SPECIAL ISSUES

CMMI 2018

Editorial. Liver imaging and hepatobiliary contrast media. Catherine M. Pastor, Oliver Langer, and Bernard E. Van Beers. CMMI

Preclinical evaluation of [18F]LCATD as a PET tracer to study drug-drug interactions caused by inhibition of hepatic transporters. Andrea Testa, Sergio Dall’Angelo, Marco Mingarelli, Andrea Augello, Lutz Schweiger, Andrew Welch, Charles S. Elmore, Dana Dawson, Pradeep Sharma, and Matteo Zanda. CMMI 

Noninvasive monitoring of liver disease regression after Hepatitis C eradication using Gadoxetic acid-enhanced MRI. Lukas Haider, Mattias Mandorfer, Zeynep Güngören, Thomas Reiberger, Nina Bastati, Jacqueline C. Hodge, David Chromy, Michael Trauner, Christian Herold, Markus Peck-Radosavljevic, and Ahmed Ba-Ssalamah. CMMI

Isolated perfused rat livers to quantify the pharmacokinetics and concentrations of Gd-BOPTA. Catherine M. Pastor. CMMI

Physiologically Based Pharmacokinetic modelling with dynamic PET data to study the in vivo effects of transporter inhibition on hepatobiliary clearance in mice. Marco F. Taddio, Linjing Mu, Claudia Keller, Roger Schibli, and Stefanie D. Krämer. CMMI

Positron Emission Tomography imaging reveals an importance of saturable liver uptake transport for the pharmacokinetics of metoclopramide. Fabien Caillé, Sébastien Goutal, Solène Marie, Sylvain Auvity, Salvatore Cisternino, Bertrand Kuhnast, Géraldine Pottier, and Nicolas Tournier. CMMI

Evaluating hepatobiliary transport with 18F-labeled bile acids: The effect of radiolabel position and bile acid structure on radiosynthesis and in vitro and in vivo performance. Stef De Lombaerde, Ken Kersemans, Sara Neyt, Jeroen Verhoeven, Christian Vanhove, and Filip De Vos. CMMI

Assessment of liver function using pharmacokinetic parameters of Gd-EOB-DTPA: experimental study in rat hepatectomy model. Myung-Won You, Hyoung Jung Kim, Hyeong-Seok Lim, So Yeon Kim, Jae Ho Byun, Kyung Won Kim, Dae Wook Hwang, and Young-Joo Lee. CMMI