Jörg KÖNIG    SITE

  • J Pharm Sci. 2021;In press. Role of uptake transporters OAT4, OATP2A1, and OATP1A2 in human placental bio-disposition of Pravastatin. Fokina VM, Patrikeeva S, Wang XM, Noguchi S, Tomi M, König J, Ahmed MS, Nanovskaya T. PubMed
  • Front Pharmacol. 2021;12:662535.Haberkorn B, Fromm MF, König J. Transport of drugs and endogenous compounds mediated by human OCT1: Studies in single- and double-transfected cell models.  PubMed
  • Pharmaceutics. 2021;13:369. Interaction of Remdesivir with clinically relevant hepatic drug uptake transporters. Nies AT, König J, Hofmann U, Kölz C, Fromm MF, Schwab M. PubMed
  • J Clin Med. 2020;9:3975. Transport of L-Arginine related cardiovascular risk markers. Banjarnahor S, Rodionov RN, König J, Maas R. PubMed
  • Amino Acids. 2020;52:975-985. Vectorial transport of the arginine derivatives asymmetric dimethylarginine (ADMA) and L-homoarginine by OATP4C1 and P-glycoprotein studied in double-transfected MDCK cells. Taghikhani E, Maas R, Taudte RV, Gessner A, Fromm MF, König J. PubMed
  • Pharmacol Rev. 2020;72:343-379. Solute carrier transporters as potential targets for the treatment of metabolic disease. Schumann T, König J, Henke C, Willmes DM, Bornstein SR, Jordan J, Fromm MF, Birkenfeld AL. PubMed
  • PLoS One. 2019;14:e0213747. The renal transport protein OATP4C1 mediates uptake of the uremic toxin asymmetric dimethylarginine (ADMA) and efflux of cardioprotective L-homoarginine. Taghikhani E, Maas R, Fromm MF, König J. PubMed
  • Mol Pharm. 2019;16:510-517. Interplay of the Organic Cation Transporters OCT1 and OCT2 with the apically localized export protein MATE1 for the polarized transport of Trospium. Deutsch B, Neumeister C, Schwantes U, Fromm MF, König J. PubMed
  • Clin Pharmacol Ther. 2019;105:1386-1394. Clinical aspects of transporter-mediated Drug-Drug Interactions. Gessner A, König J, Fromm MF. PubMed
  • Mol Pharm. 2018;15:3425-3433. Importance of OCT2 and MATE1 for the Cimetidine-Metformin interaction: Insights from investigations of polarized transport in single- and double-transfected MDCK cells with a focus on perpetrator disposition. Müller F, Weitz D, Mertsch K, König J, Fromm MF. PubMed
  • Pharmacol Rev. 2018;70:246-277. Biomarkers for in vivo assessment of transporter function. Müller F, Sharma A, König J, Fromm MF. PubMed
  • Mol Pharm. 2017;14:2991-2998. Contribution of MATE1 to renal secretion of the NMDA receptor antagonist Memantine. Müller F, Weitz D, Derdau V, Sandvoss M, Mertsch K, König J, Fromm MF. PubMed
  • Sci Rep. 2017;7:4767. The prognostic biomarker L-homoarginine is a substrate of the cationic amino acid transporters CAT1, CAT2A and CAT2B. Chafai A, Fromm MF, König J, Maas R. PubMed
  • Methods Mol Biol. 2017;1601:123-135. Assays for analyzing the role of transport proteins in the uptake and the vectorial transport of substances affecting cell viability. Taghikhani E, Fromm MF, König J. PubMed
  • Biol Chem. 2017;398:237-249. Tropane alkaloids as substrates and inhibitors of human organic cation transporters of the SLC22 (OCT) and the SLC47 (MATE) families. Chen J, Brockmöller J, Seitz T, König J, Chen X, Tzvetkov MV. PubMed
  • Biochim Biophys Acta. 2016;1858:2894-2902. Analysis of amino acid residues in the predicted transmembrane pore influencing transport kinetics of the hepatic drug transporter organic anion transporting polypeptide 1B1 (OATP1B1). Gruetz M, Sticht H, Glaeser H, Fromm MF, König J. PubMed
  • Mol Pharm. 2016;13:512-9. The nonmetabolized β-blocker Nadolol is a substrate of OCT1, OCT2, MATE1, MATE2-K, and P-Glycoprotein, but not of OATP1B1 and OATP1B3. Misaka S, Knop J, Singer K, Hoier E, Keiser M, Müller F, Glaeser H, König J, Fromm MF. PubMed
  • PLoS One. 2015;10:e0139370. Inhibitory effects of Green Tea and (-)-Epigallocatechin Gallate on transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein. Knop J, Misaka S, Singer K, Hoier E, Müller F, Glaeser H, König J, Fromm MF. PubMed
  • Biochem Pharmacol. 2013;86:808-15. Role of organic cation transporter OCT2 and multidrug and toxin extrusion proteins MATE1 and MATE2-K for transport and drug interactions of the antiviral lamivudine. Müller F, König J, Hoier E, Mandery K, Fromm MF. PubMed
  • Pharmacol Rev. 2013;65:944-66. Transporters and drug-drug interactions: important determinants of drug disposition and effects. König J, Müller F, Fromm MF. PubMed
  • Br J Pharmacol. 2013;169:21-33.  Phase I and II metabolism and MRP2-mediated export of bosentan in a MDCKII-OATP1B1-CYP3A4-UGT1A1-MRP2 quadruple-transfected cell line. Fahrmayr C, König J, Auge D, Mieth M, Münch K, Segrestaa J, Pfeifer T, Treiber A, Fromm M. PubMed
  • Basic Clin Pharmacol Toxicol. 2013;112:244-50. The influence of oral antidiabetic drugs on cellular drug uptake mediated by hepatic OATP family members. Klatt S, Fromm MF, König J. PubMed
  • Basic Clin Pharmacol Toxicol. 2012;111:81-6. Characterization of ursodeoxycholic and norursodeoxycholic acid as substrates of the hepatic uptake transporters OATP1B1, OATP1B3, OATP2B1 and NTCP. König J, Klatt S, Dilger K, Fromm MF. PubMed
  • Br J Pharmacol. 2012;165:1836-1847. Identification of drugs and drug metabolites as substrates of multidrug resistance protein 2 (MRP2) using triple-transfected MDCK-OATP1B1-UGT1A1-MRP2 cells. Fahrmayr C, König J, Auge D, Mieth M, Fromm MF. PubMed
  • Drug Metab Dispos. 2011;39:1097-102. Role of organic anion-transporting polypeptides for cellular mesalazine (5-aminosalicylic acid) uptake. König J, Glaeser H, Keiser M, Mandery K, Klotz U, Fromm MF. PubMed
  • Drug Metab Dispos. 2011;39:1047-53. Influence of non-steroidal anti-inflammatory drugs on organic anion transporting polypeptide (OATP) 1B1- and OATP1B3-mediated drug transport. Kindla J, Müller F, Mieth M, Fromm MF, König J. PubMed
  • Cancer Biol Ther. 2011;11:584-91. Expression and localization of the uptake transporters OATP2B1, OATP3A1 and OATP5A1 in non-malignant and malignant breast tissue. Kindla J, Rau TT, Jung R, Fasching PA, Strick R, Stoehr R, Hartmann A, Fromm MF, König J. PubMed
  • Pharmaceutics. 2011;3:680-705. Transporter-mediated drug-drug interactions with oral antidiabetic drugs. Klatt S, Fromm MF, König J. PubMed
  • Pharmacogenomics. 2010;11:1703-13. SLCO1B1 genetic polymorphism influences mycophenolic acid tolerance in renal transplant recipients. Michelon H, König J, Durrbach A, Quteineh L, Verstuyft C, Furlan V, Ferlicot S, Letierce A, Charpentier B, Fromm MF, Becquemont L. PubMed
  • Handb Exp Pharmacol. 2011;201:1-28. Uptake transporters of the human OATP family: molecular characteristics, substrates, their role in drug-drug interactions, and functional consequences of polymorphisms. König J. PubMed
  • Br J Pharmacol. 2011;163:546-55. Double-transfected MDCK cells expressing human OCT1/MATE1 or OCT2/MATE1: determinants of uptake and transcellular translocation of organic cations. König J, Zolk O, Singer K, Hoffmann C, Fromm MF. PubMed
  • Br J Pharmacol. 2010;159:698-708. Relevance of conserved lysine and arginine residues in transmembrane helices for the transport activity of organic anion transporting polypeptide 1B3. Glaeser H, Mandery K, Sticht H, Fromm MF, König J. PubMed
  • Drug Metab Rev. 2010;42:380-401. Hepatic OATP and OCT uptake transporters: their role for drug-drug interactions and pharmacogenetic aspects. Fahrmayr C, Fromm MF, König J. PubMed
  • Naunyn Schmiedebergs Arch Pharmacol. 2009;379:337-48. Structural determinants of inhibitor interaction with the human organic cation transporter OCT2 (SLC22A2). Zolk O, Solbach TF, König J, Fromm MF. PubMed
  • Expert Opin Drug Metab Toxicol. 2008;4:51-64. The functional consequences of genetic variations in transporter genes encoding human organic anion-transporting polypeptide family members. Seithel A, Glaeser H, Fromm MF, König J. PubMed
  • Life Sci. 2007;80:1490-4. Functional analysis of the polymorphism -211C>T in the regulatory region of the human ABCC3 gene. Gradhand U, Tegude H, Burk O, Eichelbaum M, Fromm MF, König J. PubMed
  • Drug Metab Dispos. 2007;35:779-86. The influence of macrolide antibiotics on the uptake of organic anions and drugs mediated by OATP1B1 and OATP1B3. Seithel A, Eberl S, Singer K, Auge D, Heinkele G, Wolf NB, Dörje F, Fromm MF, König J. PubMed
  • Naunyn Schmiedebergs Arch Pharmacol. 2006;372:432-43. Pharmacogenomics of human OATP transporters. König J, Seithel A, Gradhand U, Fromm MF. PubMed
  • Mol Pharmacol. 2005;68:1031-8. Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells. Kopplow K, Letschert K, König J, Walter B, Keppler D. PubMed
  • Pharmacogenetics. 2004;14:441-52. Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8). Letschert K, Keppler D, König J. PubMed
  • J Hepatol. 2003;39:693-702. Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis. Kojima H, Nies AT, König J, Hagmann W, Spring H, Uemura M, Fukui H, Keppler D. PubMed
  • Eur J Biochem. 2002;269:1866-76. Structural requirements for the apical sorting of human multidrug resistance protein 2 (ABCC2). Nies AT, König J, Cui Y, Brom M, Spring H, Keppler D. PubMed
  • Int J Cancer. 2001;94:492-9. Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma. Nies AT, König J, Pfannschmidt M, Klar E, Hofmann WJ, Keppler D. PubMed
  • Mol Pharmacol. 2001;60:934-43. Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2. Cui Y, König J, Keppler D. PubMed

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Erlangen, Germany

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Last update: October 2021