PHARMACOLOGY

Jörg KÖNIG

SITE

Chem Res Toxicol. 2022;35:315-325. Zebrafish Oatp1d1 acts as a cellular efflux transporter of the anionic herbicide Bromoxynil. Halbach K, Aulhorn S, Lechtenfeld OJ, Lecluse M, Leippe S, Reemtsma T, Seiwert B, Wagner S, König J, Luckenbach T. PubMed

J Pharm Sci. 2022;111:505-516. Role of uptake transporters OAT4, OATP2A1, and OATP1A2 in human placental bio-disposition of Pravastatin. Fokina VM, Patrikeeva S, Wang XM, Noguchi S, Tomi M, König J, Ahmed MS, Nanovskaya T. PubMed

Front Pharmacol. 2021;12:662535.Haberkorn B, Fromm MF, König J. Transport of drugs and endogenous compounds mediated by human OCT1: Studies in single- and double-transfected cell models.  PubMed

Pharmaceutics. 2021;13:369. Interaction of Remdesivir with clinically relevant hepatic drug uptake transporters. Nies AT, König J, Hofmann U, Kölz C, Fromm MF, Schwab M. PubMed

J Clin Med. 2020;9:3975. Transport of L-Arginine related cardiovascular risk markers. Banjarnahor S, Rodionov RN, König J, Maas R. PubMed

Amino Acids. 2020;52:975-985. Vectorial transport of the arginine derivatives asymmetric dimethylarginine (ADMA) and L-homoarginine by OATP4C1 and P-glycoprotein studied in double-transfected MDCK cells. Taghikhani E, Maas R, Taudte RV, Gessner A, Fromm MF, König J. PubMed

Pharmacol Rev. 2020;72:343-379. Solute carrier transporters as potential targets for the treatment of metabolic disease. Schumann T, König J, Henke C, Willmes DM, Bornstein SR, Jordan J, Fromm MF, Birkenfeld AL. PubMed

PLoS One. 2019;14:e0213747. The renal transport protein OATP4C1 mediates uptake of the uremic toxin asymmetric dimethylarginine (ADMA) and efflux of cardioprotective L-homoarginine. Taghikhani E, Maas R, Fromm MF, König J. PubMed

Mol Pharm. 2019;16:510-517. Interplay of the Organic Cation Transporters OCT1 and OCT2 with the apically localized export protein MATE1 for the polarized transport of Trospium. Deutsch B, Neumeister C, Schwantes U, Fromm MF, König J. PubMed

Clin Pharmacol Ther. 2019;105:1386-1394. Clinical aspects of transporter-mediated Drug-Drug Interactions. Gessner A, König J, Fromm MF. PubMed

Mol Pharm. 2018;15:3425-3433. Importance of OCT2 and MATE1 for the Cimetidine-Metformin interaction: Insights from investigations of polarized transport in single- and double-transfected MDCK cells with a focus on perpetrator disposition. Müller F, Weitz D, Mertsch K, König J, Fromm MF. PubMed

Pharmacol Rev. 2018;70:246-277. Biomarkers for in vivo assessment of transporter function. Müller F, Sharma A, König J, Fromm MF. PubMed

Mol Pharm. 2017;14:2991-2998. Contribution of MATE1 to renal secretion of the NMDA receptor antagonist Memantine. Müller F, Weitz D, Derdau V, Sandvoss M, Mertsch K, König J, Fromm MF. PubMed

Sci Rep. 2017;7:4767. The prognostic biomarker L-homoarginine is a substrate of the cationic amino acid transporters CAT1, CAT2A and CAT2B. Chafai A, Fromm MF, König J, Maas R. PubMed

Methods Mol Biol. 2017;1601:123-135. Assays for analyzing the role of transport proteins in the uptake and the vectorial transport of substances affecting cell viability. Taghikhani E, Fromm MF, König J. PubMed

Biol Chem. 2017;398:237-249. Tropane alkaloids as substrates and inhibitors of human organic cation transporters of the SLC22 (OCT) and the SLC47 (MATE) families. Chen J, Brockmöller J, Seitz T, König J, Chen X, Tzvetkov MV. PubMed

Biochim Biophys Acta. 2016;1858:2894-2902. Analysis of amino acid residues in the predicted transmembrane pore influencing transport kinetics of the hepatic drug transporter organic anion transporting polypeptide 1B1 (OATP1B1). Gruetz M, Sticht H, Glaeser H, Fromm MF, König J. PubMed

Mol Pharm. 2016;13:512-9. The nonmetabolized β-blocker Nadolol is a substrate of OCT1, OCT2, MATE1, MATE2-K, and P-Glycoprotein, but not of OATP1B1 and OATP1B3. Misaka S, Knop J, Singer K, Hoier E, Keiser M, Müller F, Glaeser H, König J, Fromm MF. PubMed

PLoS One. 2015;10:e0139370. Inhibitory effects of Green Tea and (-)-Epigallocatechin Gallate on transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein. Knop J, Misaka S, Singer K, Hoier E, Müller F, Glaeser H, König J, Fromm MF. PubMed

Biochem Pharmacol. 2013;86:808-15. Role of organic cation transporter OCT2 and multidrug and toxin extrusion proteins MATE1 and MATE2-K for transport and drug interactions of the antiviral lamivudine. Müller F, König J, Hoier E, Mandery K, Fromm MF. PubMed

Pharmacol Rev. 2013;65:944-66. Transporters and drug-drug interactions: important determinants of drug disposition and effects. König J, Müller F, Fromm MF. PubMed

Br J Pharmacol. 2013;169:21-33.  Phase I and II metabolism and MRP2-mediated export of bosentan in a MDCKII-OATP1B1-CYP3A4-UGT1A1-MRP2 quadruple-transfected cell line. Fahrmayr C, König J, Auge D, Mieth M, Münch K, Segrestaa J, Pfeifer T, Treiber A, Fromm M. PubMed

Basic Clin Pharmacol Toxicol. 2013;112:244-50. The influence of oral antidiabetic drugs on cellular drug uptake mediated by hepatic OATP family members. Klatt S, Fromm MF, König J. PubMed

Basic Clin Pharmacol Toxicol. 2012;111:81-6. Characterization of ursodeoxycholic and norursodeoxycholic acid as substrates of the hepatic uptake transporters OATP1B1, OATP1B3, OATP2B1 and NTCP. König J, Klatt S, Dilger K, Fromm MF. PubMed

Br J Pharmacol. 2012;165:1836-1847. Identification of drugs and drug metabolites as substrates of multidrug resistance protein 2 (MRP2) using triple-transfected MDCK-OATP1B1-UGT1A1-MRP2 cells. Fahrmayr C, König J, Auge D, Mieth M, Fromm MF. PubMed

Drug Metab Dispos. 2011;39:1097-102. Role of organic anion-transporting polypeptides for cellular mesalazine (5-aminosalicylic acid) uptake. König J, Glaeser H, Keiser M, Mandery K, Klotz U, Fromm MF. PubMed

Drug Metab Dispos. 2011;39:1047-53. Influence of non-steroidal anti-inflammatory drugs on organic anion transporting polypeptide (OATP) 1B1- and OATP1B3-mediated drug transport. Kindla J, Müller F, Mieth M, Fromm MF, König J. PubMed

Cancer Biol Ther. 2011;11:584-91. Expression and localization of the uptake transporters OATP2B1, OATP3A1 and OATP5A1 in non-malignant and malignant breast tissue. Kindla J, Rau TT, Jung R, Fasching PA, Strick R, Stoehr R, Hartmann A, Fromm MF, König J. PubMed

Pharmaceutics. 2011;3:680-705. Transporter-mediated drug-drug interactions with oral antidiabetic drugs. Klatt S, Fromm MF, König J. PubMed

Pharmacogenomics. 2010;11:1703-13. SLCO1B1 genetic polymorphism influences mycophenolic acid tolerance in renal transplant recipients. Michelon H, König J, Durrbach A, Quteineh L, Verstuyft C, Furlan V, Ferlicot S, Letierce A, Charpentier B, Fromm MF, Becquemont L. PubMed

Handb Exp Pharmacol. 2011;201:1-28. Uptake transporters of the human OATP family: molecular characteristics, substrates, their role in drug-drug interactions, and functional consequences of polymorphisms. König J. PubMed

Br J Pharmacol. 2011;163:546-55. Double-transfected MDCK cells expressing human OCT1/MATE1 or OCT2/MATE1: determinants of uptake and transcellular translocation of organic cations. König J, Zolk O, Singer K, Hoffmann C, Fromm MF. PubMed

Br J Pharmacol. 2010;159:698-708. Relevance of conserved lysine and arginine residues in transmembrane helices for the transport activity of organic anion transporting polypeptide 1B3. Glaeser H, Mandery K, Sticht H, Fromm MF, König J. PubMed

Drug Metab Rev. 2010;42:380-401. Hepatic OATP and OCT uptake transporters: their role for drug-drug interactions and pharmacogenetic aspects. Fahrmayr C, Fromm MF, König J. PubMed

Naunyn Schmiedebergs Arch Pharmacol. 2009;379:337-48. Structural determinants of inhibitor interaction with the human organic cation transporter OCT2 (SLC22A2). Zolk O, Solbach TF, König J, Fromm MF. PubMed

Expert Opin Drug Metab Toxicol. 2008;4:51-64. The functional consequences of genetic variations in transporter genes encoding human organic anion-transporting polypeptide family members. Seithel A, Glaeser H, Fromm MF, König J. PubMed

Life Sci. 2007;80:1490-4. Functional analysis of the polymorphism -211C>T in the regulatory region of the human ABCC3 gene. Gradhand U, Tegude H, Burk O, Eichelbaum M, Fromm MF, König J. PubMed

Drug Metab Dispos. 2007;35:779-86. The influence of macrolide antibiotics on the uptake of organic anions and drugs mediated by OATP1B1 and OATP1B3. Seithel A, Eberl S, Singer K, Auge D, Heinkele G, Wolf NB, Dörje F, Fromm MF, König J. PubMed

Naunyn Schmiedebergs Arch Pharmacol. 2006;372:432-43. Pharmacogenomics of human OATP transporters. König J, Seithel A, Gradhand U, Fromm MF. PubMed

Mol Pharmacol. 2005;68:1031-8. Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells. Kopplow K, Letschert K, König J, Walter B, Keppler D. PubMed

Pharmacogenetics. 2004;14:441-52. Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8). Letschert K, Keppler D, König J. PubMed

J Hepatol. 2003;39:693-702. Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis. Kojima H, Nies AT, König J, Hagmann W, Spring H, Uemura M, Fukui H, Keppler D. PubMed

Eur J Biochem. 2002;269:1866-76. Structural requirements for the apical sorting of human multidrug resistance protein 2 (ABCC2). Nies AT, König J, Cui Y, Brom M, Spring H, Keppler D. PubMed

Int J Cancer. 2001;94:492-9. Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma. Nies AT, König J, Pfannschmidt M, Klar E, Hofmann WJ, Keppler D. PubMed

Mol Pharmacol. 2001;60:934-43. Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2. Cui Y, König J, Keppler D. PubMed