Catherine PASTOR GROUP  SITE

Catherine Pastor received her MD in 1989 and her PhD on "The modifications of hepatic circulation and functions during sepsis: role of nitric oxide" in 1995 at the University of Paris V in France. Between 1992 and 1994, she studied the role of hepatic nitric oxide in the regulatory functions of the liver in the Department of Surgery at the University Hospital of Pittsburgh (US). Since then, she has been appointed director of a research laboratory at the University Hospital of Geneva in Switzerland. In 2013, she became Professor at the medical University Paris-Diderot in France.

Her research topics focused on the physiopathology of diseases in Gastroenterology and Hepatology, including acute pancreatitis and regulation of perfusion and functions in liver diseases, septic shock, and liver transplantation. More recently, she investigated the pharmacology of hepatobiliary drugs, contrast agents, and tracers that enter into hepatocytes through the sinusoidal transporters OATPs and are excreted into bile by transport through the canalicular transporter MRP2. Understanding the hepatocyte pharmacokinetics of hepatobiliary compounds in human and experimental diseases will remain her main research topic in the future.

The main experimental model she uses for these investigations is the isolated and perfused rat liver preparation. The set-up (photo) includes a gamma counter placed over rat liver lobe to measure count rates of labeled drugs ([153Gd]BOPTA and [99mTc]mebrofenin) that can be converted into concentrations. How she assesses concentrations in each liver compartment can be found at PubMed

  • Drug Metab Dispos. 2019;47:412-418. Hepatocyte concentrations of imaging compounds associated with transporter inhibition: evidence in perfused rat livers. Bonnaventure P, Cusin F, Pastor CM. PubMed
  • Contrast Media Mol Imaging. 2018:2487405. Liver imaging and hepatobiliary contrast media. Pastor CM, Langer O, Van Beers BE. PubMed
  • Contrast Media Mol Imaging. Isolated perfused rat livers to quantify the pharmacokinetics and concentrations of Gd-BOPTA. Pastor CM. PubMed
  • Clin Sci (Lond). 2018;132:813-824. Quantification of hepatic perfusion and hepatocyte function with dynamic gadoxetic acid-enhanced MRI in patients with chronic liver disease. Leporq B, Daire JL, Pastor CM, Deltenre P, Sempoux C, Schmidt S, Van Beers BE. PubMed
  • Basic Clin Pharmacol Toxicol. 2017; 120, 171-178. Hepatocyte concentrations of indocyanine green reflect transfer rates across membrane transporters. Cusin F, Fernandes Azevedo L, Bonnaventure P, Desmeules J, Daali Y, Pastor CM. PubMed
  • Eur J Drug Metab Pharmacokinet. 2017;42:657-667. Liver perfusion modifies Gd-DTPA and Gd-BOPTA hepatocyte concentrations through transfer clearances across sinusoidal membranes. Daire JL, Leporq B, Vilgrain V, Van Beers BE, Schmidt S, Pastor CM. PubMed
  • Eur Radiol. 2017;27:1804-1811. Gadoxetate-enhanced MR imaging and compartmental modelling to assess hepatocyte bidirectional transport function in rats with advanced liver fibrosis. Giraudeau C, Leporq B, Doblas S, Lagadec M, Pastor CM, Daire JL, Van Beers BE. PubMed
  • Contrast Media Mol Imaging. 2016;11:291-8. How transfer rates generate Gd-BOPTA concentrations in rat liver compartments: implications for clinical liver imaging with hepatobiliary contrast agents. Pastor CM. PubMed
  • J Hepatol. 2016;64:708-16. Insights into the diagnosis of hepatocellular carcinomas with hepatobiliary MRI. Vilgrain V, Van Beers BE, Pastor CM. PubMed
  • Int J Mol Sci. 2015;16:135-47. Quantification of drug transport function across the multiple resistance-associated protein 2 (Mrp2) in rat livers. Bonnaventure P, Pastor CM. PubMed
  • Radiology. 2015;274:379-86. Advanced fibrosis: Correlation between pharmacokinetic parameters at dynamic gadoxetate-enhanced MR imaging and hepatocyte organic anion transporter expression in rat liver. Lagadec M, Doblas S, Giraudeau C, Ronot M, Lambert SA, Fasseu M, Paradis V, Moreau R, Pastor CM, Vilgrain V, Daire JL, Van Beers BE. PubMed
  • Drug Metab Dispos. 2014;42:675-84. The role of organic anion transporters in diagnosing liver diseases by magnetic resonance imaging. Pastor CM, Müllhaupt B, Stieger B. PubMed
  • Drug Metab Dispos. 2013;41:1548-56. Evidence of drug-drug interactions through uptake and efflux transport systems in rat hepatocytes: implications for cellular concentrations of competing drugs. Daali Y, Millet P, Dayer P, Pastor CM. PubMed
  • Contrast Media Mol Imaging. 2013;8:147-56. Concentrations of Gd-BOPTA in cholestatic fatty rat livers: role of transport functions through membrane proteins. Pastor CM, Wissmeyer M, Millet P. PubMed
  • J Hepatol. 2012;57:421-9. Primovist, Eovist: what to expect? Van Beers BE, Pastor CM, Hussain HK. PubMed
  • J Pharmacol Exp Ther. 2011;336:624-32. How organic anions accumulate in hepatocytes lacking Mrp2: evidence in rat liver. Millet P, Moulin M, Stieger B, Daali Y, Pastor CM. PubMed
  • Radiology. 2010;257:589. Gadoxetic acid-enhanced hepatobiliary phase MR imaging: cellular insight. Pastor CM. PubMed
  • Invest Radiol. 2007;42:513-21.Model-based analysis of Gd-BOPTA-induced MR signal intensity changes in cirrhotic rat livers. Planchamp C, Gex-Fabry M, Becker CD, Pastor CM. PubMed
  • Mol Pharmacol. 2007;71:1089-97. Function of both sinusoidal and canalicular transporters controls the concentration of organic anions within hepatocytes. Planchamp C, Hadengue A, Stieger B, Bourquin J, Vonlaufen A, Frossard JL, Quadri R, Becker CD, Pastor CM. PubMed
  • Invest Radiol. 2005;40:705-14. Quantification of Gd-BOPTA uptake and biliary excretion from dynamic magnetic resonance imaging in rat livers: model validation with 153Gd-BOPTA. Planchamp C, Pastor CM, Balant L, Becker CD, Terrier F, Gex-Fabry M. PubMed
  • Appl Radiat Isot. 2005;62:943-9. Direct evidence of the temperature dependence of Gd-BOPTA transport in the intact rat liver. Planchamp C, Beyer GJ, Slosman DO, Terrier F, Pastor CM. PubMed
  • Invest Radiol. 2005;40:187-94. Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat livers. Planchamp C, Montet X, Frossard JL, Quadri R, Stieger B, Meier PJ, Ivancevic MK, Vallée JP, Terrier F, Pastor CM. PubMed
  • Invest Radiol. 2004;39:506-15. Gd-BOPTA transport into rat hepatocytes: pharmacokinetic analysis of dynamic magnetic resonance images using a hollow-fiber bioreactor. Planchamp C, Gex-Fabry M, Dornier C, Quadri R, Reist M, Ivancevic MK, Vallée JP, Pochon S, Terrier F, Balant L, Stieger B, Meier PJ, Pastor CM. PubMed
  • Biotechnol Bioeng. 2004;85:656-65. Hollow fiber bioreactor: new development for the study of contrast agent transport into hepatocytes by magnetic resonance imaging. Planchamp C, Ivancevic MK, Pastor CM, Vallée JP, Pochon S, Terrier F, Mayer JM, Reist M. PubMed
  • Radiology. 2003;229:119-25. Kinetics of gadobenate dimeglumine in isolated perfused rat liver: MR imaging evaluation. Pastor CM, Planchamp C, Pochon S, Lorusso V, Montet X, Mayer J, Terrier F, Vallée JP. PubMed

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Geneva, Switzerland

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Last update: August 2021