John SCHUETZ GROUP    SITE

  • Eur J Pharm Sci. 2021;163:105854. Influence of ABC transporters on the excretion of ciprofloxacin assessed with PET imaging in mice. Eur J Pharm Sci. 2021;163:105854. Hernández-Lozano I, Wanek T, Sauberer M, Filip T, Mairinger S, Stanek J, Traxl A, Karch R, Schuetz JD, Langer O. PubMed
  • FASEB J. 2021;35:e21304. Multidrug resistance-associated protein 4 (Mrp4) is a novel genetic factor in the pathogenesis of obesity and diabetes. Donepudi AC, Lee Y, Lee JY, Schuetz JD, Manautou JE. PubMed
  • Toxicol Sci. 2020;175:301-311. Lack of Multidrug Resistance-associated Protein 4 prolongs partial hepatectomy-induced hepatic steatosis. Donepudi AC, Smith GJ, Aladelokun O, Lee Y, Toro SJ, Pfohl M, Slitt AL, Wang L, Lee JY, Schuetz JD, Manautou JE. PubMed
  • FASEB J. 2020;34:4890-4903. ABCG2 requires a single aromatic amino acid to "clamp" substrates and inhibitors into the binding pocket. Gose T, Shafi T, Fukuda Y, Das S, Wang Y, Allcock A, Gavan McHarg A, Lynch J, Chen T, Tamai I, Shelat A, Ford RC, Schuetz JD. PubMed
  • Trends Biochem Sci. 2020;45:137-148. Linker Domains: Why ABC transporters 'live in fragments no longer'. Ford RC, Marshall-Sabey D, Schuetz J. PubMed
  • Toxicol Rep. 2019;6:841-849. Lack of multidrug resistance-associated protein 4 (Mrp4) alters the kinetics of acetaminophen toxicity. Donepudi AC, Goedken MJ, Schuetz JD, E Manautou J. PubMed
  • Mol Imaging Biol. 2019;21:306-316. Influence of multidrug resistance-associated proteins on the excretion of the ABCC1 imaging probe 6-Bromo-7-[11C]Methylpurine in mice. Zoufal V, Mairinger S, Krohn M, Wanek T, Filip T, Sauberer M, Stanek J, Traxl A, Schuetz JD, Kuntner C, Pahnke J, Langer O. PubMed
  • Drug Metab Dispos. 2018;46:567-580. Beyond competitive inhibition: regulation of ABC transporters by kinases and protein-protein interactions as potential mechanisms of drug-drug interactions. Crawford RR, Potukuchi PK, Schuetz EG, Schuetz JD. PubMed
  • AAPS J. 2017;20:8. ABCB6, an ABC transporter impacting drug response and disease. Boswell-Casteel RC, Fukuda Y, Schuetz JD. PubMed
  • Int J Mol Sci. 2017;18. Obstacles to brain tumor therapy: key ABC transporters. Wijaya J, Fukuda Y, Schuetz JD. PubMed
  • Sci Rep. 2017;7:16567. A novel role for OATP2A1/SLCO2A1 in a murine model of colon cancer. Nakanishi T, Ohno Y, Aotani R, Maruyama S, Shimada H, Kamo S, Oshima H, Oshima M, Schuetz JD, Tamai I. PubMed
  • Hepatology. 2018;67:1531-1545. Zebrafish abcb11b mutant reveals strategies to restore bile excretion impaired by bile salt export pump deficiency. Ellis JL, Bove KE, Schuetz EG, Leino D, Valencia CA, Schuetz JD, Miethke A, Yin C. PubMed
  • J Pharm Sci. 2017;106:2566-2575. Investigation of the importance of Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4) in the active efflux of anionic drugs across the blood-brain barrier. Kanamitsu K, Kusuhara H, Schuetz JD, Takeuchi K, Sugiyama Y. PubMed
  • Nat Commun. 2016;7:12353. The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6. Fukuda Y, Cheong PL, Lynch J, Brighton C, Frase S, Kargas V, Rampersaud E, Wang Y, Sankaran VG, Yu B, Ney PA, Weiss MJ, Vogel P, Bond PJ, Ford RC, Trent RJ, Schuetz JD. PubMed
  • Sci Rep. 2015;5:16488. Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death. Morgan JA, Lynch J, Panetta JC, Wang Y, Frase S, Bao J, Zheng J, Opferman JT, Janke L, Green DM, Chemaitilly W, Schuetz JD. PubMed
  • Blood. 2015;126:2307-19. The ABCC4 membrane transporter modulates platelet aggregation. Cheepala SB, Pitre A, Fukuda Y, Takenaka K, Zhang Y, Wang Y, Frase S, Pestina T, Gartner TK, Jackson C, Schuetz JD. PubMed
  • Nat Commun. 2015;6:8186. Maternal bile acid transporter deficiency promotes neonatal demise. Zhang Y, Li F, Wang Y, Pitre A, Fang ZZ, Frank MW, Calabrese C, Krausz KW, Neale G, Frase S, Vogel P, Rock CO, Gonzalez FJ, Schuetz JD. PubMed
  • Cancer Res. 2015;75:3879-89. ABCG2 Transporter expression impacts group 3 medulloblastoma response to chemotherapy. Morfouace M, Cheepala S, Jackson S, Fukuda Y, Patel YT, Fatima S, Kawauchi D, Shelat AA, Stewart CF, Sorrentino BP, Schuetz JD, Roussel MF. PubMed
  • Cell Signal. 2015;27:1345-55.  PKA and actin play critical roles as downstream effectors in MRP4-mediated regulation of fibroblast migration. Sinha C, Ren A, Arora K, Moon CS, Yarlagadda S, Woodrooffe K, Lin S, Schuetz JD, Ziady AG, Naren AP. PubMed
  • Cell Metab. 2014;20:787-98. The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism. Demetz E, Schroll A, Auer K, Heim C, Patsch JR, Eller P, Theurl M, Theurl I, Theurl M, Seifert M, Lener D, Stanzl U, Haschka D, Asshoff M, Dichtl S, Nairz M, Huber E, Stadlinger M, Moschen AR, Li X, Pallweber P, Scharnagl H, Stojakovic T, März W, Kleber ME, Garlaschelli K, Uboldi P, Catapano AL, Stellaard F, Rudling M, Kuba K, Imai Y, Arita M, Schuetz JD, Pramstaller PP, Tietge UJ, Trauner M, Norata GD, Claudel T, Hicks AA, Weiss G, Tancevski I. PubMed
  • Nat Cell Biol. 2014;16:841-51. Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport. Jin D, Ni TT, Sun J, Wan H, Amack JD, Yu G, Fleming J, Chiang C, Li W, Papierniak A, Cheepala S, Conseil G, Cole SP, Zhou B, Drummond IA, Schuetz JD, Malicki J, Zhong TP. PubMed
  • Arterioscler Thromb Vasc Biol. 2014;34:751-8. Deficiency of ATP-binding cassette transporter B6 in megakaryocyte progenitors accelerates atherosclerosis in mice. Murphy AJ, Sarrazy V, Wang N, Bijl N, Abramowicz S, Westerterp M, Welch CB, Schuetz JD, Yvan-Charvet L. PubMed
  • Annu Rev Pharmacol Toxicol. 2013;53:231-53. Cyclic nucleotide compartmentalization: contributions of phosphodiesterases and ATP-binding cassette transporters. Cheepala S, Hulot JS, Morgan JA, Sassi Y, Zhang W, Naren AP, Schuetz JD. PubMed
  • J Biol Chem. 2013;288:3786-94. Multi-drug resistance protein 4 (MRP4)-mediated regulation of fibroblast cell migration reflects a dichotomous role of intracellular cyclic nucleotides. Sinha C, Ren A, Arora K, Moon CS, Yarlagadda S, Zhang W, Cheepala SB, Schuetz JD, Naren AP. PubMed
  • Annu Rev Pharmacol Toxicol. 2013;53:231-53.  Cyclic nucleotide compartmentalization: contributions of phosphodiesterases and ATP-binding cassette transporters. Cheepala S, Hulot JS, Morgan JA, Sassi Y, Zhang W, Naren AP, Schuetz JD. PubMed
  • J Biol Chem. 2012;287:24784-94. Abcb11 deficiency induces cholestasis coupled to impaired β-fatty acid oxidation in mice. Zhang Y, Li F, Patterson AD, Wang Y, Krausz KW, Neale G, Thomas S, Nachagari D, Vogel P, Vore M, Gonzalez FJ, Schuetz JD. PubMed
  • Biochem Pharmacol. 2012;83:1073-83. ABC transporters and their role in nucleoside and nucleotide drug resistance. Fukuda Y, Schuetz JD. PubMed
  • J Biol Chem. 2012;287:14456-66. Deregulated hepatic metabolism exacerbates impaired testosterone production in Mrp4-deficient mice. Morgan JA, Cheepala SB, Wang Y, Neale G, Adachi M, Nachagari D, Leggas M, Zhao W, Boyd K, Venkataramanan R, Schuetz JD. PubMed
  • J Biol Chem. 2012;287(16):12679-90. ATP-dependent mitochondrial porphyrin importer ABCB6 protects against phenylhydrazine toxicity. Ulrich DL, Lynch J, Wang Y, Fukuda Y, Nachagari D, Du G, Sun D, Fan Y, Tsurkan L, Potter PM, Rehg JE, Schuetz JD. PubMed
  • Cancer Res. 2009;69:5560-7. Cell survival under stress is enhanced by a mitochondrial ATP-binding cassette transporter that regulates hemoproteins. Lynch J, Fukuda Y, Krishnamurthy P, Du G, Schuetz JD. PubMed
  • Cancer Res. 2008;68:4983-9. Transporter-mediated protection against thiopurine-induced hematopoietic toxicity. Krishnamurthy P, Schwab M, Takenaka K, Nachagari D, Morgan J, Leslie M, Du W, Boyd K, Cheok M, Nakauchi H, Marzolini C, Kim RB, Poonkuzhali B, Schuetz E, Evans W, Relling M, Schuetz JD. PubMed
  • Cell. 2007;131:940-51. Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia. Li C, Krishnamurthy PC, Penmatsa H, Marrs KL, Wang XQ, Zaccolo M, Jalink K, Li M, Nelson DJ, Schuetz JD, Naren AP. PubMed
  • Nature. 2006;443:586-9. Identification of a mammalian mitochondrial porphyrin transporter. Krishnamurthy PC, Du G, Fukuda Y, Sun D, Sampath J, Mercer KE, Wang J, Sosa-Pineda B, Murti KG, Schuetz JD. PubMed
  • Hepatology. 2006;43:1013-21. Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis. Mennone A, Soroka CJ, Cai SY, Harry K, Adachi M, Hagey L, Schuetz JD, Boyer JL. PubMed
  • J Biol Chem. 2004;279:24218-25. The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. Krishnamurthy P, Ross DD, Nakanishi T, Bailey-Dell K, Zhou S, Mercer KE, Sarkadi B, Sorrentino BP, Schuetz JD. PubMed
  • J Biol Chem. 2004;279:22250-7. Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. Assem M, Schuetz EG, Leggas M, Sun D, Yasuda K, Reid G, Zelcer N, Adachi M, Strom S, Evans RM, Moore DD, Borst P, Schuetz JD. PubMed
  • Mol Cell Biol. 2004;24:7612-21. Mrp4 confers resistance to topotecan and protects the brain from chemotherapy. Leggas M, Adachi M, Scheffer GL, Sun D, Wielinga P, Du G, Mercer KE, Zhuang Y, Panetta JC, Johnston B, Scheper RJ, Stewart CF, Schuetz JD. PubMed
  • Proc Natl Acad Sci U S A. 2002;99:12339-44. Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo. Zhou S, Morris JJ, Barnes Y, Lan L, Schuetz JD, Sorrentino BP. PubMed
  • J Biol Chem. 2002;277:38998-9004. Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing. Adachi M, Sampath J, Lan LB, Sun D, Hargrove P, Flatley R, Tatum A, Edwards MZ, Wezeman M, Matherly L, Drake R, Schuetz J. PubMed
  • Nat Med. 2001;7:1028-34. The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Zhou S, Schuetz JD, Bunting KD, Colapietro AM, Sampath J, Morris JJ, Lagutina I, Grosveld GC, Osawa M, Nakauchi H, Sorrentino BP. PubMed
  • J Biol Chem. 2001;276:39411-8.  Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. Schuetz EG, Strom S, Yasuda K, Lecureur V, Assem M, Brimer C, Lamba J, Kim RB, Ramachandran V, Komoroski BJ, Venkataramanan R, Cai H, Sinal CJ, Gonzalez FJ, Schuetz JD. PubMed
  • J Biol Chem. 2001;276:39359-67. Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 not MRP1. Sampath J, Sun D, Kidd VJ, Grenet J, Gandhi A, Shapiro LH, Wang Q, Zambetti GP, Schuetz JD. PubMed
  • Nat Med. 1999;5:1048-51.MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs. Schuetz JD, Connelly MC, Sun D, Paibir SG, Flynn PM, Srinivas RV, Kumar A, Fridland A. PubMed

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Last update: June 2021