Bile acid transport

  • JHEP Rep. 2021;3:100288. Hepatic bile acid transport increases in the postprandial state: A functional 11C-CSar PET/CT study in healthy humans. Ørntoft NW, Gormsen LC, Keiding S, Munk OL, Ott P, Sørensen M. PubMed
  • J Hepatol. 2021;75:190-201. Bile formation and secretion: An update. Boyer JL, Soroka CJ. PubMed
  • Chem Biol Interact. 2021;In press. Metformin impairs bile acid homeostasis in ethinylestradiol-induced cholestasis in mice. Faradonbeh FA, Sa II, Lastuvkova H, Cermanova J, Hroch M, Faistova H, Mokry J, Nova Z, Uher M, Nachtigal P, Pavek P, Micuda S. PubMed
  • Biochim Biophys Acta Mol Cell Biol Lipids. 2021;1866:158960. Molecular regulation of the hepatic bile acid uptake transporter and HBV entry receptor NTCP. Appelman MD, Wettengel JM, Protzer U, Oude Elferink RPJ, van de Graaf SFJ. PubMed
  • Matye DJ, Li Y, Chen C, Chao X, Wang H, Ni H, Ding WX, Li T. Gut-restricted apical sodium-dependent bile acid transporter inhibitor attenuates alcohol-induced liver steatosis and injury in mice. Alcohol Clin Exp Res. 2021;In press. PubMed
  • Biochimie. 2021;In press. Aquaporin gene transfer for hepatocellular cholestasis. Marrone J, Danielli M, Gaspari CI, Capiglioni AM, Marinelli RA. PubMed
  • J Pharmacol Exp Ther. 2021;377:346-357. Characterization of vovel fluorescent bile salt derivatives for studying human Bile Salt and Organic Anion Transporters. Leuenberger M, Häusler S, Höhn V, Euler A, Stieger B, Lochner M. PubMed
  • Am J Physiol Gastrointest Liver Physiol. 2021;In press. Dynamics of the enterohepatic circulation of bile acids in healthy humans. Stellaard F, Lütjohann D. Pubmed

Renal clearance and transporters

  • Drug Metab Dispos. 2020;49:470-478. In vivo-to-in vitro extrapolation of transporter-mediated renal clearance: Relative expression factor versus relative activity factor approach. Kumar AR, Prasad B, Bhatt DK, Mathialagan S, Varma MVS, Unadkat JD. PubMed  

Cu,cell and Kpuu

  • Expert Opin Drug Metab Toxicol. 2021;In press. Evolving approaches on measurements and applications of intracellular free drug concentration and Kpuu in drug discovery. Di L, Riccardi K, Tess D. PubMed

Experimental models

  • Nat Commun. 2021;12:3390. Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo. Tanimizu N, Ichinohe N, Sasaki Y, Itoh T, Sudo R, Yamaguchi T, Katsuda T, Ninomiya T, Tokino T, Ochiya T, Miyajima A, Mitaka T. Pubmed
  • Arch Toxicol. 2021;In press. Assessment of long-term functional maintenance of primary human hepatocytes to predict drug-induced hepatoxicity in vitro. Chen Y, Tang D, Wu H, Wu Y, Yuan T, Zhang H, Jiao Y, Yu W, Yan H. PubMed
  • Biotechnol Bioeng. 2021;In press. Bioengineering of a CLiP-derived tubular biliary-duct-like structure for bile transport in vitro. Huang Y, Sakai Y, Hara T, Katsuda T, Ochiya T, Gu WL, Miyamoto D, Hamada T, Hidaka M, Kanetaka K, Adachi T, Eguchi S. PubMed
  • Clin Pharmacol Ther. 2021;110:248-258. Exploring the use of serum-derived small extracellular vesicles as liquid biopsy to study the induction of hepatic cytochromes P450 and Organic Anion Transporting Polypeptides. Rodrigues AD, van Dyk M, Sorich MJ, Fahmy A, Useckaite Z, Newman LA, Kapetas AJ, Mounzer R, Wood LS, Johnson JG, Rowland A. PubMed

Sinusoidal endothelial cells and liver disease

  • Nat Rev Gastroenterol Hepatol. 2021;18:411-431. Role of liver sinusoidal endothelial cells in liver diseases. Gracia-Sancho J, Caparrós E, Fernández-Iglesias A, Francés R. PubMed

Simulations of liver and systemic concentrations

  • Clin Transl Sci. 2021;In press. Application of a PBPK model to elucidate the changes of systemic and liver exposures for rosuvastatin, carotegrast, and bromfenac followed by OATP inhibition in monkeys. Cheng Y, Liang X, Hao J, Niu C, Lai Y. PubMed

Regeneration and DILI

  • Food Res Int. 2021;142:110185. Resveratrol promotes liver regeneration in drug-induced liver disease in mice. de Moraes ACN, de Andrade CBV, Ramos IPR, Dias ML, Batista CMP, Pimentel CF, de Carvalho JJ, Goldenberg RCDS. PubMed


  • Clin Pharmacol Ther. 2021;110:141-148. Hypoglycemia and glycemic control with Glyburide in women with gestational diabetes and genetic variants of Cytochrome P450 2C9 and/or OATP1B3. Bouchghoul H, Bouyer J, Senat MV, Mandelbrot L, Letourneau A, Bourcigaux N, Becquemont L, Verstuyft C. PubMed
  • Clin Pharmacol Ther. 2021;In press. Effect of SLCO1B1 T521C on statin-related myotoxicity with use of Lovastatin and Atorvastatin. Lu B, Sun L, Seraydarian M, Hoffmann TJ, Medina MW, Iribarren C, Krauss RM, Risch N, Oni-Orisan A. PubMed


  • Xenobiotica. 2021;In press. Rutaecarpine enhances the anti-diabetic activity and hepatic distribution of metformin via up-regulation of Oct1 in diabetic rats. Song XM, Li BJ, Zhang YY, Ge WJ, Zhang SF, Cui WF, Li GS, Liang RF. PubMed
  • Front Pharmacol. 2021;12:662535. Transport of drugs and endogenous compounds mediated by human OCT1: Studies in single- and double-transfected cell models. Haberkorn B, Fromm MF, König J. PubMed
  • Front Pharmacol. 2021;11:607613. Regulation mechanisms of expression and function of Organic Cation Transporter 1. Ciarimboli G. PubMed


  • Eur J Pharm Sci. 2021;162:105814. Role of organic anion transporter 3 in the renal excretion of biapenem and potential drug-drug interactions. Li W, Jiao Z, Liu Y, Yao J, Li G, Dong J. PubMed


  • J Lipid Res. 2021;In press. Monomeric bile acids modulate the ATPase activity of detergent-solubilized ABCB4/MDR3. Kroll T, Smits SHJ, Schmitt L. PubMed
  • J Hepatol. 2021;74:1416-1428. Synthetic human ABCB4 mRNA therapy rescues severe liver disease phenotype in a BALB/c.Abcb4-/- mouse model of PFIC3. Wei G, Cao J, Huang P, An P, Badlani D, Vaid KA, Zhao S, Wang DQ, Zhuo J, Yin L, Frassetto A, Markel A, Presnyak V, Gandham S, Hua S, Lukacs C, Finn PF, Giangrande PH, Martini PGV, Popov YV. PubMed

Regulation of canalicular transporters

  • Int J Mol Sci. 2021;22:2113. Molecular regulation of canalicular ABC transporters. Ben Saad A, Bruneau A, Mareux E, Lapalus M, Delaunay JL, Gonzales E, Jacquemin E, Aït-Slimane T, Falguières T. PubMed
  • Eur J Pharm Sci. 2021;163:105854. Influence of ABC transporters on the excretion of ciprofloxacin assessed with PET imaging in mice. Hernández-Lozano I, Wanek T, Sauberer M, Filip T, Mairinger S, Stanek J, Traxl A, Karch R, Schuetz JD, Langer O. Pubmed