2017 MAY

In May, the topic of the month highlights the articles that were published in Drug Metab and Dispos in 2017. This journal accepts many articles dealing with membrane transporters.

  • Drug Metab Dispos. 2017; in press. Mechanisms and predictions of drug-drug interactions of the Hepatitis C Virus 3-Direct Acting Antiviral (3D) regimen: Paritaprevir/Ritonavir, Ombitasvir and Dasabuvir. Shebley M, Liu J, Kavetskaia O, Sydor J, de Morais SM, Fischer V, Nijsen MJ, Bow DA. PubMed
  • Drug Metab Dispos. 2017, in press. Comparison of methods for estimating unbound intracellular-to-medium concentration ratios in rat and human hepatocytes using statins. Yoshikado T, Toshimoto K, Nakada T, Ikejiri K, Kusuhara H, Maeda K, Sugiyama Y. PubMed
  • Drug Metab Dispos. 2017; in press. Absorption, distribution, metabolism and excretion of the oral prostaglandin D2 receptor 2 (DP2) antagonist fevipiprant (QAW039) in healthy volunteers and in vitro. Pearson D, Weiss HM, Jin Y, van Lier JJ, Erpenbeck VJ, Glaenzel U, End P, Woessner R, Eggimann F, Camenisch G. PubMed
  • Drug Metab Dispos. 2017; in press. Transporter-mediated disposition, clinical pharmacokinetics and cholestatic potential of glyburide and its primary active metabolites. Li R, Bi YA, Vildhede A, Scialis RJ, Mathialagan S, Yang X, Marroquin LD, Lin J, Varma MVS. PubMed
  • Drug Metab Dispos. 2017, in press. Interaction and transport of Methamphetamine and its primary metabolites by Organic Cation and Multidrug and Toxin Extrusion Transporters. Wagner DJ, Sager JE, Duan H, Isoherranen N, Wang J. PubMed
  • Drug Metab Dispos. 2017; in press. Leveraging of rifampicin-dosed Cynomolgus monkeys to identify bile acid 3-O-Sulfate conjugates as potential novel biomarkers for organic anion-transporting polypeptides. Thakare R, Gao H, Kosa RE, Bi YA, Varma MV, Cerny M, Sharma R, Kuhn M, Huang B, Liu Y, Yu A, Walker GS, Niosi M, Tremaine LM, Alnouti Y, Rodrigues AD. PubMed
  • Drug Metab Dispos. 2017; in press. Quantitative prediction of CYP3A4 induction: impact of measured, free and intracellular perpetrator concentrations from human hepatocyte induction studies on drug-drug interaction predictions. Sun Y, Chothe PP, Sager J, Tsao H, Moore A, Laitinen L, Hariparsad N. PubMed
  • Drug Metab Dispos. 2017; in press. Coproporphyrin-I: A fluorescent, endogenous optimal probe substrate for ABCC2 (MRP2) that is suitable for vesicle based MRP2 inhibition assay. Gilibili RR, Chatterjee S, Bagul P, Mosure KW, Murali BV, Mariappan TT, Mandlekar S, Lai Y. PubMed
  • Drug Metab Dispos. 2017; in press. Prediction of the transporter-mediated drug-drug interaction potential of Dabrafenib and its major circulating metabolites. Ellens H, Johnson M, Lawrence SK, Watson CA, Chen L, Richards-Peterson LE. PubMed
  • Drug Metab Dispos. 2017, in press. In vitro interactions of epacadostat and its major metabolites with human efflux and uptake transporters: Implications for pharmacokinetics and drug interactions. Zhang Q, Zhang Y, Boer J, Shi JG, Hu P, Diamond S, Yeleswaram S. PubMed
  • Drug Metab Dispos. 2017;45:576-580. Novel method to predict in vivo liver-to-plasma Kpuu for OATP substrates using suspension hepatocytes. Riccardi K, Lin J, Li Z, Niosi M, Ryu S, Hua W, Atkinson K, Kosa RE, Litchfield J, Di L. PubMed
  •  Drug Metab Dispos. 2017;45:523-531. Assessing the risk of drug-induced cholestasis using unbound intrahepatic concentrations. Riede J, Poller B, Huwyler J, Camenisch G. PubMed
  • Drug Metab Dispos. 2017;45:441-448. Nimesulide and 4'-Hydroxynimesulide as bile acid transporters inhibitors are contributory factors for drug-induced cholestasis. Zhou L, Pang X, Jiang J, Zhong D, Chen X. PubMed
  • Drug Metab Dispos. 2017;45:409-417. Quantitative prediction of human renal clearance and drug-drug interactions of Organic Anion Transporter substrates using in vitro transport data: a relative activity factor approach. Mathialagan S, Piotrowski MA, Tess DA, Feng B, Litchfield J, Varma MV. PubMed
  • Drug Metab Dispos. 2017;45:353-360. Regional expression levels of drug transporters and metabolizing enzymes along the pig and human intestinal tract and comparison with Caco-2 cells. Vaessen SF, van Lipzig MM, Pieters RH, Krul CA, Wortelboer HM, van de Steeg E. PubMed
  • Drug Metab Dispos. 2017;45:246-259.  Specific inhibition of the distribution of Lobeglitazone to the liver by Atorvastatin in rats: evidence for a rat Organic Anion Transporting Polypeptide 1B2-mediated interaction in hepatic transport. Yim CS, Jeong YS, Lee SY, Pyeon W, Ryu HM, Lee JH, Lee KR, Maeng HJ, Chung SJ. PubMed
  • Drug Metab Dispos. 2017;45:166-173. Impact of Organic Cation Transporters (OCT-SLC22A) on differential diagnosis of intrahepatic lesions. Visentin M, van Rosmalen BV, Hiller C, Bieze M, Hofstetter L, Verheij J, Kullak-Ublick GA, Koepsell H, Phoa SS, Tamai I, Bennink RJ, van Gulik TM, Stieger B. PubMed
  • Drug Metab Dispos. 2017;45:228-236. Organic Anion Transporter 2: An enigmatic human Solute Carrier. Shen H, Lai Y, Rodrigues AD. PubMed
  • Drug Metab Dispos. 2017;45:190-197. Extrapolation of elementary rate constants of P-glycoprotein-mediated transport from MDCKII-hMDR1-NKI to Caco-2 cells. Meng Z, Ellens H, Bentz J. PubMed
  • Drug Metab Dispos. 2017;45:145-151. Microvilli morphology can affect efflux active P-Glycoprotein in confluent MDCKII -hMDR1-NKI and Caco-2 cell monolayers. Meng Z, Le Marchand S, Agnani D, Szapacs M, Ellens H, Bentz J. PubMed
  • Drug Metab Dispos. 2017;45:86-108. What can be learned from recent new drug applications? A systematic review of drug interaction data for drugs approved by the US FDA in 2015. Yu J, Zhou Z, Owens KH, Ritchie TK, Ragueneau-Majlessi I. PubMed
  • Drug Metab Dispos. 2017;45:27-34. Inhibition of intestinal OATP2B1 by the calcium receptor antagonist Ronacaleret results in a significant drug-drug interaction by causing a 2-Fold decrease in exposure of rosuvastatin. Johnson M, Patel D, Matheny C, Ho M, Chen L, Ellens H. PubMed
  • Drug Metab Dispos. 2017;45:569-575. Effect of garlic, Gingko, and St. John's Wort extracts on the pharmacokinetics of Fexofenadine: a mechanistic study. Turkanovic J, Ward MB, Gerber JP, Milne RW. PubMed
  • Drug Metab Dispos. 2017;45:390-398.  Application of Physiologically Based Pharmacokinetic Modeling to the understanding of Bosutinib pharmacokinetics: prediction of drug-drug and drug-disease interactions. Ono C, Hsyu PH, Abbas R, Loi CM, Yamazaki S. PubMed
  • Drug Metab Dispos. 2017;45:419-429. Transcriptional, functional, and mechanistic comparisons of Stem cell-derived hepatocytes, HepaRG cells, and three-dimensional human hepatocyte spheroids as predictive in vitro systems for drug-induced liver injury. Bell CC, Lauschke VM, Vorrink SU, Palmgren H, Duffin R, Andersson TB, Ingelman-Sundberg M. PubMed
  • Drug Metab Dispos. 2017 Apr;45:342-345. Intrinsic clearance assay incubational binding: a method comparison. Chen S, Prieto Garcia L, Bergström F, Nordell P, Grime K. PubMed
  • Drug Metab Dispos. 2017;45:224-227. Comparative evaluation of Dehydroepiandrosterone Sulfate potential to predict hepatic Organic Anion Transporting Polypeptide Transporter-based drug-drug interactions. Nishizawa K, Nakanishi T, Tamai I. PubMed