2021 JUNE
Bile acid transport
JHEP Rep. 2021;3:100288. Hepatic bile acid transport increases in the postprandial state: A functional 11C-CSar PET/CT study in healthy humans. Ørntoft NW, Gormsen LC, Keiding S, Munk OL, Ott P, Sørensen M. PubMed
J Hepatol. 2021;75:190-201. Bile formation and secretion: An update. Boyer JL, Soroka CJ. PubMed
Chem Biol Interact. 2021;In press. Metformin impairs bile acid homeostasis in ethinylestradiol-induced cholestasis in mice. Faradonbeh FA, Sa II, Lastuvkova H, Cermanova J, Hroch M, Faistova H, Mokry J, Nova Z, Uher M, Nachtigal P, Pavek P, Micuda S. PubMed
Biochim Biophys Acta Mol Cell Biol Lipids. 2021;1866:158960. Molecular regulation of the hepatic bile acid uptake transporter and HBV entry receptor NTCP. Appelman MD, Wettengel JM, Protzer U, Oude Elferink RPJ, van de Graaf SFJ. PubMed
Alcohol Clin Exp Res. 2021;In press. Gut-restricted apical sodium-dependent bile acid transporter inhibitor attenuates alcohol-induced liver steatosis and injury in mice. Matye DJ, Li Y, Chen C, Chao X, Wang H, Ni H, Ding WX, Li T. PubMed
Biochimie. 2021;In press. Aquaporin gene transfer for hepatocellular cholestasis. Marrone J, Danielli M, Gaspari CI, Capiglioni AM, Marinelli RA. PubMed
J Pharmacol Exp Ther. 2021;377:346-357. Characterization of vovel fluorescent bile salt derivatives for studying human Bile Salt and Organic Anion Transporters. Leuenberger M, Häusler S, Höhn V, Euler A, Stieger B, Lochner M. PubMed
Am J Physiol Gastrointest Liver Physiol. 2021;In press. Dynamics of the enterohepatic circulation of bile acids in healthy humans. Stellaard F, Lütjohann D. Pubmed
Renal clearance and transporters
Drug Metab Dispos. 2020;49:470-478. In vivo-to-in vitro extrapolation of transporter-mediated renal clearance: Relative expression factor versus relative activity factor approach. Kumar AR, Prasad B, Bhatt DK, Mathialagan S, Varma MVS, Unadkat JD. PubMed
Cu,cell and Kpuu
Expert Opin Drug Metab Toxicol. 2021;In press. Evolving approaches on measurements and applications of intracellular free drug concentration and Kpuu in drug discovery. Di L, Riccardi K, Tess D. PubMed
Experimental models
Nat Commun. 2021;12:3390. Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo. Tanimizu N, Ichinohe N, Sasaki Y, Itoh T, Sudo R, Yamaguchi T, Katsuda T, Ninomiya T, Tokino T, Ochiya T, Miyajima A, Mitaka T. Pubmed
Arch Toxicol. 2021;In press. Assessment of long-term functional maintenance of primary human hepatocytes to predict drug-induced hepatoxicity in vitro. Chen Y, Tang D, Wu H, Wu Y, Yuan T, Zhang H, Jiao Y, Yu W, Yan H. PubMed
Biotechnol Bioeng. 2021;In press. Bioengineering of a CLiP-derived tubular biliary-duct-like structure for bile transport in vitro. Huang Y, Sakai Y, Hara T, Katsuda T, Ochiya T, Gu WL, Miyamoto D, Hamada T, Hidaka M, Kanetaka K, Adachi T, Eguchi S. PubMed
Clin Pharmacol Ther. 2021;110:248-258. Exploring the use of serum-derived small extracellular vesicles as liquid biopsy to study the induction of hepatic cytochromes P450 and Organic Anion Transporting Polypeptides. Rodrigues AD, van Dyk M, Sorich MJ, Fahmy A, Useckaite Z, Newman LA, Kapetas AJ, Mounzer R, Wood LS, Johnson JG, Rowland A. PubMed
Sinusoidal endothelial cells and liver disease
Nat Rev Gastroenterol Hepatol. 2021;18:411-431. Role of liver sinusoidal endothelial cells in liver diseases. Gracia-Sancho J, Caparrós E, Fernández-Iglesias A, Francés R. PubMed
Simulations of liver and systemic concentrations
Clin Transl Sci. 2021;In press. Application of a PBPK model to elucidate the changes of systemic and liver exposures for rosuvastatin, carotegrast, and bromfenac followed by OATP inhibition in monkeys. Cheng Y, Liang X, Hao J, Niu C, Lai Y. PubMed
Regeneration and DILI
Food Res Int. 2021;142:110185. Resveratrol promotes liver regeneration in drug-induced liver disease in mice. de Moraes ACN, de Andrade CBV, Ramos IPR, Dias ML, Batista CMP, Pimentel CF, de Carvalho JJ, Goldenberg RCDS. PubMed
OATP
Clin Pharmacol Ther. 2021;110:141-148. Hypoglycemia and glycemic control with Glyburide in women with gestational diabetes and genetic variants of Cytochrome P450 2C9 and/or OATP1B3. Bouchghoul H, Bouyer J, Senat MV, Mandelbrot L, Letourneau A, Bourcigaux N, Becquemont L, Verstuyft C. PubMed
Clin Pharmacol Ther. 2021;In press. Effect of SLCO1B1 T521C on statin-related myotoxicity with use of Lovastatin and Atorvastatin. Lu B, Sun L, Seraydarian M, Hoffmann TJ, Medina MW, Iribarren C, Krauss RM, Risch N, Oni-Orisan A. PubMed
OCT1
Xenobiotica. 2021;In press. Rutaecarpine enhances the anti-diabetic activity and hepatic distribution of metformin via up-regulation of Oct1 in diabetic rats. Song XM, Li BJ, Zhang YY, Ge WJ, Zhang SF, Cui WF, Li GS, Liang RF. PubMed
Front Pharmacol. 2021;12:662535. Transport of drugs and endogenous compounds mediated by human OCT1: Studies in single- and double-transfected cell models. Haberkorn B, Fromm MF, König J. PubMed
Front Pharmacol. 2021;11:607613. Regulation mechanisms of expression and function of Organic Cation Transporter 1. Ciarimboli G. PubMed
OAT3
Eur J Pharm Sci. 2021;162:105814. Role of organic anion transporter 3 in the renal excretion of biapenem and potential drug-drug interactions. Li W, Jiao Z, Liu Y, Yao J, Li G, Dong J. PubMed
ABCB4
J Lipid Res. 2021;In press. Monomeric bile acids modulate the ATPase activity of detergent-solubilized ABCB4/MDR3. Kroll T, Smits SHJ, Schmitt L. PubMed
J Hepatol. 2021;74:1416-1428. Synthetic human ABCB4 mRNA therapy rescues severe liver disease phenotype in a BALB/c.Abcb4-/- mouse model of PFIC3. Wei G, Cao J, Huang P, An P, Badlani D, Vaid KA, Zhao S, Wang DQ, Zhuo J, Yin L, Frassetto A, Markel A, Presnyak V, Gandham S, Hua S, Lukacs C, Finn PF, Giangrande PH, Martini PGV, Popov YV. PubMed
Regulation of canalicular transporters
Int J Mol Sci. 2021;22:2113. Molecular regulation of canalicular ABC transporters. Ben Saad A, Bruneau A, Mareux E, Lapalus M, Delaunay JL, Gonzales E, Jacquemin E, Aït-Slimane T, Falguières T. PubMed
Eur J Pharm Sci. 2021;163:105854. Influence of ABC transporters on the excretion of ciprofloxacin assessed with PET imaging in mice. Hernández-Lozano I, Wanek T, Sauberer M, Filip T, Mairinger S, Stanek J, Traxl A, Karch R, Schuetz JD, Langer O. Pubmed