Faculty of Science Faculty of Science

Publications

2024

  • Petropoulos M, Karamichali A, Rossetti GG, Freudenmann A, Iacovino LG, Dionellis VS, et al. Transcription–replication conflicts underlie sensitivity to PARP inhibitors. Nature. 2024. doi: 10.1038/s41586-024-07217-2

2023

  • S. Mesquita F, Abrami L, Bracq L, Panyain N, Mercier V, Kunz B, et al. SARS-CoV-2 hijacks a cell damage response, which induces transcription of a more efficient Spike S-acyltransferase. Nature communications. 2023;14(1):7302. doi: 10.1038/s41467-023-43027-2.

  • Bagka M, Choi H, Héritier M, Schwaemmle H, Pasquer QTL, Braun SMG, et al. Targeted protein degradation reveals BET bromodomains as the cellular target of Hedgehog pathway inhibitor-1. Nature communications. 2023;14(1):3893. doi: 10.1038/s41467-023-39657-1.

  • Bouffard J, Coelho F, Sakai N, Matile S. Dynamic Phosphorus:  Thiolate Exchange Cascades with Higher Phosphorothioates. Angewandte Chemie International Edition. n/a(n/a):e202313931. doi: https://doi.org/10.1002/anie.202313931.
  • Gehin C, Lone MA, Lee W, Capolupo L, Ho S, Adeyemi AM, et al. CERT1 mutations perturb human development by disrupting sphingolipid homeostasis. J Clin Invest. 2023;133(10). Epub 20230515. doi: 10.1172/jci165019. PubMed PMID: 36976648; PubMed Central PMCID: PMCPMC10178846
  • Pagano S, Bakker SJL, Juillard C, Vossio S, Moreau D, Brandt KJ, et al. Antibody against apolipoprotein-A1, Metabolic-Associated Fatty Liver Disease and cardiovascular risk: a translational study. European Heart Journal. 2023;44(Supplement_2). doi: 10.1093/eurheartj/ehad655.3242.
  • Maynard JRJ, Saidjalolov S, Velluz M-C, Vossio S, Aumeier C, Moreau D, et al. Toward a Traceless Tag for the Thiol-Mediated Uptake of Proteins. ChemistryEurope. 2023. doi: https://doi.org/10.1002/ceur.202300029.
  • Miesch J., Wimbish R.T., Velluz M.C., Aumeier C. Phase separation of +TIP networks regulates microtubule dynamics. Proc Natl Acad Sci U S A. 2023 Aug 29;12. doi: 10.1073/pnas.2301457120.
  • Raykov L, Mottet M, Nitschke J, Soldati T. A TRAF-like E3 ubiquitin ligase TrafE coordinates ESCRT and autophagy in endolysosomal damage response and cell-autonomous immunity to Mycobacterium marinum. eLife. 2023;12:e85727. doi: 10.7554/eLife.85727.
  • Coelho F, Saidjalolov S, Moreau D, Thorn-Seshold O, Matile S. Inhibition of Cell Motility by Cell-Penetrating Dynamic Covalent Cascade Exchangers: Integrins Participate in Thiol-Mediated Uptake. JACS Au. 2023. doi: 10.1021/jacsau.3c00113.

2022

  • Anwar MU, Sergeeva OA, Abrami L, Mesquita FS, Lukonin I, Amen T, et al. ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains. Developmental Cell. 2022. doi: https://doi.org/10.1016/j.devcel.2022.09.004.

  • Assies L, Mercier V, López-Andarias J, Roux A, Sakai N, Matile S. The Dynamic Range of Acidity: Tracking Rules for the Unidirectional Penetration of Cellular Compartments. Chembiochem. 2022. Epub 20220510. doi: 10.1002/cbic.202200192. PubMed PMID: 35535626.

  • García-Calvo J, López-Andarias J, Maillard J, Mercier V, Roffay C, Roux A, et al. HydroFlipper membrane tension probes: imaging membrane hydration and mechanical compression simultaneously in living cells. Chem Sci. 2022;13(7):2086-93. Epub 20220203. doi: 10.1039/d1sc05208j. PubMed PMID: 35308858; PubMed Central PMCID: PMCPMC8849034.
  • Jiménez-Rojo N, Feng S, Morstein J, Pritzl SD, Harayama T, Asaro A, et al. Optical Control of Membrane Fluidity Modulates Protein Secretion. bioRxiv. 2022:2022.02.14.480333. doi: 10.1101/2022.02.14.480333.
  • Kato T, Lim B, Cheng Y, Pham A-T, Maynard J, Moreau D, et al. Cyclic Thiosulfonates for Thiol-Mediated Uptake: Cascade Exchangers, Transporters, Inhibitors. JACS Au. 2022. doi: 10.1021/jacsau.1c00573.
  • Kopelyanskiy D, Desponds C, Prevel F, Rossi M, Migliorini R, Snäkä T, et al. Leishmania guyanensis suppressed inducible nitric oxide synthase provoked by its viral endosymbiont. Frontiers in Cellular and Infection Microbiology. 2022;12. doi: 10.3389/fcimb.2022.944819.
  • Lim B, Kato T, Besnard C, Poblador Bahamonde AI, Sakai N, Matile S. Pnictogen-Centered Cascade Exchangers for Thiol-Mediated Uptake: As(III)-, Sb(III)-, and Bi(III)-Expanded Cyclic Disulfides as Inhibitors of Cytosolic Delivery and Viral Entry. JACS Au. 2022;2(5):1105-14. doi: 10.1021/jacsau.2c00017.
  •  López-Andarias J, Eblighatian K, Pasquer QTL, Assies L, Sakai N, Hoogendoorn S, et al. Photocleavable Fluorescent Membrane Tension Probes: Fast Release with Spatiotemporal Control in Inner Leaflets of Plasma Membrane, Nuclear Envelope, and Secretory Pathway. Angewandte Chemie International Edition. 2022;61(1):e202113163. doi: https://doi.org/10.1002/anie.202113163.
  • Nikolova Y, Fabri B, Moneva Lorente P, Guarnieri-Ibáñez A, de Aguirre A, Soda Y, et al. Chemo- and Regioselective Multiple C(sp2)−H Insertions of Malonate Metal Carbenes for Late-Stage Functionalizations of Azahelicenes. Angewandte Chemie International Edition. 2022;n/a(n/a). doi: https://doi.org/10.1002/anie.202210798.
  • Shybeka I, Maynard JRJ, Saidjalolov S, Moreau D, Sakai N, Matile S. Dynamic Covalent Michael Acceptors to Penetrate Cells:  Thiol-Mediated Uptake with Tetrel-Centered Exchange Cascades, Assisted by Halogen-Bonding Switches. Angewandte Chemie International Edition. 2022;n/a(n/a). doi: https://doi.org/10.1002/anie.202213433.
  •  Winssinger N, Watson EE, Russo F, Moreau D. Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization. Angew Chem Int Ed Engl. 2022. Epub 20220504. doi: 10.1002/anie.202203390. PubMed PMID: 35510306.
  • Reverte M, Eren RO, Jha B, Desponds C, Snäkä T, Prevel F, et al. The antioxidant response favors Leishmania parasites survival, limits inflammation and reprograms the host cell metabolism. PLoS pathogens. 2021;17(3):e1009422. doi: 10.1371/journal.ppat.1009422.

2021

  • Laurent Q, Martinent R, Moreau D, Winssinger N, Sakai N, Matile S. Oligonucleotide Phosphorothioates Enter Cells by Thiol-Mediated Uptake. Angewandte Chemie International Edition. 2021;60(35):19102-6. doi: https://doi.org/10.1002/anie.202107327.
  • Lim B, Cheng Y, Kato T, Pham A-T, Le Du E, Mishra AK, et al. Inhibition of Thiol-Mediated Uptake with Irreversible Covalent Inhibitors. Helvetica Chimica Acta. 2021;n/a(n/a). doi: https://doi.org/10.1002/hlca.202100085.
  • Martinent R, Tawffik S, López-Andarias J, Moreau D, Laurent Q, Matile S. Dithiolane quartets: thiol-mediated uptake enables cytosolic delivery in deep tissue. Chemical Science. 2021;12(41):13922-9. doi: 10.1039/D1SC04828G.
  • Mesquita FS, Abrami L, Sergeeva O, Turelli P, Qing E, Kunz B, et al. S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity. Developmental Cell. 2021;56(20):2790-807.e8. doi: https://doi.org/10.1016/j.devcel.2021.09.016.
  • Piazzolla F, Mercier V, Assies L, Sakai N, Roux A, Matile S. Fluorescent Membrane Tension Probes for Early Endosomes. Angew Chem Int Ed Engl. 2021;60(22):12258-63. Epub 20210426. doi: 10.1002/anie.202016105. PubMed PMID: 33534935.
  • Raykov L, Mottet M, Nitschke J, Soldati T. The <em>Dictyostelium discoideum</em> E3 ubiquitin ligase TrafE coordinates endolysosomal damage response and cell-autonomous immunity to <em>Mycobacterium marinum</em>. bioRxiv. 2021:2021.06.29.450281. doi: 10.1101/2021.06.29.450281.

2020

  • Abrami L, Audagnotto M, Ho S, Marcaida MJ, Mesquita FS, Anwar MU, et al. Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains. Nat Chem Biol. 2021. doi: 10.1038/s41589-021-00753-2. PubMed PMID: 33707782.

  • Jiménez-Rojo N, Leonetti MD, Zoni V, Colom A, Feng S, Iyengar NR, et al. (2020) "Conserved Functions of Ether Lipids and Sphingolipids in the Early Secretory Pathway. Current Biology". 30(19):3775-87.e7. doi: 10.1016/j.cub.2020.07.059.
  • Bosmani C, Leuba F, Hanna N, Bach F, Burdet F, Pagni M, et al. (2020) "Vacuolins and myosin VII are required for phagocytic uptake and phagosomal membrane recycling in Dictyostelium discoideum". Journal of cell science. 2020;133(13):jcs242974. doi: 10.1242/jcs.242974.
  • Martinent R., López-Andarias J., Moreau D., Cheng Y, Sakai N., Matile S. (2020). "Automated high-content imaging for cellular uptake, from the Schmuck cation to the latest cyclic oligochalcogenides". Beilstein Journal of Organic Chemistry 16, 2007–2016. doi:10.3762/bjoc.16.167
  • Mercier V., Larios J., Molinard G., Goujon A., Matile S., Gruenberg J., Roux A. (2020). "Endosomal membrane tension regulates ESCRT-III-dependent intra-lumenal vesicle formation". Nature Cell Bioliology. doi: 10.1038/s41556-020-0546-4
  • López-Andarias J., Saarbach J., Moreau D., Cheng Y., Derivery E., Laurent Q., González-Gaitán M., Winssinger N., Sakai N., Matile S. (2020). "Cell-Penetrating Streptavidin: A General Tool for Bifunctional Delivery With Spatiotemporal Control, Mediated by Transport Systems Such as Adaptive Benzopolysulfane Networks". Journal of the American. Chemical Society. DOI: 10.1021/jacs.9b13621

2019

  • Larios J., Mercier V., Roux A., Gruenberg J. "ALIX- and ESCRT-III-dependent sorting of tetraspanins to exosomes", Journal of Cell Biology. 2020. March 2.
  • Moreau D., Vacca F., Vossio S., Scott C., Colaco A., Paz Montoya J., Ferguson C., Damme M., Moniatte M., Parton R.G., Platt F.M., Gruenberg J., “Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice”, EMBO Rep., 2019 May 22.
  • Vacca F., Vossio S., Mercier V., Moreau D., Johnson S., Scott C.C., Paz Montoya J., Moniatte M., Gruenberg J., “Cyclodextrin triggers MCOLN1-dependent endo-lysosome secretion in Niemann-Pick type C cells“, J. Lipid Res., pii: jlr.M089979, doi: 10.1194/jlr.M089979, 2019.
  •  Abrami L, Audagnotto M, Ho S, Marcaida MJ, Mesquita FS, Anwar MU, et al. Molecular mode of action of an Acyl Protein thioesterase. bioRxiv. 2020.

  • Bosmani C, Leuba F, Hanna N, Bach F, Burdet F, Pagni M, et al. Vacuolins and myosin VII are required for phagocytic uptake and phagosomal membrane recycling in &lt;em&gt;Dictyostelium discoideum&lt;/em&gt. Journal of cell science. 2020;133(13):jcs242974. doi: 10.1242/jcs.242974.

  • Jiménez-Rojo N, Leonetti MD, Zoni V, Colom A, Feng S, Iyengar NR, et al. Conserved Functions of Ether Lipids and Sphingolipids in the Early Secretory Pathway. Current Biology. 2020;30(19):3775-87.e7. doi: https://doi.org/10.1016/j.cub.2020.07.059.
  • López-Andarias J, Saarbach J, Moreau D, Cheng Y, Derivery E, Laurent Q, et al. Cell-Penetrating Streptavidin: A General Tool for Bifunctional Delivery with Spatiotemporal Control, Mediated by Transport Systems Such as Adaptive Benzopolysulfane Networks. Journal of the American Chemical Society. 2020;142(10):4784-92. Epub 2020/02/29. doi: 10.1021/jacs.9b13621. PubMed PMID: 32109058; PubMed Central PMCID: PMCPMC7307903.
  • Martinent R, López-Andarias J, Moreau D, Cheng Y, Sakai N, Matile S. Automated high-content imaging for cellular uptake, from the Schmuck cation to the latest cyclic oligochalcogenides. Beilstein Journal of Organic Chemistry. 2020;16:2007-16. doi: 10.3762/bjoc.16.167.
  • Mercier V, Larios J, Molinard G, Goujon A, Matile S, Gruenberg J, et al. Endosomal membrane tension regulates ESCRT-III-dependent intra-lumenal vesicle formation. Nature Cell Biology. 2020;22(8):947-59. doi: 10.1038/s41556-020-0546-4.

2018

  • Banach-Orłowska M., Jastrzębski K., Cendrowski J., Maksymowicz M., Wojciechowska K., Korostyński M., Moreau D., Gruenberg J., Miaczynska M., “The topology of lymphotoxin &[beta] receptor (LT&[beta]R) accumulated upon endolysosomal dysfunction dictates the NF-&[kappa]B signaling outcome“, Journal of Cell Science, 2018.
  • Eren R. O., Kopelyanskiy D., Moreau D., Chapalay J. B., Chambon M., Turcatti G., Lye L.-F., Beverley S. M., Fasel N., “Development of a semi-automated image-based high-throughput drug screening system“, Frontiers in bioscience (Elite edition), 10, 242-253, 2018.
  • Moreau D., Gruenberg J., “Automated Microscopy and High Content Screens (Phenotypic Screens) in Academia Labs“, Chimia, Vol. 70, Number 12, December 2016, pp. 878-882(5).
  • Wu K.X., Phuektes P., Kumar P., Yen Lin Goh G., Moreau D., Tak Kwong Chow V., Bard F., Jang Hann Chu J., “Human genome-wide RNAi screen reveals host factors required for enterovirus 71 replication“, Nature Communications, 2016.
  • Wong H.H., Kumar P., Tay F.P., Moreau D., Liu D.X., Bard F., “Genome-wide screen reveals VCP requirement for coronavirus exit from endosomes“, Journal of Virology, 2015, 89(21):11116-28.
  • Kumar P., Goh G., Wongphayak S., Moreau D., Bard F., “ScreenSifter: analysis and visualization of RNAi screening data“, BMC Bioinformatics, 2013, 14(1):290.
  • Moreau D., Bard F., “Comprendre et combattre les toxines A/B en décryptant leur transport intracellulaire“, Medecine/sciences, 2012, 28, 1, 28-31.
  • Moreau D., Scott C., Gruenberg J., “A Novel Strategy to Identify Drugs that Interfere with Endosomal Lipids“, CHIMIA International Journal for Chemistry, 2011, 65, 846-848.
  • Moreau D., Kumar P., Wang S.C., Chaumet A., Chew S.Y., Chevalley H., Bard F., “Genome-wide RNAi screens identify genes required for Ricin and PE intoxications“, Developmental Cell, 2011, 21, 2, 231-244.
  • Chia N.Y., Chan Y.S., Feng B., Lu X., Orlov Y.L., Moreau D., Kumar P., Jiang J., Soh B.S., Huss M., Kraus P., Lufkin T., Lim B., Clarke N., Bard F., Ng. H.H., “A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity“, Nature, 2010, 468, 316-320.