Bhagwat PRASAD SITE

  • Drug Metab Dispos. 2021;In press. Quantitative investigation of irinotecan metabolism, transport and gut microbiome activation. Parvez MM, Basit A, Jariwala PB, Gáborik Z, Kis E, Heyward S, Redinbo MR, Prasad B. PubMed
  • Drug Metab Dispos. 2020;49:470-478. In vivo-to-in vitro extrapolation of transporter-mediated renal clearance: Relative expression factor versus relative activity factor approach. Kumar AR, Prasad B, Bhatt DK, Mathialagan S, Varma MVS, Unadkat JD. PubMed
  • J Pharm Sci. 2021;In press. Ultrasensitive quantification of drug-metabolizing enzymes and transporters in small sample volume by microflow LC-MS/MS. Ahire DS, Basit A, Karasu M, Prasad B. PubMed
  • ACS Omega. 2020;5:32939-32950. Contribution of uptake and efflux transporters to oral pharmacokinetics of furosemide. Chapa R, Li CY, Basit A, Thakur A, Ladumor MK, Sharma S, Singh S, Selen A, Prasad B. PubMed
  • Pharm Res. 2020;37:250. Physiologically based pharmacokinetic models of Probenecid and Furosemide to predict transporter mediated Drug-Drug interactions. Britz H, Hanke N, Taub ME, Wang T, Prasad B, Fernandez É, Stopfer P, Nock V, Lehr T. PubMed
  • Mol Pharm. 2020;17:4114-4124. Characterization of differential Ttssue abundance of major non-CYP enzymes in human. Basit A, Neradugomma NK, Wolford C, Fan PW, Murray B, Takahashi RH, Khojasteh SC, Smith BJ, Heyward S, Totah RA, Kelly EJ, Prasad B.  PubMed
  • J Pharm Sci. 2020;In press. P-glycoprotein substrate assessment in drug discovery: Application of modeling to bridge differential protein expression across in vitro tools. Li N, Kulkarni P, Badrinarayanan A, Kefelegn A, Manoukian R, Li X, Prasad B, Karasu M, McCarty WJ, Knutson CG, Gupta A. PubMed
  • Mol Pharmacol. 2020;98:234-242. Organic Anion Transporting Polypeptide-mediated hepatic uptake of Glucuronide metabolites of Androgens. Li CY, Gupta A, Gáborik Z, Kis E, Prasad B. PubMed
  • Drug Metab Rev. 2020:1-13. Advances in the study of drug metabolism - symposium report of the 12th Meeting of the International Society for the Study of Xenobiotics (ISSX). Russell LE, Schleiff MA, Gonzalez E, Bart AG, Broccatelli F, Hartman JH, Humphreys WG, Lauschke VM, Martin I, Nwabufo C, Prasad B, Scott EE, Segall M, Takahashi R, Taub ME, Sodhi JK. PubMed
  • Drug Metab Dispos. 2020;In press. Regional proteomic quantification of clinically relevant non-cytochrome P450 enzymes along the human small intestine. Zhang H, Wolford C, Basit A, Li AP, Fan PW, Takahashi RH, Khojasteh SC, Smith BJ, Murray BP, Thummel K, Prasad B. PubMed
  • Clin Pharmacol Ther. 2020;107:1149-1158. Normalized testosterone glucuronide (TG/AG) as a potential urinary biomarker for highly variable UGT2B17 in children 7 to 18 years. Zhang H, Basit A, Wolford C, Chen KF, Gaedigk A, Lin YS, Leeder JS, Prasad B. PubMed
  • Clin Transl Sci. 2020;13:147-156. Interrogation of CYP2D6 structural variant alleles improves the correlation between CYP2D6 genotype and CYP2D6-mediated metabolic activity. Dalton R, Lee SB, Claw KG, Prasad B, Phillips BR, Shen DD, Wong LH, Fade M, McDonald MG, Dunham MJ, Fowler DM, Rettie AE, Schuetz E, Thornton TA, Nickerson DA, Gaedigk A, Thummel KE, Woodahl EL. PubMed
  • Am J Physiol Renal Physiol. 2019;317:F805-F814. Renal secretion of hydrochlorothiazide involves organic anion transporter 1/3, organic cation transporter 2, and multidrug and toxin extrusion protein 2-K. Yin J, Wagner DJ, Prasad B, Isoherranen N, Thummel KE, Wang J. PubMed
  • AAPS J. 2019;21:88. Optimized renal transporter quantification by using Aquaporin 1 and Aquaporin 2 as anatomical markers: Application in characterizing the ontogeny of renal transporters and its correlation with hepatic transporters in paired human samples. Li CY, Hosey-Cojocari C, Basit A, Unadkat JD, Leeder JS, Prasad B. PubMed
  • Sci Rep. 2019;9:9709. A repository of protein abundance data of drug metabolizing enzymes and transporters for applications in physiologically based pharmacokinetic (PBPK) modelling and simulation. Ladumor MK, Thakur A, Sharma S, Rachapally A, Mishra S, Bobe P, Rao VK, Pammi P, Kangne H, Levi D, Balhara A, Ghandikota S, Joshi A, Nautiyal V, Prasad B, Singh S. PubMed
  • Drug Metab Dispos. 2019;47:802-808. Kidney cortical transporter expression across species using quantitative proteomics. Basit A, Radi Z, Vaidya VS, Karasu M, Prasad B. PubMed
  • J Steroid Biochem Mol Biol. 2019;191:105350. Major glucuronide metabolites of testosterone are primarily transported by MRP2 and MRP3 in human liver, intestine and kidney. Li CY, Basit A, Gupta A, Gáborik Z, Kis E, Prasad B. PubMed
  • Clin Pharmacol Ther. 2019;In press. Interindividual and regional variability in drug transporter abundance at the human Blood-Brain Barrier measured by Quantitative Targeted Proteomics. Billington S, Salphati L, Hop CECA, Chu X, Evers R, Burdette D, Rowbottom C, Lai Y, Xiao G, Humphreys WG, Nguyen TB, Prasad B, Unadkat JD. PubMed
  • Anal Chem. 2018;90:11873-11882. Targeted LC-MS/MS proteomics-based strategy to characterize in vitro models used in drug metabolism and transport studies. Xu M, Saxena N, Vrana M, Zhang H, Kumar V, Billington S, Khojasteh C, Heyward S, Unadkat JD, Prasad B. PubMed
  • Drug Metab Dispos. 2018;46:1581-1587. Physiologically relevant, humanized intestinal systems to study metabolism and transport of small molecule therapeutics. Sawant-Basak A, Rodrigues AD, Lech M, Doyonnas R, Kasaian M, Prasad B, Tsamandouras N. PubMed
  • Drug Metab Dispos. 2018;46:1441-1445. The importance of incorporating OCT2 plasma membrane expression and membrane potential in IVIVE of Metformin renal secretory clearance. Kumar V, Yin J, Billington S, Prasad B, Brown CDA, Wang J, Unadkat JD. PubMed
  • Drug Metab Lett.;12:145-152. Quantitative Proteomics reveals changes in transporter protein abundance in liver, kidney and brain of mice by pregnancy. Liao MZ, Gao C, Bhatt DK, Prasad B, Mao Q. PubMed
  • Mol Pharmacol. 2018;94:689-699. Molecular mechanisms for species differences in Organic Anion Transporter 1, OAT1: Implications for renal drug toxicity. Zou L, Stecula A, Gupta A, Prasad B, Chien HC, Yee SW, Wang L, Unadkat JD, Stahl SH, Fenner KS, Giacomini KM. PubMed
  • Drug Metab Dispos. 2018;46:189-196. Transporter expression in noncancerous and cancerous liver tissue from donors with Hepatocellular Carcinoma and Chronic Hepatitis C infection quantified by LC-MS/MS proteomics. Billington S, Ray AS, Salphati L, Xiao G, Chu X, Humphreys WG, Liao M, Lee CA, Mathias A, Hop CECA, Rowbottom C, Evers R, Lai Y, Kelly EJ, Prasad B, Unadkat JD. PubMed
  • Clin Pharmacol Ther. 2018;103:619-630. Critical issues and optimized practices in quantification of protein abundance level to determine interindividual variability in DMET proteins by LC-MS/MS proteomics. Bhatt DK, Prasad B. PubMed
  • Molecules. 2017;22. pii: E539. Harnessing Solute Carrier Transporters for precision oncology. Nyquist MD, Prasad B, Mostaghel EA. PubMed
  • J Pharm Sci. 2017;106:738-744. The promises of quantitative proteomics in Precision Medicine. Prasad B, Vrana M, Mehrotra A, Johnson K, Bhatt DK. PubMed
  • Drug Metab Dispos. 2016;44:1920-1924. Abundance of drug transporters in the human kidney cortex as quantified by quantitative targeted proteomics. Prasad B, Johnson K, Billington S, Lee C, Chung GW, Brown CD1, Kelly EJ, Himmelfarb J, Unadkat JD. PubMed
  • Clin Pharmacol Ther. 2016;100:362-70. Ontogeny of hepatic drug transporters as quantified by LC-MS/MS proteomics. Prasad B, Gaedigk A, Vrana M, Gaedigk R, Leeder JS, Salphati L, Chu X, Xiao G, Hop C, Evers R, Gan L, Unadkat JD. PubMed
  • Drug Metab Dispos. 2015;43:1872-81. Atenolol renal secretion is mediated by Human Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Proteins. Yin J, Duan H, Shirasaka Y, Prasad B, Wang J. PubMed
  • Drug Metab Dispos. 2015;43:367-74. Interspecies variability in expression of hepatobiliary transporters across human, dog, monkey, and rat as determined by quantitative proteomics. Wang L, Prasad B, Salphati L, Chu X, Gupta A, Hop CE, Evers R, Unadkat JD. PubMed
  • Drug Metab Dispos. 2015;43:284-8. Quantitative transporter proteomics by liquid chromatography with tandem mass spectrometry: addressing methodologic issues of plasma membrane isolation and expression-activity relationship. Kumar V, Prasad B, Patilea G, Gupta A, Salphati L, Evers R, Hop CE, Unadkat JD. PubMed
  • Drug Metab Dispos. 2014;42:2007-15. Role of (drug) transporters in imaging in health and disease. Stieger B, Unadkat JD, Prasad B, Langer O, Gali H. PubMed
  • Mol Pharm. 2014;11:3547-55. Protein abundance of clinically relevant multidrug transporters along the entire length of the human intestine. Drozdzik M, Gröer C, Penski J, Lapczuk J, Ostrowski M, Lai Y, Prasad B, Unadkat JD, Siegmund W, Oswald S. PubMed
  • Mol Pharm. 2014;11:2745-54. PET imaging of Oatp-mediated hepatobiliary transport of [(11)C] rosuvastatin in the rat. He J, Yu Y, Prasad B, Link J, Miyaoka RS, Chen X, Unadkat JD. PubMed
  • Drug Metab Dispos. 2014;42:1301-13. Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins. Salphati L, Chu X, Chen L, Prasad B, Dallas S, Evers R, Mamaril-Fishman D, Geier EG, Kehler J, Kunta J, Mezler M, Laplanche L, Pang J, Rode A, Soars MG, Unadkat JD, van Waterschoot RA, Yabut J, Schinkel AH, Scheer N. PubMed
  • AAPS J. 2014;16:634-48. Optimized approaches for quantification of drug transporters in tissues and cells by MRM proteomics. Prasad B, Unadkat JD. PubMed
  • Int J Proteomics. 2014;2014:451510. Comparison of Heavy Labeled (SIL) peptide versus SILAC protein internal standards for LC-MS/MS quantification of hepatic drug transporters. Prasad B, Unadkat JD. PubMed
  • Drug Metab Dispos. 2014;42:78-88. Interindividual variability in hepatic organic anion-transporting polypeptides and P-glycoprotein (ABCB1) protein expression: quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex. Prasad B, Evers R, Gupta A, Hop CE, Salphati L, Shukla S, Ambudkar SV, Unadkat JD. PubMed
  • Drug Metab Dispos. 2013;41:2225-32. Effect of gestational age on mRNA and protein expression of polyspecific organic cation transporters during pregnancy. Lee N, Hebert MF, Prasad B, Easterling TR, Kelly EJ, Unadkat JD, Wang J. PubMed
  • J Pharm Sci. 2013;102:787-93. Interindividual variability in the hepatic expression of the human breast cancer resistance protein (BCRP/ABCG2): effect of age, sex, and genotype. Prasad B, Lai Y, Lin Y, Unadkat JD. PubMed
  • Drug Metab Dispos. 2012;40:852-5. Interindividual variability in hepatic expression of the multidrug resistance-associated protein 2 (MRP2/ABCC2): quantification by liquid chromatography/tandem mass spectrometry. Deo AK, Prasad B, Balogh L, Lai Y, Unadkat JD. PubMed

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Last update: June 2021