2016 JULY-2 PHARMACOGENETICS OF OATP (2016-2010)

The second topic of the month highlights how genetic polymorphisms of OATP modify transporter functions. Interestingly, two studies visualise the inter-individual variability of hepatocyte OATP function by human liver imaging (PubMed and PubMed)

  • Drug Metab Dispos. 2015;43:1045-55. Ethnic variability in the expression of hepatic drug transporters: absolute quantification by an optimized targeted quantitative proteomic approach. Peng KW, Bacon J, Zheng M, Guo Y, Wang MZ. PubMed
  • Pharmacology. 2015;95:201-8. Genetic polymorphisms and function of the organic anion-transporting polypeptide 1A2 and its clinical relevance in drug disposition. Zhou Y, Yuan J, Li Z, Wang Z, Cheng D, Du Y, Li W, Kan Q, Zhang W. PubMed
  • Biol Pharm Bull. 2015;38:155-68. Organic anion transporting polypeptide (OATP)1B1 and OATP1B3 as important regulators of the pharmacokinetics of substrate drugs. Maeda K. PubMed
  • Tuberculosis (Edinb). 2015;95:68-74. Association of polymorphisms in drug transporter genes (SLCO1B1 and SLC10A1) and anti-tuberculosis drug-induced hepatotoxicity in a Chinese cohort. Chen R, Wang J, Tang S, Zhang Y, Lv X, Wu S, Xia Y, Deng P, Ma Y, Tu D, Chen D, Zhan S. PubMed
  • Pharm Res. 2015;32:1864-83. Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach. Tsamandouras N, Dickinson G, Guo Y, Hall S, Rostami-Hodjegan A, Galetin A, Aarons L. PubMed
  • Drug Metab Dispos. 2014;42:78-88. Interindividual variability in hepatic organic anion-transporting polypeptides and P-glycoprotein (ABCB1) protein expression: quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex. Prasad B, Evers R, Gupta A, Hop CE, Salphati L, Shukla S, Ambudkar SV, Unadkat JD. PubMed
  • Pharmacogenomics. 2013;14:1573-82. IMAGING. Polymorphisms in the organic anion transporting polypeptide genes influence liver parenchymal enhancement in gadoxetic acid-enhanced MRI. Okubo H1, Ando H, Kokubu S, Miyazaki A, Watanabe S, Fujimura A. PubMed
  • Basic Clin Pharmacol Toxicol. 2013;113:43-8. Fentanyl pharmacokinetics is not dependent on hepatic uptake by organic anion-transporting polypeptide 1B1 in human beings. Ziesenitz VC, König SK, Mahlke N, Jantos R, Skopp G, Weiss J, Haefeli WE, Mikus G. PubMed
  • J Pharm Sci. 2013;102:2924-9. Gene-gene-environment interactions between drugs, transporters, receptors, and metabolizing enzymes: Statins, SLCO1B1, and CYP3A4 as an example. Sadee W. PubMed
  • Biopharm Drug Dispos. 2013;34:45-78. Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption. Shitara Y, Maeda K, Ikejiri K, Yoshida K, Horie T, Sugiyama Y. PubMed
  • Mol Pharm. 2012;9:3535-42. Characterization of organic anion transporting polypeptide (OATP) expression and its functional contribution to the uptake of substrates in human hepatocytes. Kimoto E1, Yoshida K, Balogh LM, Bi YA, Maeda K, El-Kattan A, Sugiyama Y, Lai Y. PubMed
  • Drug Metab Pharmacokinet. 2013;28:4-18. Impact of genetic variation in OATP transporters to drug disposition and response. Gong IY, Kim RB. PubMed
  • Drug Metab Pharmacokinet. 2013;28:196-202. Impact of ABCC2, ABCG2 and SLCO1B1 polymorphisms on the pharmacokinetics of pitavastatin in humans. Oh ES, Kim CO, Cho SK, Park MS, Chung JY. PubMed
  • Radiology. 2012;264:741-50. IMAGING. Visualization of hepatic uptake transporter function in healthy subjects by using gadoxetic acid-enhanced MR imaging. Nassif A, Jia J, Keiser M, Oswald S, Modess C, Nagel S, Weitschies W, Hosten N, Siegmund W, Kühn JP. PubMed
  • Clin Cancer Res. 2012;18:4433-40. Influence of polymorphic OATP1B-type carriers on the disposition of docetaxel. de Graan AJ, Lancaster CS, Obaidat A, Hagenbuch B, Elens L, Friberg LE, de Bruijn P, Hu S, Gibson AA, Bruun GH, Corydon TJ, Mikkelsen TS, Walker AL, Du G, Loos WJ, van Schaik RH, Baker SD, Mathijssen RH, Sparreboom A. PubMed
  • Mol Med Rep. 2012;6:75-82. SLCO1B1 *15 haplotype is associated with rifampin-induced liver injury. Li LM, Chen L, Deng GH, Tan WT, Dan YJ, Wang RQ, Chen WS. PubMed
  • Expert Opin Drug Metab Toxicol. 2012;8:349-60. Genetics or environment in drug transport: the case of organic anion transporting polypeptides and adverse drug reactions. Clarke JD, Cherrington NJ. PubMed
  • Atherosclerosis. 2012;220:413-7.  Genetic variation at the SLCO1B1 gene locus and low density lipoprotein cholesterol lowering response to pravastatin in the elderly. Akao H1, Polisecki E, Kajinami K, Trompet S, Robertson M, Ford I, Jukema JW, de Craen AJ, Westendorp RG, Shepherd J, Packard C, Buckley BM, Schaefer EJ. PubMed
  • Drug Metab Pharmacokinet. 2012;27:106-21. Genetic polymorphisms of OATP transporters and their impact on intestinal absorption and hepatic disposition of drugs. Nakanishi T, Tamai I. PubMed
  • Tuberculosis (Edinb). 2012 Jan;92:100-4.  Polymorphisms in drug transporter genes (ABCB1, SLCO1B1 and ABCC2) and hepatitis induced by antituberculosis drugs. Kim SH, Kim SH, Lee JH, Lee BH, Kim YS, Park JS, Jee YK. PubMed
  • Arch Pharm Res. 2011;34:1817-28. Interplay of pharmacogenetic variations in ABCB1 transporters and cytochrome P450 enzymes. Yoo HD, Lee YB. PubMed
  • Pharmacogenet Genomics. 2011;21:523-30. The impact of pharmacogenetics of metabolic enzymes and transporters on the pharmacokinetics of telmisartan in healthy volunteers. Yamada A, Maeda K, Ishiguro N, Tsuda Y, Igarashi T, Ebner T, Roth W, Ikushiro S, Sugiyama Y. PubMed
  • Expert Opin Pharmacother. 2011;12:1499-509.  Pharmacogenomics and adverse drug reactions: the case of statins. Giorgi MA, Caroli C, Arazi HC, Di Girolamo G. PubMed
  • Pharmacogenet Genomics. 2011;21:103-14. Identification of novel functional organic anion-transporting polypeptide 1B3 polymorphisms and assessment of substrate specificity. Schwarz UI, Meyer zu Schwabedissen HE, Tirona RG, Suzuki A, Leake BF, Mokrab Y, Mizuguchi K, Ho RH, Kim RB. PubMed
  • Pharmacol Rev. 2011;63:157-81. Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Niemi M, Pasanen MK, Neuvonen PJ. PubMed
  • Handb Exp Pharmacol. 2011;201:1-28. Uptake transporters of the human OATP family: molecular characteristics, substrates, their role in drug-drug interactions, and functional consequences of polymorphisms. König J. PubMed
  • Xenobiotica. 2010;40:782-9. Influence of drug-transporter polymorphisms on the pharmacokinetics of fexofenadine enantiomers. Akamine Y, Miura M, Sunagawa S, Kagaya H, Yasui-Furukori N, Uno T. PubMed