WOLFENDER Jean-Luc



Prof. Président de Section


Jean-Luc WOLFENDER

Université de Genève
Faculté des Sciences

Phytochimie et produits naturels bioactifs
Rue Michel-Servet 1
CH-1211 Genève 4
Switzerland

Site: Centre Médical Universitaire
Office: B06.1716.a
Phone: +41 22 37 933 85
Fax: +41-22 379 33 99
E-mail: Jean-Luc.Wolfender@unige.ch

Research interests

  • Lead discovery based on bioactive natural products

  • Plant metabolomics (MS and NMR based approaches)

  • Crude extracts metabolite profiling and dereplication with hyphenated LC methods

  • Exploitation of chemical ecology interactions for the search of new lead compounds

  • Study of long distance signaling in the wound response of plants

  • Investigation fungal co-culture interactions as a source for new natural products

  • Study of the permeation and metabolisation behaviour of natural products for a better understating of their mode of action in phytopharmaceuticals and nutraceuticals


Selected Publications


J.-L. Wolfender, P. J. Eugster, N. Bohni and M. Cuendet Advanced Methods for Natural Product Drug Discovery in the Field of Nutraceuticals. Chimia, 2011. 65(6): 400-406.

G. Glauser, J. Boccard, S. Rudaz and J.-L. Wolfender Mass spectrometry-based metabolomics oriented by correlation analysis for wound-induced molecule discovery: identification of a novel jasmonate glucoside. Phytochem. Anal., 2010. 21: 95-101.

M. Lambert, J.-L. Wolfender, D. Staerk, B. Christensen, K. Hostettmann and J. W. Jaroszewski Identification of natural products using HPLC-SPE combined with CapNMR. Anal. Chem., 2007. 79: 727-735.

 

Education and positions held



Year

Description

since 2009

Full Professor in Phytochemistry and Bioactive Natural Products (School of Pharmaceutical Sciences, University of Geneva)

2004-2008

Adjunct Professor in Phytochemistry and Pharmacognosy (School of Pharmaceutical Sciences, University of Geneva)

2001-2004

President of the Section of Pharmacy (University of Lausanne), in charge of the transfer of the school to Geneva as representative of the UNIL side

2000-2003

Associated Professor in Pharmacognosy and Phytochemistry (School of Pharmacy, University of Lausanne)

1999-2000

'Maitre d'Enseignement et de Recherche' (MER) in pharmaceutical analysis (School of Pharmacy, University of Lausanne)

1998-1999

Post-doctoral fellow (Prof. A. L. Burlingame, Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, USA)

1993-1998

Chemist, in charge of the analytical facilites (School of Pharmacy, University of Lausanne)

1993

PhD in Science, Laboratoire de Pharmacognosie et Phytochimie, Sciences Pharmaceutiques, University of Lausanne, Switzerland

1989

Chemistry degree, University of Neuchâtel, Switzerland


Publication list


Full papers

1. Süss-Fink, G., Wolfender, J.-L. and Neumann, F. (1990). Organometallic Macrocycles: Synthesis and Molecular Structure of Trimeric Tartratodiruthenium Complexes. Angewandte Chemie 29, 429-431.

2. Wolfender, J.-L., Neumann, F. and Süss-Fink, G. (1990). Chirale Modifizierung zweikerniger Rutheniumcluster zur Entwicklung enantioselektiver Hydrierkatalysoren. J. Organometallic Chem. 389, 351-359.

3. Wolfender, J.-L., Hamburger, M., Msonthi, J. D. and Hostettmann, K. (1991). Xanthones from Chironia krebsii. Phytochemistry 30, 3625-3629.

4. Wolfender, J.-L., Maillard, M. and Hostettmann, K. (1992). Mass spectrometry of underivatized naturally occurring glycosides. Phytochem. Anal. 3, 193-214.

5. Hamburger, M., Wolfender, J.-L. and Hostettmann, K. (1993). Search for chlorinated sesquiterpene lactones in the neurotoxic thistle Centaurea solstitialis by liquid chromatography-mass spectrometry, and model studies on their possible artifactual formation. Nat. Toxins 1, 315-327.

6. Maillard, M., Wolfender, J.-L. and Hostettmann, K. (1993). Use of liquid chromatography-thermospray mass spectrometry in phytochemical analysis of crude plant extracts. J. Chromatogr. 647, 147-154.

7. Wolfender, J.-L., Hamburger, M., Hostettmann, K., Msonthi, J. D. and Mavi, S. (1993). Search for bitter principles in Chironia species by LC-MS and isolation of a new secoiridoid diglycoside from Chironia krebsii. J. Nat. Prod. 56, 682-689.

8. Wolfender, J.-L., Maillard, M. and Hostettmann, K. (1993). Liquid chromatographic-thermospray mass spectrometric analysis of crude plant extracts containing phenolic and terpene glycosides. J. Chromatogr. 647, 183-190.

9. Wolfender, J.-L. and Hostettmann, K. (1993). Liquid chromatographic-UV detection and liquid chromatographic-thermospray mass spectrometric analysis of Chironia (Gentianaceae) species. A rapid method for the screening of polyphenols in crude plant extracts. J. Chromatogr. 647, 191-202.

10. Ma, W.-G., Fuzzati, N., Wolfender, J.-L., Hostettmann, K. and Yang, C. (1994). Rhodenthoside A, a new type of acylated secoiridoid glycoside from Gentiana rhodentha. Helv. Chim. Acta 77, 1660-1671.

11. Wolfender, J.-L., Maillard, M. and Hostettmann, K. (1994). Thermospray liquid chromatography-mass spectrometry in phytochemical analysis. Phytochem. Anal. 5, 153-182.

12. Camponovo, F. F., Wolfender, J.-L., Maillard, M., Potterat, O. and Hostettmann, K. (1995). Evaporative light scattering and thermospray mass spectrometry: two alternative methods for detection and quantitative liquid chromatography determination of ginkgolides and bilobalide in Ginkgo biloba leaf extracts and phytopharmaceuticals. Phytochem. Anal. 6, 141-148.

13. Cremin, P., Donnely, D. M. X., Wolfender, J.-L. and Hostettmann, K. (1995). Liquid chromatographic-thermospray mass spectrometric analysis of sesquiterpenes of Armillaria (Eumycota: Basidiomycotina) species. J. Chromatogr. A. 710, 273-285.

14. Ducrey, B., Wolfender, J.-L., Marston, A. and Hostettmann, K. (1995). Analysis of flavonol glycosides of thirteen Epilobium species (Onagraceae) by LC-UV and thermospray LC-MS. Phytochemistry 38, 129-137.

15. Rath, G., Touré, A., Wolfender, J.-L. and Hostettmann, K. (1995). Characterization of C-glycosylflavones from Dissotis rotundifolia T. by liquid chromatography-tandem mass spectrometry. Chromatographia 41, 332-342.

16. Rodriguez, S., Wolfender, J.-L., Hakizamungu, E. and Hostettmann, K. (1995). An antifungal naphthoquinone, xanthones and secoiridoids from Swertia calycina. Planta Med. 61, 362-364.

17. Rodriguez, S., Wolfender, J.-L., Odontuya, G., Purev, O. and Hostettmann, K. (1995). Xanthones, secoiridoids and flavonoids from Halenia corniculata. Phytochemistry 40, 1265-1272.

18. Wolfender, J.-L., Abe, F., Nagao, T., Okabe, H., Yamauchi, T. and Hostettmann, K. (1995). Liquid chromatography combined with thermospray and continuous-flow fast atom bombardment mass spectrometry of glycosides in crude plant extracts. J. Chromatogr. A 712, 155-168.

19. Wolfender, J.-L., Rodriguez, S., Hostettmann, K. and Wagner-Redeker, W. (1995). Comparison of liquid chromatography/electrospray, atmospheric pressure chemical ionisation, themospray and continuous-flow fast atom bombardment mass spectrometry for the determination of secondary metabolites in crude plant extracts. J. Mass Spectrom. S35-S46.

20. Fuzzati, N., Wolfender, J.-L., Hostettmann, K., Msonthi, J. D., Mavi, S. and Molleyres, L. P. (1996). Isolation of antifungal valepotriates from Valeriana capense and the search for valepotriates in crude Valerianaceae extracts. J. Nat. Prod. 7, 76-85.

21. Gafner, S., Wolfender, J.-L., Nianga, M., Stoeckli-Evans, E. and Hostettmann, K. (1996). Antifungal and antibacterial naphthoquinones from Newbouldia laevis roots. Phytochemistry 42, 1315-1320.

22. Gafner, S., Wolfender, J.-L., Mavi, S. and Hostettmann, K. (1996). Antifungal and antibacterial chalcones from Myrica serrata. Planta Med. 62, 67-69.

23. Ma, W.-G., Fuzzati, N., Wolfender, J.-L., Yang, C. -R. and Hostettmann, K. (1997). Further acylated secoiridoid glucosides from Gentiana rhodantha. Phytochemistry 43,805-810.

24. Rodriguez, S., Wolfender, J.-L., Odontuya, G., Purev, O. and Hostettmann, K. (1996). Corniculoside, a new biosidic ester secoiridoid from Halenia corniculata. Helv. Chim. Acta 79, 363-370.

25. Tan, R. X., Wolfender, J.-L., Zhang, L. X., Ma, W.-G., Fuzzati, N., Marston, A. and Hostettmann, K. (1996). Acyl secoiridoids and antifungal constituents from Gentiana macrophylla. Phytochemistry 42, 1305-1313.

26. Tan, R. X., Wolfender, J.-L., Ma, W.-G., Zhang, L. X. and Hostettmann, K. (1996). Secoiridoids and antifungal aromatic acids from Gentiana algida. Phytochemistry 41, 111-116.

27. Wolfender, J.-L. and Hostettmann, K. (1996). Importance of LC/MS in plant analysis. Spectroscopy Europe 8, 7-12.

28. Wolfender, J.-L., Hostettmann, M., Rodriguez, S. and Hostettmann, K. (1996). Les xanthones marqueurs chimiotaxonomiques chez les Gentianacées. Bulletin CEEG 10-11.

29. Bergeron, C., Marston, A., Wolfender, J.-L., Mavi, S., Rogers, C. and Hostettmann, K. (1997). Isolation of polyphenols from Polygala gazensis and liquid chromatography-mass spectrometry of related African Polygala species. Phytochem. Anal. 8, 32-36.

30. Gafner, S., Wolfender, J.-L., Nianga, M. and Hostettmann, K. (1997). Phenylpropanoid glycosides from Newbouldia laevis roots. Phytochemistry 44, 687-690.

31. Hostettmann, K. and Wolfender, J.-L. (1997). The search for biologically active secondary metabolites. Pesticide Science 51,471-482.

32. Hostettmann, K., Wolfender, J.-L. and Rodriguez, S. (1997). Rapid detection and subsequent isolation of bioactive constituents of crude plant extracts. Planta Med. 63, 2-10.

33. Hostettmann, K., Potterat, O. and Wolfender, J.-L. (1997). Strategy in the search for new bioactive plant constituents. Pharm. Ind. 59, 339-347.

34. Hostettmann, K., Wolfender, J.-L. and Potterat, O. (1997). Rationelles Screening; Schnelle Detektion und Isolierung Bioaktiver Substanzen in Pflanzenextrakten. Deutsch. Apot. Z. 137, 49-68.

35. Ma, W.-G., Tan, R. X., Fuzzati, N., Li, Q. S., Wolfender, J.-L. and Hostettmann, K. (1997). Wahlenbergioside, a new phenylpropanoid glucoside from Wahlenbergia marginata. Phytochemistry 45, 411-415.

36. Rodriguez, S., Hostettmann, M., Wolfender, J.-L., Hostettmann, K. and Jollès, C. (1997). Apéritifs et liqueurs de gentiane: entre amertume et antidépresseurs. Bull. CEEG 9, 7-9.

37. Tan, R. X., Hu, J., Wolfender, J.-L. and Hostettmann, K. (1997). Two new secoiridoid glycosides from Gentiana algida. Planta Med. 63, 567-569.

38. Wolfender, J.-L., Rodriguez, S., Hiller, W. and Hostettmann, K. (1997). LC/UV/MS and LC/NMR analyses of crude extracts of Gentianaceae species. Phytochem. Anal. 8, 97-104.

39. Zhao, W., Wolfender, J.-L., Hostettmann, K., Chen, C., Xu, R. and Qin, G. (1997). Triterpenes and triterpenoids saponins from Mussaenda pubescens. Phytochemistry 45, 1073-1078.

40. Cavin, A., Potterat, O., Wolfender, J.-L. and Hostettmann, K. (1998). LC/UV/MS and LC/NMR of an antioxidant fraction from Orophea enneandra and isolation of a polyacetylene, lignans and a tocopherol derivative. J. Nat. Prod. 61, 1497-1501.

41. Cortez, D. A. G, Marston, A., Wolfender, J.-L. and Hostettmann, K. (1998). Xanthones, triterpenes and a biphenyl from Kielmeyera coriaceae. Phytochemistry 47, 1367-1373.

42. Gafner, S., Wolfender, J.-L. and Hostettmann, K. (1998). A naphtoquinone from Newbouldia Laevis. Phytochemistry 48, 215-216.

43. Gafner, S., Wolfender, J.-L., Hostettmann, K., Stoeckli-Evans, H. and Mavi, S. (1998). Phenols, acetylenes and sesquiterpene lactones from Inulanthera nuda. Helv. Chim. Acta 81, 2062-2071.

44. Garo, E., Wolfender, J.-L., Hostettmann, K., Hiller, W., Antus, S. and Mavi, S. (1998). Prenylated flavanones from Monotes engleri: On-line structure elucidation by LC/UV/NMR. Helv. Chim. Acta 81, 754-763.

45. Hostettmann, K., Potterat, O. and Wolfender, J.-L. (1998). The potential of higher plants as a source of new drugs. Chimia. 52, 10-17.

46. Ndjoko, K., Wolfender, J.-L. and Hostettmann, K. (1998). Analysis of cannabinoids by liquid chromatography/thermospray-mass spectrometry and liquid chromatography tandem mass spectrometry. Chromatographia 47, 72-76.

47. Rodriguez, S., Marston, A., Wolfender, J.-L. and Hostettmann, K. (1998). Iridoids and secoiridoids in the Gentianaceae. Curr. Org. Chem. 2, 627-648.

48. Rodriguez, S., Wolfender, J.-L., Stoeckli-Evans, H., Gupta, M. P. and Hostettmann, K. (1998). Monoterpene dimers from Lisianthius seemannii (Gentianaceae). Helv. Chim. Acta 81, 1393-1403.

49. Wolfender, J.-L., Rodriguez, S. and Hostettmann, K. (1998). Liquid chromatography coupled to mass spectrometry and nuclear magnetic resonance spectroscopy for the screening of plant constituents. J. Chromatogr. A 794, 299-316.

50. Wolfender, J.-L., Ndjoko, K. and Hostettmann, K. (1998). LC/NMR in natural products chemistry. Curr. Org. Chem. 2, 575-596.

51. Zhao, W., Wolfender, J.-L., Hostettmann, K., Xu, R. and Qin, G. (1998). Antifungal alkaloids and limonoid derivatives from Dictamnus dasycarpus. Phytochemistry 47, 7-11.

52. Zhao, W., Wolfender, J.-L., Hostettmann, K., Li, H. Y., Stoeckli-Evans, H., Xu, R. and Qin, G. (1998). Sesquiterpene glycosides from Dictamnus dasycarpus. Phytochemistry 47, 63-68.

53. Nindi, M. M., Kgarebe, B. V., Wolfender, J. -L. and Abegaz, B. M. (1999). Electrospray liquid chromatography-mass spectrometry of the leaf extract of Rhamnus prinoides. Phytochem. Anal. 10, 69-75.

54. Ioset, J. R., Wolfender, J. -L., Marston, A., Gupta, M. P. and Hostettmann, K. (1999). Identification of two isomeric meroterpenoid naphthoquinones from Cordia linnaei by liquid chromatography / mass spectrometry and liquid chromatography nuclear magnetic resonance. Phytochem. Anal. 10, 137-142.

55. Kong, L. D., Wolfender, J. -L., Cheng, Ch. H. K., Hostettmann, K. and Tan, R. X. (1999). Xanthine oxidase inhibitors from Brandisia hancei. Planta Med. 65, 744-746.

56. Lu, H., Wolfender, J. -L., Yu, T. T., Zheng, W. H., Yang, L., Gafner, S., Hostettmann, K. and Tan, R. X. (1999). New mono- and sesquiterpenes and antifungal constituents from Artemisia species. Planta Med. 65, 64-67.

57. Ndjoko, K., Wolfender, J. -L., Röder, E. and Hostettmann, K. (1999). Determination of pyrrolizidine alkaloids in Senecio species by liquid chromatography/thermospray-mass spectrometry and liquid chromatography/nuclear magnetic resonance spectroscopy. Planta Med. 65, 562-566.

58. Perret, C., Wolfender, J. -L. and Hostettmann, K. (1999). LC/ES-MS analysis of triterpene glycosides: Rapid estimation of the saponin content of Phytolacca dodecandra dried berries. Phytochem. Anal. 10, 272-27.

59. Wolfender, J. -L., Chu, F., Ball, H., Wolfender, F., Fainzilber, M., Baldwin, M. and Burlingame, A. L. (1999). Identification of tyrosine sulfation in Conus pennaceus conotoxins a-PnIA and a-PnIB: further investigation of labile sulfo- and phosphopeptides by Electrospray, Matrix-assisted Laser Desorption/Ionization (MALDI) and Atmospheric Pressure MALDI mass spectrometry. J. Mass Spectrom. 34, 447-454.

60. Cremin, P., Guiry, P. J., Wolfender, J. -L., Hostettmann, K. and Donnelly, D. M. X. (2000). A liquid chromatography-thermospray ionisation-mass spectrometry guided isolation of a new sesquiterpene aryl ester from Armillaria novae-zelandiae. J. Chem. Soc. Perkin Trans. I 2325-2329.

61. Ferrari, F., Terreaux, C., Sahpaz, S., Msonthi, J. D., Wolfender, J. -L. and Hostettmann, K. (2000). Benzophenone glycosides from Gnidia involucrata. Phytochemistry 54, 883-889.

62. Hostettmann, K., Marston, A., Ndjoko, K. and Wolfender, J. -L. (2000). The potential of African plants as a source of drugs. Curr. Org. Chem. 4, 973-1010.

63. Ndjoko, K., Wolfender, J. -L. and Hostettmann, K. (2000). Determination of trace amounts of Ginkgolic acids in Ginkgo biloba leaf extracts and phytophamaceuticals by LC/ES-MS. J. Chromatogr. B 744, 249-255.

64. Schmidt, W., Abb El-Mawla, A. M. A., Wolfender, J. -L., Hostettmann, K. and Beerhues, L. (2000). Xanthones in cell cultures of Hypericum androsaemum L. Planta Med. 66, 380-381.

65. Silva, O., Gomes, E. T., Wolfender, J.-L., Marston, A. and Hostettmann, K. (2000). Application of high performance liquid chromatography coupled with ultraviolet spectroscopy and electrospray mass spectrometry to the characterisation of ellagitannins from Terminalia macroptera roots. Pharm. Res., 17, 1396-1401.

66. Wolfender, J. -L., Waridel, P., Ndjoko, K., Hobby, K. R., Major, H. and Hostettmann, K. (2000). Evaluation of Q-TOF-MS/MS and multiple stage IT-MSn for the dereplication of flavonoids and related compounds in crude plant extract. Analusis 28, 11-21.

67. Wolfender, J.-L., Terreaux, C. and Hostettmann, K. (2000). The importance of LC/MS and LC/NMR in the discovery of new lead compounds from plants. Pharm. Biol., 38 suppl., 41-54.

68. Wolfender, J.-L., Waridel, P., Ndjoko, K., Hobby, K. R., Major, H. and Hostettmann, K. (2000). Evaluation of Q-TOF-MS/MS and multiple stage IT-MSn for the dereplication of flavonoids and related compounds in crude plant extract. Analusis, 28, 895-906.

69. Gnerre, C., Thull, U., Gaillard, P., Carrupt, P.-A., Testa, B., Fernandes, E., Silva, F., Pinto, M., Pinto, M. M. M., Wolfender, J.-L., Hostettmann, K. and Cruciani, G. (2001). Natural and synthetic xanthones as monoamine oxydase inhibitors: Biological assay and 3D-QSAR. Helv. Chim. Acta, 84, 552-570.

70. Hostettmann, K., Wolfender, J.-L. and Terreaux, C. (2001). Modern screening techniques for plant extracts. Pharm. Biol., 39: 18-32.

71. Rauha, J.-P., Wolfender, J.-L., Salminen, J.-P., Pihlaja, K., Hostettmann, K. and Vuorela, H. (2001). Characterization of the polyphenolic composition of purple loosestrife (Lythrum salicaria). Z. Naturforsch., 56c, 13-20.

72. Schaller, F., Wolfender, J.-L. and Hostettmann, K. (2001). New antifungal 'quinone methide' diterpenes from Bobgunnia madagascariensis and study of their interconversion by LC/NMR. Helv. Chim. Acta, 84, 222-229.

73. Waridel, P., Wolfender, J.-L., Ndjoko, K., Hobby, K. R., Major, H. and Hostettmann, K. (2001). Evaluation of quadrupole time of flight tandem mass spectromtry and ion-trap multiple-stage mass spectrometry for the differentiation of C-glycosidic flavonoid isomers. J. Chromatogr. A, 926, 29-41.

74. Wolfender, J.-L., Ndjoko, K. and Hostettmann, K. (2001). The potential of LC-NMR in phytochemical analysis. Phytochem. Anal., 12, 2-22.

75. Jensen, A. G., Ndjoko, K., Wolfender, J.-L., Hostettmann, K., Camponovo, F. and Soldati, F. (2002). Liquid chromatography-atmospheric pressure chemical ionisation mass spectrometry: a rapid and selective method for the quantitative determination of ginkgolides and bilobalide in Ginkgo leaf extracts and phytopharmaceuticals. Phytochem. Anal., 13, 31-38.

76. Hostettmann, K., Wolfender, J.-L. and Marston, A. (2002). Chemical screening of secondary metabolites including quality control - past, present and future. Deutsch Apoth. Ztg., 99-108.

77. Queiroz, E. F., Wolfender, J.-L., Atindehou, K., Traore, D. and Hostettmann, K. (2002). On-line identification of the antifungal constituents of Erythrina vogelii by LC/MS-MS, LC/UV-DAD and LC/NMR combined with HPLC micro-fractionation. J. Chromatogr. A 974, 123-134.

78. Cogne, A. L., Queiroz, E. F., Wolfender, J.-L., Marston, A., Mavi, S. and Hostettmann, K. (2003). On-line identification of unstable catalpol derivatives from Jamesbrittenia fodina by LC/MS and LC/NMR. Phytochem. Anal. 14, 67-73.

79. Wolfender, J.-L., Verotta, L., Fuzzati, N., Strepponi, I. and Hostettmann, K. (2003). Structural investigations of isomeric oxidised forms of hyperforin by LC/NMR and LC/MSn. Phytochem. Anal. 14, 290-297.

80. Queiroz, E. F., Wolfender, J.-L., Raoelison, G. E. and Hostettmann, K. (2003). Determination of the absolute configuration of 6-alkylated a-pyrones from Ravensara crassifolia by LC/NMR. Phytochem. Anal. 14, 34-39.

81. Waridel, P., Wolfender, J.-L., Lachavanne, J.-B. and Hostettmann, K. (2003). ent-Labdane diterpenes from the aquatic plant Potamogeton pectinatus. Phytochemistry 64, 1309-1317.

82. Zanolari, B., Wolfender, J.-L., Guilet, D., Marston, A., Queiroz, E. F., Paulo, M. Q. and Hostettmann, K. (2003). On-line identification of tropane alkaloids from Erythroxylum catuaba (“catuaba”) by LC-MSn and LC-NMR. J. Chromatogr. A 1020, 75-89.

83. Wolfender, J.-L., Ndjoko, K. and Hostettmann, K. (2003). Liquid chromatography with ultraviolet absorbance-mass spectrometric detection and with nuclear magnetic resonance spectroscopy: a powerful combination for the on-line structural investigation of plant metabolites. J. Chromatogr. A, 1000, 437-455.

84. Politi, M., Sanogo, R., Ndjoko, K., Guilet, D., Wolfender, J.-L., Hostettmann, K. and Morelli, I. (2004). HPLC-UV/PAD and HPLC-MSn analyses of leaf and root extracts of Vismia guineensis and isolation and identification of two new bianthrones. Phytochem. Anal. 15, 00-00.

85. Waridel, P., Wolfender, J.-L., Lachavanne, J.-B. and Hostettmann, K. (2004). Identification of the polar constituents of Potamogeton species by HPLC-UV with post-column derivatization, HPLC-MSn and HPLC-NMR, and isolation of a new ent-labdane diglycoside. Phytochemistry 65, 2401-2410.

86. Waridel, P., Wolfender, J.-L., Lachavanne, J.-B. and Hostettmann, K. (2004). ent-Labdane glycosides from the aquatic plant Potamogeton lucens and analytical evaluation of the lipophilic extract constituents of various Potamogeton species. Phytochemistry 65, 945-954.

87. Ramm, M., Wolfender, J.-L., Queiroz, E. F., Hostettmann, K. and Hamburger, M. (2004). Rapid analysis of nucletotide activated sugars by high performance liquid chromatography coupled with diode-array detection, electrospray ionization mass spectrometry and nuclear magnetic resonance. J. Chromatogr. A 1034, 139-148.

88. Cogne, A. L., Queiroz, E. F., Marston, A., Wolfender, J. L., Mavi, S. and Hostettmann, K. (2005). On-line identification of unstable iridoids from Jamesbrittenia fodina by HPLC-MS and HPLC-NMR. Phytochem. Anal. 16, 429-439.

89. Hostettmann, K., Marston, A. and Wolfender, J.-L. (2005). Strategy in the search for new lead compounds and drugs from plants. Chimia 59, 291-294.

90. Maver, M., Queiroz, E. F., Wolfender, J.-L. and Hostettmann, K. (2005). Four new flavonoids from the stem of Eriophorum scheuchzeri Hoppe (Cyperaceae). J. Nat. Prod. 68, 1094-1098.

91. Thiocone, A., Grata, E., Boccard, J., Carrupt, P.-A., Rudaz, S. and Wolfender, J.-L. (2005). Synergy at the 'Ecole de Pharmacie Genève-Lausanne': Methodology developments for the treatment of complex metabolomic datasets with data mining. Chimia 59, 362-365.

92. Wolfender, J.-L., Queiroz, E. F. and Hostettmann, K. (2005). Phytochemistry in the microgram domain – a LC–NMR perspective. Magn. Res. Chem. 43, 697-709.

93. Wolfender, J. L., Queiroz, E. F. and Hostettmann, K. (2006). The importance of hyphenated techniques in the discovery of new lead compounds from nature. Exp. Opin. Drug Discovery 1, 237-260.

94. Boccard, J., Grata, E., Thiocone, A., Gauvrit, J. Y., Lanteri, P., Carrupt, P. A., Wolfender, J. L. and Rudaz, S. (2007). Multivariate data analysis of rapid LC-TOF/MS experiments from Arabidopsis thaliana stressed by wounding. Chemom. Intell. Lab. Syst. 86, 189-197.

95. Glauser, G., Guillarme, D., Grata, E., Boccard, J., Thiocone, A., Carrupt, P. A., Veuthey, J. L., Rudaz, S. and Wolfender, J. L. (2007). Optimized liquid chromatography–mass spectrometry approach for the isolation of minor stress biomarkers in plant extracts and their identification by capillary nuclear magnetic resonance. J Chromatogr A
doi:10.1016/j.chroma.2007.12.021.

96. Grata, E., Boccard, J., Glauser, G., Carrupt, P. A., Farmer, E. E., Wolfender, J. L. and Rudaz, S. (2007). Development of a two-step screening ESI-TOF-MS method for rapid determination of significant stress-induced metabolome modifications in plant leaf extracts: The wound response in Arabidopsis thaliana as a case study. J. Sep. Sci. 30, 2268-2278.

97. Lambert, M., Wolfender, J. L., Staerk, D., Christensen, B., Hostettmann, K. and Jaroszewski, J. W. (2007). Identification of natural products using HPLC-SPE combined with CapNMR. Anal. Chem. 79, 727-735.

98. Glauser, G., Guillarme, D., Grata, E., Boccard, J., Thiocone, A., Carrupt, P. A., Veuthey, J. L., Rudaz, S. and Wolfender, J. L. (2008). Optimized liquid chromatography–mass spectrometry approach for the isolation of minor stress biomarkers in plant extracts and their identification by capillary nuclear magnetic resonance. J Chromatogr A 1180, 90-98.

99. Glauser, G., Grata, E., Boccard, J., Marsden-Edwards, E., Major, H., Carrupt, P. A., Rudaz, S. and Wolfender, J. L. (2008). UPLC-TOF-MS for plant metabolomics. A powerful tool for discriminating stress states in plants and detecting low level wound-biomarkers. American Labotatory On-line Edition 3-6.

100. Glauser, G., Grata, E., Dubugnon, L., Rudaz, S., Farmer, E. and Wolfender, J. L. (2008). Spatial and temporal dynamics of Jasmonate synthesis and accumulation in Arabidopsis in response to wounding. J. Biol. Chem. 283, 16400-16407.

101. Glauser, G., Grata, E., Rudaz, S. and Wolfender, J. L. (2008). High resolution profiling of oxylipin-containing galactolipids in Arabidopsis extracts by ultra-performance liquid chromatography/time-of-flight mass spectrometry. Rap. Comm. Mass Spectrom. 22, 3154–3160.

102. Grata, E., Boccard, J., Guillarme, D., Glauser, G., Carrupt, P. A., Farmer, E., Wolfender, J. L. and Rudaz, S. (2008). UPLC–TOF-MS for plant metabolomics: A sequential approach for wound marker analysis in Arabidopsis thaliana. J. Chromatogr. B 871, 261–270.

103. Politi, M., Braca, A., Altinier, G., Sosa, S., Ndjoko, K., Wolfender, J.-L., Hostettmann, K. and Jimenez-Barbero, J. (2008). Different approaches to study the traditional remedy of "hierba del canto", Sisymbrium officinale (L.) Scop. Bol. Latinoam. Caribe Plant. Med. Aromat. 7, 30-37.

104. Thiocone, A., Farmer, E. E. and Wolfender, J. L. (2008). Screening for wound-induced oxylipins in Arabidopsis thaliana by differential HPLC-APCI/MS profiling of crude leaf extracts and subsequent Characterisation by capillary-scale NMR. Phytochem. Anal. 19 198-205.

105. Grata, E., Boccard, J., Glauser, G., Guillarme, D., Carrupt, P. A., Wolfender, J. L. and Rudaz, S. (2008). Plant Metabolomics – Strategies for Biomarker, Detection, Isolation, and Identification. Chimia 62, 685.

106. Wolfender, J. L., Glauser, G., Grata, E. and Rudaz, S. (2008). UPLC-TOF-MS for high resolution plant metabolite profiling and metabolomics. Planta Med. 74, 919-920.

107. Glauser, G., Gindro, K., Fringeli, J., de Joffrey, J.-P., Rudaz, S. and Wolfender, J.-L. (2009). Differential analysis of mycoalexins in confrontation zones of grapevine fungal pathogens by ultra-high pressure liquid chromatography/time-of-flight mass spectrometry and capillary nuclear magnetic resonance. J. Agric. Food Chem. 57, 1127–1134.

108. Glauser, G., Dubugnon, L., Mousavi, S. A. R., Rudaz, S., Wolfender, J.-L. and Farmer, E. E. (2009). Velocity Estimates for Signal Propagation Leading to Systemic Jasmonic Acid Accumulation in Wounded Arabidopsis. J. Biol. Chem. 284, 34506-34513.

109. Grata, E., Guillarme, D., Glauser, G., Boccard, J., Carrupt, P. A., Veuthey, J. L., Rudaz, S. and Wolfender, J. L. (2009). Metabolite profiling of plant extracts by ultra-high-pressure liquid chromatography at elevated temperature coupled to time-of-flight mass spectrometry. J Chromatogr A 1216, 5660-5668.

110. Guillarme, D., Grata, E., Glauser, G., Wolfender, J.-L., Veuthey, J. L. and Rudaz, S. (2009). Some solutions to obtain very efficient separations in isocratic and gradient modes using UHPLC technology. J. Chromatogr. A 1216, 3232-3243.

111. Queiroz, E. F., Wolfender, J. L. and Hostettmann, K. (2009). Modern Approaches in the Search for New Lead Antiparasitic Compounds from Higher Plants. Curr. Drug Targets 10, 202-211.

112. Wolfender, J.-L. (2009). HPLC in Natural Product Analysis: The Detection Issue. Planta Med. 75, 719-734.

113. Wolfender, J. L., Glauser, G., Boccard, J. and Rudaz, S. (2009). MS-based Plant Metabolomic Approaches for Biomarker Discovery. Nat. Prod. Comm. 4, 1417-1430.

114. Glauser, G., Boccard, J., Rudaz, S. and Wolfender, J. L. (2010). Mass spectrometry-based metabolomics oriented by correlation analysis for wound-induced molecule discovery: identification of a novel jasmonate glucoside. Phytochem. Anal. 21, 95–101.

Book chapters

1. Hostettmann, K., Marston, A. and Wolfender, J.-L. (1995). Strategy in the search for new biologically active plant constituents. In Phytochemistry of Plants Used in Traditional Medicine (Hostettmann, K., Marston, M., Maillard, M. and Hamburger, M., eds.), Oxford Science Publications, Oxford, pp. 17-45.

2. Hostettmann, K., Marston, A. and Wolfender, J.-L. (1995). Search for bioactive polyphenols from higher plants. In Polyphenol 94 (Brouillard, R., Jay, M. and Scalbert, A., eds.), INRA Editions, Paris, pp. 133-142.

3. Hostettmann, K., Marston, A., Wolfender, J.-L. and Maillard, M. (1995). Screening for flavonoids and related compounds in medicinal plants by LC-UV-MS and subsequent isolation of bioactive compounds. In Flavonoids and Bioflavonoids 1995. Proceedings of the International Bioflavonoid Symposium. 9th Hungarian Bioflavonoid Symposium (Antus, S., Gabor, M. and Vetschera, K., eds.), Akadémiai Kiado, Budapest, pp. 35-51.

4. Hostettmann, K., Potterat, O. and Wolfender, J.-L. (1995). Millepertuis et Gentianes: Nouveaux antidépresseurs? In Ressources et potentiels de la flore médicinale des Alpes (Etat du Valais, ed.), Mediplant, Conthey, pp. 51-58.

5. Hostettmann, K., Wolfender, J.-L. and Hostettmann, M. (1995). Xanthones. In Encyclopedia of Analytical Science, Academic Press, pp. 5651-5655.

6. Wolfender, J.-L. and Hostettmann, K. (1995). Applications of liquid chromatography-mass spectrometry to the investigation of medicinal plants. In Phytochemistry of Medicinal Plants (Arnason, J.T., Mata, R. and Romeo, J., eds.), Plenum Press, New York, pp. 189-215.

7. Hostettmann, K., Marston, A., Maillard, M. and Wolfender, J. -L. (1996). Search for molluscicidal and antifungal saponins from tropical plants. In Saponins Used in Traditional and Modern Medicine, Advances in Experimental Medicine and Biology, vol. 404 (Waller, G.R. and Yamasaki, K., eds.), Plenum Press, New York, pp. 117-128.

8. Hostettmann, K., Wolfender, J.-L., Rodriguez, S. and Marston, A. (1996). Strategy in the search for bioactive plant constituents. In Chemistry, Biological and Pharmacological Properties of African Medicinal Plants (Hostettmann, K., Chinyanganya, F., Maillard, M. and Wolfender, J.-L., eds.), University of Zimbabwe Publications, Harare, pp. 21-42.

9. Wolfender, J.-L. and Hostettmann, K. (1996). LC-UV-MS: a powerful approach for the rapid screening of metabolites in crude plant extracts. In Applications of Modern Mass Spectrometry in Plant Science Research (Proceedings of the Phytochemical Society of Europe) (Newton, R.P. and Walton, T.J., eds.), Clarendon Press, Oxford, pp. 216-221.

10. Hostettmann, K., Potterat, O. and Wolfender, J.-L. (1997). Search for biologically active compounds from tropical plants. In Medicinal Chemistry Today and Tomorrow, Proceedings of the AFMC International Medicinal Chemistry Symposium held in Tokyo, Japan, 3-8 September 1995 (Yamazaki, M., ed.), Blackwell Science, Oxford, pp. 117-123.

11. Wolfender, J.-L., Rodriguez, S. and Hostettmann, K. (1997). LC/MS: a useful tool in the search for new bioactive plant constituents. In Virtual activity, real pharmacology. Differents approaches to the search for bioactive natural compounds (Verotta, L., ed.), Research Signpost, Trivandrim, India, pp. 137-158.

12. Hostettmann, K. and Wolfender, J.-L. (1999). Application of LC/MS and LC/NMR in the search for new bioactive compounds from plants of the Americas. In Medicinal Plants of the Americas (Hostettmann, K., Gupta, M.P. and Marston, M., eds.), Harwood Academic Publishers, New York, pp. 19-30.

13. Hostettmann, K. and Wolfender, J. -L. (1999). Rapid determination of plant glycosides by LC/MS and LC/NMR. In Advances in Plant Glycosides, Chemistry and Biology (Yang, C.-R. and Tanaka, O., eds.), Elsevier, Amsterdam, pp. 233-260.

14. Hostettmann, K., Hostettmann, M., Rodriguez, S. and Wolfender, J.-L. (1999). LC-hyphenated techniques in the search for new bioactive plant constituents. In The Biology-Chemistry Interface (Cooper, R. and Snyder, J.K., eds.), Marcel Dekker, New York, pp. 65-101.

15. Hostettmann, K. and Wolfender, J. -L. (2000). Applications of liquid chromatography/UV/MS and liquid chromatography/NMR for the on-line identification of plant metabolites. In Bioactive natural products: Isolation, Structure elucidation and biological properties (Tringali, C., ed.), Taylor and Francis, London, pp. 31-68

16. Marston, A., Wolfender, J. -L. and Hostettmann, K. (2000). Analysis and isolation of saponins. In Saponins in Food, Feedstuffs and Medicinal Plants (Oleszek, W. and Marston, A., eds.), Kluwer Academic Publishers, Dordrecht, The Netherlands, pp. 1-12.

17. Hostettmann, K. and Wolfender, J.-L (2000). Liquid chromatography, in Encyclopedia of Separation Science (Wilson I., ed.), Academic Press. p. 3424-3434

18. Hostettmann, K., Wolfender, J.-L. and Marston, A. (2003). Hyphenated HPLC techniques for screening and quality control, in Society for Medicinal Plant Research - 50 Years 1953-2003 a Jubilee Edition (Sprecher, E., Caesar, W., Eds.), Wissenschaftliche Verlagsgesellschaft mbh, Stuttgart, pp. 99-108.

19. Wolfender, J.-L., Ndjoko, K. and Hostettmann, K. (2003). Application of LC/NMR in the structure elucidation of polyphenols, in Methods in Polyphenol Analysis, (Santos-Bulga T. and Williamson G., Eds.), The Royal Society of Chemistry, Cambridge. p. 128-154.

20. Hostettmann, K. and Wolfender, J.-L. (2005). Phytochemistry, in St. John's Wort and its active principles in depression and anxiety (Müller, W. E., ed.), Birkhauser: Basel.

21. Wolfender, J.-L. and Hostettmann, K. (2005). LC/NMR, in Encyclopedia of Analytical Sciences.

22. Wolfender, J. L. and Hostettmann, K. (2006). Applications in Characterization of Natural Products: Dereplication of flavonoids using multidimensional LC-MS techniques, In Encyclopedia of Mass Spectrometry Volume 8: Hyphenated Methods; Niessen, W. M. A., Ed.; Elsevier Science: Oxford; Vol. 8, pp 760-775.

23. Wolfender, J. L., Queiroz, E. F. and Hostettmann, K. (2007). Development and application of LC/NMR techniques to the identification of bioactive natural products, In Bioactive Natural Products; Detection, Isolation and Structural determination; Colegate, S. M., Molyneux, R. J., Eds.; CRC press, pp 143-190.

Books / proceedings:

1. Hostettmann, K., Chinyanganya, F., Maillard, M. and Wolfender, J.-L. (1996), Chemistry, Biological and Pharmacological Properties of African Medicinal Plants, University of Zimbabwe Publications, Harare.

2. Hostettmann, K., Dyatmiko, W., Prajogo, B., Marston, A. and Wolfender, J. L. (2008) Proceedings of the IOCD International Symposium, Biology, Chemistry, Pharmacology and Clinical Studies of Asian Plants; Airlangga University Press: Surabaya.

3. Hostettmann, K., Wolfender, J. L., Christen, P., Marston, A., Martin, F., Ndjoko, K. and Violette, A. (2009). Proceeding of the 57th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product research. Planta Med. 75 (9)..



 

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