Drug Metabolism and Disposition (May 2018)

Special section on transporters in drug disposition and pharmacokinetic prediction

  • Drug Metab Dispos. 2018;46:561-566. Drug transporters in xenobiotic disposition and pharmacokinetic prediction. Mao Q, Lai Y, Wang J. PubMed
  • Drug Metab Dispos. 2018;46:567-580. Beyond competitive inhibition: Regulation of ABC transporters by kinases and protein-protein interactions as potential mechanisms of drug-drug interactions. Crawford RR, Potukuchi PK, Schuetz EG, Schuetz JD. PubMed
  • Drug Metab Dispos. 2018;46:581-591. Hepatic transport of 25-Hydroxyvitamin D3 conjugates: a mechanism of 25-Hydroxyvitamin D3 delivery to the intestinal tract. Gao C, Liao MZ, Han LW, Thummel KE, Mao Q. PubMed
  • Drug Metab Dispos. 2018;46:592-599. Expression of Organic Anion Transporter 1 or 3 in human kidney proximal tubule cells reduces Cisplatin sensitivity. Nieskens TTG, Peters JGP, Dabaghie D, Korte D, Jansen K, Van Asbeck AH, Tavraz NN, Friedrich T, Russel FGM, Masereeuw R, Wilmer MJ. PubMed
  • Drug Metab Dispos. 2018;46:610-618. Liver zonation index of drug transporter and metabolizing enzyme protein expressions in mouse liver acinus. Tachikawa M, Sumiyoshiya Y, Saigusa D, Sasaki K, Watanabe M, Uchida Y, Terasaki T. PubMed
  • Drug Metab Dispos. 2018;46:636-642. Rare variants in the ABCG2 promoter modulate in vivo activity. Eclov RJ, Kim MJ, Smith R, Ahituv N, Kroetz DL. PubMed
  • Drug Metab Dispos. 2018;46:643-651. Identification of a NFκB inhibition site on the proximal promoter region of human Organic Anion Transporting Polypeptide 1A2 coding gene SLCO1A2. Xiang Z, Li W, Wang L, Yi J, Chen K, Hong M. PubMed
  • Drug Metab Dispos. 2018;46:652-657. Organic Anion Transporting Polypeptide 1a4 is responsible for the hepatic uptake of cardiac glycosides in mice. Takano J, Maeda K, Kusuhara H, Sugiyama Y. PubMed
  • Drug Metab Dispos. 2018;46:680-691. Sandwich-Cultured Hepatocytes for mechanistic understanding of hepatic disposition of parent drugs and metabolites by transporter-enzyme interplay. Matsunaga N, Fukuchi Y, Imawaka H, Tamai. PubMed
  • Drug Metab Dispos. 2018;46:692-696. Comparison of proteomic quantification approaches for hepatic drug transporters: multiplexed global quantitation correlates with targeted proteomic quantitation. Vildhede A, Nguyen C, Erickson BK, Kunz RC, Jones R, Kimoto E, Bourbonais F, Rodrigues AD, Varma MVS. PubMed
  • Drug Metab Dispos. 2018;46:697-703. MRP2 inhibition by HIV protease inhibitors in rat and human hepatocytes: a quantitative confocal microscopy study. Holmstock N, Oorts M, Snoeys J, Annaert P. PubMed
  • Drug Metab Dispos. 2018;46:704-718. Intravital multiphoton microscopy with fluorescent bile salts in rats as an in vivo biomarker for hepatobiliary transport inhibition. Ryan J, Morgan RE, Chen Y, Volak LP, Dunn RT, Dunn KW. PubMed
  • Drug Metab Dispos. 2018;46:719-728. Imaging. A clinical quantitative evaluation of hepatobiliary transport of [11C]Dehydropravastatin in humans using Positron Emission Tomography. Kaneko KI, Tanaka M, Ishii A, Katayama Y, Nakaoka T, Irie S, Kawahata H, Yamanaga T, Wada Y, Miyake T, Toshimoto K, Maeda K, Cui Y, Enomoto M, Kawamura E, Kawada N, Kawabe J, Shiomi S, Kusuhara H, Sugiyama Y, Watanabe Y. PubMed
  • Drug Metab Dispos. 2018;46:729-739. Navigating transporter sciences in pharmacokinetics characterization using the Extended Clearance Classification System. El-Kattan AF, Varma MVS. PubMed
  • Drug Metab Dispos. 2018;46:740-748. Physiologically based pharmacokinetic modeling of Bosentan identifies the saturable hepatic uptake as a major contributor to its nonlinear pharmacokinetics. Sato M, Toshimoto K, Tomaru A, Yoshikado T, Tanaka Y, Hisaka A, Lee W, Sugiyama Y. PubMed
  • Drug Metab Dispos. 2018;46:749-757. Evaluation of alteration in hepatic and intestinal BCRP function in vivo from ABCG2 c.421C>A polymorphism based on PBPK analysis of Rosuvastatin. Futatsugi A, Toshimoto K, Yoshikado T, Sugiyama Y, Kato Y. PubMed
  • Drug Metab Dispos. 2018;46:758-769. Prediction of the effects of renal impairment on clearance for organic cation drugs that undergo renal secretion: a simulation-based study. Follman KE, Morris ME. PubMed

Drug Metabolism and Disposition (May 2018): Symposium Report

  • Drug Metab Dispos. 2018;46:503-513. Physiological regulation of drug metabolism and transport: pregnancy, microbiome, inflammation, infection, and fasting. Morgan ET, Dempsey JL, Mimche SM, Lamb TJ, Kulkarni S, Cui JY, Jeong H, Slitt AL. PubMed