Norbert Lange

Professeur associé


 
Address :    

Université de Genève
Section des sciences pharmaceutiques
Technologie pharmaceutique
Rue Michel-Servet 1
CH-1211 Genève 4

Room :   B08.1714.b
Phone :     +41 22 37 933 35
Fax :     +41 22 37 965 67
e-mail :     Norbert.Lange@unige.ch


Education


1995-1991   PhD student, Institute of Physical Chemistry, University of Göttingen, Germany
1990-1991   Diploma student, Institute of Physical Chemistry, University of Göttingen, Germany
1985-1990   Study of Chemistry, University of Göttingen, Germany
1978-1985   Secondary School, Gymnasium Otterndorf, Germany
   


Professional Experience


2004-  

Assistant Professor/Lecturer (MER) : School of Pharmaceutical Sciences, Geneva, Switzerland

2002-2004   SMER at the of Institute for Biopharmacy and Pharmaceutical Technology, School of Pharmacy, University of Lausanne
1996-2002   Research Associate, Department of Rural Engineering, Swiss Fed. Inst. of Technology
1999-2002   Research Associate, Institute of Physiology, University of Lausanne
1990-1996   Scientific Collaborator, Institute of Physical Chemistry, University of Göttingen
   
  • Teaching Activities
2002 -   Lecturer in the European Diploma "Medical Lasers"
1999 -   Supervision of diploma and PhD students
1995 -   Leading assistant, responsible for the examinations in several courses in Physical Chemistry
1996   Supervision of students in practical training in thermodynamics
1991-1995   Mathematics for undergraduate students in chemistry
1989-1991   Supervision of graduate biology students in practical work in Physical Chemistry
1989   Supervision of students in Organic Chemistry
   

Research Interests

  • Photodynamic Therapy and Fluorescence Photodetection


Publications

2013    
  M. F. Zuluaga, N. Sekkat, D. Gabriel, H. Van den Bergh and N. Lange
"Selective Photodetection and Photodynamic Therapy for Prostate Cancer through Targeting of Proteolytic Activity"
Molecular Cancer Therapeutics, 12, 306-313 (2013)
 
2012    
  D. Gabriel, N. Lange, V. Chobaz-Peclat, M. F. Zuluaga, R. Gurny, H. van den Bergh and N. Busso
"Thrombin-sensitive dual fluorescence imaging and therapeutic agent for detection and treatment of synovial inflammation in murine rheumatoid arthritis"
Journal of Controlled Release, 163, 178-186 (2012)
 
  N. Sekkat, H. ven den Bergh, T. Nyokong and N. Lange
"Like a Bolt from the Blue: Phthalocyanines in Biomedical Optics"
Molecules, 17, 98-144 (2012)
 
  G. Heuck and N. Lange
"Matrix mediated fluorescence enhancement - why nano-particles and PPIX make a friendly couple"
Journal of Porphyrins and Phthalocyanines, 16, 878-884 (2012)
 
  E. Allemann, F. Delie and N. Lange
"Pharmaceutical Technology at the Service of Targeted Drug Delivery"
Chimia, 66, 308-12 (2012)
 
  M. F. Zuluaga, D. Gabriel and N. Lange
"Enhanced Prostate Cancer Targeting by Modified Protease Sensitive Photosensitizer Prodrugs"
Molecular Pharmaceutics, 9, 1570-1579 (2012)
 
2011    
  N. Sekkat, H. van den Bergh, T. Nyokong and N. Lange
"Like a bolt from the blue: Phthalocyanines in Biomedicine"
Molecules, 17(1), 98-144 (2011)
 
  P. Mroz, T. J. Hashmi, Y. Y. Huang, N. Lange and M. R. Hamblin
"Stimulation of anti-tumor immunity by photodynamic therapy"
Expert Review of Clinical Immunology, 7 (1), 75-91 (2011)
 
  D. Gabriel, M. F. Zuluaga, H. van den Bergh, R. Gurny and N. Lange
"It is all about proteases: From drug delivery to in vivo imaging and photomedicine"
Current Medical Chemistry, 18 (12), 1785-805 (2011)
 
  D. Gabriel, M. F. Zuluaga and N. Lange
"On the cutting edge: Protease sensitive prodrugs for the delivery of photoactive compounds"
Photochemistry and Photobiology Science, 10 (5), 689-703 (2011)
 
2010    
  S. Bouillaguet, J. C. Wataha, O. Zapata, M. Campo, N. Lange and J. Schrenzel
"Production of reactive oxygen species from photosensitizers activated with visible light sources available in dental offices"
Photomedicine and Laser Surgery, 28(4), 519-25 (2010)
 
  A. Cirstoiu-Hapca, F. Buchegger, N. Lange, R. Gurny and F. Delie
"Benefit of anti-HER2-coated paclitaxel-loaded immuno-nanoparticles in the treatment of disseminated ovarian cancer: Therapeutic efficacy and biodistribution in mice"
Journal of Control Release, 144(3), 324-31 (2010)
 
2009    
  N. Fotinos, J. Mikulic, M. Convert, M. A. Campo, J. C. Piffaretti, R. Gurny and N. Lange
"5-ALA derivative-mediated photoinactivation of Propionibacterium acnes."
Journal of Dermatological Science, 56(3), 214-6 (2009 )
 
  S. Létoffé, G. Heuck, P. Delepelaire, N. Lange and C. Wandersman
"Capturing iron from heme by keeping tetrapyrrol skeleton intact: a new bacterial pathway"
Proceedings of the National Academy of Sciences, 106(28), 11719-24 (2009 )
 
  M. Zeisser-Labouèbe, M. Mattiuzzo, N. Lange, R. Gurny and F. Delie
"Quenching-induced deactivation of photosensitizer by nanoencapsulation to improve phototherapy of cancer"
Journal of Drug Targetting, 17(8), 619-26 (2009 )
 
  A. Vargas, N. Lange, T. Arvinte, R. Cerny, R. Gurny and F. Delie
"Toward the understanding of the photodynamic activity of m-THPP encapsulated in PLGA nanoparticles: correlation between nanoparticle properties and in vivo activity"
Journal of Drug Targetting, 17(8), 599-609 (2009 )
 
  D. Gabriel, N. Busso, H. van den Bergh, A. So, R. Gurny and N. Lange
"Thrombin-sensitive photodynamic agents: A novel strategy for selective synovectomy in rheumatoid arthritis"
Journal of Controlled Release, 138(3), 225-34 (2009 )
 
  M. Zeisser-Labouèbe, F. Delie, R. Gurny and N. Lange
"Screening of nanoparticulate delivery systems for the photodetection of cancer in a simple and cost-effective model"
Nanomedicine, 4(2), 135-43 (2009 )
 
  M. Zeisser-Labouèbe, F. Delie, R. Gurny and N. Lange
"Benefits of nanoencapsulation fort the hypercin-mediated photodetection of ovarian micrometastases"
European Journal of Pharmaceutics and Biopharmaceutics, 71, 207-213 (2009) doi:10.1016/j.ejpb.2008.10.005
2008    
  S. Berrahmoune, N. Fotinos, L. Bezdetnaya, N. Lange, J. C. Guedenet, F. Guillemin and M. A. D'Hallewin
"Analysis of differential PDT effect in rat bladder tumor models according to concentrations of intravesical hexyl-aminolevulinate"
Photochemical & Photobiological Science, 7(9), 1018-24 (2008)
  M.-F. Zuluaga and N. Lange
"Combination of photodynamic therapy with anti-cancer agents"
Current Medicinal Chemistry, 15(17), 1655-1673 (2008)
  E. Debefve, B. Pegaz, H. van den Bergh, G. Wagnières, N. Lange and J. P. Ballini
"Video monitoring of neovessel occlusion induced by photodynamic therapy with verteporfin (Visudyne((R))), in the CAM model"
Angiogenesis, 11(3), 1655-1673 (2008)
  S. Bouillaguet, B. Owen, J. C. Wataha, M. A. Campo, N. Lange and J. Schrenzel
"Intracellular reactive oxygen species in monocytes generated by photosensitive chromophores activated with blue light"
Dental Materials, 24(8), 1070-1076 (2008)
  M. Ju, C. Mailhos, J. Bradley, T. Dowie, M. Ganley, G. Cook, P. Calias, N. Lange, A. P. Adamis, D. T. Shima and G. S. Robinson
"Simultaneous but Not Prior Inhibition of VEGF165 Enhances the Efficacy of Photodynamic Therapy in Multiple Models of Ocular Neovascularization"
Investigative Ophthalmology & Visual Science, 49(2), 662-70 (2008)
  N. Fotinos, M. Convert, J.-C. Piffaretti, R. Gurny and N. Lange
"Effects on gramm-negative and gram-positive bacteria mediated by 5-aminolevulinic acid and 5-aminolevulinic acid derivatives"
Antimicrobial agents and Chemotherapy, 52(4), 1366-1373 (2008)
  S. Collaud, Q. Peng, R. Gurny and N. Lange
"Thermosetting gel for the delivery of 5-aminolevulinic acid esters to the cervix"
Journal of Pharmaceutical Science, 97(7), 2680-90 (2008)
2007    
  S. Collaud, T. Warloe, O. Jordan, R. Gurny and N. Lange
"Clinical evaluation of bioadhesive hydrogels for topical delivery of hexylaminolevulinate to Barrett's esophagus"
Journal of Controlled Release, 123, 203-210 (2007)
  Y. Fradet, H. B. Grossman, L. Gomella, S. Lerner, M. Cookson, D. Albala and M. J. Droller
"A comparison of hexaminolevulinate fluorescence cystoscopy and white light cystoscopy for the detection of carcinoma in situ in patients with bladder cancer: a phase III, multicenter study"
Journal of Urology, 178(1), 68-73 (2007) (NL was part of the PC B302/01 study Group)
  H. B. Grossman, L. Gomella, Y. Fradet, A. Morales, J. Presti, C. Ritenour, U. Nseyo and M. J. Droller
"PC B302/01 Study Group. A phase III, multicenter comparison of hexaminolevulinate fluorescence cystoscopy and white light cystoscopy for the detection of superficial papillary lesions in patients with bladder cancer"
Journal of Urology, 178 (1), 62-7 (2007) (NL was part of the PC B302/01 study Group)
  A. Vargas, M. Zeisser-Labouèbe, N. Lange, R. Gurny and F. Delie
"The chick embryo and its chorioallantoic membrane (CAM) for the in vivo evaluation of drug delivery systems"
Advanced Drug Delivery Reviews, 59, 1162-1176 (2007)
  M. A. Campo, D. Gabriel, P. Kucera, R. Gurny and N. Lange
"Polymeric photosensitizer prodrugs for photodynamic therapy"
Photochemistry and Photobiology, 83, 958-965 (2007)
  M. F. Zuluaga, C. Maihos G. Robinson, D. T. Shima R. Gurny and N. Lange
"Synergies of VEGF inhibition and photodynamic therapy in the treatment of age-related macular degeneration"
Investigative Ophthalmology Visual Science, 48 (4), 1767-1772 (2007)
  D. Gabriel, M. A. Campo, R. Gurny and N. Lange
"Tailoring protease-sensitive photodynamic agents to specific disease-associated enzymes"
Bioconjugate Chemistry, 18, 1070-1077 (2007)
  L. Vaucher, P. Jichlinski, N. Lange, C. Ritter-Schenk, H. van den Bergh and P. Kucera
"Hexyl-aminolevulinate-mediated photodynamic therapy: How to spare normal urothelium. An in vitro approach"
Lasers in Surgery and Medicine, 39 1, 67-75 (2007)
2006  
  N. Fotinos, M. A. Campo, F. Popowycz, R. Gurny and N. Lange
"5-Aminolevulinic acid derivatives in photomedicine: Characteristics, application and persperctives"
Photochemistry and Photobiology, 82, 994-1015 (2006)
  M. Zeisser-Labouèbe, N. Lange, R. Gurny and F. Delie
"Hypericin-loaded nanoparticles for the photodynamic treatment of ovarian cancer"
International Journal of Pharmaceutics, 326, 174-181 (2006)
  S. Collaud, P. Jichlinski, A. Marti, D. Aymon, R. Gurny and N. Lange
"An open pharmacokinetic study of hexylaminolevulinate-induced photodiagnosis after intravesical administration"
Drugs in R&D , 7 (3), 173-186 (2006)
  M. A. Campo and N. Lange
"Fluorescence diagnosis using enzyme-related metabolic abnormalities of neoplasia"
Journal of Environmental Pathology, Toxicology and Oncology, 25 (1-2), 341-372 (2006)
2005  
  L. VAUCHER, P. JICHLINSKI, N. LANGE, C. RITTER-SCHENK, H. van den BERGH and P. KUCERA
"Sparing of normal urothelium in hexyl-aminolevulinate mediated photodynamic therapy"
Proc. of SPIE, Bellingham, WA, vol. 5686, 193-198 (2005)
  A. SARRE, N. LANGE, P. KUCERA and E. RADDATZ
"mitoK ATP channel activation in the postanoxic developing heart protects E-coupling via NO-, ROS-, and PKC- dependent pathways"
American Journal of Physiology -Heart and Circulatory Physiology, 288, H1611-H1619 (2005)
2004  
  A. SARRE, N. LANGE, P. KUCERA and E. RADDATZ
"Opening the potassium adenosine triphosphate channel improves post anoxic recovery of conduction and excitation-contraction coupling in the developing heart."
J Am Coll Cardiol. 43, 254 (2004)
 
2003  
  T. STEPINAC, C. FELLEY, P. JORNOD, N. LANGE, T.GABRECHT, C. FONTOLLIET, P. GROSJEAN, G. VANMELLE, H. VAN DEN BERGH, P. MONNIER G. WAGNIERES and G. DORTAS
"Endoscopic fluorescence detection of intraepithelial neoplasia in Barrett's esophagus after oral administration of aminolevulinic acid"
Endoscopy. 2003 Aug;35(8):pp663
 
  Marti A, Jichlinski P, Lange N, Ballini JP, Guillou L, Leisinger HJ, Kucera P. 
Comparison of aminolevulinic acid and hexylester aminolevulinate induced protoporphyrin IX distribution in human bladder cancer. 
J Urol. 2003 Aug;170(2 Pt 1):428-32.
 
  Lüdecke F, Gabrecht T, Lange N, Wagnières G, van den Bergh H, Major A. 
Optimization of fluorescence photodetection of ovarian cancer by using 5-aminolevulinic acid hexylester. 
Br J Cancer. 2003 Jun 2;88(11):1780-4. 
 
  Lange N, 
Controlled Drug delivery in photodynamic therapy and fluorescence-based diagnosis of cancer, 
pp 568, in Mycek, Pogue eds. "Fluorescence in Biomedicine" Marcel Decker, NY (2003)
 
  De Rosa FS; Tudesco AC; Lopez RV; Pierre MBR; Lange N, Marchetti JM, Bentley MVLB, 
In vitro skin permeation and retention of 5-aminolevulinic acid ester derivatives for photodynamic therapy of skin cancer, 
J Contr. Release 89, 261-269 (2003)
 
  De Rosa FS, Lopez RV, Thomazine JA, Tedesco AC, Lange N, Bentley MVLB. 
In vitro metabolism of 5-ALA esters in hairless mice skin homogenate and in vivo PpIX accumulation studies. 
Accepted for publication in J Contr. Release (2003) 
 
  Lopez RFV, Bentley MVLB, Delgado-Charro MB, Salomon D, van den Bergh H, Lange N, Guy RH. 
Iontophoretic delivery of 5-aminolevulinic acid (ALA) and a series of ALA esters into and through the skin. 
Photochem. Photobiol. 77: 304-308 (2003)
 
  Vaucher L, Lange N, Jichlinski P, van den Bergh H, Kucera P. 
Correlation of phototherapeutical irradiation doses with cell death in the urothelium, 
submitted to J. Urol. (2003)
 
  Jichlinski P, Guillou L, Karlsen SJ, Malmstrom PU, Jocham D, Brennhovd B, Johansson E, Gartner T, Lange N, van den Bergh H, Leisinger HJ. 
Hexyl aminolevulinate fluorescence cystoscopy: new diagnostic tool for photodiagnosis of superficial bladder cancer-a multicenter study. 
J Urol. 2003 Jul;170(1):226-9
 
  Sarre A, Gabioud H, Lange N, Raddatz E. 
The mitochondrial KATP channel is not involved in the oxidative burst induced by anoxia-reoxygenation in the embryonic heart. 
Eur J Heart Failure. 2, 90 (2003)
 
  Sarre A, Gabioud H, Lange N, Raddatz E. 
Opening the mitochondrial KATP channel in the embryonic heart is prooxidant during reoxygenation but not under normoxia. Archives des Maladies du Cour et des Vaisseaux.96, 90 (2003)
 
2002  
  Juzeniene A, Ma LW, Juzenas P, Iani V, Lange N, Moan J. 
Production of protoporphyrin IX from 5-aminolevulinic acid and two of its esters in cells in vitro and tissues in vivo. 
Cellular and Molecular Biology 48 (8), 911-916 (2002)
 
  H. van den Bergh, N. Lange, P. Jichlinski, 
Photodetection of superficial bladder cancer with ALA-hexyl ester: Phase II and Phase III trials 
Photodynamic News, 5(1), pp 5, 2002.
 
  Kirdaite G, Lange N, Busso N, van den Bergh H, So A. 
Protoporphyrin IX Photodynamic Therapy for Synovitis. 
Arthritis Rheumatism. 46, 1371-1378 (2002)
 
2001
  Lange N, Ballini JP, Wagnières G, van den Bergh H. 
Evaluation of the Hen's egg chorioallantoic membrane as a model for PDT of choroidal neovascularization in age-related macular degeneration. J. Invest.
Ophthalm. Sci.42, 38-46 (2001)
 
  Lange N, Vaucher L, van den Bergh H, Marti A, Jichlinski P, Etter, AL, Gerber,P, Kucera P. 
A simple and low-cost tissue culture model for testing conditions used in photodynamic therapy and fluorescence photodetection of neoplastic and non-neoplastic human diseases. 
J. Biomed. Optics, 6, 151-159 (2001)
 
  Abel B, Lange N, Troe J. 
Specific rate constants k(E, J) for the dissociation of NO 2 . II. Linewidths of rotationally selected NO 2 near to the dissociation threshold. 
J Chem. Phys 115: 6531-6537 (2001)
 
  L. Vaucher, N. Lange, C. Ritter-Schenk, P. Jichlinski, P. Kucera, 
Phototoxic effects in the protoporphyrin IX loaded urothelium
Eur. Urol, 39(S5), p 173, 2001
 
  P. Jichlinski, A. Marti, L. Guillou, N. Lange, G. Wagnières, H.-J. Leisinger,
First report on hexyl-ester aminolevulinic acid (h-ALA) induced fluorescence cystoscopy in superficial bladder cancer
Eur. Urol, 39(S5), p 37, 2001
 
2000  
  Kirdaite G, Lange N, Busso N, Kucera P, 
So A H-ALA-induced protoporphyrin IX in arthritic synovial tissues: Basis for photodynamic therapy.
ARTHRITIS AND RHEUMATISM 43: 1349, Suppl. S (2000)
 
  Jornod P, Stepinac T, Lange N, Andrejevic-Blant S, Fontolliet C, Radu A, Monnier P, Wagnieres G, Ollyo JB, van den Bergh HL, Blum AL, Dorta GO. 
Barrett's esophagus: High detection rate for dysplasia and early adenocarcinoma by combined screening with 4-quadrant biopsies and photodynamic detection. 
Gastroenterology 118: 3763, Part 1, Suppl. 2 (2000)
 
  Uehlinger P, Zellweger M, Wagnières G, Juillerat L, van den Bergh H, Lange N. 
Determination of physical chemical properties of ALA and its derivatives and their impact on the PpIX formation in cultured cells. 
J. of Photochem. Photobiol. 54, 72-80 (2000)
 
  N. Dögnitz, G. Wagnières, N. Lange, H. van den Bergh, D. Salomon,
Quantitative fluorescence microscopy analysis of protoporphyrin IX distribution in basal cell carcinoma after application of aminolevulinic acid or aminolevulinic acid hexyl ester
J. European Academy of Dermatology and Venereology, 14(S1), p 235, 2000.
 
  F. Lüdicke, T. Gabrecht, N. Lange, G. Wagnières, A. Campana and A. Major,
Fluorescence Detection of Ovarian Cancer in the NuTu-19 Epithelial Ovarian Cancer Animal Model using Aminolaevulinic Acid hexylester
Proc. SPIE, 4156, 2000
 
1999  
  Marti A, Lange N, van den Bergh H, Sedmera D, Jichlinski P, Kucera P.
Optimisation of the formation and distribution of Protoporphyrin IX in the urothelium: an in vitro approach. 
J. of Urol. 162, 546-552 (1999)
 
  Lange N, Jichlinski P, Zellweger M, Forrer M, Marti A, Guillou L, Kucera P, Wagnières G, van den Bergh H. 
Photodetection of Early Human Bladder Cancer Based on the Fluorescence of 5-Aminolevulinic Acid Hexylester-Induced Protoporphyrin IX: A Pilot Study. 
British J. of Cancer, 80, 185-193 (1999)
 
  Abel B, Lange N, Reiche F, Troe J. 
State-resolved collisional energy transfer in highly excited NO2. I. Cross sections and propensities for J, K, and mJ changing collisions. 
J. Chem. Phys., 110, 1389 (1999)
 
  Abel B, Lange N, Reiche F, Troe J. 
State-resolved collisional energy transfer in highly excited NO2. II. Vibrational energy transfer in the presence of strong chemical interaction. 
J. Chem. Phys., 110, 1404 (1999)
 
  van den Bergh H, Lange N, Jichlinski P. 
ALA Hexyl Ester: A second generation precursor for protoporphyrin IX in photodynamic therapy and photodetection of early bladder cancer.
PDT News, 2, 4-8 (1999)
 
1998  
  Hadjur C. Lange N, Rebstein J, Monnier P, van den Bergh H, Wagnières G.
Spectroscopic studies of photobleaching and photoproduct formation of meta (tetrahydroxyphenyl)chlorin (m-THPC) used in photodynamic therapy. The production of singlet oxygen by m-THPC. 
J. Photochem. Photobiol., 45, 170 (1998)
 
1995  
  Abel B, Hamann H, Lange N. 
State Resolved Dynamics in Highly Excited States of NO 2 : Collisional Relaxation and Unimolecular Dissociation.
Farad. Dis. Chem. Soc., 102 (1995)
 
 


Patents

  Campo Marino, Lange Norbert.
Pat. appl. 2008
"Compounds for fluorescence imaging"
 
 

Lange N., Campo M. A.
WO2007/023398 A2 - 2007
"Compounds for photochemotherapy"

 
 

Lange N., M. Campo M.A.
US Pat. Appl. 60/871,330 - 2006
"Compounds for Fluorescence Imaging"

 
 

Lange N., Campo M. A, Gurny R.
US Pat. Appl. 60/681,244 - 2005
"Compounds for Photochemotherapy"

 
  H. van den Bergh, P. Jichlinski, P. Kucera, A. Marti, N. Lange, M. Zellweger, and G. Wagnières 
FR 2777782
"Solution pour la préparation d´une substance pharmaceutique pour le diagnostic et/ou le traitement de lésions tissulaires" 
 
  H. van den Bergh, P. Jichlinski, P. Kucera, A. Marti, N. Lange, M. Zellweger, and G. Wagnières
WO 9953962
"Pharmaceutical use of 5-aminolevulinic acid ester solution"
 
  H. van den Bergh, P. Jichlinski, P. Kucera, A. Marti, N. Lange, M. Zellweger, G. Wagnières
US 09/673 871
"Solutions for diagnosing or treating tissue pathologies"
 
  G. Wagnières, M. Zellweger, N. Chauvin, N. Lange, U. Zanger, A. Studinski, H. van den Bergh
US 6148227
"Diagnosis apparatus for the picture providing recording of fluorescing biological tissue regions"
 
  G. Wagnières, M. Zellweger, N. Chauvin, N. Lange, U. Zanger, A. Studinski, H. van den Berg
DE 198 00 312
"Diagnosegerät zur bildgebenden Aufnahme fluoreszierender, biologischer Gewebebereiche"
 
  G. Wagnières, N. Lange, D. Salomon, H. van den Bergh, N. Dögnitz. 
FR 01811103.9
"Method for hair removal"
 
  N. Lange, H. van den Bergh
UK Patent Application - 2003
"Selective Photochemotherapy by Means of Dual Conformation Oligonucleodite Targeting Agents, Methods, Kits and Assays"
 
  N. Lange, G. Heuck
PCT/IB2011/052520
"5-ALA Ester Formulations and Use Thereof"
 
 



 


Awards and Fellowships

  • 1999 - 2001: Schering Research Foundation
  • 1996 - 1998: Deutsche Forschungsgemeinschaft (DFG)
  • 1994: Karl-Heinz Beckurtz Foundation


Scientific Advisor

  • Schering SA (Germany)
  • Since 2001        Photocure SA (Norway)
  • Since 2003        Photoderma SA (Switzerland)
  • Since 2004        Eyetech Pharmaceutics (USA)


Referee

  • International Journal of Cancer
  • British Journal of Cancer
  • Journal of Photochemistry and Photobiology
  •  European Journal of Pharmaceutics and Biopharmaceutics
  •  Photochemistry and Photobiology
  •  Journal of Biomedical Optics
  • Recent Patent Reviews on Anti-Cancer Drug Discovery
  • Journal of Pharmacology and Experimental Therapeutics
  • Journal of Controlled Release
  • Journal of Pharmaceutical Sciences
  • British Journal of Pharmacology
  • International Journal of Biochemistry & Cell Biology
  • Journal of Investigative Dermatology
  • Pharmaceutical Research

Editorial Board Member

  • Recent Patent Reviews on Anti-Cancer Drug Discovery
  • Current Medical Chemistry-Anti-Cancer Agents


Collaborations

Academic

  • Prof H van den Bergh, Dr. G. Wagnières (EPFL)
  • Dr. P. Jichlinski (CHUV)
  • Prof. A. So, Dr N. Busso (CHUV)
  • Prof. P. Kucera (UNIL), Dr. E. Raddatz (UNIL)
  • Prof. J. C. Piffaretti (University of Geneva)
  • Prof. V. Bentley (University of Sao Paolo, Brazil)
  • Prof. Q. Peng (Norwegian Radium Hospital, Norway)
  • Prof. Th. Foster (Strong Memorial Hospital, Rochester, NY, USA)

Industrial

  • Sifi (I)
  • Eyetech Pharma (US)
  • Photocure (N)
  • Meddiscovery  (CH)
  • Photoderma (CH)
  • Calipals (US)

Entrepreneurship

  • Co-founder of Photoderma SA, Switzerland
  • Donation of used scientific instruments to developing countries
  • Respondent for questions about Swiss-Latin American Relations at the University of Geneva
  • Organization of art exhibitions for Uruguayan artists

last update: May 2014 / NSH