Andreas GEIER GROUP  SITE

  • Expert Rev Clin Pharmacol. 2021;In press. An update on drug development for the treatment of non-alcoholic fatty liver disease - from ongoing clinical trials to future therapy. Rau M, Geier A. PubMed
  • Br J Pharmacol. 2019;176:787-800. Epigenetic events involved in organic cation transporter 1-dependent impaired response of hepatocellular carcinoma to sorafenib. Al-Abdulla R, Lozano E, Macias RIR, Monte MJ, Briz O, O'Rourke CJ, Serrano MA, Banales JM, Avila MA, Martinez-Chantar ML, Geier A, Andersen JB, Marin JJG. PubMed
  • Biochim Biophys Acta Mol Basis Dis. 2019;1865:943-953. Animal models of NAFLD from a hepatologist's point of view. Jahn D, Kircher S, Hermanns HM, Geier A. PubMed
  • Gut. 2018;67:1565-1567. Manipulation of the gut-liver axis by interruption of bile acid recirculation: an option for the treatment of sclerosing cholangitis? Jahn D, Marzioni M, Geier A. PubMed
  • Hepatology. 2017;In press. Bile acids in nonalcoholic steatohepatitis: Pathophysiological driving force or innocent bystanders? Jahn D, Geier A. PubMed
  • Expert Opin Drug Metab Toxicol. 2017;13:625-640. Changes in drug transport and metabolism and their clinical implications in non-alcoholic fatty liver disease. Dietrich CG, Rau M, Jahn D, Geier A. PubMed
  • Expert Rev Clin Pharmacol. 2017;10:467-469. Emerging therapies for NASH - the future is now. Geier A, Rau M. PubMed
  • Oncotarget. 2017;8:15846-15857. The lack of the organic cation transporter OCT1 at the plasma membrane of tumor cells precludes a positive response to sorafenib in patients with hepatocellular carcinoma. Geier A, Macias RI, Bettinger D, Weiss J, Bantel H, Jahn D, Al-Abdulla R, Marin JJ. PubMed
  • Hepatology. 2017;66:666-667. The ABCB4 p.T175A variant as potential modulator of hepatic fibrosis in patients with chronic liver diseases: Looking beyond the cholestatic realm. Krawczyk M1, Rau M, Grünhage F, Schattenberg JM, Bantel H, Pathil A, Demir M, Kluwe J, Boettler T, Geier A, Lammert F; NAFLD Clinical Study Group (NAFLD CSG). PubMed
  • PLoS One. 2016;11:e0166956. Role of PTEN in oxidative stress and DNA damage in the liver of whole-body Pten haplodeficient mice. Bankoglu EE, Tschopp O, Schmitt J, Burkard P, Jahn D, Geier A, Stopper H. PubMed
  • J Lipid Res. 2017;58:247-255. Combined effects of the TM6SF2 rs58542926, PNPLA3 rs738409 and MBOAT7 rs641738 variants on NAFLD severity: multicentre biopsy-based study. Krawczyk M, Rau M, Schattenberg JM, Bantel H, Pathil A, Demir M, Kluwe J, Boettler T, Lammert F, Geier A. PubMed
  • Inflamm Bowel Dis. 2016;22:2382-9. Alterations in enterohepatic Fgf15 signaling and changes in bile acid composition depend on localization of murine intestinal inflammation. Rau M, Stieger B, Monte MJ, Schmitt J, Jahn D, Frey-Wagner I, Raselli T, Marin JJ, Müllhaupt B, Rogler G, Geier A. PubMed
  • PLoS One. 2016;11:e0158512. Influence of Ribavirin serum levels on outcome of antiviral treatment and anemia in hepatitis C virus infection. Kuntzen T, Kuhn S, Kuntzen D, Seifert B, Müllhaupt B, Geier A. PubMed
  • Scand J Gastroenterol. 2016;51:1263-8. Feasibility of liver stiffness measurement in morbidly obese patients undergoing bariatric surgery using XL probe. Weiss J, Rau M, Meertens J, Hering I, Reichert L, Kudlich T, Koschker AK, Jurowich C, Geier A. PubMed
  • Dig Dis. 2016;34:356-63. Non-alcoholic steatohepatitis: from pathophysiology to novel therapies. Jahn D, Rau M, Wohlfahrt J, Hermanns HM, Geier A. PubMed
  • Clin Nucl Med. 2016;41:490-1. IMAGING. Recurrent extrahepatic hepatocellular carcinoma detected by 18F-Choline PET/CT. Lapa C, Schmid JS, Weiss J, Geier A, Götze O. PubMed
  • World J Gastroenterol. 2016;22:72-88. Molecular changes in hepatic metabolism and transport in cirrhosis and their functional importance. Dietrich CG, Götze O, Geier A. PubMed
  • Cytokine Growth Factor Rev. 2015;26:625-35.  Mechanisms of enterohepatic fibroblast growth factor 15/19 signaling in health and disease. Jahn D, Rau M, Hermanns HM, Geier A. PubMed
  • Expert Opin Drug Metab Toxicol. 2014;10:1533-51. Effect of drug transporter pharmacogenetics on cholestasis. Dietrich CG, Geier A. PubMed
  • Am J Physiol. 2014;307:G673-88. Downregulation of duodenal SLC transporters and activation of proinflammatory signaling constitute the early response to high altitude in humans. Wojtal KA, Cee A, Lang S, Götze O, Frühauf H, Geier A, Pastor-Anglada M, Torres-Torronteras J, Martí R, Fried M, Lutz TA, Maggiorini M, Gassmann M, Rogler G, Vavricka SR. PubMed
  • Hepatology. 2013;58:2153-62. Adaptation of iron transport and metabolism to acute high-altitude hypoxia in mountaineers. Goetze O, Schmitt J, Spliethoff K, Theurl I, Weiss G, Swinkels DW, Tjalsma H, Maggiorini M, Krayenbühl P, Rau M, Fruehauf H, Wojtal KA, Müllhaupt B, Fried M, Gassmann M, Lutz T, Geier A. PubMed
  • Hepatology. 2013;57:1394-406. Free fatty acids repress small heterodimer partner (SHP) activation and adiponectin counteracts bile acid-induced liver injury in superobese patients with nonalcoholic steatohepatitis. Bechmann LP, Kocabayoglu P, Sowa JP, Sydor S, Best J, Schlattjan M, Beilfuss A, Schmitt J, Hannivoort RA, Kilicarslan A, Rust C, Berr F, Tschopp O, Gerken G, Friedman SL, Geier A, Canbay A. PubMed
  • J Hepatol. 2013;58:669-75. Impact of genetic SLC28 transporter and ITPA variants on ribavirin serum level, hemoglobin drop and therapeutic response in patients with HCV infection. Rau M, Stickel F, Russmann S, Manser CN, Becker PP, Weisskopf M, Schmitt J, Dill MT, Dufour JF, Moradpour D, Semela D, Müllhaupt B, Geier A; Swiss Hepatitis C Cohort Study Group (SCCS). PubMed
  • Viruses. 2012;4:3281-302. Host genetic variants in the pathogenesis of hepatitis C. Rau M, Baur K, Geier A. PubMed
  • Mutagenesis. 2012;27:567-72. Genetic variations in bile acid homeostasis are not overrepresented in alcoholic cirrhosis compared to patients with heavy alcohol abuse and absent liver disease. Many N, Stickel F, Schmitt J, Stieger B, Soyka M, Frei P, Götze O, Müllhaupt B, Geier A. PubMed
  • Eur J Cell Biol. 2012;91:533-41. Rat Mrp2 gene expression is regulated by an interleukin-1β-stimulated biphasic response with enhanced transcription and subcellular shuttling of YB-1. Mertens PR, Martin IV, Frye BC, Rauen T, Strauch S, Pabst M, Geier A. PubMed
  • Int J Cancer. 2011;129:546-52. Downregulation of breast cancer resistance protein in colon adenomas reduces cellular xenobiotic resistance and leads to accumulation of a food-derived carcinogen. Dietrich CG, Vehr AK, Martin IV, Gassler N, Rath T, Roeb E, Schmitt J, Trautwein C, Geier A. PubMed
  • Expert Opin Drug Metab Toxicol. 2011;7:411-25. Genetic variations of bile salt transporters as predisposing factors for drug-induced cholestasis, intrahepatic cholestasis of pregnancy and therapeutic response of viral hepatitis. Stieger B, Geier A. PubMed
  • Clin Sci (Lond). 2011;120:287-96. A common polymorphism in the ABCB11 gene is associated with advanced fibrosis in hepatitis C but not in non-alcoholic fatty liver disease. Iwata R, Baur K, Stieger B, Mertens JC, Daly AK, Frei P, Braun J, Vergopoulos A, Stickel F, Sabrane K, Martin IV, Schmitt J, Goetze O, Day CP, Müllhaupt B, Geier A; Swiss Hepatitis C Cohort Study Group. PubMed
  • J Viral Hepat. 2011;18:768-78. The role of bile acid retention and a common polymorphism in the ABCB11 gene as host factors affecting antiviral treatment response in chronic hepatitis C. Iwata R, Stieger B, Mertens JC, Müller T, Baur K, Frei P, Braun J, Vergopoulos A, Martin IV, Schmitt J, Goetze O, Bibert S, Bochud PY, Müllhaupt B, Berg T, Geier A; Swiss Hepatitis C Cohort Study Group. PubMed
  • Biol Chem. 2010;391:1441-9. Bile acid retention and activation of endogenous hepatic farnesoid-X-receptor in the pathogenesis of fatty liver disease in ob/ob-mice. Martin IV, Schmitt J, Minkenberg A, Mertens JC, Stieger B, Mullhaupt B, Geier A. PubMed
  • Am J Physiol. 2008;295:G226-33. Hepatocyte nuclear factor-4alpha is a central transactivator of the mouse Ntcp gene. Geier A, Martin IV, Dietrich CG, Balasubramaniyan N, Strauch S, Suchy FJ, Gartung C, Trautwein C, Ananthanarayanan M. PubMed
  • Liver Int. 2007;27:1056-65. Extrahepatic cholestasis downregulates Oatp1 by TNF-alpha signalling without affecting Oatp2 and Oatp4 expression and sodium-independent bile salt uptake in rat liver. Geier A, Dietrich CG, Trauner M, Gartung C. PubMed
  • Am J Physiol. 2007;293:G585-90. Fasting induces basolateral uptake transporters of the SLC family in the liver via HNF4alpha and PGC1alpha. Dietrich CG, Martin IV, Porn AC, Voigt S, Gartung C, Trautwein C, Geier A. PubMed
  • Biochim Biophys Acta. 2007;1773:283-308. Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration. Geier A, Wagner M, Dietrich CG, Trauner M. PubMed
  • J Hepatol. 2005;43:1021-30. Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat. Geier A, Dietrich CG, Grote T, Beuers U, Prüfer T, Fraunberger P, Matern S, Gartung C, Gerbes AL, Bilzer M. PubMed
  • Am J Physiol. 2005;289:G798-805. Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver. Zollner G, Wagner M, Fickert P, Geier A, Fuchsbichler A, Silbert D, Gumhold J, Zatloukal K, Kaser A, Tilg H, Denk H, Trauner M. PubMed
  • Am J Physiol. 2005;289:G831-41. Cytokine-dependent regulation of hepatic organic anion transporter gene transactivators in mouse liver. Geier A, Dietrich CG, Voigt S, Ananthanarayanan M, Lammert F, Schmitz A, Trauner M, Wasmuth HE, Boraschi D, Balasubramaniyan N, Suchy FJ, Matern S, Gartung C. PubMed
  • Hepatology. 2005;41:470-7.Cytokine-independent repression of rodent Ntcp in obstructive cholestasis. Geier A, Zollner G, Dietrich CG, Wagner M, Fickert P, Denk H, van Rooijen N, Matern S, Gartung C, Trauner M. PubMed
  • Biochem Biophys Res Commun. 2004;322:232-8. Interleukin-6 regulates hepatic transporters during acute-phase response. Siewert E, Dietrich CG, Lammert F, Heinrich PC, Matern S, Gartung C, Geier A. PubMed
  • Gut. 2003;52:1788-95. ABC of oral bioavailability: transporters as gatekeepers in the gut. Dietrich CG, Geier A, Oude Elferink RP. PubMed
  • Biochem Biophys Res Commun. 2003;309:612-8. Constitutive rat multidrug-resistance protein 2 gene transcription is down-regulated by Y-box protein 1. Geier A, Mertens PR, Gerloff T, Dietrich CG, En-Nia A, Kullak-Ublick GA, Karpen SJ, Matern S, Gartung C. PubMed
  • Hepatology. 2003;38:345-54. Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis. Geier A, Dietrich CG, Voigt S, Kim SK, Gerloff T, Kullak-Ublick GA, Lorenzen J, Matern S, Gartung C. PubMed
  • Biochim Biophys Acta. 2003;1609:87-94. Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat. Geier A, Dietrich CG, Gerloff T, Haendly J, Kullak-Ublick GA, Stieger B, Meier PJ, Matern S, Gartung C. PubMed
  • Eur J Biochem. 2002;269:3495-503. Functional analysis of the rat bile salt export pump gene promoter. Gerloff T, Geier A, Roots I, Meier PJ, Gartung C. PubMed
  • J Hepatol. 2002;37:198-205. Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride. Geier A, Kim SK, Gerloff T, Dietrich CG, Lammert F, Karpen SJ, Stieger B, Meier PJ, Matern S, Gartung C. PubMed
  • J Hepatol. 2002;36:718-24. Regulation of organic anion transporters in a new rat model of acute and chronic cholangitis resembling human primary sclerosing cholangitis. Geier A, Dietrich CG, Lammert F, Orth T, Mayet WJ, Matern S, Gartung C. PubMed
  • Gastroenterology. 1999;117:1408-15. Differential expression of basolateral and canalicular organic anion transporters during regeneration of rat liver. Gerloff T, Geier A, Stieger B, Hagenbuch B, Meier PJ, Matern S, Gartung C. PubMed

PubMed

Würzburg, Germany

GEIER ANDREAS.jpg

Last update: October 2021