CUENDET Muriel



Professeure associée


Muriel CUENDET

Université de Genève
Faculté des Sciences

Pharmacognosie
Rue Michel-Servet 1
CH-1211 Genève 4
Switzerland

Site: Centre Médical Universitaire
Office: B06.2018.a
Phone: +41 22 37 933 86
Fax: +41-22 379 33 60
E-mail: Muriel.Cuendet@unige.ch

Research interests

  • Natural products drug discovery

  • Cancer chemoprevention

  • Traditional medicine

 

Education



Year

Description

1999

Ph.D. degree in pharmaceutical sciences, Institut de Pharmacognosie et Phytochimie, Université de Lausanne, Switzerland

1994

PharmD. Degree, Université de Lausanne, Switzerland


Positions held



Year

Description

2009

Associate professor, school of pharmaceutical sciences, Université de Genève, Switzerland

2007-2009

Research Scientist, Gerald P Murphy Cancer Foundation, West Lafayette, IN, USA

2005-2006

Visiting Assistant Professor, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA

2003-2005

Research Assistant Professor, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL, USA

1999-2003

Postdoctoral Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL, USA

Supervisor: John M. Pezzuto, Ph.D

1995-1999

Doctoral Studies, School of Pharmacy, Université de Lausanne, Switzerland

Supervisor: Kurt Hostettmann, Ph.D



Publication list


1. Cuendet, M., Guo, J., Zhu, D., Oteham, C.P., Nikolic, D., Moon, R.C., van Breemen, R.B., Pezzuto, J.M. (2009) In vitro and in vivo investigation of isoliquiritigenin as a chemopreventive agent, Cancer Prevention Research, 3 (2), 221-232.

2. Kang, S.S., Cuendet, M., Endringer, D.C., Croy, V.L., Pezzuto, J.M., Lipton, M.A. (2009) Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors fo COX-1, COX-2 and NF-ΚB, Bioorganic and Medicinal Chemistry, 17 (3), 1044-1054.

3. Cuendet, M., Oteham, C.P., Craig, B.A., Moon, R.C., Pezzuto, J.M. (2008) Zapotin prevents mouse skin tumorigenesis during the stage of promotion, Anticancer Research, 28 (6A), 3705-3709.

4. Cuendet, M., Oteham, C.P., Moon, R.C., Keller, W.J., Peaden, P.A., Pezzuto, J.M. (2008) Dietary administration of Asimina triloba (Paw Paw) extract increases tumor latency in N-methyl-N-nitrosourea-treated rats, Pharmaceutical Biology, 46 (1-2), 3-7.

5. Maiti, A., Cuendet, M., Endringer, D.C., Croy, V.L., Pezzuto, J.M., Cushman, M. (2007) Synthesis, SAR and biological evaluation of racemic abyssinone II and analogues as potential aromatase inhibitors for prevention of breast cancer, Journal of Medicinal Chemistry, 50 (12), 2799-2806.

6. Maiti*, A., Cuendet*, M., Kondratyuk, T., Croy, V.L., Pezzuto, J.M., Cushman, M. (2007) Synthesis and Cancer Chemopreventive Activity of Zapotin, a Natural Product from Casimiroa edulis, Journal of Medicinal Chemistry, 50 (2), 350-355. * contributed equally to this work

7. Cuendet, M., Mesecar, A.D., DeWitt, D.L., Pezzuto, J.M. (2006) An ELISA method to measure inhibition of the COX enzymes, Nature Protocols, 1 (4), 1915-1921.

8. Thole, J.M., Burns Kraft, T.F., Sueiro, L.A., Kang, Y.-H., Gills, J.J., Cuendet, M., Pezzuto, J.M., Seigler, D.S., Lila, M.A. (2006) A comparative evaluation of the anticancer properties of European and american elderberry fruits, Journal of Medicinal Food, 9 (4), 498-504.

9. Cuendet, M., Bolton, J.L. (2006) Response of human mammary epithelial cells to DNA damage induced by 4-hydroxyequilenin: lack of p53-mediated G1 arrest, Chemico-Biological Interactions, 161 (3), 271-278.

10. Cuendet, M., Oteham, C.P., Moon, R.C., Pezzuto, J.M. (2006) Quinone reductase induction as a biomarker for cancer chemoprevention, Journal of Natural Products, 69 (3), 460-463.

11. Overk, C.R., Yao, P., Chadwick, L.R., Nikolic, D., Sun, Y., Cuendet, M., Deng, Y., Hedayat, A.S., Pauli, G., Farnsworth, N.R., van Breeman, R.B., Bolton, J.L. (2005) Comparison of the in vitro estrogenic activities of hops (Humulus lupulus) and red clover (Trifolium pratense), Journal of Agricultural and Food Chemistry, 53 (16), 6246-6253.

12. Carcache-Blanco, E.J., Cuendet, M., Park, E.J., Su, B.-N., Rivero-Cruz, J.F., Farnsworth, N.R., Pezzuto, J.M., Kinghorn, A.D. (2005) Potential cancer chemopreventive agents from Arbutus unedo, Natural Product Research, 20 (4), 327-334.

13. Burns Kraft, T.F., Schmidt, B.M., Knight, C.T.G., Cuendet, M., Gills, J.J., Kang, Y.-H., Pezzuto, J.M., Seigler, D.S., Lila, M.A. (2005) Chemopreventive potential of wild lowbush blueberry fruits in multiple stages of carcinogenesis, Journal of Food Science, 70 (3), S159-S166.

14. Su, B.-N., Jones, W., Cuendet, M., Kardono, L.B.S., Ismail, R., Riswan, S., Fong, H.H.S., Farnsworth, N.R., Pezzuto, J.M., Kinghorn, A.D. (2004) Constituents of the stems of Macrococculus pomiferus and their inhibitory activities against cyclooxygenases-1 and -2, Phytochemistry, 65 (21), 2861-2866.

15. Gafner, S., Lee, S.K., Cuendet, M., Barthélémy, S., Vergnes, L., Labidalle, S., Mehta, R.G., Boone, C.W., Pezzuto, J.M. (2004) Biologic evaluation of curcumin and structural derivatives in cancer chemoprevention model systems, Phytochemistry, 65 (21), 2849-2859.

16. Li, Y., Yao, J., Chang, M., Cuendet, M., Bolton, J.L. (2004) Altered apoptotic response in MCF 10A cells treated with the equine estrogen metabolite, 4-hydroxyequilenin, Toxicology Letters, 154 (3), 225-233.

17. Jang, D.S., Cuendet, M., Su, B.-N., Tortura, S., Riswan, S., Fong, H.H.S., Pezzuto, J.M., Kinghorn, A.D. (2004) Constituents of the seeds of Hernandia ovigera with inhibitory activity against cyclooxygenase-2, Planta Medica, 70 (10), 893-896.

18. Kinghorn, A.D., Su, B.N., Jang, D.S., Chang, L.C., Lee, D., Gu, J.Q., Carcache-Blanco, E.J., Pawlus, A.D., Lee, S.K., Park, E.J., Cuendet, M., Gills, J.J., Bhat, K., Park, H.S., Mata-Greenwood, E., Song, L.L., Jang, M., Pezzuto, J.M. (2004) Natural inhibitors of carcinogenesis, Planta Medica, 70 (8), 691-705.

19. Cuendet, M., Liu, X., Pisha, E., Li, Y., Yao, J., Yu, L., Bolton, J.L. (2004) Equine estrogen metabolite 4-hydroxyequilenin induces anchorage-independent growth of human mammary epithelial MCF-10A cells: differential gene expression, Mutation Research, 550 (1-2), 109-121.

20. Jang, D.S., Cuendet, M., Fong, H.H.S., Pezzuto, J.M., Kinghorn, A.D. (2004) Constituents of Asparagus officinalis (Asparagus) evaluated for inhibitory activity against cyclooxygenase-2, Journal of Agricultural and Food Chemistry, 52 (8), 2218-2222.

21. Cuendet, M., Pezzuto, J.M. (2004) Antitumor activity of bruceantin: an old drug with new promise, Journal of Natural Products, 67 (2), 269-272.

22. Cuendet, M., Gills, J.J., Pezzuto, J.M. (2004) Brusatol-induced HL-60 cell differentiation involves NF-?B activation, Cancer Letters, 206 (1), 43-50.

23. Cuendet, M., Christov, K., Lantvit, D.D., Deng, Y., Hedayat, S., Helson, L., McChesney, J.D., Pezzuto, J.M. (2004) Multiple myeloma regression mediated by bruceantin, Clinical Cancer Research, 10 (3), 1170-1179.

24. Jang, D.S., Cuendet, M., Pawlus, A., Kardono, L.B.S., Kawanisi, K., Farnsworth, N.R., Fong, H.H.S., Pezzuto, J.M., Kinghorn, A.D. (2004) Potential cancer chemopreventive constituents of the leaves of Macaranga triloba, Phytochemistry, 65 (3), 345-350.

25. Su, B.-N., Cuendet, M., Nikolic, D., Kristinsson, H., Ingólfsdóttir, K., van Breemen, R.B., Fong, H.H.S., Pezzuto, J.M., Kinghorn, A.D. (2003) NMR study of fumarprotocetratic acid, a complex lichen depsidone derivative from Cladonia furcata, Magnetic Resonance in Chemistry, 41 (5), 391-394.

26. Duncan, C.J.G., Cuendet, M., Fronczek, F.R., Pezzuto, J.M., Mehta, R.G., Hamman, M.T., Ross, S.A. (2003) Chemical and biological investigation of the fungus Pulveroboletus ravenelii, Journal of Natural Products, 66 (1), 103-107.

27. Jang, D.S., Cuendet, M., Hawthorne, M.E., Kardono, L.B.S., Kawanishi, K., Fong, H.H.S., Mehta, R.G., Pezzuto, J.M., Kinghorn, A.D. (2002) Prenylated flavonoids of the leaves of Macaranga conifera with activity against cyclooxygenase-2, Phytochemistry, 61 (7), 867-872.

28. Su, B.-N., Cuendet, M., Farnsworth, N.R., Fong, H.H.S., Pezzuto, J.M., Kinghorn, A.D. (2002) Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay, Planta medica, 68 (12), 1125-1128.

29. Mata-Greenwood*, E., Cuendet*, M., Sher, D., Gustin, D., Stock, W., Pezzuto, J.M. (2002) Brusatol-mediated induction of leukemic cell differentiation and G1 arrest is associated with down-regulation of c-myc, Leukemia, 16 (11), 2275-2284. * contributed equally to this work

30. Su, B.-N., Chang, L.C., Park, E.J., Cuendet, M., Santarsiero, B.D., Mesecar, A.D., Meha, R.G., Fong, H.H.S., Pezzuto, J.M., Kinghorn, A.D. (2002) Bioactive constituents of the seeds of Brucea javanica, Planta Medica, 68 (8), 730-733.

31. Cuendet, M., Pezzuto, J.M. (2002) Non-steroidal anti-inflammatory drugs in cancer treatment, Expert Opinion on Therapeutic Patents, 12 (6), 827-835.

32. Rimando, A.M., Cuendet, M., Desmarchelier, C., Mehta, R.G., Pezzuto, J.M., Duke, S.O. (2002) Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol, Journal of Agricultural and Food Chemistry, 50 (12), 3453-3457.

33. Su, B.-N., Cuendet, M., Hawthorne, M.E., Kardono, L.B.S., Riswan, S., Fong, H.H.S., Meha, R.G., Pezzuto, J.M., Kinghorn, A.D. (2002) Constituents of the barks and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity, Journal of Natural Products, 65 (2), 163-169.

34. Waffo-Teguo, P., Hawthorne, M.E., Cuendet, M., Mérillon, J.-M., Kinghorn, A.D., Pezzuto, J.M., Mehta, R.G. (2001) Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures, Nutrition and Cancer, 40 (2), 173-179.

35. Lee, D., Cuendet, M., Axelrod, F., Chavez, P.I., Fong, H.H.S., Pezzuto, J.M., Kinghorn, A.D. (2001) Novel 29-nor-3,4-seco-cycloartane triterpene methyl esters from the aerial parts of Antirhea acutata, Tetrahedron, 57 (33), 7107-7112.

36. Lee, D., Cuendet, M., Vigo, J.S., Graham, J.G., Cabieses, F., Fong, H.H.S., Pezzuto, J.M., Kinghorn, A.D. (2001) A novel cyclooxygenase-inhibitory stilbenolignan from the seeds of Aiphanes aculeata, Organic Letters, 3 (14), 2169-2171.

37. Lee, D., Park, E.J., Cuendet, M., Axelrod, F., Chavez, P.I., Fong, H.H.S., Pezzuto, J.M., Kinghorn, A.D. (2001) Cyclooxygenase-inhibitory and antioxidant constituents of the aerial parts of Antirhea acutata, Bioorganic and Medicinal Chemistry Letters, 11 (12),1565-1568.

38. Waffo-Teguo, P., Lee, D., Cuendet, M., Mérillon, J.-M., Pezzuto, J.M., Kinghorn, A.D. (2001) Two new stilbene dimer glucosides from grape (Vitis vinifera) cell cultures, Journal of Natural Products, 64 (1), 136-138.

39. Cuendet, M., Potterat, O., Hostettmann, K. (2001) Flavonoids and phenylpropanoid derivatives from Campanula barbata, Phytochemistry, 56 (6), 631-636.

40. Cuendet, M., Pezzuto, J.M. (2000) The role of cyclooxygenase and lipoxygenase in cancer chemoprevention, Drug Metabolism and Drug Interactions, 17, 109-157.

41. Cuendet, M., Potterat, O., Hostettmann, K. (2000) A stilbene and dihydrochalcones with radical scavenging activities from Loiseleuria procumbens, Phytochemistry, 54 (8), 871-874.

42. Cuendet, M., Potterat, O., Hostettmann, K. (1999) Iridoid glucosides, phenylpropanoid derivatives and flavonoids from Bartsia alpina, Pharmaceutical Biology, 37 (4), 318-320.

43. Cuendet, M., Hostettmann, K., Dyatmiko, W., Potterat, O. (1997) Iridoid glucosides with free radical scavenging properties from Fagraea blumei, Helvetica Chimica Acta, 80 (4), 1144-1152.


Book chapters


1. Cuendet, M., Pezzuto, J.M. (2009) Molecular targets of botanicals used for chemoprevention. In Integrative Oncology. Abrams, D.I., Weil, A., eds. Oxford University Press, New York, NY; pp. 41-56.

2. Cuendet, M., Pezzuto, J.M. (2006) Antitumor alkaloids in clinical use or in clinical trials. In Modern Alkaloids-Structure, Isolation, Synthesis and Biology. Fattorusso, E., Taglialatela-Scafati, O., eds. Wiley-VCH, Hoboken, NJ; pp. 25-52.

3. Pezzuto, J.M., Kosmeder II, J.W., Park, E.J., Lee, S.K., Cuendet, M., Gills, J., Bhat, K., Grubjesic, S., Park, H.-S., Mata-Greenwood, E., Tan, Y.M., Yu, R., Lantvit, D.D., Kinghorn, A.D. (2005) Characterization of chemopreventive agents in natural products. In Cancer Chemoprevention, Volume 2: Strategies for Cancer Chemoprevention. Kelloff, G.J., Hawk, E.T., Sigman, C.C., eds. Humana Press Inc., Totowa, NJ; pp. 3-37.



 

© University of Geneva | Oct 26, 2009