Toxicology
To our knowledge, no recent, updated review on the toxicology of tantalum exists. Neither on its ecotoxicology.
Tantalum is well-known for its biocompatibility and most of the published papers deals with medical applications.
Below a list of references. It will be updated. Thanks for helping!
Alberius P 1983. Bone reaction to tantalum markers. A scanning electron microscope study. Acta Anat. 115, 310–318.
Ando A, Ando I 1990. Biodistribution of 95Nb and 182Ta in tumor-bearing animals and mechanisms for accumulation in tumor and liver. J. Radiat. Res. 31, 97–109.
Aronson AS. Jonsson N, Alberius P 1985. Tantalum markers in radiography. An assessment of tissue reactions. Skel. Radio. 14, 207–211.
Bailey OT, Ingraham FD, Weadon PS, Susen AF 1952. Tissue reactions to powdered tantalum in the central nervous system. J. Neurosurg. 9, 83–92.
Baker GS 1946. Cranioplasty with tantalum plate in the postwar period. Surg. Clin. North Am. 26, 841–845.
Bakody JT 1946. Tantalum cranioplasty. Ohio Med. 42, 29–33.
Balla VK, Banerjee S, Bose S, Bandyopadhyay A 2010. Direct laser processing of a tantalum coating on titanium for bone replacement structures. Acta Biomater. 6, 2329–2334.
Balla VK, Bodhak S, Bose S, Bandyopadhyay A 2010. Porous tantalum structures for bone implants: fabrication, mechanical and in vitro biological properties. Acta Biomater. 6, 3349–3359.
Barth KL, Virmani R, Stecker EP, Savin MA, Lindisch D, Matsumoto AH, Tietlebaum GP 1990. Flexible tantalum stents implanted in aortas and iliac arteries: Effects in normal canines. Radiology 175, 91–96.
Bates JI, Lewey FH, Reiners CR 1948. The reaction of cerebral tissue to silver, tantalum and zirconium. J. Neurosurg. 5, 349–353.
Black J 1994. Biological performance of tantalum. Clin. Mater. 16, 167–173.
Bobyn JD, Poggie RA, Krygier JJ, Lewallen DG, Hanssen AD, Lewis RJ, Unger AS, O’Keefe TJ, Christie MJ,Nasser S, Wood JE, Stulberg SD, Tanzer M 2004. Clinical validation of a structural porous tantalum biomaterial for adult reconstruction. J. Bone Joint Surg. Am. 86-A Suppl 2, 123–129.
Bobyn JD, Stackpool GJ, Hacking SA, Tanzer M, Krygier JJ 1999. Characteristics of bone ingrowth and interface mechanics of a new porous tantalum biomaterial. J. Bone Joint Surg. Br. 81, 907–914.
Bonitatibus JPJ, Torres AS, Goddard GD, FitzGerald PF, Kulkarni AM 2010. Synthesis, characterization, and computed tomography imaging of a tantalum oxide nanoparticle imaging agent. Chem. Commun. 46(47), 8956–8958.
Bonitatibus PJ Jr, Torres AS, Kandapallil B, et al. 2012. Preclinical assessment of a zwitterionic tantalum oxide nanoparticle x-ray contrast agent. ACS Nano 6, 6650–6658.
Bradford FK, Livingston KE 1946. Failure in early secondary repair of skull defects with tantalum. J. Neurostag. 3, 318–328.
Burke GL 1940. The corrosion of metals in tissues; and an introduction to tantalum. Can. Med. Assoc. J.43, 125–128.
Canfield N 1945. Tantalum implants for skull defects. Proc. R. Soc. Med. 38, 293–298.
Carney HM 1942. An experimental study with tantalum. Proc. Sot. Exp. Biol. Med. 51, 147–148.
Chan DC, Titus HW, Chung KH, Dixon H, Wellinghoff ST, Rawls HR 1999. Radiopacity of tantalum oxide nanoparticle filled resins. Dent,.Mater. 15, 219–222.
Cochran KW, Doull J, Mazur M, DuBois KP 1950. Acute toxicity of zirconium, columbium, strontium, lanthanum, cesium, tantalum and yttrium. Arch. Ind. Hyg. 1, 637–650.
Cohen R 2002. A porous tantalum trabecular metal: basic science. Am. J. Orthop. 31, 216–217.
Dahleen HC 1947. Tantalum cranioplasty, a method for one-piece fixation. Surgery 21, 546–555.
Delarue NC, Linell EA, McKenzie KG 1944. An experimental study on the use of tantalum in the subdural space. J. Neurosurg. 1, 239–242.
Echols DH, Colclough JA 1945. Cranioplasty with tantalum plate. Report of eight cases. Surgery 17, 304–314.
Fernandez-Fairen M, Murcia A, Torres A, Hernandez-Vaquero D, Menzie AM 2012. Is anterior cervical fusion with a porous tantalum implant a cost-effective method to treat cervical disc disease with radiculopathy? Spine 37, 1734–1741.
Fernandez-Fairen M, Querales V, Jakowlew A, Murcia A, Ballester J 2010. Tantalum is a good bone graft substitute in tibial tubercle advancement. Clin. Orthop. Relat. Res. 468, 1284–1295.
FitzGerald PF, Butts MD, Roberts JC, Colborn RE, Torres AS, Lee BD, Yeh BM, Bonitatibus PJ Jr, 2016. A proposed computed tomography contrast agent using carboxybetaine zwitterionic tantalum oxide nanoparticles Imaging, biological, and physicochemical performance. Investigative Radiology 51, 786–796.
Flanigan P, Kshettry VR, Benzel, EC 2014. World War II, tantalum, and the evolution of modern cranioplasty technique. Neurosurg. Focus 36(4), E22.
Frigg A, Dougall H, Boyd S, Nigg B 2010. Can porous tantalum be used to achieve ankle and subtalar arthrodesis?: a pilot study. Clin. Orthop. Relat. Res. 468, 209–216.
Fulcher OH 1943. Tantalum as a metallic implant to repair cranial defects. JAMA 121, 931–933.
Fulcher OH 1948. Cranioplasty; a technic with tantalum. Med. Ann. Dist. Columbia 17, 485–492.
Gamsu G, Weintraub RM, Nadef JA 1973. Clearance of tantalum from airways of different caliber in man evaluated by a roentgenographic method. American Review of Respiratory Disease 107, 214–224.
Gardner W 1945. Closure of defects of the skull with tantalum. Surg. Gynecol. Obstet. 80, 303–312.
Gardner WJ 1946. The use of tantalum for repair of cranial defects in infected cases. Cleve. Clin. Q. 13, 72–87.
Gardner WJ 1950. Encephalography in the presence of a tantalum implant. J. Neurosurg. 7, 590–591.
Goldberg HI, Dodds WJ, Jenis EH 1970. Experimental esophagitis: Roentgenographic findings after insufflation of tantalum powder. Am. J. Roentgenol. 110(2), 288–294.
Goldberg SJ., Porper, RP, Chyzus P, Friedman JM 1976. A fractured mandible, from initial operation to removal of tantalum mesh. Oral Surg. 41, 32–38.
Graf CJ, Hamby WB 1945. Roentgenographic demonstration by tantalum powder of sinuses resulting from extraction of intervertebral disc protrusions. Am. J. Roentgenol. 53, 157–160.
Hacking SA, Bobyn JD, Toh K, Tanzer M, Krygier JJ 2000. Fibrous tissue ingrowth and attachment to porous tantalum. J. Biomed. Mater. Res. 52, 631–638.
Harris HE 1948. The use of tantalum tubes in frontal sinus surgery. Cleve. Clin. Q. 15, 129–133.
Hemberger AJ, Whitcomb BB, Woodhall B 1945. The technique of tantalum plating of skull defects. J. Neurosurg. 2, 21–25.
IARC 1999. Surgical implants and other foreign bodies. IARC monographs on the evaluation of carcinogenic risks to humans. volume 74. World Health Organization, International Agency for Research on Cancer, Lyon, France.
Jaschke W, Klose KJ, Strecker EP 1992. A new balloon-expandible tantalum stem (Strecker-Stent) for the biliary system: Preliminary experience. Cardiovasc. Intervent. Radiol. 15, 356–359.
Jin Y, Ma X, Zhang S, Meng H, Xu M, Yang X, Xu W, Tian J 2017. A tantalum oxide-based core/shell nanoparticle for triple -modality image-guided chemo-thermal synergetic therapy of esophageal carcinoma. Cancer Letters 397, 61–71
Jin YS, Li YY, Ma XB, Zha ZB, Shi LL, Tian J, et al., 2014. Encapsulating-tantalum oxide into polypyrrole nanoparticles for X-ray CT/photoacoustic bimodal imaging-guided photothermal ablation of cancer, Biomaterials 35, 5795–5804.
Johansson CB, Hansson HA, Albrektsson T 1990. Qualitative interfacial study between bone and tantalum, niobium or commercially pure titanium. Biomaterials 11, 277–280.
Keyes TF 1954. Braided tantalum as a bronchial suture material. Experimental and clinical observations. J. Thorac. Cardiov. Surg. 27, 291–292.
Kim DG, Huja SS, Tee BC, Larsen PE, Kennedy KS, Chien HH, Lee JW, Wen HB 2013. Bone ingrowth and initial stability of titanium and porous tantalum dental implants: a pilot canine study. Implant. Dent. 22, 399–405.
Koontz AR 1947. Preliminary report on the use of tantalum mesh in the repair of ventral hernias. Trans. South Surg. Assoc. 59, 382–388.
Koontz AR, Kimberly RC 1953. Tissue reactions to tantalum gauze and stainless steel gauze: An experimental comparison. Ann. Surg. 137, 833–840.
Laitakari K, Suonpaa J, Kortekangas AE 1983. Radiography of the maxillary sinus mucosal surface with tantalum. Acta Otolaryngol. 95, 454-459.
Lane S, Webster JE 1947. A report of the early results in tantalum cranioplasty. J. Neurosurg. 4, 526–529.
Lawson TL, Margulis AR, Nadel JA, Rambo ON, Wolfe WG 1969. Intraperitoneal introduction of tantalum powder. A roentgenographic and pathologic study. Invest. Radiol. 4(5), 293–300.
Lee N, Cho HR, Oh MH, Lee SH, Kim K, Kim BH, Shin K, Ahn TY, Choi JW, Kim YW, Choi SH, Hyeon T 2012. Multifunctional Fe3O4/TaO(x) core/shell nanoparticles for simultaneous magnetic resonance imaging and X-ray computed tomography. J. Am. Chem. Soc. 134, 10309–10312.
Levine BR, Sporer S, Poggie RA, Della Valle CJ, Jacobs JJ 2006. Experimental and clinical performance of porous tantalum in orthopedic surgery. Biomaterials 27, 4671–4681.
Lewin W, Graham MP, Northcroft GB 1948. Tantalum in the repair of traumatic skull defects. Brit. J. Surg. 36, 26–41.
Lockhart WS Jr, Van Den Noort G, Kimsey WH, Groff RA 1952. A comparison of polyethylene and tantalum for cranioplasty. A preliminary report. J. Neurosurg. 9, 254–257.
Lu Y-C, Yang C-X, X-P Yan 2015. Radiopaque tantalum oxide coated persistent luminescent nanoparticles as multimodal probes for in vivo near-infrared luminescence and computed tomography bioimaging, Nanoscale, 7, 17929.
MacKay HJ, Russell LA 1946. A method of cranioplasty using a ready made tantalum cranioprosthesis. Surgery 20, 830–844.
Makela T 1949. Tantalum cranioplasty of war wounds of the skull. Ann. Chir. Gynaecol. Fenn. 38, 13–19.
Malkani AL, Price MR, Crawford CH, 3rd, Baker DL 2009. Acetabular component revision using a porous tantalum biomaterial: a case series. J. Arthroplasty 24, 1068–1073.
Matsuno H, Yokoyama A, Watari F, Uo M, Kawasaki T 2001. Biocompatibility and osteogenesis of refractory metal implants, titanium, hafnium, niobium, tantalum and rhenium. Biomaterials 22, 1253–1262.
Mayfield FH, Levitch LA 1945. Repair of cranial defects with tantalum. Am. J. Surg. 67, 319–332.
Meenaghan MA, Natiella JR, Moresi JL, Flynn HE, Wirth JE, Baier RE 1979. Tissue response to surface-treated tantalum implants: Preliminary observations in primates. J. Biomed. Mater. Res. 13, 631–643.
Meirowsky AM, Hazouri LA, Greiner DJ 1950. Epidural granulomata in the presence of tantalum plates. J. Neurosurgy. 7, 485–491.
Miller AC, Fuciarelli AF, Jackson WE, Ejnik EJ, Emond C, Strocko S, Hogan J, Page N, Pellmar T 1998. Urinary and serum mutagenicity studies with rats implanted with depleted uranium or tantalum pellets. Mutagenesis 13, 643–648
Mohandas G, Oskolkov N, McMahon MT, Walczak P, Janowski M 2014. Porous tantalum and tantalum oxide nanoparticles for regenerative medicine. Acta Neurobiol. Exp. 74, 188–196
Morrison R, Thompson J, Bird L, Hill MA, Townley H 2015. Synthesis and characterization of polystyrene embolization particles doped with tantalum oxide nanoparticles for X-ray contrast. J. Mater. Sci.: Mater. Med. 26, 218.
Mount LA 1948. Tantalum discs for covering trephine defects and tantalum clips for ligation of internal carotid artery intracranially. J. Neurosurg. 5, 208–210.
Muhlestein JB, Phillips HR, Quigley PJ, Bauman RP, Gammon RS, Chapman, GD, Mikat EM, Palmos LE, Overman AB, Stack RS 1992. Early and late outcome following deployment of a new flexible tantalum intracoronary stent in dogs. Am. Heart J. 124(4), 1058–1067.
Nadel JA, Dodds WJ, Goldberg H, Graf PD 1969. Insufflation of powdered tantalum in the esophagus. New esophagographic technique. Invest. Radiol. 4, 57–62.
Nadel JA, Wolfe WG, Graf PD 1968. Powdered tantalum as a medium for bronchography in canine and human lungs. Investigative Radiology 3, 229–238.
Nadel JA, Wolfe WG, Graf PD, Youker JE, Zamel N, Austin JHM, Hinchcliffe WA, Greenspan RH, Wright RR 1970. Powdered tantalum: A new contrast medium for roentgenographic examination of human airways. New England Journal of Medicine 283, 281–286.
Newton D 1977. Clearance of radioactive tantalum from the human lung after accidental inhalation. Am. Roentgenol. 129, 327–328.
Norcross NC and Bakody JT 1947. Observations on the use of tantalum foil in peripheral nerve surgery. J. Neurosurg. 4, 69–71.
Oh MH, Lee N, Kim H, Park SP, Piao Y, Lee J, et al. 2011. Large-scale synthesis of bioinert tantalum oxide nanoparticles for X-ray computed tomography imaging and bimodal image-guided sentinel lymph node mapping. J. Am. Chem. Soc. 133(14), 5508–5515.
Omarova D, Ismailova A, Sultanbekov Z 2010. Peculiarities of circulatory system response on influence of modern tantalum manufacture factors in workers. Georgian Med. News 184–185, 70–76.
Oppenheimer BS, Oppenheimer ET, Danishefsky I, Stout AP 1956. Carcinogenic effect of metals in rodent. Cancer Res. 16, 439–441.
Pacheco KA 2015. Allergy to surgical implants. J. Allergy Clin. Immunol. Pract. 3(5), 683–695
Przybyla VA, La Piana FG 1982. Complications associated with the use of tantalum-mesh-covered implants. Opthalmology 89, 121–123.
Pudenz RH 1942. The use of tantalum clips for hemostasis in neurosurgery. Surgery 12, 791-797.
Pudenz RH 1943. The repair of cranial defects with tantalum: an experimental study. JAMA 121, 478–481.
Reach JS, Jr., Dickey ID, Zobitz ME, Adams JE, Scully SP, Lewallen DG 2007. Direct tendon attachment and healing to porous tantalum: an experimental animal study. J. Bone Joint Surg. Am. 89, 1000–1009.
Robertson RCL 1944. Repair of cranial defects with tantalum. J. Neurosurg. 1, 227–236.
Robertson RCL, Peacher WG 1945. The use of tantalum foil in the subdural space. J. Neurosurg. 2, 281–284.
Schepers GWH 1955. The biological action of tantalum oxide. Arch. Ind. Health 12, 121–123.
Scott M, Wycis HT 1946. Experimental observations on the use of stainless steel for cranioplasty: a comparison with tantalum. J. Neurosurg. 3, 310–317.
Smith JC, Stitik FP, Swift DL 1976. Airway visualisation by tantalum inhalation bronchography. American Review of Respiratory Disease 113, 515–529.
Smith P, Stitik F, Smith J, Rosenthal R, Menkes H 1979. Tantalum inhalation and airway responses. Thorax 34(4), 486–492.
Spurling RG 1943. The use of tantalum wire and foil in the repair of peripheral nerves. Surg. Clin. North Am. 23, 491–1504.
Stitik FP, Barfelt D, James AE Jr, Proctor DF 1978. Tantalum tracheography in upper airway obstruction: 100 experiences in adults. Am. J. Roentgenol. 130, 35–41.
Stitik FP, Proctor DF 1973. Tracheography with the experimental contrast agent tantalum. Annals of Otology, Rhinology and Laryngology 82, 838–843.
Stitik FP, Proctor DF 1975. Delayed clearance of tantalum by radiologically occult cancer. Annals of Otology, Rhinology and Laryngology 84, 589–595.
Tang Z, Xie Y, Yang F, Huang Y, Wang C, Dai K, Zheng X, Zhang X 2013. Porous tantalum coatings prepared by vacuum plasma spraying enhance bmscs osteogenic differentiation and bone regeneration in vitro and in vivo. PLoS One 8, e66263.
Tegtmeyer CJ, Smith NJ, El-Mahdi AM, Fitz-Hugh GS, Constable WC 1975. The value of tantalum powder as a contrast medium in laryngography. Can. J. Otolaryng. 4, 81–85.
Torres AS, Bonitatibus PJ Jr, Colborn RE, et al. 2012. Biological performance of a size fractionated core-shell tantalum oxide nanoparticle x-ray contrast agent. Invest Radiol. 47, 578–587.
Trapozzano VR, Grant FC, Spitz EB 1948. Acrylic cranioplasty. Oral Surg. Oral Med. Oral Pathol. 1, 815–826.
Turner OA 1946. Tantalum cranioplasty. Ohio Med. 42, 604–607.
Turner OA 1952. Tantalum cranioplasty and repeated trauma. J. Neurosurg. 9, 100–103.
Veith RG, Tindall GT., Odom GL 1966. The use of tantalum dust as an adjunct in the postoperative management of subdural hematomas. J. Neurosurg. 24, 514–519.
von Hoist H, Collins P, Steiner L 1981. Titanium, silver and tantalum clips in brain tissue. Acta Neurochirurgica 56, 239–242.
Voris RC 1946. The repair of skull defects with special reference to the use of tantalum. Surg. Clin. North. Am. Feb: 33–55.
Weeden SH, Schmidt RH 2007. The use of tantalum porous metal implants for Paprosky 3A and 3B defects. J. Arthroplasty 22, 151–155.
Weiford EC, Gardner WJ 1949. Tantalum cranioplasty. Review of 106 cases in civilian practice. J. Neurosurg. 6, 13-32.
Weiss EW, Lam CR 1950. Tantalum tubes in the non-suture method of blood vessel anastomosis. Am. J. Surg. 80, 452–454.
Wexler SA, Frueh BR, Musch DC, Pachtman MA 1985. Exposure of tantalum mesh orbital implants. Ofthalmology 92(5), 671–675.
White CJ, Ramee SR, Banks AK, Mesa JE, Chokshi S, Isner JM 1992. A new balloon-expandible tantalum coil stent: Angiographic patency and histologic findings in an atherogenic swine model. J. Amer. Cal. Cardiol. 19, 870–876.
Wigfield C, Robertson J, Gill S, Nelson R 2003. Clinical experience with porous tantalum cervical interbody implants in a prospective randomized controlled trial. Br. J. Neurosurg. 17, 418–425.
Woodhall B, Spurling RG 1945. Tantalum cranioplasty for war wounds of the skull. Ann. Surg. 121, 649–668.
Xu J, Weng XJ, Wang X, Huang JZ, Zhang C, Muhammad H, Ma X, Liao QD 2013. Potential use of porous titanium-niobium alloy in orthopedic implants: preparation and experimental study of its biocompatibility in vitro. PLoS One 8, e79289.
Zamel N, Austin JHM, Graf PD, Dedo HH, Jones MD, Nadel JA 1970. Powdered tantalum as a medium for human laryngography. Radiology 94, 947–953.
Zeng J, Li1 L, Zhang H, Li J, Liu L, Zhou G, Du Q, Zheng C, Yang X, Jin Y, Ma X, Zhang S, Meng H, Xu M, Yang X 2018. Radiopaque and uniform alginate microspheres loaded with tantalum nanoparticles for real-time imaging during transcatheter arterial embolization. Theranostics 8, 4591–4600.
Zou X, Li H, Bunger M, Egund N, Lind M, Bunger C 2004. Bone ingrowth characteristics of porous tantalum and carbon fiber interbody devices: an experimental study in pigs. Spine J. 4, 99–105.