Hepatic clearance modelling

  • Drug Metab Dispos. 2020;48:537-543. Are there any experimental perfusion data that preferentially support the dispersion and parallel-tube models over the well-stirred model of organ elimination? Sodhi JK, Wang HJ, Benet LZ. PubMed
  • Clin Pharmacol Ther. 2020:In press. A simple methodology to differentiate changes in bioavailability from changes in clearance following oral dosing of metabolized drugs. Sodhi JK, Benet LZ. PubMed
  • Drug Metab Dispos. 2020;48:570-579. Investigating the role of altered systemic albumin concentration on the disposition of Theophylline in adult and pediatric patients with asthma by using the Physiologically Based Pharmacokinetic approach. Rasool MF, Khalid R, Imran I, Majeed A, Saeed H, Alasmari F, Alanazi MM, Alqahtani F. PubMed

DDI prediction

  • Pharm Res. 2020;37:73. Challenging the relevance of unbound tissue-to-blood partition coefficient (Kpuu) on prediction of Drug-Drug Interactions. Sodhi JK, Liu S, Benet LZ. PubMed
  • Pharmacotherapy. 2020;40:274-290. Predicting interactions between Rifampin and antihypertensive drugs using the Biopharmaceutics Drug Disposition Classification System. Liu W, Yan T, Chen K, Yang L, Benet LZ, Zhai S. PubMed

Transporters and liver toxicity

  • Toxicol Sci. 2020:kfaa052. Role of Organic Solute Transporter Alpha/Beta in hepatotoxic bile acid transport and drug interactions. Beaudoin JJ, Bezençon J, Sjöstedt N, Fallon JK, Brouwer KLR. PubMed
  • Expert Opin Drug Metab Toxicol. 2020;16:493-506. Role of SLC transporters in toxicity induced by anticancer drugs. Huang KM, Uddin ME, DiGiacomo D, Lustberg MB, Hu S, Sparreboom A. PubMed

Transporters and pesticides

  • Xenobiotica. 2020 Jun 4:1-13. Differential interactions of carbamate pesticides with drug transporters. Guéniche N, Bruyere A, Ringeval M, Jouan E, Huguet A, Le Hégarat L, Fardel O. PubMed

State-of-the-art on intestinal P-gp and hepatic OATP1B induction (ITC publication)

  • Clin Pharmacol Ther. 2020; In press. Intestinal P-gp and putative hepatic OATP1B induction: ITC perspective on drug development implications. Zamek-Gliszczynski MJ, Patel M, Yang X, Lutz JD, Chu X, Brouwer KLR, Lai Y, Lee CA, Neuhoff S, Paine MF, Sugiyama Y, Taskar KS, Galetin A. PubMed

Mechanistic models of creatinine kinetics

  • CPT Pharmacometrics Syst Pharmacol. 2020;9:282-293. Mechanistic models as framework for understanding biomarker disposition: Prediction of creatinine-drug interactions. Scotcher D, Arya V, Yang X, Zhao P, Zhang L, Huang SM, Rostami-Hodjegan A, Galetin APubMed

Drug concentrations in tissues

  • Clin Pharmacol Ther. 2020;107:1045-1047. Novel technologies enable mechanistic understanding and modeling of drug exposure and response. Giacomini KM. PubMed
  • Pharmacol Res Perspect. 2020;8:e00597. Metabolism and disposition of oseltamivir (OS) in rats, determined by immunohistochemistry with monospecific antibody for OS or its active metabolite oseltamivir carboxylate (OC): A possibility of transporters dividing the drug excretion into the bile and kidney. Fujiwara K, Yamamoto Y, Saita T, Matsufuji S. PubMed

Transporters and liver disease

  • Int J Mol Sci. 2020;21:1606. Monocarboxylate Transporter 1 (MCT1) in liver pathology. Droździk M, Szeląg-Pieniek S, Grzegółkowska J, Łapczuk-Romańska J, Post M, Domagała P, Miętkiewski J, Oswald S, Kurzawski M.  PubMed
  • Biochem Pharmacol. 2020;174:113780. Interaction of Oatp1b2 expression and nonalcoholic steatohepatitis on pravastatin plasma clearance. Toth EL, Clarke JD, Csanaky IL, Cherrington NJ. PubMed

Physiology and pathophysiology handling of bilirubin

  • Physiol Rev. 2020;100:1291-1346. Molecular physiology and pathophysiology of bilirubin handling by the blood, liver, intestine, and brain in the newborn. Hansen TWR, Wong RJ, Stevenson DK. PubMed

Transporter regulation and function

  • Eur J Pharm Sci. 2020 May 29;151. Fluorescent probes for the dual investigation of MRP2 and OATP1B1 function and drug interactions. Székely V, Patik I, Ungvári O, Telbisz Á, Szakács G, Bakos É, Özvegy-Laczka C. PubMed
  • Arch Toxicol. 2020;in press. Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates. Koenderink JB, van den Heuvel JJMW, Bilos A, Vredenburg G, Vermeulen NPE, Russel FGM. PubMed
  • Drug Metab Dispos. 2020;In press. OATP1B3 expression and function is modulated by co-expression with OCT1, OATP1B1, and NTCP. Zhang Y, Ruggiero M, Hagenbuch B. PubMed
  • Int J Mol Sci. 2020;21:2202. Apical Sodium-Dependent Bile Acid Cotransporter, a novel transporter of Indocyanine Green, and its application in drug screening. Wu MR, Hsiao JK. PubMed
  • Toxicol Appl Pharmacol. 2020;399:115039. Elucidation of OATP1B1 and 1B3 transporter function using transgenic rodent models and commonly known single nucleotide polymorphisms. Choudhuri S, Klaassen CD. PubMed
  • Acta Pharm Sin B. 2020;10:850-860 Characterization of organic anion transporting polypeptide 1b2 knockout rats generated by CRISPR/Cas9: a novel model for drug transport and hyperbilirubinemia disease. Ma X, Shang X, Qin X, Lu J, Liu M, Wang X. PubMed
  • Mol Pharm. 2020;17:1987-1995. OATP1A2 and OATP2B1 are interacting with Dopamine-Receptor agonists and antagonists. Schäfer AM, Meyer Zu Schwabedissen HE, Bien-Möller S, Hubeny A, Vogelgesang S, Oswald S, Grube M. PubMed
  • Mol Pharm. 2020;17:748-756. Interactions of oral molecular excipients with Breast Cancer Resistance Protein, BCRP. Zou L, Pottel J, Khuri N, Ngo HX, Ni Z, Tsakalozou E, Warren MS, Huang Y, Shoichet BK, Giacomini KM. PubMed

Liver imaging

  • Pharmaceutics. 2020;12:E486. Validation of pharmacological protocols for targeted Inhibition of canalicular MRP2 activity in hepatocytes using [99mTc]mebrofenin imaging in rats. Marie S, Hernández-Lozano I, Breuil L, Saba W, Novell A, Gennisson JL, Langer O, Truillet C, Tournier N. PubMed