Drug Metabolism and Disposition 2016 SITE

  • Drug Metab Dispos. 2016;44:916-23. Challenges and opportunities for increasing the knowledge base related to drug biotransformation and pharmacokinetics during growth and development. Leeder JS, Meibohm B. PubMed
  • Drug Metab Dispos. 2016;44:992-8. Ontogeny of hepatic drug transporters and relevance to drugs used in pediatrics. Elmorsi Y, Barber J, Rostami-Hodjegan A. PubMed
  • Drug Metab Dispos. 2016;44:1005-13. Proteomic analysis of the developmental trajectory of human hepatic membrane transporter proteins in the first three months of life. Mooij MG, van de Steeg E, van Rosmalen J, Windster JD, de Koning BA, Vaes WH, van Groen BD, Tibboel D, Wortelboer HM, de Wildt SN. PubMed
  • Drug Metab Dispos. 2016;44:1014-9. Human intestinal PEPT1 transporter expression and localization in preterm and term infants. Mooij MG, de Koning BE, Lindenbergh-Kortleve DJ, Simons-Oosterhuis Y, van Groen BD, Tibboel D, Samsom JN, de Wildt SN. PubMed
  • Drug Metab Dispos. 2016;44:1050-60. Kidney versus liver specification of SLC and ABC drug transporters, tight junction molecules, and miomarkers. Martovetsky G, Bush KT, Nigam SK. PubMed
  • Drug Metab Dispos. 2016;44:1090-8. How does in vivo biliary elimination of drugs change with age? Evidence from in vitro and clinical data using a systems pharmacology approach. Johnson TN, Jamei M, Rowland-Yeo K. PubMed
  • Drug Metab Dispos. 2016;44:1099-102. Considering age variation when coining drugs as high versus low hepatic extraction ratio. Salem F, Abduljalil K, Kamiyama Y, Rostami-Hodjegan A. PubMed
  • Drug Metab Dispos. 2016;44:1116-22.  Population pharmacokinetics of oral Topotecan in infants and very young children with brain tumors demonstrates a role of ABCG2 rs4148157 on the absorption rate constant. Roberts JK, Birg AV, Lin T, Daryani VM, Panetta JC, Broniscer A, Robinson GW, Gajjar AJ, Stewart CF. PubMed
  • Drug Metab Dispos. 2016;44:1061-5. Correlation between conjugated Bisphenol A concentrations and efflux transporter expression in human fetal livers. Moscovitz JE, Nahar MS, Shalat SL, Slitt AL, Dolinoy DC, Aleksunes LM. PubMed