2021 APRIL: RECENT PUBLICATIONS

Transporters of bile acids

  • Drug Metab Dispos. 2021;49:314-321. Function and expression of Bile Salt Export Pump in suspension human hepatocytes. Chothe PP, Pemberton R, Hariparsad N. PubMed
  • J Pharmacol Exp Ther. 2021;In press. Characterization of novel fluorescent Bile Salt derivatives for studying human bile salt and organic anion transporters. Leuenberger M, Häusler S, Höhn V, Euler A, Stieger B, Lochner M. PubMed
  • Drug Metab Dispos. 2021;49:353-360. Identification of Triterpene acids in Poria cocos extract as bile acid uptake transporter inhibitors. Cai H, Cheng Y, Zhu Q, Kong D, Chen X, Tamai I, Lu Y. PubMed

Prediction of human brain kp,uu

  • Clin Pharmacol Ther. 2021;In press. Successful prediction of human brain Kp,uu of P-gp substrates using the proteomics-informed relative expression factor approach. Storelli F, Anoshchenko O, Unadkat JD. PubMed

Liver and renal imaging

  • Nucl Med Biol. 2021;94-95:92-97. Assessment of drug transporters involved in the urinary secretion of [99mTc]dimercaptosuccinic acid. Kobayashi M, Mizutani A, Okamoto T, Muranaka Y, Nishi K, Nishii R, Shikano N, Nakanishi T, Tamai I, Kleinerman ES, Kawai K. PubMed
  • J Nucl Med. 2021;In press. Repurposing 99mTc-mebrofenin as a probe for molecular imaging of hepatocyte transporters. Marie S, Hernandez-Lozano I, Langer O, Tournier N. PubMed

COVID19 and transporter-mediated DDI

  • Clin Pharmacol Ther. 2021;In press. Drugs in COVID19 clinical trials: Predicting transporter-mediated drug-drug interactions using in vitro assays and real-world data. Yee SW, Vora B, Oskotsky TT, Zou L, Jakobsen S, Enogieru OJ, Koleske ML, Kosti I, Rödin M, Sirota M, Giacomini KM. PubMed

Genetics and drug transporters

  • Drug Metab Pharmacokinet. 2021;In press. Current progress in identifying endogenous biomarker candidates for drug transporter phenotyping and their potential application to drug development. Mochizuki T, Mizuno T, Maeda K, Kusuhara H. PubMed
  • Drug Metab Pharmacokinet. 2021;In press. Update on next generation sequencing of pharmacokinetics-related genes: Development of the PKseq panel, a platform for amplicon sequencing of drug-metabolizing enzyme and drug transporter genes. Fukunaga K, Momozawa Y, Mushiroda T. PubMed
  • Drug Metab Dispos. 2021;49:395-404. SLCO1B1: Application and limitations of deep mutational scanning for genomic missense variant function. Zhang L, Sarangi V, Ho MF, Moon I, Kalari KR, Wang L, Weinshilboum RM. PubMed

Quantification of drug transporters

  • J Pharm Sci. 2021;In press. Ultrasensitive quantification of drug-metabolizing enzymes and transporters in small sample volume by microflow LC-MS/MS. Ahire DS, Basit A, Karasu M, Prasad B. PubMed

Transporter-mediated drug interactions

  • Eur J Pharm Sci. 2021;In press. Identification of novel inhibitors of rat Mrp3. De Vocht T, Buyck C, Deferm N, Qi B, Van Brantegem P, van Vlijmen H, Snoeys J, Hoeben E, Vermeulen A, Annaert P. PubMed
  • Pharmacol Res Perspect. 2021;9:e00748. In vitro cytochrome P450- and transporter-mediated drug interaction potential of 6β-hydroxy-21-desacetyl deflazacort - A major human metabolite of deflazacort. Ma J, Beers B, Manohar R, Roe S, Colacino JM, Kong R. PubMed
  • Curr Drug Metab. 2021;In press. Absorption, metabolism, distribution, and excretion of Letermovir. Menzel K, Kothare P, McCrea JB, Chu X, Kropeit D. PubMed
  • J Pharm Sci. 2021;In press. Effects of Probenecid on hepatic and renal disposition of Hexadecanedioate, an endogenous substrate of Organic Anion Transporting Polypeptide 1B in rats. Futatsugi A, Masuo Y, Kato Y. PubMed
  • J Viral Hepat. 2021;In press. Clinical effects of NTCP-inhibitor myrcludex B. Cheng D, Han B, Zhang W, Wu W. PubMed
  • Drug Metab Dispos. 2021;49:389-394. Clinical investigation of metabolic and renal clearance pathways contributing to the elimination of Fevipiprant using probenecid as perpetrator. Weiss HM, Langenickel T, Cain M, Kulkarni S, Shah B, Vemula J, Rahmanzadeh G, Poller B. PubMed
  • Clin Pharmacol Ther. 2021;In press. The effects of single dose Rifampin on the pharmacokinetics of Fluvastatin in healthy volunteers. Xiang Y, Okochi H, Kozachenko I, Sodhi JK, Frassetto LA, Benet LZ. PubMed
  • J. Clin Pharmacokinet. 2021;In press. Clinical investigation on endogenous biomarkers to predict strong OAT-mediated Drug-Drug Interactions. Willemin ME, Van Der Made TK, Pijpers I, Dillen L, Kunze A, Jonkers S, Steemans K, Tuytelaars A, Jacobs F, Monshouwer M, Scotcher D, Rostami-Hodjegan A, Galetin A, Snoeys. PubMed

Multicellular liver microtissues

  • Small. 2021;In press. Bioengineered multicellular liver microtissues for modeling advanced hepatic fibrosis driven through Non-Alcoholic Fatty Liver Disease. Cho HJ, Kim HJ, Lee K, Lasli S, Ung A, Hoffman T, Nasiri R, Bandaru P, Ahadian S, Dokmeci MR, Lee J, Khademhosseini A. PubMed

Transporter regulation

  • Clin Cancer Res. 2021;In press. Regulation of OATP1B1 function by tyrosine kinase-mediated phosphorylation. Hayden E, Chen M, Pasquariello KZ, Gibson AA, Petti JJ, Shen S, Qu J, Ong SS, Chen T, Jin Y, Uddin ME, Huang KM, Paz A, Sparreboom A, Hu S, Sprowl JA. PubMed
  • Front Pharmacol. 2021;11:620197. Transporter gene regulation in Sandwich Cultured Human Hepatocytes through the activation of constitutive androstane receptor (CAR) or Aryl Hydrocarbon receptor (AhR). Niu C, Smith B, Lai Y. PubMed

Hepatic clearance and IVIVE

  • J Med Chem. 2021;64:3546-3559. Successful and unsuccessful prediction of human hepatic clearance for lead optimization. Sodhi JK, Benet LZ. PubMed