Board (Canada), the Austrian Fonds zur Förderung der wissenschaftlichen Forschung (FWF) and the Israelian Science Foundation (ISF).

 

Scientific Advisor, FeyeCon Development and Implementation b.v., Weesp, The Netherlands and Nextstep Pharma, Utrecht, The Netherlands.

 


Publications

2011    
  A. MISRA, A.J. HICKEY, C. ROSSI, G. BORCHARD, H. TERADA, K. MAKINO, P.B. FOURIE, P. COLOMBO
"Inhaled drug therapy for treatment of tuberculosis"
Tuberculosis, 91, 71-81 (2011)
 
  C. MUELLER, M.A.H. CAPELLE, A. TUDOR, E. SEYREK, G. BORCHARD
"Noncovalent pegylation by dansyl-poly(ethylene glycol)s as a new means against aggregation of salmon calcitonin"
Journal of Pharmaceutical Sciences, 100 (5), 1648-1662 (2011)
 
2010    
  F. LEBRE, G. BORCHARD, M.C. PEDROSO DE LIMA, O. BORGES.
"Progress towards a needle-free hepatitis B vaccine"
Pharmaceutical Research. DOI: 10.1007/s11095-010-0314-4. (2010)
 
  G. BORCHARD
" Nanomedicine and immunotherapy"
Expert review of vaccines, 9(11), 1245-1246 ( 2010 )
 
  F. ESMAEILI, S. HEUKING, H.E. JUNGINGER et G. BORCHARD
“Progress in chitosan-based vaccine delivery systems”
Journal of Drug Delivery Science and Technology, 20(1), 53-61 (2010)
 
  O. BORGES, F. LEBRE, D. BENTO, G. BORCHARD et H.E. JUNGINGER
“Mucosal vaccines: Recent progress in understanding the natural barriers”
Pharmaceutical Research, 27(2), 211-223 (2010)
 
2009    
  S. HEUKING, S. ADAM-MALPEL, E. SUBLET, A. IANNITELLI, A. DI STEFANO e G. BORCHARD
"Stimulation of human macrophages (THP-1) using Toll-like receptor-2 (TLR-2) agonist decorated nanocarriers"
Journal of Drug Targeting, 17(8), 662-670 (2009)
 
  M. TROCCAZ, G. BORCHARD, C. VUILLEUMIER, S. RAVIOT-DERRIEN, Y. VAN NICLASS, S. BECCUCCI et C. STARKENMANN
"Gender-specific differences between the concentrations of nonvolatile (R)/(S)-3-methyl-3-sulfanylhexan-1-ol and (R)/(S)-3-hydroxy-3-methyl-hexanoic acid odor precursors in axillary secretions"
Chemical Senses, 34(3), 203-210 (2009)
 
 

S. HEUKING, A. IANNITELLI, A. DI STEFANO et G. BORCHARD
“Toll-like receptor-2 agonist functionalized biopolymer for mucosal vaccination”
International Journal of Pharmaceutics, 381, 97-105 (2009)

 
 

M. BIVAS-BENITA, M.Y. LIN, S.M. BAL, K.E. VAN MEIJGAARDEN, K.L.M.C. FRANKEN, A.H. FRIGGEN, H.E. JUNGINGER, G. BORCHARD, M.R. KLEIN, T.H.M. OTTENHOFF
" Pulmonary delivery of DNA encoding Mycobacterium tuberculosis latency antigen Rv1733c associated to PLGA-PEI nanoparticles enhances T cell responses in a DNA prime/protein boost vaccination regimen in mice"
Vaccine, 27(30), 4010-4017 (2009) doi: 10.1016/j.vaccine.2009.04.033

 
2008    
 

O. Borges, A.Cordeiro-da-Silva, J.Tavares, N.Santarem, A.de Sousa, G.Borchard et H. E.Junginger
"Immune response by nasal delivery of hepatitis B surface antigen and codelivery of a CpG ODN in alginate coated chitosan nanoparticles"
European Journal of Pharmaceutics and Biopharmaceutics, 69(2), 405-416 (2008)

 
 

O. BORGES, M. SILVA, A. DE SOUSA, G. BORCHARD, H.E. JUNGIGER et A. CORDEIRO-DA-SILVA
"A lginate coated chitosan nanoparticles are an effective subcutaneous adjuvant for hepatitis B surface antigen"
International immunopharmacology, 8, 1773-1780 (2008) doi: 10.1016/j.intimp.2008.08.013

 
2007    
  O. BORGES, G. BORCHARD, A. DE SOUSA, H.E. JUNGINGER, A. CORDEIRO-DA-SILVA
"Induction of lymphocytes activated marker CD69 following exposure to chitosan and alginate biopolymers"
International Journal of Pharmaceutics, 337, 254-264 (2007)
 
2006  
 

O. Borges, A.C. da Silva, G. Borchard, S.G. Romeijn, M. Amidi, A. de Sousa and H.E. Junginger
"Uptake studies in rat Peyer's patches, cytotoxicity and release studies of alginate-coated chitosan nanoparticles for mucosal vaccination."
J. Control. Rel. 114 (2006) 348-358.


 

M. Amidi, S.G. Romeijn, G. Borchard, H.E. Junginger, W.E. Hennink, W. Jiskoot
"Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system."
J. Control. Rel. 111 (2006) 107-116.

 
 

B.I. Florea, M. Thanou, H.E. Junginger and G. Borchard
"Enhancement of bronchial octreotide absorption by chitosan and N -trimethyl chitosan shows linear in vitro / in vivo correlation."
J. Control. Rel. 110 (2006) 353-361.

 
 

Y. Pérez de Diego, H.C. Pellikaan, F.E. Wubbolts, G. Borchard, G.J. Witkamp and P.J. Jansens
"Opening new operating windows for polymer and protein micronisation using the PCA process." 
J. Supercrit. Fluids 36 (2006) 216-224 .

 
2005  
 

D. Yu, P. Peng, S.S. Dharap, Y. Wang, M. Mehlig, P. Chandna, H. Zhao, D. Filpula, K. Yang, V. Borowski, G. Borchard, Z. Zhang and T. Minko
"Antitumor activity of poly(ethylene glycol)-camptothecin conjugate: The inhibition of tumor growth in vivo."
J. Control. Rel. 110 (2005) 90-102.

 
 

O. Borges, G. Borchard, J.C. Verhoef, A. de Sousa and H.E. Junginger
"Preparation of coated nanoparticles for a new mucosal vaccine delivery system."
Int. J. Pharm . 299 (2005) 155-166.

 
 

M. Bivas-Benita, T.H.M. Ottenhoff, H.E. Junginger and G. Borchard
"Pulmonary DNA vaccination: Concepts, possibilities and perspectives."
J. Control. Rel. 107 (2005) 1-29.

 
 

M. Bivas-Benita, R. Zwier, H.E. Junginger and G. Borchard
"Non-invasive pulmonary aerosol delivery in mice by the endotracheal route."
Eur. J. Pharm. Biopharm. 61 (2005) 214-218.

 
2004  
 

F.A. Dorkoosh, M.P.M. Stokkel, D. Blok, G. Borchard, M. Rafiee-Tehrani, J.C. Verhoef and H.E. Junginger
"Feasibility study on the retention of superporous hydrogel composite polymer in the intestinal tract of man using scintigraphy."
J. Control. Rel. 99 (2004) 199-206.

 
 

J. Haas, M.N.V. Ravi Kumar, G. Borchard, U. Bakowsky and C.-M. Lehr
"Preparation and characterization of trimethyl-chitosan modified PCL nanoparticles as DNA carriers."
AAPS Pharm. Sci. Tech. 6 (2004) E22-E30.

 
 

B.I. Florea, T. Molenaar, I. Bot, E. Biessen, T. van Berkel, H.E. Junginger and G. Borchard
"Identification of an internalizing peptide in differentiated Calu-3 cells by phage display technology; application to gene delivery to the airway epithelium."
J. Drug Target. 11 (2004) 383-390.

 
 

M. Bivas-Benita, K.E. van Meijgaarden, K.L.M.C. Franken, H.E. Junginger, G. Borchard, T.H.M. Ottenhoff and A. Geluk
"Pulmonary delivery of chitosan-DNA nanoparticles enhances the immunogenicity of a DNA vaccine encoding HLA-A*0201-restricted T-cell epitopes of Mycobacterium tuberculosis ."
Vaccine 22 (2004) 1609-1615.

 
 

M. Bivas-Benita, S. Romeijn, H.E. Junginger and G. Borchard
"PLGA-PEI nanoparticles for gene delivery to pulmonary epithelium."
Eur. J. Pharm. Biopharm. 58 (2004) 1-6.

 
 

Polnok, J.C. Verhoef, G. Borchard, N. Sarisuta and H.E. Junginger
"In vitro evaluation of intestinal absorption of desmopressin using drug-delivery systems based on superporous hydrogels."
Int. J. Pharm. 269 (2004) 303-310.

 
 

Polnok, G. Borchard, J.C. Verhoef, N. Sarisuta and H.E. Junginger
"Influence of methylation process on the degree of quaternization of N-trimethyl chitosan chloride."
Eur. J. Pharm. Biopharm . 57 (2004) 77-83.

 
 

F.A. Dorkoosh, C.A. Broekhuizen, G. Borchard, M. Rafiee-Tehrani, J.C. Verhoef and H.E. Junginger
"Transport of octreotide and evaluation of mechanism of opening the paracellular tight junctions using superporous hydrogel polymers in Caco-2 cell monolayers."
J. Pharm. Sci . 93 (2004) 743-752.

 
 

M. Bivas-Benita, M. Oudshoorn, S. Romeijn, K. van Meijgaarden, G. Lambert, T. Ottenhoff, S. Benita, H.E. Junginger and G. Borchard
"Cationic submicron emulsions for pulmonary DNA immunization."
J. Control. Rel. 100 (2004) 145-155.

 
2003  
 

B.I. Florea, M. Luz Cassara, H.E. Junginger and G. Borchard
"Drug transport and metabolism characteristics of the human airway epithelial cell line Calu-3."
J. Control. Rel. 87 (2003) 131-138.

 
 

C.A. Jansma, M. Thanou, H.E. Junginger and G. Borchard
"Preparation and characterization of 6-O-carboxymethyl-N-trimethyl chitosan derivative as a potential carrier for targeted polymeric gene and drug delivery."
STP Pharma Sci. 13 (2003) 63-67.

 
 

M. Bivas-Benita, M. Laloup , S. Versteyhe, J. Dewit, J. De Braekeleer , E. Jongert and G. Borchard
"Generation of Toxoplasma gondii GRA1 protein and DNA vaccine loaded chitosan particles: preparation, characterization and preliminary in vivo studies."
Int. J. Pharm. 266 (2003) 17-27.

 
2002  
  M. Thanou, B.I. Florea, M. Geldof, H.E. Junginger and G. Borchard
"Quaternized chitosan oligomers as novel gene delivery vectors: synthesis, cytotoxicity and transfection efficiency in epithelial cell lines."
Biomaterials 23 (2002) 153-159 .
 
 

F. Dorkoosh, G. Borchard, M. Rafiee-Tehrani, J.C. Verhoef and H.E. Junginger
"Evaluation of superporous hydrogel (SPH) and SPH composite in porcine intestine ex-vivo : assessment of drug transport, morphology effect, and mechanical fixation to intestinal wall."
Eur. J. Pharm. Biopharm. 53 (2002) 161-166.

 
 

G. Borchard, M. Luz Cassará, P.E.H. Roemelé, B.I. Florea and H.E. Junginger
"Transport and local metabolism of budesonide in a human bronchial epithelial cell line (Calu-3)."
J. Pharm. Sci . 91 (2002) 1561-1567.

 
 

F.A. Dorkoosh, D. Setyaningsih, G. Borchard, M. Rafiee-Tehrani, J.C. Verhoef and H.E. Junginger
"Effects of superporous hydrogels on paracellular drug permeability and cytotoxicity studies in Caco-2 cell monolayers."
Int. J. Pharm. 241(2002) 35-42.

 
 

F.A. Dorkoosh, J.C. Verhoef, M. Rafiee-Tehrani, G. Borchard and H.E. Junginger
"Peroral drug delivery systems for peptides and proteins."
STP Pharma Sci. 12 (2002) 213-221.

 
 

B.I. Florea, C. Meaney, H.E. Junginger and G. Borchard
"Transfection efficiency and toxicity of PEIs in Calu-3 and COS-1 cell cultures."
AAPS Pharm. Sci. 3 (2002).

 
 

G. Borchard
"Calu-3 cells - a valid model for the airway epithelium?"
STP Pharma Sci. 12 (2002) 205-211.

 
 

B.I. Florea, P. Ravensteijn, H.E. Junginger and G. Borchard
"Complexes of chitosan derivatives and pDNA: DNase stability."
STP Pharma Sci 12 (2002) 243-249 .

 
 

F.A. Dorkoosh, J.C. Verhoef, M.H.C. Ambagts, M. Rafiee-Tehrani, G. Borchard and H.E. Junginger
"Peroral delivery systems based on superporous hydrogel polymers: Release characteristics for the peptide drugs buserelin, octreotide and insulin."
Eur. J. Pharm. Sci. 15 (2002) 433-439.

 
 

F.A. Dorkoosh, J.C. Verhoef, G. Borchard, M. Rafiee-Tehrani, J.H.M. Verheijden and H.E. Junginger
"Intestinal absorption of human insulin in pigs using delivery systems based on superporous hydrogel polymers."
Int. J. Pharm . 247 (2002) 47-55.

 
 

F.A. Dorkoosh, J.C. Verhoef, J.H.M. Verheijden, M. Rafiee-Tehrani, G. Borchard and H.E. Junginger
"Peroral absorption of octreotide in pigs formulated in delivery systems based on superporous hydrogel polymers." Pharm. Res. 19 (2002) 1532-1536.

 
 

I.M. van der Lubben, F.A.C. van Opdorp, R. Hengeveld, J. Onderwater, H. Koerten, J.C. Verhoef, G. Borchard and H.E. Junginger
"Transport of chitosan microparticles by a human intestinal M-cell model."
J. Drug Target. 10 (2002) 449-456.

 
2001  
 

I.M. van der Lubben, J.C. Verhoef, A.C. van Aelst, G. Borchard and H.E. Junginger
"Chitosan microparticles for oral vaccination: preparation, characterization and initial in vivo uptake studies in murine Peyer´s Patches."
Biomaterials 22 (2001) 687-694.

 
 

A. Brück, R. Abu-Dahab, K.J. Elbert, G. Borchard, U.F. Schäfer and C.-M. Lehr
"Lectin-functionalized liposomes for pulmonary drug delivery: Interaction with human alveolar epithelial cells."
J. Drug Target. 9 (2001) 241-252.

 
 

I.M. van der Lubben, F.A.J. Konings, G. Borchard, J.C. Verhoef and H.E. Junginger
"In vivo uptake of chitosan microparticles by murine Peyer's patches: visualization studies using confocal laser scanning microscopy and immunohistochemistry."
J. Drug Target. 9 (2001) 39-47.

 
 

F.A. Dorkoosh, J.C. Verhoef, G. Borchard, M. Rafiee-Tehrani and H.E. Junginger
"Development and characterization of a novel peroral peptide drug delivery system."
J. Control. Rel. 71 (2001) 307-318.

 
 

R. Lizio, T. Klenner, A.W. Sarlikiotis, P. Romeis, D. Marx, T. Nolte, D. Jahn, G. Borchard and C.-M. Lehr
"Systemic delivery of the GnRH-antagonist cetrorelix to anesthetized and orotracheally cannulated rats by a new aerosol delivery system."
Pharm. Res . 18 (2001) 771-779.

 
 

R. Lizio, D. Marx, T. Nolte, C.-M. Lehr, A.W. Sarlikiotis, G. Borchard and T. Klenner
"Development of a new delivery system for systemic pulmonary delivery in anesthetized and orotracheal cannulated rats."
Lab. Animals 35 (2001) 261-270.

 
 

I.M. van der Lubben, J.C. Verhoef, G. Borchard and H.E. Junginger
"Chitosan and its derivatives in mucosal drug and vaccine delivery."
Eur. J. Pharm. Sci. (2001) 201-207.

 
 

I.M. van der Lubben, J.C. Verhoef, G. Borchard and H.E. Junginger
"Chitosan for mucosal vaccination."
Adv. Drug Del. Rev. 52 (2001) 139-144.

 
 

G. Borchard
"Modern drug delivery applications of chitosan."
Adv. Drug Deliv. Rev . 52 (2001) 103.

 
 

G. Borchard
"Chitosan in gene delivery."
Adv. Drug Del. Rev . 52 (2001) 145-150.

 
 

B.I. Florea, I. v.d. Sandt, S.M. Schrier, K. Kooiman, K. Derijckere, A.G. de Boer, H.E. Junginger and G. Borchard
"Evidence of P-glycoprotein mediated apical to basolateral export system for flunisolide in human broncho-tracheal epithelial cells (Calu-3)."
Br. J. Pharmacol . 134 (2001) 1555-1563.

 
2000  
 

R. Lizio, G. Borchard, T. Klenner, P. Romeis, A.W. Sarlikiotis and C.-M. Lehr
"Systemic delivery of the GnRH-antagonist cetrorelix by intratracheal instillation in anesthetized rats."
Eur. J. Pharm. Sci. 9 (2000) 253-258.

 
 

I.M. van der Lubben, F.A.J. Konings, G. Borchard, J.C. Verhoef and H.E. Junginger
"Chitosan microparticles for oral vaccination: optimization and characterization."
Adv. Chitin Sci. 4 (2000) 250-253.

 
 

F.A. Dorkoosh, J. Brussee, J.C. Verhoef, G. Borchard, M. Rafiee-Tehrani and H.E. Junginger
"Preparation and NMR characterization of superporous hydrogels and SPH composites."
Polymer 41 (2000) 8213-8220.

 
1998    
 

U. Bock, C. Kolac, G. Borchard, K. Koch, R. Fuchs, P. Streichhan and C.-M. Lehr
"Transport of proteolytic enzymes across Caco-2 cell monolayers."
Pharm. Res. 15, (1998) 1393-1400.

 
 

R. Schaffnit, P. Wicklandt, G. Borchard and F. Moll
"Effects of electrical current on the permeability of epithelial cell monolayers."
Pharm. Pharmacol. Lett. 8 (1998) 140-143.

 
1996  
 

G. Borchard, H.L. Luessen, A.G. de Boer, J.C. Verhoef, C.-M. Lehr and H.E. Junginger
"The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III: Effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro."
J. Control. Rel. 39 (1996) 131-138.

 
 

G. Borchard and J. Kreuter
"The role of serum complement on the organ distribution of intravenously administered poly(methyl methacrylate) nanoparticles: effects of pre-coating with plasma and with serum complement."
Pharm. Res. 13 (1996) 1055-1058.

 
1995    
 

S. Brandriss, G. Borchard, J. Kreuter and S. Margel
"Radiolabeled 75Se-silica nanoparticles: synthesis, characterization and coating with ?-functionalized alkylsilane surfactants."
Reactive Polymers 25 (1995) 111-125.

 
 

H.L. Luessen, J.C. Verhoef, G. Borchard, C.-M. Lehr, A.G. de Boer and H.E. Junginger
"Mucoadhesive polymers in peroral peptide drug delivery. II. Carbomer and polycarbophil are potent inhibitors of the intestinal proteolytic enzyme trypsin."
Pharm. Res. 12 (1995) 1293-1298.

 
1994  
 

G. Borchard, K.L. Audus, F. Shi and J. Kreuter
"Uptake of surfactant-coated poly(methyl methacrylate)-nanoparticles by bovine brain microvessel endothelial cell monolayers."
Int. J. Pharm. 110 (1994) 29-35.

 
 

G. Borchard, S. Brandriss, S. Margel and J. Kreuter
"Body distribution of 75 Se-radiolabeled silica nanoparticles covalently coated with ?-functionalized surfactants after intravenous injection in rats."
J. Drug Target. 2 (1994) 61 - 77.

 
1993    
 

G. Borchard and J. Kreuter
"Interaction of serum components with poly(methyl methacrylate) nanoparticles and the resulting body distribution after intravenous injection in rats."
J. Drug Target . 1 (1993) 15-19.

 
 


Book Chapters

  C. Mueller, G. Borchard
Pegylation and Drug Modifying Techniques for Sustained Drug Action.
In: Protein Pharmaceuticals, Formulation, Analytics and Delivery, ditio Cantor Verlar, Mahler, H.-Ch.; Borchard, G; Luessen, H. L.,1st edition, 2010, p.312.
 
 

G. Borchard
"Understanding the mechanisms of local pulmonary drug absorption and metabolism: An in vitro model of the airway epithelium"
in: L. Gradon and J. Marijnissen (eds.), Optimization of aerosol drug delivery, Kluwer Academic Publishers, Dordrecht, The Netherlands (2003), 295-308.

 
 

C. Meaney, B.I. Florea, C. Ehrhardt, U.F. Schäfer, C.-M. Lehr, H.E. Junginger and G. Borchard
"Bronchial epithelial cell cultures"
in: C.-M. Lehr (ed.), Cell culture models of biological barriers: In vitro test systems for drug absorption and delivery, Taylor & Francis, London, UK (2002), 211-227.

 
 

G. Borchard, F.A. Dorkoosh, J.C. Verhoef, M. Rafiee-Tehrani and H.E. Junginger
"In vivo evaluation of a novel peroral delivery system based on superporous hydrogel (SPH) polymers for the peptide drug octreotide"
in: S. Svenson (ed.), Carrier based drug delivery, ACS Symposium Series (2002), 296-317.

 
 

G. Borchard,
"Drug Transport at the Blood Brain Barrier"
in: R.H. Müller, G. Hildebrand (eds.) Pharmaceutical Technology: Modern Drug Carrier Systems WVG, Stuttgart, Germany (2001).

 
 

G. Borchard
"Formulierung biotechnologischer Arzneimittel: Delivery von Peptiden, Proteinen und Oligonucleotiden"
in: O. Kayser and R.H. Müller (eds.), Pharmazeutische Biotechnologie, Wissenschaftliche Verlagsgesellschaft, Stuttgart, Germany (2000), 125-144.

 
 

I.M. van der Lubben, J.C. Verhoef, G. Borchard and H.E. Junginger
"Chitosan microparticles for oral vaccination: optimisation, characterization and preliminary in vivo uptake studies in Peyer´s Patches"
in: R.A.A. Muzzarelli (ed.), Chitosan per os: From dietary supplement to drug carrier, Atec, Grottamare (2000), 115-126.

 
 

H.E. Junginger, M. Thanou, F.A. Dorkoosh, G. Borchard and J.C. Verhoef
"New developments in peroral drug delivery and absorption"
in: K.D. Park, I.C. Kwon, N. Yui, S.Y. Jeong and K.D. Park (eds.), Biomaterials and drug delivery toward the new millenium (2000), 37-47.

 
 

H.L. Luessen, J.C. Verhoef, A.G. de Boer, H.E. Junginger, B.J. de Leeuw, G. Borchard and C.-M. Lehr
"Multifunctional polymers for the peroral delivery of peptide drugs"
in: E. Mathiowitz, D.E. Chickering and C.-M. Lehr (eds.), Bioadhesive drug delivery systems, Marcel Dekker, New York (1999), 299-340.

 
 

E. Haltner, G. Borchard and C.-M. Lehr
"The application of lectins in drug delivery - absorption enhancement by lectin-mediated endo- and transcytosis"
in: J.M. Rhodes and J.D. Milton (eds.), Methods in Molecular Biology Research - Lectins in Medical Research, Humana Press, Totowa, New Jersey (1998), 576-582.

 
 

G. Borchard
"Arzneistofftransport an der Bluthirnschranke"
in: R.H. Müller, G. Hildebrand (eds.) Pharmazeutische Technologie: Moderne Arzneiformen, WVG, Stuttgart, Germany (1996), 413-418.

 

 


Other Publications


G. Borchard
"PEGylation: Quo Vadis?"
APV Focus Group Drug Delivery Newsletter, Issue 3, 2006, 4-8.



G. Borchard
"Macromolecular engineering"
Drug Delivery Companies Report, 2004.



G. Borchard
"Mucosal immunization using plasmid deoxyribonucleic acid (DNA) vaccines."
Business Briefing Series, January 2002, 40-43.



B.I. Florea, M. Thanou, H.E. Junginger, and G. Borchard
"Performance and costs of bovine sera used in epithelial cell cultures."
NewDrugs 4 (2001) 20-24 .



 


Patents

  G. Borchardt, C. Mueller, M.-A.H. Capelle, T. Arvinte
"Stabilization of protein solutions with a PEG derivatives for injections"
WO 2011051916, PCT Int. Appl. (2011)
 
  H.C. Pellikaan, G. Borchard
"Method for particle precipitation using near-critical and supercritical antisolvents"
WO 2004006893, PCT Int. Appl. (2004)
 

G. Borchard, H. Pellikaan
"Method for the manufacture of a drug delivery system."
EPA 02077848.6, 15.7.2002.



H.E. Junginger, F.A. Dorkoosh, G. Borchard, M. Rafiee-Tehrani, J.C. Verhoef
"Double-phase time-controlled release system."
EP 99203578, 29.10.1999.



H.L. Luessen, G. Borchard, A.G. de Boer, H.E. Junginger, K. Kolter, V. Schehlmann, A. Sanner
"Application of (meth) acrylic acid-maleinic acid co-polymers as absorption enhancers at mucosal tissues."
EP 97112660.2, 24.7.1997.



 


Personal Grants and Awards of Team Members

 

Discoverer of the year 2006 award (Ontdekker van het jaar 2006 publieksprijs), Leiden University, The Netherlands, January 2007 (M. Bivas-Benita).

 
 

Best Dissertation Thesis Award, Dutch Association of Pharmaceutical Sciences (NVFW), Lunteren, The Netherlands, September 2006 (M. Bivas-Benita).

 
 

Anselmus Stimulating Prize November 2004, Belgian-Dutch Biopharmacy Society, Oss, The Netherlands, December 2004 (M. Wiggenhorn).

 
 

Best Lecturer Award, CRS Local Chapter Germany, Munich, Germany, March 2003 (M. Wiggenhorn)

 
 

Anselmus Stimulating Prize November 2003, Belgian-Dutch Biopharmacy Society, Oss, The Netherlands (M. Oudshoorn).

 
 

AAPS Graduate Award, AAPS Annual Meeting, Toronto, Canada, November 2002 (F.A. Dorkoosh).

 
 

Best Poster Award, DNA Vaccine Conference 2002, Edinburgh, UK, October 2002 (M. Bivas-Benita).

 

Anselmus Stimulating Prize (best M.Sc. thesis in Biopharmaceutical Sciences in Belgium and The Netherlands), Belgian-Dutch Biopharmacy Society, Court-Saint-Etienne, Belgium, November 2001 (I. Bot).


 

CRS-Capsugel Graduate/Post-Doc Award, CRS Meeting, San Diego, CA, USA, June 2001 (F.A. Dorkoosh).

 
 

Organon Research Talent Award (best Dutch M.Sc. thesis in Biopharmaceutical Sciences), Organon b.v., Oss, The Netherlands, November 2000 (M. Geldof).

 
 

Poster Award, Annual Meeting of Royal Dutch Chemical Society, Utrecht, The Netherlands, March 2000 (M. Geldof).

 
 

Susanne Hovinga Award (best M.Sc. thesis in Biopharmaceutical Sciences), Leiden University, The Netherlands, November 2000 (K. Kooiman).

 
 

Best Lecturer Award, CRS Local Chapter Germany, Erlangen, March 1999 (B.I. Florea).

 
 

Dutch Science Foundation (NWO) travel grant, June 1998.

 
 

German Israelian Foundation (GIF) grant, 1992 - 1993.

 

German Academic Exchange Service (DAAD) travel grant, October 1991 - March 1992.



German Science Foundation (DFG) grant, 1990 - 1992.



 


Team members

  Di Francesco Tiziana
  Duvillard Adrien
  Ehrenberger Stella
  Fuchs Katrin
  Groell Floriane
  Jordan Olivier
  Lemoine Celine
  Marquet Franck
  Möller Michael
  Patrulea Viorica
  Ragupathy Sakthikumar
  Sakr Omar
  Sublet Emmanuelle
  Witta Anne-Francoise
 

Last update: July 2011