Bruno HAGENBUCH GROUP     SITE

  • Br J Pharmacol. 2021;178:S412-S513. The concise guide to pharmacology 2021/22: Transpor-ters. Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Amarosi L, Anderson CMH, Beart PM, Broer S, Dawson PA, Hagenbuch B, Hammond JR, Inui KI, Kanai Y, Kemp S, Stewart G, Thwaites DT, Verri T. PubMed
  • J Biol Chem. 2021; 296: 100047. A clinically-relevant polymorphism in the Na+/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position. Ruggiero MJ, Malhotra S, Fenton AW, Swint-Kruse L, Karanicolas J, Hagenbuch B. PubMed
  • Drug Metab Dispos. 2020;48:1192-1198. Functional consequences of Pravastatin isomerization on OATP1B1-mediated transport. Wagner JB, Ruggiero M, Leeder JS, Hagenbuch B. PubMed
  • Med Chem Res. 2020;29:1133-1146. Rheostat positions: A new classification of protein positions relevant to pharmacogenomics. Fenton AW, Page BM, Spellman-Kruse A, Hagenbuch B, Swint-Kruse L. PubMed
  • Drug Metab Dispos. 2020;48:622-630. OATP1B3 expression and function is modulated by co-expression with OCT1, OATP1B1, and NTCP. Zhang Y, Ruggiero M, Hagenbuch B. PubMed
  • Br J Pharmacol. 2019;176:S397-S493. The concise guide of pharmacology 2019/20: Transporters. Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. PubMed
  • J Pharmacol Exp Ther. 2019;371:385-393. A Pharmacokinetic natural product-disease-drug interaction: A double hit of Silymarin and Nonalcoholic Steatohepatitis on hepatic transporters in a rat model. Montonye ML, Tian DD, Arman T, Lynch KD, Hagenbuch B, Paine MF, Clarke JD. PubMed
  • Biochem Pharmacol. 2019;168:384-391. Protein-protein interactions of drug uptake transporters that are important for liver and kidney. Zhang Y, Hagenbuch B. PubMed
  • J Agric Food Chem. 2019;67:9079-9087. Gly45 and Phe555 in transmembrane domains 1 and 10 are critical for the activation of Organic Anion Transporting Polypeptide 1B3 by Epigallocatechin Gallate. Yue M, Yang J, Jin M, Steiert B, Xiang Y, Zhang H, Hagenbuch B, Gui C. PubMed
  • Diabetes. 2019;68:271-280. Dynamic Contrast-Enhanced MRI of OATP dysfunction in diabetes. Shuboni-Mulligan DD, Parys M, Blanco-Fernandez B, Mallett CL, Schnegelberger R, Takada M, Chakravarty S, Hagenbuch B, Shapiro EM. PubMed
  • Biochem Pharmacol. 2018;156:371-384. Ligand-dependent modulation of hOCT1 transport reveals discrete ligand binding sites within the substrate translocation channel. Boxberger KH, Hagenbuch B, Lampe JN. PubMed
  • PLoS One. 2017;12:e0180257. Organic anion transporting polypeptide 1B3 can form homo- and hetero-oligomers. Zhang Y, Boxberger KH, Hagenbuch B. PubMed
  • Toxicol Sci. 2018;161:34-47. Sortilin 1 loss-of-function protects against cholestatic liver injury by attenuating hepatic bile acid accumulation in bile duct ligated mice. Li J, Woolbright BL, Zhao W, Wang Y, Matye D, Hagenbuch B, Jaeschke H, Li T. PubMed
  • Toxicol Sci. 2017;156:84-95. Organic Anion Transporting Polypeptides contribute to the disposition of perfluoroalkyl acids in humans and rats. Zhao W, Zitzow JD, Weaver Y, Ehresman DJ, Chang SC, Butenhoff JL, Hagenbuch B. PubMed  
  • F1000Res. 2016;5:2465. Recent advances in understanding hepatic drug transport. Stieger B, Hagenbuch B. PubMed 
  • Biochem Pharmacol. 2015;98:649-58. Functional expression of the 11 human Organic Anion Transporting Polypeptides in insect cells reveals that sodium fluorescein is a general OATP substrate. Patik I, Kovacsics D, Német O, Gera M, Várady G, Stieger B, Hagenbuch B, Szakács G, Özvegy-Laczka C. PubMed
  • Toxicol Sci. 2015;146:363-73. Na+/Taurocholate Cotransporting Polypeptide and Apical Sodium-Dependent Bile Acid Transporter are involved in the disposition of Perfluoroalkyl Sulfonates in humans and rats. Zhao W, Zitzow JD, Ehresman DJ, Chang SC, Butenhoff JL, Forster J, Hagenbuch B. PubMed
  • Cancer Res. 2014;74:3137-45. Influence of drug formulation on OATP1B-mediated transport of paclitaxel. Nieuweboer AJ, Hu S, Gui C, Hagenbuch B, Ghobadi Moghaddam-Helmantel IM, Gibson AA, de Bruijn P, Mathijssen RH, Sparreboom. PubMed
  • Curr Top Membr. 2014;73:205-32. Organic anion-transporting polypeptides. Stieger B, Hagenbuch B. PubMed
  • Drug Metab Dispos. 2014;42:990-5. Common drugs inhibit human organic cation transporter 1 (OCT1)-mediated neurotransmitter uptake. Boxberger KH, Hagenbuch B, Lampe JN. PubMed
  • J Nat Prod. 2013;76:368-73. Transport by OATP1B1 and OATP1B3 enhances the cytotoxicity of epigallocatechin 3-O-gallate and several quercetin derivatives. Zhang Y, Hays A, Noblett A, Thapa M, Hua DH, Hagenbuch B. PubMed
  • Mol Aspects Med. 2013;34:396-412. The SLCO (former SLC21) superfamily of transporters. Hagenbuch B, Stieger B. PubMed
  • Clin Cancer Res. 2012;18:4433-40. Influence of polymorphic OATP1B-type carriers on the disposition of docetaxel. de Graan AJ, Lancaster CS, Obaidat A, Hagenbuch B, Elens L, Friberg LE, de Bruijn P, Hu S, Gibson AA, Bruun GH, Corydon TJ, Mikkelsen TS, Walker AL, Du G, Loos WJ, van Schaik RH, Baker SD, Mathijssen RH, Sparreboom A. PubMed
  • Br J Pharmacol. 2012;165:1260-87. OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies. Roth M, Obaidat A, Hagenbuch B. PubMed
  • Toxicol Appl Pharmacol. 2011;257:23-31. Organic anion transporting polypeptides in the hepatic uptake of PBDE congeners in mice. Pacyniak E, Hagenbuch B, Klaassen CD, Lehman-McKeeman L, Guo GL. PubMed
  • Annu Rev Pharmacol Toxicol. 2012;52:135-51. The expression and function of organic anion transporting polypeptides in normal tissues and in cancer. Obaidat A, Roth M, Hagenbuch B. PubMed
  • J Pharmacol Exp Ther. 2011;339:624-32. Isolation of modulators of the liver-specific organic anion-transporting polypeptides (OATPs) 1B1 and 1B3 from Rollinia emarginata Schlecht (Annonaceae). Roth M, Araya JJ, Timmermann BN, Hagenbuch B. PubMe
  • Drug Metab Dispos. 2011;39:920-6. Interactions of green tea catechins with organic anion-transporting polypeptides. Roth M, Timmermann BN, Hagenbuch B. PubMed
  • J Membr Biol. 2010;236:279-90. Several conserved positively charged amino acids in OATP1B1 are involved in binding or translocation of different substrates. Weaver YM, Hagenbuch B. PubMed
  • Toxicol Sci. 2010;115:344-53. Mechanism of polybrominated diphenyl ether uptake into the liver: PBDE congeners are substrates of human hepatic OATP transporters. Pacyniak E, Roth M, Hagenbuch B, Guo GL. PubMed
  • Clin Pharmacol Ther. 2010;87:39-47. Drug uptake systems in liver and kidney: a historic perspective. Hagenbuch B. PubMed
  • Protein Sci. 2009;18:2298-306. Role of transmembrane domain 10 for the function of organic anion transporting polypeptide 1B1. Gui C, Hagenbuch B. PubMed
  • Am J Physiol Cell Physiol. 2009;296:C570-82. Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters. Leuthold S, Hagenbuch B, Mohebbi N, Wagner CA, Meier PJ, Stieger B. PubMed
  • Biochemistry. 2008;47:9090-7. Amino acid residues in transmembrane domain 10 of organic anion transporting polypeptide 1B3 are critical for cholecystokinin octapeptide transport. Gui C, Hagenbuch B. PubMed
  • Xenobiotica. 2008;38:778-801. Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family. Hagenbuch B, Gui C. PubMed
  • Eur J Pharmacol. 2008;584:57-65. Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Gui C, Miao Y, Thompson L, Wahlgren B, Mock M, Stieger B, Hagenbuch B. PubMed
  • Best Pract Res Clin Endocrinol Metab. 2007;21:209-21. Cellular entry of thyroid hormones by organic anion transporting polypeptides. Hagenbuch B. PubMed
  • Am J Physiol Gastrointest Liver Physiol. 2005;288:G771-8.  Identification and localization of sodium-phosphate cotransporters in hepatocytes and cholangiocytes of rat liver. Frei P, Gao B, Hagenbuch B, Mate A, Biber J, Murer H, Meier PJ, Stieger B. PubMed
  • Pflugers Arch. 2004;447:653-65. Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties. Hagenbuch B, Meier PJ. PubMed
  • Pflugers Arch. 2004;447:566-70. The sodium bile salt cotransport family SLC10. Hagenbuch B, Dawson P. PubMed
  • Curr Drug Metab. 2003;4:185-211. Drug uptake systems in liver and kidney.van Montfoort JE, Hagenbuch B, Groothuis GM, Koepsell H, Meier PJ, Meijer DK. PubMed
  • Biochim Biophys Acta. 2003;1609:1-18. The superfamily of organic anion transporting polypeptides. Hagenbuch B, Meier PJ. PubMed
  • Mol Endocrinol. 2002;16:2283-96. Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ. PubMed
  • Biochim Biophys Acta. 2002;1564:183-8. Functional characterization of the mouse organic-anion-transporting polypeptide 2. van Montfoort JE, Schmid TE, Adler ID, Meier PJ, Hagenbuch B. PubMed
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Last update: October 2021