Publications of 2006
Birringer, M. S., R. Perozzo, E. Kut, C. Stillhart, W. Surber, L. Scapozza, G. Folkers (2006). High-level expression and purification of human thymidine kinase 1: quaternary structure, stability, and kinetics. Protein Expr Purif. 47(2): 506-15.
Glaser, A. G., A. Limacher, S. Fluckiger, A. Scheynius, L. Scapozza, R. Crameri (2006). Analysis of the cross-reactivity and of the 1.5 A crystal structure of the Malassezia sympodialis Mala s 6 allergen, a member of the cyclophilin pan-allergen family. Biochem J. 396(1): 41-9.
Gunby, R. H., S. Ahmed, R. Sottocornola, M. Gasser, S. Redaelli, L. Mologni, C. J. Tartari, V. Belloni, C. Gambacorti-Passerini, L. Scapozza (2006). Structural insights into the ATP binding pocket of the anaplastic lymphoma kinase by site-directed mutagenesis, inhibitor binding analysis, and homology modeling. J Med Chem. 49(19): 5759-68.
Johayem, A., S. Raic-Malic, K. Lazzati, P. A. Schubiger, L. Scapozza, S. M. Ametamey (2006). Synthesis and characterization of a C6 nucleoside analogue for the in vivo imaging of the gene expression of herpes simplex virus type-1 thymidine kinase (HSV1 TK). Chem Biodivers. 3(3): 274-83.
Lack, G., E. Homberger-Zizzari, G. Folkers, L. Scapozza, R. Perozzo (2006). Recombinant expression and biochemical characterization of the unique elongating beta-ketoacyl-acyl carrier protein synthase involved in fatty acid biosynthesis of Plasmodium falciparum using natural and artificial substrates. J Biol Chem. 281(14): 9538-46.
Limacher, A., D. P. Kloer, S. Fluckiger, G. Folkers, R. Crameri, L. Scapozza (2006). The crystal structure of Aspergillus fumigatus cyclophilin reveals 3D domain swapping of a central element. Structure. 14(2): 185-95.
Mologni, L., E. Sala, S. Cazzaniga, R. Rostagno, T. Kuoni, M. Puttini, J. Bain, L. Cleris, S. Redaelli, B. Riva, F. Formelli, L. Scapozza, C. Gambacorti-Passerini (2006). Inhibition of RET tyrosine kinase by SU5416. J Mol Endocrinol. 37(2): 199-212.
Moretti L., Tchernin L., Scapozza L. (2006). Tyrosine kinase drug discovery: What can be learned from solved crystal structures? Arkivoc (viii), 38-49.
Orhan, I., B. Sener, T. Atici, R. Brun, R. Perozzo, D. Tasdemir (2006). Turkish freshwater and marine macrophyte extracts show in vitro antiprotozoal activity and inhibit FabI, a key enzyme of Plasmodium falciparum fatty acid biosynthesis. Phytomedicine. 13(6): 388-93.
Puttini, M., A. M. Coluccia, F. Boschelli, L. Cleris, E. Marchesi, A. Donella-Deana, S. Ahmed, S. Redaelli, R. Piazza, V. Magistroni, F. Andreoni, L. Scapozza, F. Formelli, C. Gambacorti-Passerini (2006). In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cells. Cancer Res. 66(23): 11314-22.
Stichelberger M, Desbouis D, Spiwok V, Scapozza L, Schubiger PA, Schibli R (2006). Synthesis, in vitro and in silico assessment of organometallic Rhenium(I) and Technetium(I) thymidine kinase complexes. J Organomet Chem. 51(21):6689-98.
Tasdemir, D., G. Lack, R. Brun, P. Ruedi, L. Scapozza, R. Perozzo (2006). Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 49(11): 3345-53.
Yousefi, S., R. Perozzo, I. Schmid, A. Ziemiecki, T. Schaffner, L. Scapozza, T. Brunner, H. U. Simon (2006). Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol. 8(10): 1124-32.
