Transporter regulation and function

  • Clin Pharmacol Ther. 2020;107:628-638. Variability and heritability of Thiamine pharmacokinetics with focus on OCT1 effects on membrane transport and pharmacokinetics in humans. Jensen O, Matthaei J, Blome F, Schwab M, Tzvetkov MV, Brockmöller J. PubMed
  • Pharmacol Ther. 2020;In press. Novel insights into the organic solute transporter alpha/beta, OSTα/β: From the bench to the bedside. Beaudoin JJ, Brouwer KLR, Malinen MM.  PubMed
  • Eur J Pharm Sci. 2020;146:105264. Rheumatoid arthritis downregulates the drug transporter OATP1B1: Fluvastatin as a probe. Caris JA, Benzi JRL, de Souza FFL, de Oliveira RDR, Donadi EA, Lanchote VL. PubMed
  • Arch Toxicol. 2020;In press. Regulation of hepatic P-gp expression and activity by genistein in rats. Semeniuk M, Ceré LI, Ciriaci N, Bucci-Muñoz M, Villanueva SSM, Mottino AD, Catania VA, Rigalli JP, Ruiz ML. PubMed
  • J Pharmacol Exp Ther. 2020;In press. Hepatic transporter alterations by nuclear receptor agonist T0901317 in sandwich-cultured human hepatocytes: Proteomic analysis and PBPK modeling to evaluate drug-drug interaction risk. Ito K, Sjöstedt N, Malinen MM, Guo C, Brouwer KL. PubMed
  • Drug Metab Dispos. 2020;In press. Role of OATP2B1 in drug absorption and drug-drug interactions. Chen M, Hu S, Li Y, Gibson AA, Fu Q, Baker SD, Sparreboom A. PubMed
  • Toxicol Sci. 2020;In press. Lack of multidrug-resistance associated protein 4 prolongs partial hepatectomy-induced hepatic steatosis. Donepudi AC, Smith GJ, Aladelokun O, Lee Y, Toro SJ, Pfohl M, Slitt AL, Wang L, Lee JY, Schuetz JD, Manautou JE. PubMed
  • J Clin Pharmacol. 2020;In press. Influence of MRP3 genetics and hepatic expression ontogeny for morphine disposition in neonatal and pediatric patients. Hahn D, Fukuda T, Euteneuer JC, Mizuno T, Vinks AA, Sadhasivam S, Emoto C. PubMed
  • Biochem Pharmacol. 2020;174:113829 Nicotinic acid transport into human liver involves organic anion transporter 2 (SLC22A7). Mathialagan S, Bi YA, Costales C, Kalgutkar AS, Rodrigues AD, Varma MVS. PubMed
  • Br J Pharmacol. 2020;In press. Timing in drug absorption and disposition: The past, present, and future of chronopharmacokinetics. Bicker J, Alves G, Falcão A, Fortuna A. PubMed
  • Drug Metab Pharmacokinet. 2020;35:220-227. pH-dependent transport kinetics of the human organic anion-transporting polypeptide 1A2. Morita T, Akiyoshi T, Sato R, Katayama K, Yajima K, Kataoka H, Imaoka A, Sugimoto Y, Ohtani H. PubMed

System biology of transporters

  • Int J Mol Sci. 2020;21. pii: E1791. Systems biology analysis reveals eight SLC22 transporter subgroups, including OATs, OCTs, and OCTNs. Engelhart DC, Granados JC, Shi D, Saier MH, Baker ME, Abagyan R, Nigam SK. PubMed
  • Clin Pharmacol Ther. 2020;In press. The systems biology of drug metabolizing enzymes and transporters: Relevance to quantitative systems pharmacology. Nigam SK, Bush KT, Bhatnagar V, Poloyac SM, Momper JD. PubMed
  • J Biol Chem. 2020;295:1829-1842. Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning. Nigam AK, Li JG, Lall K, Shi D, Bush KT, Bhatnagar V, Abagyan R, Nigam SKPubMed.

Intercorrelation transporters-metabolic enzymes

  • Drug Metab Dispos. 2020;48:245-254. Quantitative proteomics of clinically relevant drug-metabolizing enzymes and drug transporters and their intercorrelations in the human small intestine. Couto N, Al-Majdoub ZM, Gibson S, Davies PJ, Achour B, Harwood MD, Carlson G, Barber J, Rostami-Hodjegan A, Warhurst G. PubMed

Liver diseases and transporters

  • Clin Liver Dis (Hoboken). 2020;15:91-94. Bile acid biology, pathophysiology, and therapeutics. Chiang JYL, Ferrell JM. PubMed
  • Clin Liver Dis (Hoboken). 2020;15:105-109. Inherited cholestatic diseases in the era of personalized medicine. Goldberg A, Mack CL. PubMed
  • Clin Liver Dis (Hoboken). 2020;15:110-114. The pathophysiology of cholestasis and its relevance to clinical practice. Onofrio FQ, Hirschfield GM. PubMed
  • Clin Liver Dis (Hoboken). 2020;15:95-99. Novel therapies for managing cholestasis. Santiago P, Levy C. PubMed
  • World J Hepatol. 2020;12:64-71. Nonsense variant of ATP8B1 gene in heterozygosis and benign recurrent intrahepatic cholestasis: A case report and review of literature. Piazzolla M, Castellaneta N, Novelli A, Agolini E, Cocciadiferro D, Resta L, Duda L, Barone M, Ierardi E, Di Leo A. PubMed

Transporter inhibition

  • Clin Pharmacol Ther. 2020;107:1004-1013. Dose-dependent inhibition of OATP1B by rifampicin in healthy volunteers: Comprehensive evaluation of candidate biomarkers and OATP1B probe drugs. Mori D, Kimoto E, Rago B, Kondo Y, King-Ahmad A, Ramanathan R, Wood LS, Johnson JG, Le VH, Vourvahis M, David Rodrigues A, Muto C, Furihata K, Sugiyama Y, Kusuhara H. PubMed
  • Clin Pharmacol Ther. 2020;In press. P-glycoprotein inhibition exacerbates Paclitaxel neurotoxicity in neurons and cancer patients. Stage TB, Mortensen C, Khalaf S, Steffensen V, Hammer HS, Xiong C, Nielsen F, Poetz O, Svenningsen ÅF, Rodriguez-Antona C, Kroetz DL. PubMed

In vitro models of hepatocytes

  • Biomed Res Int. 2020;2020:6354183. 3D culture system for liver tissue mimicking hepatic plates for improvement of human hepatocyte (C3A) function and polarity. Jia Z, Cheng Y, Jiang X, Zhang C, Wang G, Xu J, Li Y, Peng Q, Gao Y. PubMed
  • PLoS One. 2020;15:e0227751. The importance of transporters and cell polarization for the evaluation of human stem cell-derived hepatic cells. Török G, Erdei Z, Lilienberg J, Apáti Á, Homolya L. PubMed

Liver imaging

  • Mol Pharm. 2020;In press. Practical synthesis of [18F]pitavastatin and evaluation of hepatobiliary transport activity in rats by positron emission tomography. Nakaoka T, Uetake Y, Kaneko KI, Niwa T, Ochiai H, Irie S, Suezaki Y, Otsuka N, Hayashinaka E, Wada Y, Cui Y, Maeda K, Kusuhara H, Sugiyama Y, Hosoya T, Watanabe Y. PubMed
  • Acta Pharm Sin B. 2020;10:79-90. Targeting uptake transporters for cancer imaging and treatment. Zhang Y, Wang J. PubMed
  • Nucl Med Biol. 2020;84-85:33-37. Transport mechanism and affinity of [99mTc]mercaptoacetyltriglycine ([99mTc]MAG3) on the apical membrane of renal proximal tubule cells. Kobayashi M, Nishi K, Mizutani A, Okudaira H, Nakanishi T, Shikano N, Nishii R, Tamai I, Kawai K. PubMed