IMI TRISTAN: Translational imaging methods in drug safety assessment

Noninvasive preclinical and clinical imaging of liver transporter function relevant to drug-induced liver injury in Drug-induced liver toxicity (2018)    PDF

  • Mol Pharm. 2021;18:2997-3009. Physiologically based pharmacokinetic modeling of transporter-mediated hepatic disposition of imaging biomarker Gadoxetate in rats. Scotcher D, Melillo N, Tadimalla S, Darwich AS, Ziemian S, Ogungbenro K, Schütz G, Sourbron S, Galetin A. PubMed
  • Magn Reson Imaging. 2019;59:121-129. Repeatability and reproducibility of longitudinal relaxation rate in 12 small-animal MRI systems. Waterton JC, Hines CDG, Hockings PD, Laitinen I, Ziemian S, Campbell S, Gottschalk M, Green C, Haase M, Hassemer K, Juretschke HP, Koehler S, Lloyd W, Luo Y, Mahmutovic Persson I, O'Connor JPB, Olsson LE, Pindoria K, Schneider JE, Sourbron S, Steinmann D, Strobel K, Tadimalla S, Teh I, Veltien A, Zhang X, Schütz G. PubMed
  • Alzheimers Dement (Amst). 2019;11:191-204. Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration. Smith EE, Biessels GJ, De Guio F, de Leeuw FE, Duchesne S, Düring M, Frayne R, Ikram MA, Jouvent E, MacIntosh BJ, Thrippleton MJ, Vernooij MW, Adams H, Backes WH, Ballerini L, Black SE, Chen C, Corriveau R, DeCarli C, Greenberg SM, Gurol ME, Ingrisch M, Job D1, Lam BYK, Launer LJ, Linn J, McCreary CR, Mok VCT, Pantoni L, Pike GB, Ramirez J, Reijmer YD, Romero JR, Ropele S, Rost NS, Sachdev PS, Scott CJM, Seshadri S, Sharma M, Sourbron S, Steketee RME, Swartz RH, van Oostenbrugge R, van Osch M, van Rooden S, Viswanathan A, Werring D, Dichgans M, Wardlaw JM. PubMed
  • Nephrol Dial Transplant. 2018;33:ii4-ii14. Magnetic resonance imaging biomarkers for chronic kidney disease: a position paper from the European Cooperation in Science and Technology Action PARENCHIMA. Selby NM, Blankestijn PJ, Boor P, Combe C, Eckardt KU, Eikefjord E, Garcia-Fernandez N, Golay X, Gordon I, Grenier N, Hockings PD, Jensen JD, Joles JA, Kalra PA, Krämer BK, Mark PB, Mendichovszky IA, Nikolic O, Odudu A, Ong ACM, Ortiz A, Pruijm M, Remuzzi G, Rørvik J, de Seigneux S, Simms RJ, Slatinska J, Summers P, Taal MW, Thoeny HC, Vallée JP, Wolf M, Caroli A, Sourbron S. PubMed
  • J Belg Soc Radiol. 2018;102:40. DCE-MRI for early prediction of response in hepatocellular carcinoma after TACE and Sorafenib therapy: A pilot study. Saito K, Ledsam J, Sugimoto K, Sourbron S, Araki Y, Tokuuye K. PubMed
  • Diagnostics (Basel). 2018;8(1). pii: E3. Renal cell carcinoma perfusion before and after radiofrequency ablation measured with Dynamic Contrast Enhanced MRI: a pilot study. Wah TM, Sourbron S, Wilson DJ, Magee D, Gregory WM, Selby PJ, Buckley DL. PubMed
  • Acta Radiol. 2017;58:748-757. Dynamic contrast-enhanced MRI measurement of renal function in healthy participants. Eikefjord E, Andersen E, Hodneland E, Hanson EA, Sourbron S, Svarstad E, Lundervold A, Rørvik JT. PubMed
  • Magn Reson Med. 2017;77:2414-2423. Comparison of linear and nonlinear implementation of the compartmental tissue uptake model for dynamic contrast-enhanced MRI. Kallehauge JF, Sourbron S, Irving B, Tanderup K, Schnabel JA, Chappell MA. PubMed
  • J Magn Reson Imaging. 2017;45:1177-1185. Diagnostic accuracy of intracellular uptake rates calculated using dynamic Gd-EOB-DTPA-enhanced MRI for hepatic fibrosis stage. Juluru K, Talal AH, Yantiss RK, Spincemaille P, Weidman EK, Giambrone AE, Jalili S, Sourbron SP, Dyke JP. PubMed
  • BMC Med Imaging. 2016;16:7. An open source software for analysis of dynamic contrast enhanced magnetic resonance images: UMMPerfusion revisited. Zöllner FG, Daab M, Sourbron SP, Schad LR, Schoenberg SO, Weisser G. PubMed
  • Magn Reson Med. 2016;76:998-1006. Fitting the two-compartment model in DCE-MRI by linear inversion. Flouri D, Lesnic D, Sourbron SP. PubMed
  • Invest Radiol. 2015;50:584-93. Fifty years of technological innovation: potential and limitations of current technologies in abdominal Magnetic Resonance Imaging and Computed Tomography. Attenberger UI, Morelli J, Budjan J, Henzler T, Sourbron S, Bock M, Riffel P, Hernando D, Ong MM, Schoenberg SO. PubMed
  • IEEE Trans Med Imaging. 2014;33:935-46. A tracer-kinetic field theory for medical imaging. Sourbron S. PubMed
  • Cancer Imaging. 2013;13:557-66. In vivo monitoring of sorafenib therapy effects on experimental prostate carcinomas using dynamic contrast-enhanced MRI and macromolecular contrast media. Cyran CC, Schwarz B, Paprottka PM, Sourbron S, von Einem JC, Dietrich O, Hinkel R, Clevert DA, Bruns CJ, Reiser MF, Nikolaou K, Wintersperger BJ. PubMed
  • J Magn Reson Imaging. 2014;40:457-66. Diagnostic accuracy of dynamic gadoxetic-acid-enhanced MRI and PET/CT compared in patients with liver metastases from neuroendocrine neoplasms. Armbruster M, Zech CJ, Sourbron S, Ceelen F, Auernhammer CJ, Rist C, Haug A, Singnurkar A, Reiser MF, Sommer WH. PubMed
  • Invest Radiol. 2014;49:7-14. Evaluation of neuroendocrine liver metastases: a comparison of dynamic contrast-enhanced magnetic resonance imaging and positron emission tomography/computed tomography. Armbruster M, Sourbron S, Haug A, Zech CJ, Ingrisch M, Auernhammer CJ, Nikolaou K, Paprottka PM, Rist C, Reiser MF, Sommer WH. PubMed
  • Eur Radiol. 2014;24:112-9. Measuring hepatic functional reserve using low temporal resolution Gd-EOB-DTPA dynamic contrast-enhanced MRI: a preliminary study comparing galactosyl human serum albumin scintigraphy with indocyanine green retention. Saito K, Ledsam J, Sourbron S, Hashimoto T, Araki Y, Akata S, Tokuuye K. PubMed
  • NMR Biomed. 2013;26:1004-27. Classic models for dynamic contrast-enhanced MRI. Sourbron SP, Buckley DL. PubMed
  • J Pharmacokinet Pharmacodyn. 2013;40:281-300. Tracer-kinetic modeling of dynamic contrast-enhanced MRI and CT: a primer. Ingrisch M, Sourbron S. PubMed
  • J Magn Reson Imaging. 2013;37:1109-14. Assessing liver function using dynamic Gd-EOB-DTPA-enhanced MRI with a standard 5-phase imaging protocol. Saito K, Ledsam J, Sourbron S, Otaka J, Araki Y, Akata S, Tokuuye K. PubMed
  • J Digit Imaging. 2013;26:344-52. UMM Perfusion: an open source software tool towards quantitative MRI perfusion analysis in clinical routine. Zöllner FG, Weisser G, Reich M, Kaiser S, Schoenberg SO, Sourbron SP, Schad LR. PubMed
  • Radiology. 2012;263(3):874-83. Combined quantification of liver perfusion and function with dynamic gadoxetic acid-enhanced MR imaging. Sourbron S, Sommer WH, Reiser MF, Zech CJ. PubMed
  • Phys Med Biol. 2012;57:3609-28. The Akaike information criterion in DCE-MRI: does it improve the haemodynamic parameter estimates? Luypaert R, Ingrisch M, Sourbron S, de Mey J. PubMed
  • Phys Med Biol. 2012;57:R1-33.  Tracer kinetic modelling in MRI: estimating perfusion and capillary permeability. Sourbron SP, Buckley DL. PubMed
  • J Magn Reson Imaging. 2011;34:595-607. Comparison of Gd-DTPA and Gd-BOPTA for studying renal perfusion and filtration. Notohamiprodjo M, Pedersen M, Glaser C, Helck AD, Lodemann KP, Jespersen B, Fischereder M, Reiser MF, Sourbron SP. PubMed
  • Abdom Imaging. 2012;37:164-79. Contrast agents as a biological marker in magnetic resonance imaging of the liver: conventional and new approaches. Sommer WH, Sourbron S, Huppertz A, Ingrisch M, Reiser MF, Zech CJ. PubMed
  • Magn Reson Med. 2011;65:1491-7. Validity of perfusion parameters obtained using the modified Tofts model: a simulation study. Luypaert R, Sourbron S, de Mey J. PubMed
  • Magn Reson Med. 2011;66:735-45. On the scope and interpretation of the Tofts models for DCE-MRI. Sourbron SP, Buckley DL. PubMed
  • Phys Med Biol. 2010;55:6431-43. Error estimation for perfusion parameters obtained using the two-compartment exchange model in dynamic contrast-enhanced MRI: a simulation study. Luypaert R, Sourbron S, Makkat S, de Mey J. PubMed


Sheffield (United Kingdom)


Last update: August 2021